Obesity Medicine最新文献

{"title":"Effects of high fat diet on blood lipids and liver enzymes in murine model: the systemic and experimental study","authors":"Thuy-Duong Vu ,&nbsp;Anh-Dao Ngo ,&nbsp;Son-Tung Nguyen ,&nbsp;Yen-Nhi Khuong ,&nbsp;Van-Bao Phan ,&nbsp;Tien-Dat Pham ,&nbsp;Duc-Anh Le ,&nbsp;Thanh-Thuy To ,&nbsp;Chia-Ching Wu ,&nbsp;Dinh-Toi Chu","doi":"10.1016/j.obmed.2025.100614","DOIUrl":"10.1016/j.obmed.2025.100614","url":null,"abstract":"<div><h3>Background</h3><div>A high fat diet is associated various metabolic disorders, including fatty liver disease and dyslipidemia. This work is aimed to examine effects of excess lard usage from diet on blood lipids and liver enzymes in murine models in the aspects of genetics and food types.</div></div><div><h3>Methods</h3><div>A systematic review was conducted to form a general picture of the effects of high fat diet (HFD) on blood lipid and liver enzyme profiles of mice and compare these indices between study designs. At the same time, 24 Swiss albino mice were included in an experimental study, two groups with different diets (HFD and standard diet - STD) in 18 weeks to examine serum levels of liver enzymes and blood lipids.</div></div><div><h3>Results</h3><div>Our results in the systematic review indicate that HFD from lard increased TG, TC, LDL-C, ALT indexes in the majority of studies. C57BL/6 strain was used the most as well as being seen as the best results in these studies. In addition, the most popular types of HFD used in these results were HFD 60 % and HFD 45 %. They also showed the most appropriate results, in which those related to HFD 60 % had lower dispersion than those of HFD 40 %. The change in blood lipids and serum liver enzymes due to HFD from lard also varied among studies using the same strain as well as different strains, especially that of HDL-C and AST. Our experiment on Swiss mice confirmed these results. After 18 weeks eating HFD, mice gained weight and accumulated white fat. All four indices of blood lipids including TC, TG, HDL-C and LDL-C of HFD group were significantly higher than STD group, with 15.90 %, 28.49 %, 20.12 % and 41.79 %, respectively. Although AST level did not show a difference between two groups, HFD leads to a 1.29-fold-increase in ALT level in mice.</div></div><div><h3>Conclusion</h3><div>In conclusion, both our systematic and experimental results indicate that HFD can increase blood lipids and liver enzymes in mice, and systematic analysis suggests that dyslipidemia and detrimental effects on the liver by HFD are depending on the animal genetics and types of diet.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100614"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major dietary patterns in candidates for bariatric surgery and their relationships with metabolic syndrome","authors":"Hastimansooreh Ansar ,&nbsp;Negar Zamaninour ,&nbsp;Gholamreza Mohammadi Farsani ,&nbsp;Atefeh Seifollahi ,&nbsp;Mohadeseh Hassan zadeh ,&nbsp;Abdolreza Pazouki ,&nbsp;Khadijeh Mirzaei ,&nbsp;Ali Kabir","doi":"10.1016/j.obmed.2025.100612","DOIUrl":"10.1016/j.obmed.2025.100612","url":null,"abstract":"<div><h3>Background</h3><div>The study examined 374 individuals who were candidates for bariatric surgery due to morbid obesity. The primary objective was to explore the significant dietary patterns and their potential correlation with metabolic syndrome (MetS).</div></div><div><h3>Methods</h3><div>Two distinct dietary patterns were determined in this cross-sectional study using principal components analysis: a healthy dietary pattern (HDP) that contains an abundance of fruits, veggies, and lean protein sources, and a western dietary pattern (WDP) that is identified by the intake of processed foods and high-fat items. The odds ratio was estimated using multivariate logistic regression.</div></div><div><h3>Results</h3><div>The findings showed a concerning link between the WDP and a reduced amount of high-density lipoprotein cholesterol (HDL-C), a crucial element of lipid metabolism and cardiovascular health. Conversely, the HDP did not show a significant link with MetS or its components in this cohort of individuals with morbid obesity.</div></div><div><h3>Conclusion</h3><div>These results underscore the potential adverse impact of a Western-style diet on metabolic health parameters, particularly HDL-C levels, in this population. The study highlights the importance of dietary patterns in influencing metabolic outcomes in individuals with morbid obesity and emphasizes that further researches may elucidate the interventions to reduce the risk of MetS in this high-risk group.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100612"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of polyherbal formulation on Obesity: A review of preclinical and clinical trial studies","authors":"Mozhgan Mohammadzadeh ,&nbsp;Ali Shamsizadeh ,&nbsp;Jalal Hassanshahi ,&nbsp;Ayat Kaeidi ,&nbsp;Mohammad-Reza Shafiepour","doi":"10.1016/j.obmed.2025.100617","DOIUrl":"10.1016/j.obmed.2025.100617","url":null,"abstract":"<div><div>This comprehensive review delves into the potential of polyherbal formulations for obesity management, exploring the scientific evidence from preclinical and clinical trials. Given the global prevalence of obesity and the limitations of conventional treatments, the need for safe, effective, and holistic alternatives is paramount. Polyherbalism, leveraging the synergistic effects of multiple medicinal plants, offers a promising avenue for addressing this complex metabolic disorder.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100617"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay of the pathophysiological mechanisms of non-alcoholic fatty liver disease, diabetes mellitus, and inflammation: A growing threat to public health","authors":"Sharon Olabisoye Oladipupo ,&nbsp;Emmanuel Henry Ezenabor ,&nbsp;Adebola Busola Ojo ,&nbsp;Akingbolabo Daniel Ogunlakin ,&nbsp;Oluwafemi Adeleke Ojo","doi":"10.1016/j.obmed.2025.100613","DOIUrl":"10.1016/j.obmed.2025.100613","url":null,"abstract":"<div><div>Non-Alcoholic Fatty Liver Disease (NAFLD), diabetes, and chronic inflammation are growing health problems that often go unnoticed, yet they are closely linked. NAFLD occurs when fat builds up in the liver, and it is strongly connected to metabolic disorders like obesity and diabetes. Over time, NAFLD can lead to insulin resistance, making diabetes worse, while diabetes itself can increase liver damage, creating a harmful cycle. Inflammation plays a key role in connecting these conditions, worsening disease progression and raising the risk of serious complications like heart disease and liver failure. Despite their widespread impact, these issues are often not diagnosed or treated early enough. This review explores how NAFLD, diabetes, and inflammation are related, their effects on public health, and new treatment options, including lifestyle changes and emerging therapies. By understanding these connections, we can develop better strategies for prevention, early detection, and treatment to improve long-term health outcomes.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100613"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring genes related to impaired insulin secretion and the interaction with diet in type 2 diabetes mellitus: A scoping review of observational studies","authors":"Rambu L.N.K.R. Triandhini ,&nbsp;Ahmad Hamim Sadewa ,&nbsp;Siti Helmiyati","doi":"10.1016/j.obmed.2025.100611","DOIUrl":"10.1016/j.obmed.2025.100611","url":null,"abstract":"<div><div>Diabetes mellitus is a metabolic disorder and a major global health concern. This scoping review aimed to systematically map current data that describe the relationship between genetic variant interactions related to insulin secretion and diet with the incidence of type 2 diabetes mellitus. A literature search was conducted through PubMed, Cochrane, EBSCO, ProQuest, and hand searching. Thirteen eligible articles were obtained from 1375 searches in the database; TCF7L2 variants were the most frequently examined and demonstrated interactions with fiber, followed by the CDKAL1 gene variant, which showed interactions mainly with dietary components, such as fats, proteins, and coffee. Statistically significant findings were also reported for IGFBP2, NOTCH2, KCNJ11, GIPR, HFE, and ZBED3 variants. Nevertheless, most of these studies are yet to be replicated, and some findings indicated inconsistencies. Gene interactions related to insulin secretion and diet play important roles in the risk of type 2 diabetes, although further research is required to validate these findings.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100611"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic memory in obesity: Can early-life interventions reverse lifelong risks?","authors":"Esther Ugo Alum","doi":"10.1016/j.obmed.2025.100610","DOIUrl":"10.1016/j.obmed.2025.100610","url":null,"abstract":"<div><div>Obesity, a major global health challenge, is increasingly linked to early-life exposures that program long-term metabolic health—a phenomenon termed metabolic memory. This commentary explores the mechanisms underlying metabolic memory, including epigenetic modifications, hormonal signaling alterations, and adipose tissue changes during critical developmental windows such as gestation, infancy, and early childhood. Evidence from epidemiological and experimental studies underscores the profound influence of maternal health, infant feeding practices, and early childhood diet on lifelong obesity risk. Early-life interventions, such as promoting maternal nutrition, exclusive breastfeeding, and healthy lifestyle practices, offer promising avenues to disrupt the trajectory of metabolic memory. However, barriers such as socioeconomic disparities and limited long-t,erm efficacy of interventions present significant challenges. Addressing these obstacles requires robust research, policy reforms, and innovative approaches, including personalized nutrition and digital health technologies. This commentary highlights the urgent need for preventive strategies targeting early-life exposures to mitigate obesity-related health risks and improve global health outcomes. This commentary was developed through a comprehensive review of recent literature on metabolic memory and obesity. Peer-reviewed articles, epidemiological studies, and experimental research were identified from databases such as PubMed, Scopus, and Google Scholar. Keywords included “metabolic memory,” “obesity,” “early-life interventions,” and “epigenetics.” Sources were selected based on their relevance, methodological rigor, and recency. Insights were synthesized to provide a multidisciplinary perspective on the mechanisms, evidence, and potential interventions for addressing metabolic memory in obesity. Emphasis was placed on translational and actionable strategies to inform policy and practice.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100610"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hypothyroidism and metabolic dysfunction-associated steatohepatitis in adults with obesity without diabetes","authors":"Sasha D. Macedo-Lozano ,&nbsp;Maria A. Garcia-Aguilar ,&nbsp;Gustavo Salinas-Sedo ,&nbsp;Kennlly Cardoza-Jiménez ,&nbsp;Wah Yang ,&nbsp;Ming-Hua Zheng ,&nbsp;Carlos J. Toro-Huamanchumo","doi":"10.1016/j.obmed.2025.100604","DOIUrl":"10.1016/j.obmed.2025.100604","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic dysfunction-associated steatohepatitis (MASH), often linked with obesity-related fat deposition, is increasingly prevalent as global obesity rates rise. Data from Latin America, and particularly Peru, remain limited. Research suggests that hypothyroidism may contribute to MASH development through mechanisms such as dysregulated fatty acids, elevated FGF21 concentrations, mitochondrial dysfunction, oxidative stress, and altered leptin levels, all of which may drive the associated inflammatory processes.</div></div><div><h3>Objectives</h3><div>To assess the association between hypothyroidism and MASH in adults living with obesity without a history of diabetes mellitus.</div></div><div><h3>Methods</h3><div>This cross-sectional study included adults seeking bariatric surgery at a private center in Peru. MASH was defined via biopsy results, and hypothyroidism was diagnosed based on medical history or laboratory values. The association of interest was assessed using generalized linear models to calculate prevalence ratios (PR), adjusting for confounders.</div></div><div><h3>Results</h3><div>Data from 398 patients were analyzed; the mean age was 34.3 years, and 70.6 % were female. Hypothyroidism and MASH prevalences were 9.5 % and 84 %, respectively. After adjustments for sex, age, BMI, insulin resistance, and smoking, hypothyroidism was associated with a 1.18-fold increased prevalence of MASH (adjusted PR: 1.18; 95 % CI: 1.07–1.30, p = 0.001).</div></div><div><h3>Conclusion</h3><div>Hypothyroidism was significantly associated with MASH in adults with obesity and without diabetes mellitus. This suggests a critical role of thyroid dysfunction in MASH pathogenesis, also underscoring the importance of considering thyroid health in MASH management strategies.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100604"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Abdominal Obesity A Predictor of Pain after Laparoscopic Surgery? Insights from a cross-sectional study","authors":"Morteza Hashemian ,&nbsp;Habibeh Ahmadipour ,&nbsp;Mohammad Shafiee ,&nbsp;Alireza Shakeri ,&nbsp;Kosha Keramati ,&nbsp;Mohammad Amin Rajizadeh ,&nbsp;Ladan Amirkhosravi","doi":"10.1016/j.obmed.2025.100608","DOIUrl":"10.1016/j.obmed.2025.100608","url":null,"abstract":"<div><h3>Aim</h3><div>Postoperative pain is the most undesirable complication after surgery.Waist circumference can be a screening tool to determine overweight and abdominal obesity. Furthermore, obesity, metabolic syndrome, and pain have some proinflammatory features in common. The present study investigates the relationship between waist circumference and pain intensity after laparoscopic cholecystectomy (LC).</div></div><div><h3>Methods</h3><div>This cross-sectional study was directed at 160 candidates of LC referred to Afzalipour and Bahonar hospitals in Kerman from September to December 2022. All patients underwent general anesthesia and were operated on by the same surgery group. After each operation, the patient's clinical information form was again measured. The patient's pain level was objectively assessed based on the Visual Analog Scale (VAS) scoring system when entering the recovery (0) and 12 and 24 h later. The amount of opioids (morphine and pethidine) and other painkillers (such as NSAIDs) consumed was also extracted from the patient records.</div></div><div><h3>Results</h3><div>In this study, 70 % of the patients had abdominal obesity. The mean pain intensity score in the recovery phase was significantly higher in patients with abdominal obesity. Also, the mean pain intensity score in patients with abdominal obesity who had a history of drug abuse or non-use of drugs was higher in the recovery phase than those without abdominal obesity. The frequency of narcotic drug distribution in patients with abdominal obesity in recovery and first 12 h was higher.</div></div><div><h3>Conclusion</h3><div>The pain intensity score in patients with abdominal obesity increased during recovery. Also, obese patients consume more analgesics.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100608"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of thyroid disorders in patients with diabetes and hypertension in India: A systematic review and meta-analysis","authors":"Bhavya Sharma,&nbsp;Vaibhav Chaudhary,&nbsp;Sweta Kumari,&nbsp;Biplab Pal","doi":"10.1016/j.obmed.2025.100609","DOIUrl":"10.1016/j.obmed.2025.100609","url":null,"abstract":"<div><h3>Background and aims</h3><div>Thyroid disorders are common in people with hypertension and diabetes. Given the rising spread of these conditions in India, this study determined the prevalence of thyroid disorders in Indian patients with hypertension and diabetes.</div></div><div><h3>Methods</h3><div>Literature search was done for studies published between 2000 and August 2024, reporting thyroid disorder prevalence in Indian patients with hypertension and diabetes. Analysis was conducted using RStudio, with subgroup analysis by region. Quality assessment was performed using Joanna Briggs Institute checklist. Heterogeneity and publication bias were appraised.</div></div><div><h3>Results</h3><div>The pooled prevalence of thyroid disorders was 16.1 % (95 % CI: 1.8–67.2, I² = 100 %, <em>p</em> &lt; 0.01) in hypertensive patients and 23.8 % (95 % CI: 20.5–27.5, I² = 95 %, <em>p</em> &lt; 0.01) in diabetic patients. Subclinical hypothyroidism (47.5 %) was the most common thyroid disorder in diabetic patients, followed by hypothyroidism (39.7 %). Among diabetic patients, prevalence was 32.6 % in Eastern, 25.2 % in Northern, 24.5 % in Western, and 19.5 % in Southern region, with no significant differences (<em>p</em> = 0.12).</div></div><div><h3>Conclusion</h3><div>Thyroid disorders are common in patients with hypertension and diabetes. Routine screening and integrating thyroid monitoring into diabetes and hypertension care can improve outcomes. More research is needed to standardize diagnostic methods and identify risk factors.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100609"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Efficacy and safety of liraglutide in pediatric Obesity:A systematic review and meta analysis of randomized controlled trials”","authors":"Abdullah Afridi ,&nbsp;Fathimathul Henna ,&nbsp;Umaima Cheema ,&nbsp;Ayesha Sehar ,&nbsp;Muhammad Fakhir Iftikhar Rana ,&nbsp;Areej Dar ,&nbsp;Bibi Hafza ,&nbsp;Iqra khan ,&nbsp;Laiba Ali Khan ,&nbsp;Aafeen Mujeeb ,&nbsp;Ayesha Khalid Sheikhani ,&nbsp;Insha Habib ,&nbsp;Muhammad Abdullah Ali ,&nbsp;Momina Ali ,&nbsp;Mizhgan Abid ,&nbsp;Ansar Hussain","doi":"10.1016/j.obmed.2025.100605","DOIUrl":"10.1016/j.obmed.2025.100605","url":null,"abstract":"<div><h3>Introduction</h3><div>Liraglutide, a GLP-1 receptor agonist, has been explored for its potential benefits in managing paediatric obesity. This meta-analysis aims to assess the efficacy and safety of liraglutide compared to placebo in this paediatric population with obesity.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Embase, and Cochrane for randomized controlled trials (RCTs) on liraglutide in children with obesity. Five studies with 247 participants were included. Primary outcomes included changes in BMI SDS, BMI, and body weight, and secondary outcomes included fasting serum insulin, HbA1c, fasting plasma glucose, SBP, DSP, and safety outcomes.</div></div><div><h3>Results</h3><div>The meta-analysis included five randomized controlled trials with 247 participants evaluating liraglutide in pediatric obesity. Liraglutide significantly reduced BMI SDS, with a pooled mean difference of −0.17 (p = 0.003), BMI (mean difference: 1.28, p = 0.0008), and body weight (mean difference: 1.83, p = 0.03). Secondary outcomes showed significant reductions in fasting serum insulin levels (pooled effect size: 0.39, p &lt; 0.00001), but no significant effects were observed for DSP (p = 0.29), fasting plasma glucose (p = 0.07), HbA1c (p = 0.09), or systolic blood pressure (p = 0.09). Safety analysis revealed a higher incidence of adverse events in the treatment group (risk ratio: 1.25, p = 0.18), but no significant differences were found in serious adverse events or adverse events leading to therapy discontinuation.</div></div><div><h3>Conclusions</h3><div>Liraglutide is effective in reducing BMI SDS, BMI, and body weight in pediatric obesity. While it significantly reduces fasting serum insulin levels, other secondary outcomes did not show significant changes. The safety profile of liraglutide shows a higher incidence of adverse events but no increase in serious adverse events or discontinuation rates. These findings support liraglutide's role as an effective and manageable treatment option for pediatric obesity.</div></div>","PeriodicalId":37876,"journal":{"name":"Obesity Medicine","volume":"55 ","pages":"Article 100605"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}