Obesity Medicine最新文献_第6页

Swimming exercise regulates indices of skeletal muscle glucose metabolism and attenuates cardiac inflammatory cytokines activity via IL-6/TNF-α pathway in streptozotocin-induced diabetic rats 游泳运动通过 IL-6/TNF-α 途径调节链脲佐菌素诱导的糖尿病大鼠骨骼肌葡萄糖代谢指标并减轻心脏炎症细胞因子的活性

Obesity Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.obmed.2024.100559

Idara Asuquo Okon , David Chukwunyerem Nwachukwu , Favor Akpakpan Udoeyop , Bubaraye Robson Uko , Elizabeth Bassey Umoren , Tolunigba Abisola Kolawole , Ngozi glory Amadi , Deborah melford Owaji-Teleyem , Daniel Udofia Owu

{"title":"Swimming exercise regulates indices of skeletal muscle glucose metabolism and attenuates cardiac inflammatory cytokines activity via IL-6/TNF-α pathway in streptozotocin-induced diabetic rats","authors":"Idara Asuquo Okon , David Chukwunyerem Nwachukwu , Favor Akpakpan Udoeyop , Bubaraye Robson Uko , Elizabeth Bassey Umoren , Tolunigba Abisola Kolawole , Ngozi glory Amadi , Deborah melford Owaji-Teleyem , Daniel Udofia Owu","doi":"10.1016/j.obmed.2024.100559","DOIUrl":"10.1016/j.obmed.2024.100559","url":null,"abstract":"<div><div>Diabetes mellitus (DM) manifests with impaired glucose metabolism that affects the musculoskeletal and cardiovascular systems. This study investigated the effects of swimming exercise on some indices of muscle glucose metabolism and cardiac inflammatory markers in diabetic rats induced with streptozotocin. Wistar rats of both sexes (150–200 g) were assigned into five groups of seven (7) rats. Group 1: Control (CON), Group 2: Diabetes only (DM), Group 3: Exercise only (EX), Group 4: Diabetes + Exercise (DM + EX), Group 5: Diabetes + Insulin (DM + IN). Type 1 DM was induced via intraperitoneal injection of streptozotocin (60 mg/kg). Insulin (6 IU/g) was administered (IP) to animals in group 5. Swimming exercise test was done for 27 days after which animals were euthanized. Blood samples were collected while hamstring muscles and heart were harvested and homogenized to assess biochemical parameters. The body weight, serum insulin level, muscle glucose metabolic indices (glycogen, Glut-4, CK-MB), and cardiac troponin-T were significantly (P < 0.05) decreased. In contrast, the random blood glucose, cardiac TNF-α, and IL-6 levels were increased (P < 0.05) in diabetic rats when compared with the control group. Swimming exercise regimen significantly (P < 0.05) reversed these anomalies by reducing blood glucose and cardiac inflammatory cytokines (TNF-α and IL-6) levels, improving serum insulin, muscle glycogen, and GLUT-4 expression in diabetic rats when compared to the DM group. The cardiac inflammatory cytokine levels in DM + EX were comparable to the DM + IN group. In conclusion, swimming exercise improves muscle glucose metabolism and protects the heart against cardiac inflammation in diabetic conditions.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"51 ","pages":"Article 100559"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sestrin2 at the crossroads of cardiovascular disease and diabetes: A comprehensive review 处于心血管疾病和糖尿病十字路口的 Sestrin2：全面回顾

Obesity Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.obmed.2024.100558

S. Rooban , K.A. Arul Senghor , V.M. Vinodhini , J.S. Kumar

{"title":"Sestrin2 at the crossroads of cardiovascular disease and diabetes: A comprehensive review","authors":"S. Rooban , K.A. Arul Senghor , V.M. Vinodhini , J.S. Kumar","doi":"10.1016/j.obmed.2024.100558","DOIUrl":"10.1016/j.obmed.2024.100558","url":null,"abstract":"<div><div>Cardiovascular diseases and Diabetes Mellitus are major global burdens, ranked at the highest in mortality rates; hence, there is an immediate need for new therapeutic targets. This review focuses on Sestrins and, in particular, SESN2, since it has a dual role in modulating oxidative stress and regulating cardiovascular health. Sestrins are stress-responsive proteins of great importance in cellular defense from oxidative damage, which is a key contributor to cardiovascular pathologies such as heart failure, atherosclerosis, and myocardial infarction. The last advances have shown that Sestrins participate in defense mechanisms against oxidative insults and mismanagement of metabolic and immune responses. These features place Sestrins among the valuable biomarkers and possible therapeutic targets in cardiovascular medicine. We synthesize current research relating molecular mechanisms to clinical application with a focus on the potential of Sestrins to shift treatment paradigms. In this article, we capture the translation of Sestrins for clinical use and their role in the management and disease prevention. We also outline the need for future research for the validation of this therapeutic efficacy of Sestrins across diverse populations and further characterization of their interactions within the complex network of cardiovascular pathology. Such research may, therefore, unlock novel treatment options and strategies toward managing and preventing CVD and DM in line with the urgent need for more effective intervention in the face of the rising prevalence of cardiovascular disease globally.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"51 ","pages":"Article 100558"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Effect of low-calorie ketogenic vs low-carbohydrate diets on body composition and other biomarkers of overweight/obese women: An 8 weeks randomised controlled trial” [Obes. Med. 41C (2023) 100496] 对 "低热量生酮饮食与低碳水化合物饮食对超重/肥胖女性身体成分和其他生物标志物的影响：一项为期 8 周的随机对照试验" [Obes.

Obesity Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.obmed.2024.100556

Nour Amin Elsahoryi , Refat A. Alkurd , Hadil Subih , Ruba Musharbash

引用次数: 0

Neurologic complications after bariatric surgery: An integrative review of the literature with case report 减肥手术后的神经并发症：文献综述与病例报告

Obesity Medicine Pub Date : 2024-09-13 DOI: 10.1016/j.obmed.2024.100553

Ingrid Brandão Cardoso Paz , Wallyson Pablo de Oliveira Souza , Carlos Antônio Soares de Sousa Filho , Antonione Santos Bezerra Pinto , Giuliano da Paz Oliveira

引用次数: 0

Effects of black mulberry leaf extract on liver health and metabolic parameters in rats with high-fat diet-induced liver changes 黑桑叶提取物对高脂饮食引起肝脏变化的大鼠肝脏健康和代谢参数的影响

Obesity Medicine Pub Date : 2024-09-01 DOI: 10.1016/j.obmed.2024.100554

Leyli Zahra Bahreini Boroujeni , Mohammad Mehdi Haghighat_Lari , Abolfazl Ghandi , Seyed Mahmood Hashemian , Rana Shafabakhsh , Zarrin Banikazemi , Mohsen Taghizadeh

{"title":"Effects of black mulberry leaf extract on liver health and metabolic parameters in rats with high-fat diet-induced liver changes","authors":"Leyli Zahra Bahreini Boroujeni , Mohammad Mehdi Haghighat_Lari , Abolfazl Ghandi , Seyed Mahmood Hashemian , Rana Shafabakhsh , Zarrin Banikazemi , Mohsen Taghizadeh","doi":"10.1016/j.obmed.2024.100554","DOIUrl":"10.1016/j.obmed.2024.100554","url":null,"abstract":"<div><h3>Aim</h3><p>Non-alcoholic fatty liver disease (NAFLD) lacks a definitive treatment. Previous research indicates that fruits and vegetables may alleviate inflammatory markers and improve NAFLD outcomes. This study investigates the effects of black mulberry leaf extract on NAFLD induced by a high-fat diet in rats.</p></div><div><h3>Methods</h3><p>Male rats were randomized into control and high-fat diet groups. After four months on a high-fat diet, rats received black mulberry leaf extract at doses of 150, 300, and 600 mg/kg for eight weeks. Evaluations included weight, blood sugar, total cholesterol, triglycerides, and liver enzyme activities (AST, ALT).</p></div><div><h3>Results</h3><p>The high-fat diet resulted in increased weight (P < 0.0001), fasting plasma glucose (FPG) (P < 0.0001), triglycerides (P = 0.031), and total cholesterol (P < 0.0001), along with elevated serum levels of AST (P < 0.0001) and ALT (P = 0.009). Administration of black mulberry leaf extract significantly reduced weight (P = 0.008), FPG (P < 0.0001), total cholesterol (P = 0.0001), and ALT (P = 0.0001) and AST (P = 0.0001) levels in a dose-dependent manner at doses of 600 mg, 300 mg, and 150 mg per day.</p></div><div><h3>Conclusion</h3><p>Black mulberry leaf extract exhibits therapeutic potential in managing NAFLD. Further studies are warranted to comprehensively assess its impacts.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"50 ","pages":"Article 100554"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vanillin, ferulic acid and their 1:1 combination inhibit lipid accumulation in 3T3 L1 adipocytes and 3D spheroids 香兰素、阿魏酸及其 1:1 组合可抑制 3T3 L1 脂肪细胞和三维球状体中的脂质积累

Obesity Medicine Pub Date : 2024-09-01 DOI: 10.1016/j.obmed.2024.100552

Sruthi N. Kumar, Prakash Kumar B., Harikumaran R. Nair

{"title":"Vanillin, ferulic acid and their 1:1 combination inhibit lipid accumulation in 3T3 L1 adipocytes and 3D spheroids","authors":"Sruthi N. Kumar, Prakash Kumar B., Harikumaran R. Nair","doi":"10.1016/j.obmed.2024.100552","DOIUrl":"10.1016/j.obmed.2024.100552","url":null,"abstract":"<div><h3>Background</h3><p>Obesity is poised to be a major healthcare crisis worldwide. Genetic predisposition, inadequate activity, changing lifestyle and dietary patterns are cited as major causes for obesity. Even as a number of anti-obesity medications hit the market, there is still an ongoing quest to explore natural compounds, which are perceived as safer alternatives, for their anti-obesity activity. This study explores the anti-obesity potential of dietary polyphenols vanillin, ferulic acid and their combination using 3T3 L1 adipocytes and their 3D spheroids.</p></div><div><h3>Methods</h3><p>Studies were conducted on differentiated 3T3 L1 adipocytes and their 3D spheroids. Assays conducted on 3T3 L1 adipocytes include Oil red O, fluorescent Nile Red staining and triglyceride quantification to assess effect on lipid droplet accumulation. 2 NBDG was used to assess glucose uptake following drug treatment. 3D spheroid cultures were generated and triglyceride content was quantified. Effect of drug treatment on gene expression was analysed using qRT-PCR. Results of monolayer culture were compared with 3D spheroid models.</p></div><div><h3>Results</h3><p>Vanillin, ferulic acid and their combination lower intracellular triglyceride content and lipid droplet accumulation, inhibiting glucose uptake and conversion to triglycerides in 3T3 L1 adipocytes and their 3D spheroids. Compounds and their combination downregulated mRNA expression of C/EBP <strong><em>α</em></strong> and PPAR ɣ, FAS, ACC1, GLUT4, LPL, aP2. Vanillin treatment upregulated leptin mRNA expression.</p></div><div><h3>Conclusion</h3><p>Vanillin, ferulic acid and their combination lower lipid accumulation and glucose uptake in 3T3 L1 adipocytes and 3D spheroids.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"50 ","pages":"Article 100552"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of gut microbiota in non-alcoholic fatty liver disease pathogenesis 肠道微生物群在非酒精性脂肪肝发病机制中的作用

Obesity Medicine Pub Date : 2024-09-01 DOI: 10.1016/j.obmed.2024.100551

Hessam Yaghmaei , Seyed Ali Nojoumi , Masood Soltanipur , Hossein Yarmohammadi , Seyed Mohsen Mirhosseini , Mahdi Rezaei , Mohammadreza Jalali Nadoushan , Seyed Davar Siadat

引用次数: 0

Efficacy of low carbohydrate ketogenic diet in weight management: A narrative review 低碳水化合物生酮饮食对控制体重的功效：叙述性综述

Obesity Medicine Pub Date : 2024-07-15 DOI: 10.1016/j.obmed.2024.100550

Sabrina Zaman, Tamsel Ahammed

{"title":"Efficacy of low carbohydrate ketogenic diet in weight management: A narrative review","authors":"Sabrina Zaman, Tamsel Ahammed","doi":"10.1016/j.obmed.2024.100550","DOIUrl":"10.1016/j.obmed.2024.100550","url":null,"abstract":"<div><p>Obesity is a condition when the BMI (Body Mass Index) is 30 or higher. This body condition has become a serious health issue all over the world as it is the potential risk factor of many non-communicable diseases such as diabetes, hypertension, cardiovascular disease etc. Ketogenic diet has gained immense popularity as a means of weight loss. Ketogenic diet or low carbohydrate diet with high-fat content has turned out to be effective in weight management and reduce the potential risk factor of non-communicable diseases. However, the aim of this review is to understand the mechanism of production of ketone bodies which mainly act as the source of energy, and the impact of a ketogenic diet on reducing body weight. Extensive literature review was conducted to find out the related original research papers and review papers. This study revealed that timeframe of a ketogenic diet is an important factor in the weight management program. Studies with 6 months time periods were found to be significantly reduce weight than those with more than 6 months study duration. It was also observed that ketogenic diet-based studies with more than 6 months time period are not superior to a normal diet whereas within 6 months of ketogenic diet initiation program, a drastic change in weight can be experienced. Moreover, health practitioners are not fully convinced about this popular weight-reducing diet. Adherence to a ketogenic diet for longer periods is difficult, and the associated risk factors such as increased risk of heart disease, fatty liver, and insulin resistance are also a matter of health concern.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"49 ","pages":"Article 100550"},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic syndrome in personnel of TUMS☆ and its association with types of occupations: A cross-sectional study TUMS☆ 人员的代谢综合征及其与职业类型的关系：横断面研究

Obesity Medicine Pub Date : 2024-07-11 DOI: 10.1016/j.obmed.2024.100549

Maryam Saraei , Nazanin Izadi , Omid Aminian , Matin Hajihashemi

{"title":"Metabolic syndrome in personnel of TUMS☆ and its association with types of occupations: A cross-sectional study","authors":"Maryam Saraei , Nazanin Izadi , Omid Aminian , Matin Hajihashemi","doi":"10.1016/j.obmed.2024.100549","DOIUrl":"10.1016/j.obmed.2024.100549","url":null,"abstract":"<div><h3>Background</h3><p>Metabolic syndrome (MetS) causes an increased risk of cardiovascular disease and death. Hospital staff as an influential segment of the population are at risk of developing MetS. This study aimed to determine the occupational distribution of MetS in hospital staff and to examine the association between the type of occupation and the likelihood of developing MetS.</p></div><div><h3>Methods</h3><p>In this cross-sectional study we recruited 3128 personnel of TUMS, including healthcare workers, office workers and supportive workers of Tehran's University Teaching Hospitals during 2020–2022. Demographic, anthropometric indices and laboratory tests were recorded. MetS was determined using three definitions including ATP III recommendations, IDF and regional IDF criteria. Statistical analysis was performed using SPSS 26.</p></div><div><h3>Results</h3><p>MetS was observed in 641 (20.5%) subjects according to ATP III recommendations, 923 (29.5%) based on IDF and 713 (22.8%) using regional IDF criteria. Using regional IDF criteria, age, gender and occupational status were associated with the MetS occurrence (all p < 0.0001). Adjusting for the age and gender of participants, healthcare workers were less likely to develop MetS compared to both office workers (OR = 0.66, 95%CI for OR: 0.55–0.80, p < 0.0001) and supportive workers (OR = 0.72, 95%CI for OR: 0.58–0.90, p = .003). However, office workers and supportive workers did not differ significantly regarding this parameter (p = .44).</p></div><div><h3>Conclusion</h3><p>Regardless of the MetS definition criteria, the findings indicated an alarming MetS prevalence, particularly among supportive workers and office workers. Considering the significant role of hospital staff in patients’ health promotion, effective management is essential.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"49 ","pages":"Article 100549"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted therapeutic potential of corosolic acid: A novel bioactive compound 科罗索酸的多方面治疗潜力：一种新型生物活性化合物

Obesity Medicine Pub Date : 2024-06-14 DOI: 10.1016/j.obmed.2024.100548

Loushambam Samananda Singh, Waikhom Somraj Singh

{"title":"Multifaceted therapeutic potential of corosolic acid: A novel bioactive compound","authors":"Loushambam Samananda Singh, Waikhom Somraj Singh","doi":"10.1016/j.obmed.2024.100548","DOIUrl":"10.1016/j.obmed.2024.100548","url":null,"abstract":"<div><p>Corosolic acid (CRA) is a pentacyclic triterpenoid found in plants such as <em>Lagerstroemia speciosa</em> (Banaba). CRA has attracted attention for its potential therapeutic benefits, including anti-diabetic, anti-obesity, antihyperlipidemic, anti-inflammatory, and anti-tumor effects. CRA's complex structure and structural analogs, such as ursolic and oleanolic acids, exhibit activities akin to CRA. CRA demonstrates promising anti-diabetic properties by enhancing glucose uptake, increasing insulin sensitivity, and inhibiting carbohydrate-absorbing enzymes. These mechanisms have potential implications in the management of diabetes mellitus and its associated complications. Furthermore, CRA inhibits adipogenesis, promotes lipolysis, and regulates lipid metabolism, indicating its potential role in addressing obesity-related lipid abnormalities. Reducing oxidative stress, suppressing pro-inflammatory cytokines, and inhibiting inflammatory pathways suggest CRA's utility in preventing or mitigating metabolic disorders, including insulin resistance and chronic inflammation. While CRA shows promise, addressing regulatory gaps and conducting rigorous research are crucial for establishing its efficacy and ensuring its safe utilization in various health conditions. This review emphasizes the significance of understanding the pharmacokinetics and therapeutic potential of corosolic acid in preclinical and clinical observations.</p></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"49 ","pages":"Article 100548"},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141397107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0