Investigating the multifactorial correlation between obesity and rheumatoid arthritis: A study of immunological and biochemical markers

Q2 Medicine

Obesity Medicine Pub Date : 2025-01-01 DOI:10.1016/j.obmed.2024.100578

Ali Saad Kadhim , Abdullah Salim Al-Karawi

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引用次数: 0

Abstract

Background

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation that primarily affects the synovial joints, leading to various clinical manifestations.

Objective

This study investigated the impact of obesity in immunologically affected individuals on the triggering of autoimmune response in RA patients, as well as the associated increased risk of RA progression.

Materials and methods

The comparative study that was carried out on a total of 300 participants were enrolled in this study, categorized into three distinct groups; 100 obese RA patients, 100 non-obese RA patients, and 100 healthy controls matched by age and sex. Serum and whole blood samples were collected for the analysis of oxidative stress markers, biochemical and serological parameters, immune cells, Autoantibodies, and interleukin levels.

Results

A notable significantly increase in the serum level of obese patients compared to other groups was observed in the concentration of oxidative stress, particularly 8-oxodG, which reached 101.9 ± 12.0 Pg/ml and positively correlated with the elevated levels of risk-1 (8.9 ± 3.6). The results indicated a significant increase in the interleukins, particularly IL-17 and IL-6 (230 ± 3.0 pg/ml), (116.0 ± 10.8 pg/ml) respectively. This increase was accompanied by a significant rise in autoantibodies, especially ANA (77.7 ± 5.9 AU/ml) and anti-MCV (155.7 ± 10.3 AU/ml). Finally, a strong significant correlation was observed between the elevated levels of antibodies ANA and the concentrations of IL-17, IL-6, and IL-4, (+0.44, +0.59 m and 0.59) along with an increase in the concentration of lymphocytic immune cells (58.2 ± 2.6 m/mm3).

Conclusion

Obesity and increased oxidative stress contribute to the development of RA, amplify inflammation through mechanisms such as molecular mimicry and neoantigen formation. Finally, this underscores the significance of managing obesity to potentially lessen the progression of RA.

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研究肥胖与类风湿关节炎之间的多因素相关性：免疫和生化标志物的研究

背景类风湿性关节炎（RA）是一种慢性自身免疫性疾病，其特征是持续炎症，主要影响滑膜关节，导致各种临床表现。目的：本研究探讨免疫影响个体肥胖对RA患者自身免疫反应触发的影响，以及相关的RA进展风险增加。材料和方法本研究对300名参与者进行了比较研究，他们被分为三个不同的组；100名肥胖类风湿性关节炎患者，100名非肥胖类风湿性关节炎患者，以及100名年龄和性别匹配的健康对照。采集血清和全血样本，分析氧化应激标志物、生化和血清学参数、免疫细胞、自身抗体和白细胞介素水平。结果肥胖患者血清氧化应激浓度，尤其是8-oxodG，与其他组相比显著升高，达到101.9±12.0 Pg/ml，与风险-1升高呈正相关（8.9±3.6）。结果显示白细胞介素显著升高，其中以IL-17和IL-6显著升高，分别为（230±3.0 pg/ml）和（116.0±10.8 pg/ml）。这种增加伴随着自身抗体的显著增加，特别是ANA（77.7±5.9 AU/ml）和抗mcv（155.7±10.3 AU/ml）。最后，ANA抗体水平的升高与IL-17、IL-6和IL-4浓度（+0.44、+0.59 m和0.59 m）以及淋巴细胞免疫细胞浓度（58.2±2.6 m/mm3）的升高之间存在很强的显著相关性。结论肥胖和氧化应激增加可通过分子模拟和新抗原形成等机制促进RA的发展，扩大炎症。最后，这强调了控制肥胖的重要性，以潜在地减少RA的进展。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.