Journal of Mid-life Health最新文献

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Erratum: A Rare Case of Massive Molar Pregnancy in a Postmenopausal Woman: Challenges in Diagnosis and Management. 勘误:一个罕见的病例在绝经后妇女巨大的磨牙妊娠:在诊断和管理的挑战。
IF 1
Journal of Mid-life Health Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/jmh.jmh_48_26
{"title":"Erratum: A Rare Case of Massive Molar Pregnancy in a Postmenopausal Woman: Challenges in Diagnosis and Management.","authors":"","doi":"10.4103/jmh.jmh_48_26","DOIUrl":"10.4103/jmh.jmh_48_26","url":null,"abstract":"<p><p>[This corrects the article on p. 482 in vol. 4.].</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"198"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Vasomotor Symptoms and Cardiac Autonomic Functions in Perimenopausal Women. 围绝经期妇女血管舒缩症状与心脏自主神经功能的关系
IF 1
Journal of Mid-life Health Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/jmh.jmh_238_25
Vibha Gangwar, Neetu Singh, Manish Raj Kulshreshtha, Arvind Kumar Singh, Manish Kumar Verma, Sunita Tiwari, Akanksha Gupta, Anumesh Kumar Pathak
{"title":"Association of Vasomotor Symptoms and Cardiac Autonomic Functions in Perimenopausal Women.","authors":"Vibha Gangwar, Neetu Singh, Manish Raj Kulshreshtha, Arvind Kumar Singh, Manish Kumar Verma, Sunita Tiwari, Akanksha Gupta, Anumesh Kumar Pathak","doi":"10.4103/jmh.jmh_238_25","DOIUrl":"10.4103/jmh.jmh_238_25","url":null,"abstract":"<p><strong>Context: </strong>Women going through the menopause transition frequently have vasomotor symptoms (VMS), which have been linked to an increased risk of cardiovascular disease.</p><p><strong>Aim: </strong>This study aims to explore the association of VMS with cardiac autonomic functions in perimenopausal women, a group with increased cardiovascular risk.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 200 perimenopausal women aged 40-50 years. Women with a history of any chronic illness, hormone replacement therapy, smoking, alcohol use, medication use and surgical removal of the uterus or ovaries were excluded. Their age, body mass index, and blood pressure were recorded. Data on the complete history of VMS, clinical history, medications, menstrual history, and exercise habits were collected using a self-reported questionnaire. Cardiac autonomic function was evaluated using heart rate variability (HRV), heart rate response to standing and deep breathing, and Valsalva ratio. Data were analyzed using SPSS 21 IBM software, and correlation and regression analyses were applied for statistical evaluation.</p><p><strong>Results: </strong>The participants' average age was 43.31 ± 4.10 years. VMS included mood swings, night sweats, sleep disturbances, and hot flashes. Women experiencing night sweats had significantly lower levels of low frequency (LF) and high frequency (HF) components of HRV (<i>P</i> = 0.043, 0.005), whereas those experiencing hot flushes exhibited significantly higher LF/HF Ratio (<i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>The study concluded that both night sweats and hot flushes were associated with autonomic imbalance, reflected by reduced parasympathetic activity. However, no significant correlation was found between frequency or duration of VMS with autonomic functions. These findings suggest that night sweats and hot flushes were associated with altered cardiac autonomic functions in perimenopausal women.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"93-99"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Domestic Violence - Are Women Safe Now? A Comparison between Nationwide Surveys of India. 家庭暴力——女性现在安全了吗?印度全国调查的比较。
IF 1
Journal of Mid-life Health Pub Date : 2026-01-01 Epub Date: 2026-03-31 DOI: 10.4103/jmh.jmh_224_25
Ramesh Holla, S R Sreedevi, Mithun Rao, Jobinse Jose
{"title":"Domestic Violence - Are Women Safe Now? A Comparison between Nationwide Surveys of India.","authors":"Ramesh Holla, S R Sreedevi, Mithun Rao, Jobinse Jose","doi":"10.4103/jmh.jmh_224_25","DOIUrl":"10.4103/jmh.jmh_224_25","url":null,"abstract":"<p><p>The Protection of Women from Domestic Violence Act 2005 comprehensively defines domestic violence, which encompasses physical, emotional, verbal, sexual, and economic abuse, as well as threats. Domestic violence is a prevalent form of gender-based violence against women. Regardless of the extent, every form of unlawful act is considered a form of abuse. To assess the trend of domestic violence against women over the last 8 years and the factors affecting the changing trends of domestic violence against women. Data were taken from the National Family Health Survey (NFHS-4 and NFHS-5) reports. A total of 79,729 women completed the NFHS-4 module, and 72,056 women completed the NFHS-5 module. Data used in this study are based on publicly available secondary data from the NFHS-4 and NFHS-5 surveys. The type of population included never-married and ever-married women with respect to their experiences of violence committed by their current and former husbands. A decreasing trend of domestic violence from 31.2% to 29.3% was observed. The number of states with higher percentages of spousal violence and sexual violence among women decreased, and women reporting physical violence declined. Help-seeking behavior remained almost constant across both surveys; women whose husbands often drink have experienced greater violence on comparison. Though domestic Violence remains endemic, structural determinants like education, wealth, urbanization, and alcohol use remain vital for positive change. A multitiered strategy, anchored in health systems and legal reforms, community empowerment, and tailored programming, is essential to effectively reduce domestic violence against women.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"23-30"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Ovarian Leiomyoma with Torsion in a Postmenopausal Woman: A Rare Case with Progesterone Receptor Positivity. 绝经后妇女原发性卵巢平滑肌瘤伴扭转:一例罕见的黄体酮受体阳性病例。
IF 1
Journal of Mid-life Health Pub Date : 2025-10-01 Epub Date: 2025-12-08 DOI: 10.4103/jmh.jmh_223_24
Banashree Nath, Shruti Gupta, Vaibhav Kanti, Aparna Baranwal, Shraddha Krupa, Neha Nohria
{"title":"Primary Ovarian Leiomyoma with Torsion in a Postmenopausal Woman: A Rare Case with Progesterone Receptor Positivity.","authors":"Banashree Nath, Shruti Gupta, Vaibhav Kanti, Aparna Baranwal, Shraddha Krupa, Neha Nohria","doi":"10.4103/jmh.jmh_223_24","DOIUrl":"10.4103/jmh.jmh_223_24","url":null,"abstract":"<p><p>Ovarian leiomyomas are rare benign smooth muscle tumors, accounting for <1% of all ovarian neoplasms. While most commonly found in premenopausal women, their occurrence in postmenopausal women is rare and often raises concerns about malignancy. We report a unique case of ovarian leiomyoma torsion in a 73-year-old postmenopausal woman who presented with postmenopausal bleeding and acute pelvic pain. Imaging studies initially suggested an ovarian mass and surgical exploration revealed a twisted mass, which was histologically confirmed as a leiomyoma. Immunohistochemical analysis of the tumor demonstrated strong positivity for progesterone receptors, suggesting a potential role for progesterone in the tumor's growth, even in a postmenopausal setting. This case highlights the diagnostic challenge of ovarian leiomyomas in older women and underscores the importance of histopathological examination, including immunohistochemistry, to guide management and provide insights into the potential hormonal influence on tumor development.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 4","pages":"469-473"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bisphosphonates and Periodontal Health: A Systematic Review in Postmenopausal Women. 双膦酸盐与牙周健康:绝经后妇女的系统综述。
IF 1
Journal of Mid-life Health Pub Date : 2025-10-01 Epub Date: 2025-12-08 DOI: 10.4103/jmh.jmh_120_25
Meghana Gangolu, Vintha Jaswitha, Ramanarayana Boyapati, Ravindranath Dhulipalla, Tejaswi Maddukuri, Sai Charan Pasupuleti
{"title":"Bisphosphonates and Periodontal Health: A Systematic Review in Postmenopausal Women.","authors":"Meghana Gangolu, Vintha Jaswitha, Ramanarayana Boyapati, Ravindranath Dhulipalla, Tejaswi Maddukuri, Sai Charan Pasupuleti","doi":"10.4103/jmh.jmh_120_25","DOIUrl":"10.4103/jmh.jmh_120_25","url":null,"abstract":"<p><p>Postmenopausal women are disproportionately affected by two prevalent chronic conditions: osteoporosis and periodontitis. Bisphosphonates (BPs) are synthetic compounds with a high affinity for bone, widely used for treating postmenopausal osteoporosis due to their ability to inhibit bone resorption, thereby increasing BMD and reducing fracture risk. This systematic review evaluates various bisphosphonate therapies in improving periodontal conditions in postmenopausal women. Fifteen studies involving 776 participants were included. These comprised randomized controlled trials (RCTs), one split-mouth RCT, and one single-group follow-up. BPs studied included zoledronic acid, alendronate, and risedronate, administered via IV, oral, or local delivery. Evaluated parameters included clinical (probing depth [PD], clinical attachment loss [CAL], plaque index [PI], gingival index [GI], bleeding on probing [BOP], sulcus bleeding index [SBI], etc.), radiographic (bone fill, density, height changes), and biochemical/microbiological (N-terminal telopeptide [NTx], bone-specific alkaline phosphatase, and bacterial counts). Most studies reported significant improvements in PD, CAL, and indices like PI, GI, and BOP. Xu <i>et al</i>. And Bhavsar <i>et al</i>. demonstrated major reductions in PD and CAL. High bone fill percentages and improved alveolar crest height was seen in some studies. Alendronate reduced ntx levels and improved BMD when evaluated under biochemical or microbiological findings. Bacterial counts also decreased post-treatment. Alendronate outperformed atorvastatin and placebo in several studies for periodontal outcomes. Bisphosphonate therapy, in various forms, provides significant benefits in managing periodontitis among postmenopausal women, with improvements noted in clinical, radiographic, and biochemical parameters. Further high-quality research is necessary to optimize treatment protocols and ensure long-term safety.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 4","pages":"371-385"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
G-Mesh for Laparoscopic Pectopexy: A Single-center Evaluation of a Novel Technique for Apical Prolapse Repair. 腹腔镜下g -补片术:一种根尖脱垂修复新技术的单中心评价。
IF 1
Journal of Mid-life Health Pub Date : 2025-10-01 Epub Date: 2025-12-08 DOI: 10.4103/jmh.jmh_278_25
Sujal Atul Munshi, Mohit Laxmikant Marda, Ami Sujal Munshi, Janki Pranjal Patel
{"title":"G-Mesh for Laparoscopic Pectopexy: A Single-center Evaluation of a Novel Technique for Apical Prolapse Repair.","authors":"Sujal Atul Munshi, Mohit Laxmikant Marda, Ami Sujal Munshi, Janki Pranjal Patel","doi":"10.4103/jmh.jmh_278_25","DOIUrl":"10.4103/jmh.jmh_278_25","url":null,"abstract":"<p><p>Apical prolapse, characterized by descent of the vaginal vault or uterus, continues to pose significant challenges in pelvic reconstructive surgery. Although laparoscopic sacropexy has long been considered the standard approach, it is often associated with defecatory, urinary, and mesh-related complications. Laparoscopic pectopexy, which anchors the suspension to the iliopectineal ligaments, has emerged as a safer and anatomically favorable alternative. This study evaluated the safety, feasibility, and anatomical and functional outcomes of a modified \"G-mesh\" laparoscopic pectopexy technique performed at a single tertiary-care center. A retrospective observational analysis was conducted on women who underwent the procedure between 2021 and 2025, assessing demographic characteristics, intraoperative details, and postoperative outcomes. Follow-up included POP-Q assessment, recurrence rates, and complication profile. The mean operative duration was 72 minutes with an average blood loss of 50 mL, and no major complications were recorded. Two minor intraoperative incidents-bladder wall thinning and vesicovaginal bleeding-were successfully managed laparoscopically. At 12-month follow-up, 13.3% of patients demonstrated mild prolapse recurrence, all managed conservatively with pelvic-floor rehabilitation. Overall, the G-mesh laparoscopic pectopexy technique appears safe, feasible, and associated with low morbidity and favorable anatomical outcomes. Further large-scale multicentric studies with extended follow-up are recommended to strengthen the evidence base for this technique.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 4","pages":"500-504"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcopenia in Menopausal Women: Prevalence, Risk Factors, Hormonal Mechanisms, and Management Strategies. 绝经期妇女肌肉减少症:患病率、危险因素、激素机制和管理策略。
IF 1
Journal of Mid-life Health Pub Date : 2025-10-01 Epub Date: 2025-12-08 DOI: 10.4103/jmh.jmh_134_25
Laxmi Shrikhande, Khsama Kedar, Dondapati Chandra Mounisa, Ruchika Garg, Prabhat Agrawal, Aditya Shrikhande
{"title":"Sarcopenia in Menopausal Women: Prevalence, Risk Factors, Hormonal Mechanisms, and Management Strategies.","authors":"Laxmi Shrikhande, Khsama Kedar, Dondapati Chandra Mounisa, Ruchika Garg, Prabhat Agrawal, Aditya Shrikhande","doi":"10.4103/jmh.jmh_134_25","DOIUrl":"10.4103/jmh.jmh_134_25","url":null,"abstract":"<p><p>Sarcopenia, an age-related loss of muscle mass and function, represents a significant musculoskeletal condition in menopausal women, affecting up to 80% of those with musculoskeletal complaints, and poses a growing public health concern in India where 71% of the population lives in rural areas with high prevalence of risk factors like poor nutrition and physical inactivity. This systematic review aimed to examine the prevalence, risk factors, hormonal mechanisms, and management strategies for sarcopenia in menopausal women, with emphasis on implications for maternal health and preventive interventions. A literature search from 2015 to 2025 was conducted via PubMed and Google Scholar using terms such as sarcopenia, menopausal complaints, and preventive measures, including only original, peer-reviewed, English-language full-text articles relevant to menopause and sarcopenia. From 92 identified articles, 12 met the criteria, revealing sarcopenia prevalence in India ranging from 10% to 43.6%, higher in rural settings and among diabetics. Hormonal declines in estrogen, testosterone, dehydroepiandrosterone (DHEA), progesterone, and growth hormone (GH)/insulin-like growth factor 1 (IGF-1), coupled with increased cortisol, contribute to muscle loss. Effective interventions include protein intake of 0.8-1.2 g/kg/day, vitamin D supplementation of 800-1000 IU/day, physical activity comprising 150 min/week of aerobic exercise plus resistance training, and hormone therapy. Maternal complications encompass elevated fall risk and physical disability, which indirectly impact fetal health in perimenopausal pregnancies. Overall, sarcopenia in menopausal women demands heightened awareness and targeted interventions, especially in rural India, with future research needed on biomarkers and optimized protocols.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 4","pages":"367-370"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Midlife Crisis in Women - Specificity and Challenges: A Narrative Literature Review. 女性中年危机的特殊性与挑战:叙事文献综述。
IF 1
Journal of Mid-life Health Pub Date : 2025-10-01 Epub Date: 2025-12-08 DOI: 10.4103/jmh.jmh_115_25
Aleksandra Mrugalska, Anna Klimkiewicz
{"title":"Midlife Crisis in Women - Specificity and Challenges: A Narrative Literature Review.","authors":"Aleksandra Mrugalska, Anna Klimkiewicz","doi":"10.4103/jmh.jmh_115_25","DOIUrl":"10.4103/jmh.jmh_115_25","url":null,"abstract":"<p><p>This article present current perspectives on the midlife crisis in women, incorporating the latest research, analyses, and coping strategies within the context of contemporary challenges. Contemporary research highlights various aspects of this phenomenon, including biological, social, professional, and psychological changes that affect the functioning of middle-aged women. Emotional difficulties experienced by women in midlife have often been narrowly attributed to the effects of menopause, which oversimplifies the complexity of this experience. Stereotypes and cultural narratives reinforce negative perceptions of this stage, neglecting its significance as a psychological challenge. Indeed, modern transformations, such as increased professional activity and a growing sense of autonomy, point to the need for a holistic approach to this issue. Awareness of the challenges faced during this life stage underscores the necessity for further research that could form the basis for supportive, preventive, and educational programs. This article reviews literature recently published literature to understand contemporary approaches to this issue, identify knowledge gaps, and propose directions for future research.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 4","pages":"349-355"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Disease Risk Assessment of Adults in Mid to Late Life Attending Outpatient Clinics in West Bengal: A Cross-sectional Analysis. 西孟加拉邦参加门诊的中老年成人心血管疾病风险评估:一项横断面分析
IF 1
Journal of Mid-life Health Pub Date : 2025-10-01 Epub Date: 2025-12-08 DOI: 10.4103/jmh.jmh_209_25
Biswadip Chattopadhyay, Trina Sengupta, Susmita Chaudhuri, Sauryadripta Ghose, Saptarshi Sarkar, Rupesh Roy, Sakshi Agarwal
{"title":"Cardiovascular Disease Risk Assessment of Adults in Mid to Late Life Attending Outpatient Clinics in West Bengal: A Cross-sectional Analysis.","authors":"Biswadip Chattopadhyay, Trina Sengupta, Susmita Chaudhuri, Sauryadripta Ghose, Saptarshi Sarkar, Rupesh Roy, Sakshi Agarwal","doi":"10.4103/jmh.jmh_209_25","DOIUrl":"10.4103/jmh.jmh_209_25","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVDs) account for 32% of global deaths, with a significant share occurring prematurely in low- and middle-income countries such as India. Adults in mid-to late life face increased vulnerability due to cumulative exposure to behavioral and metabolic risk factors. Early identification of at-risk individuals can enable timely preventive interventions.</p><p><strong>Objective: </strong>To estimate the 10-year CVD risk and identify associated factors among adults aged 40-74 years attending a tertiary care hospital in Kolkata, West Bengal.</p><p><strong>Materials and methods: </strong>An institution-based cross-sectional study was conducted from August to December 2024 among 221 adults aged 40-74 years, excluding those with preexisting CVD or severe comorbidities. Data on sociodemographic, clinical, and lifestyle factors were collected through face-to-face interviews using a pretested schedule. The World Health Organization/ISH nonlaboratory-based risk prediction chart was used to estimate 10-year CVD risk. Logistic regression analyses identified predictors of moderate-to-high CVD risk.</p><p><strong>Results: </strong>The median age was 53 years; 46.1% were aged 40-50 years. Overweight or obesity affected 47.9% of participants, 38.9% had prehypertension, and 19.5% had Stage II hypertension. Moderate (10-<20%) CVD risk was present in 25.7%, while 0.7% had high risk (≥30%). Psychological distress increased the odds of moderate-to-high CVD risk (adjusted odds ratio [AOR] 2.01, 95% confidence interval [CI]: 1.08-3.71), while moderate-to-high intensity physical activity was protective (AOR 0.39, 95% CI: 0.19-0.82).</p><p><strong>Conclusion: </strong>Among mid-to late-life adults, obesity, elevated blood pressure, and psychological distress were common, with over one-quarter at moderate 10-year CVD risk. Integrating mental health support and promoting physical activity into midlife health programs could reduce future CVD burden.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 4","pages":"458-463"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between NAD (P) H: Quinone Oxidoreductase 1 C609T Gene Polymorphism and Risk Factors in Cases of Cervical Cancer in Indian Women. NAD (P) H:醌氧化还原酶1 C609T基因多态性与印度妇女宫颈癌危险因素的关系
IF 1
Journal of Mid-life Health Pub Date : 2025-10-01 Epub Date: 2025-12-08 DOI: 10.4103/jmh.jmh_47_25
Sangeeta Kumari, Shuchi Agrawal, Nitu Nigam, Nisha Singh, Sudhir Singh, Praveen Kumar, Avinash Agrawal
{"title":"Association between NAD (P) H: Quinone Oxidoreductase 1 C609T Gene Polymorphism and Risk Factors in Cases of Cervical Cancer in Indian Women.","authors":"Sangeeta Kumari, Shuchi Agrawal, Nitu Nigam, Nisha Singh, Sudhir Singh, Praveen Kumar, Avinash Agrawal","doi":"10.4103/jmh.jmh_47_25","DOIUrl":"10.4103/jmh.jmh_47_25","url":null,"abstract":"<p><strong>Introduction: </strong>HPV infection is causative agent for cervical cancer, majority of HPV infections are low-grade, self-limited, and revert spontaneously in some HPV infection fails to clear this hints towards presence of certain genetic factors which predispose them to increase risk of pre-cancer and cancer. We aimed to investigate the factors which have bearing on rising cancer cases in India and to elucidate the genetic susceptibility distribution of NAD (P) H: quinone oxidoreductase 1 C609T gene polymorphism.</p><p><strong>Materials and methods: </strong>Study recruited 142 women with biopsy-proven cervical cancer (the case group) and 142 women with normal cytology (the control group). DNA extracted from blood via QIAamp DNA mini kit. The DNA of each participant was amplified and the genotype and allelic frequency were compared.</p><p><strong>Results: </strong>In our study, maximum women in the case group had stage II (69.7%) squamous cell carcinoma (97.2%). 75.4% of the cases had moderately differentiated carcinoma and had no treatment before (43.7%). Among cases, the prevalence of genotype CC, CT and TT was 42.3%, 19.7% and 38.0%, respectively compared to 54.9%, 13.4% and 31.7%, in controls. The odds of having CC (odds ratio [OR] =0.64; 95% confidence interval [CI] =0.38-1.08), CC or CT in contrast to TT (OR = 0.756; 95% CI = 0.46-1.23), CC in contrast to TT/CT (OR = 0.694; 95% CI = 0.44-1.10) was lesser in cases compared to the controls, while Odds of allele T as compared to C were significantly elevated in cases as compared to that in the controls (OR = 1.48; 95% CI = 1.06-2.06). The proportion of TT genotype was elevated in advanced stages as compared to early stages.</p><p><strong>Conclusion: </strong>We found the odds of allele T as compared to C were markedly elevated in cases as compared to controls.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 4","pages":"425-433"},"PeriodicalIF":1.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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