Journal of Mid-life Health最新文献

{"title":"Comparison of the Relationships between Traditional and Regional Bone Mineral Density Values and Strength and Lean Mass for Younger and Older Women.","authors":"Michele LeBlanc, Tracy White, Steve Hawkins","doi":"10.4103/jmh.jmh_186_24","DOIUrl":"10.4103/jmh.jmh_186_24","url":null,"abstract":"<p><strong>Background: </strong>While studies focused on the relationships between bone mineral density (BMD) and strength or lean body mass have been conducted, there are not studies that have investigated these relationships for both age groups using the same methodology and population criteria (especially physical activity levels).</p><p><strong>Aims and objectives: </strong>The aim of this study was to compare the relationships between traditional and regional bone mineral density (BMD) and strength and lean mass values in younger and older women.</p><p><strong>Materials and methods: </strong>Forty-four younger (18-30 years) and 40 older (65-80 years) healthy females were recruited for this study. All had a physical activity rating of four or lower on the Physical Activity Rating Questionnaire. Muscle strength was tested for hand grip, leg press, and isokinetic knee flexion and extension. Total and regional lean body mass and BMD values were determined using dual-energy x-ray absorptiometry (DXA). Correlations and stepwise regressions were run between traditional (hip, spine, and forearm) and regional (arm and leg) BMD and strength and lean mass values. Significance was determined with <i>P</i> < 0.05.</p><p><strong>Results: </strong>The relationships for traditional BMD and strength measures for the two groups were quite similar with few significant relationships being identified for either group. The two groups had differing relationships between traditional BMD values and lean mass measures. The relationships between regional BMD and strength and lean mass values had good agreement for the two groups for the arm, but not the leg.</p><p><strong>Conclusions: </strong>The relationships investigated were most similar between the two age groups for the upper body but did not have good agreement for the lower body. These differences were likely due to greater declines in muscle quality associated with aging that occur more drastically for the lower body.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"137-143"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encrusted Cystitis: A Rare Morbid Disease.","authors":"Rahul Gupta, Yasir Mehmood, Arti Mahajan, Sindhu Sharma","doi":"10.4103/jmh.jmh_38_25","DOIUrl":"10.4103/jmh.jmh_38_25","url":null,"abstract":"<p><p>Encrusted cystitis (EC) is a rare clinical entity, with the first description dating back to 1914 by Francois J. This variety of debilitating and rare cystitis is caused by urea-splitting <i>Corynebacterium urealyticum</i>, especially <i>Corynebacterium</i> type 2B2 (CBGD2). Patients with prior urinary trauma, a history of intravesical bacillus Calmette-Guérin instillation, or chemotherapy are at higher risk for developing EC. Clinical presentation varies from dysuria, pain, hematuria, or passage of mucus or calcified mucopurulent stones. Diagnosis of Encrusted cystitis is done after excluding the other pathologies and is confirmed on isolation of Corynebacterium Type 2B2 organism and its characteristic features on radiotherapy. Medical management involves glycopeptide antibiotics and acidification of urine, either topical or systemic. Surgical treatment is done in rare cases with failed medical management or spontaneous bladder rupture. We report a rare case of morbid EC who required cystectomy and diversion.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"215-217"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse Presentations of Extrauterine Leiomyomas in the Female Urogenital Tract: A Retrospective Series of 51 Cases.","authors":"Tanvi Jha, Arvind Ahuja, Anuj Chachra, Purnima Paliwal, Kamna Dutta","doi":"10.4103/jmh.jmh_7_25","DOIUrl":"10.4103/jmh.jmh_7_25","url":null,"abstract":"<p><strong>Background: </strong>Extrauterine leiomyomas (EULs) are rare benign smooth muscle tumors that arise outside the uterus, often leading to diagnostic challenges.</p><p><strong>Objective: </strong>To evaluate the clinical and pathological characteristics of EULs and their management in a tertiary care setting.</p><p><strong>Methods: </strong>This retrospective study reviewed 51 cases of EULs over a 5.5-year period. Data on demographics, clinical presentation, tumor location, histology, and treatment were analyzed.</p><p><strong>Results: </strong>The mean patient age was 41.6 years, with 41.2% aged 40-50 and 15.7% post-menopausal. Abnormal uterine bleeding (AUB) was the most common symptom (66.7%). Tumors were most frequently located in the cervix (72.5%), followed by the broad ligament (11.8%) and ovaries (7.8%). Histologically, EULs resembled uterine leiomyomas, showing spindle-shaped cells and low mitotic activity. Surgical excision was the primary treatment.</p><p><strong>Conclusion: </strong>EULs, though uncommon, should be considered in differential diagnoses of pelvic masses. Accurate histopathological evaluation is essential to avoid misdiagnosis and unnecessary intervention. This study enhances current understanding of EUL presentation and management.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"144-147"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Sleep Disorders and Their Association with Neurocognitive, Psychological, or Physical Alterations in Postmenopausal Women.","authors":"Álvaro Monterrosa-Castro, Andrea Castilla-Casalins, Mayra Colmenares-Gúzman, Peter Chedraui","doi":"10.4103/jmh.jmh_215_24","DOIUrl":"10.4103/jmh.jmh_215_24","url":null,"abstract":"<p><strong>Objective: </strong>The objective of the study was to determine the frequency of sleep disorders and their association with neurocognitive, psychological, or physical alterations in postmenopausal Colombian women.</p><p><strong>Materials and methods: </strong>A cross-sectional study carried out on postmenopausal women (50-75 years). Participants were surveyed on a general questionnaire, the Jenkins Sleep Scale, the Mini-Mental State Examination tool, the Menopause Rating Scale (MRS), and the Strength, Assistance with walking, Rising from a chair, Climbing stairs, and Falling scale. Crude and adjusted logistic regression analyses were performed to determine the association between sleep problems (dependent variable) with the neurocognitive, psychological, and physical established impairments (independent variables). The covariates were age, age at menopause, years of being postmenopausal, coffee consumption, smoking habit, and nutritional status.</p><p><strong>Results: </strong>Among 601 participants, 53 (8.8%) had sleep problems. Bivariate analysis found that overall impairment of quality of life and its domains (somato-vegetative, psychological, and urogenital), and cognitive impairment and its various aspects (memory, language, fixation, and temporal fixation) were found at a higher rate among women with sleep problems. The risk of sarcopenia was similar among those with and without sleep problems. Adjusted logistic regression determined that sleep problems were associated with somato-vegetative (odds ratio [OR]: 3.44, 95% confidence interval [CI]: 1.56-7.59), urogenital (OR: 2.35, 95% CI: 1.00-5.51) and cognitive impairment (OR: 2.20, 95% CI: 1.02-4.71).</p><p><strong>Conclusion: </strong>8.8% of this sample of postmenopausal women had sleep problems, which were significantly associated with impairment of quality-of-life aspects and cognition.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"166-173"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EuroQoL-Visual Analog Scale as a Tool for Assessing Health Status in Breast Cancer Patients: A Cross-sectional Study.","authors":"Richha Prabhakar, Rajat Prabhakar, Dharmapuri R Rao","doi":"10.4103/jmh.jmh_222_24","DOIUrl":"10.4103/jmh.jmh_222_24","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer significantly influences women's health and overall well-being, necessitating comprehensive assessments to guide effective supportive care during cancer treatment. This study utilizes the EuroQoL-Visual Analog Scale (EQ-VAS) to systematically evaluate the health status and quality of life in women undergoing treatment for breast cancer.</p><p><strong>Materials and methods: </strong>A study was conducted on a sample of 100 patients with breast cancer who were treated at a tertiary care hospital in New Delhi. The EQ-VAS, a part of the EuroQoL five-dimension instrument, was used to evaluate the participants. It measures the participants' self-rated health on a vertical visual analog scale, with 0 representing the worst possible health and 100 representing the best health.</p><p><strong>Results: </strong>The participants' mean EQ-VAS score was 46.95 (standard deviation = 9.4), which denotes low self-perceived health. There were notable differences in EQ-VAS ratings between the various stages of breast cancer, with advanced stages exhibiting lower scores. Patients who underwent surgery for breast cancer were reported with high EQ-VAS scores (52.00 ± 16.71).</p><p><strong>Conclusion: </strong>The results emphasize the different health experiences of women suffering from breast cancer and the value of individualized care programs during cancer care. The EQ-VAS has shown to be a valuable instrument for gathering patient self-perceived health status, providing important information for healthcare professionals to improve supportive care and the overall health of women struggling with breast cancer.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"174-178"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Organochlorine Pesticide Exposure as Endocrine Disruptors with Polycystic Ovarian Syndrome in North India.","authors":"Ruchika Garg, Binita Goswami, Kamna Singh, Shaifali Singh, Prabhat Agrawal, Prashant Gupta, Urvashi Verma","doi":"10.4103/jmh.jmh_50_25","DOIUrl":"10.4103/jmh.jmh_50_25","url":null,"abstract":"<p><strong>Aim and background: </strong>This study explores the correlation of blood levels of organochlorine pesticides (OCPs) between PCOS and non-PCOS women, considering the endocrine-disrupting properties of OCPs and their potential role in PCOS pathogenesis.</p><p><strong>Materials and methods: </strong>A case-control study was conducted at Sarojini Naidu Medical College, Agra, from September 2022 to March 2024. Serum samples from 110 women diagnosed with PCOS and 110 age- and weight-matched controls were analyzed for 17°CP residues using gas chromatography. Clinical examination to calculate height, weight, body mass index, and waist-hip ratio was conducted. Signs of hyperandrogenism, such as acne and hirsutism, along with acanthosis nigricans, were documented. Hormonal profiles through chemiluminescence immunoassay were assessed. Correlation analysis entails examining connections between OCP and polycystic ovarian syndrome (PCOS) through the application of the Pearson correlation coefficient.</p><p><strong>Results: </strong>PCOS patients exhibited significantly higher levels of several OCPs, including Alpha BHC, Beta BHC, Gamma BHC, Delta BHC, Heptachlor, Heptachlor Epoxide, Endosulfan I, Endosulfan II, Endosulfan Sulfate, Aldrin, Endrin, Endrin Aldehyde, PP-DDE, PP-DDT, and PP-DDD (<i>P</i> < 0.05) in comparison to their age- and weight-matched controls. Dieldrin levels showed no significant difference in both cohorts. Elevated OCP levels correlated with increased androgens, insulin resistance, menstrual irregularities, and disrupted gonadotropin secretion in PCOS patients while no association was measured in controls.</p><p><strong>Conclusion: </strong>The findings suggest that environmental exposure to OCPs is associated with PCOS exacerbates the disease by disrupting hormonal balance and acting as endocrine disruptors. Further research is needed to confirm these associations and inform targeted interventions.</p><p><strong>Clinical significance: </strong>This study highlights the potential role of OCPs in association with PCOS, emphasizing the need for public health measures to reduce exposure to these harmful chemicals, which may help manage PCOS symptoms and improve health outcomes for affected women.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"201-207"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Single-dose Fosfomycin for Uncomplicated Urinary Tract Infection in Women: Systematic Review and Meta-analysis.","authors":"Tania Verma, Gaurav Singh Manhas, Rameshwar Singh Manhas","doi":"10.4103/jmh.jmh_77_24","DOIUrl":"10.4103/jmh.jmh_77_24","url":null,"abstract":"<p><p>In this meta-analysis and systematic review, the effectiveness and safety of single-dose fosfomycin were evaluated in comparison to other antibiotics for treating uncomplicated urinary tract infections (UTIs) in women, including asymptomatic bacteriuria (ASB) in pregnant women. Two independent reviewers conducted an electronic search on until December 2023 to search for randomized controlled trials that studied the efficacy and safety of fosfomycin for management of uncomplicated UTI in women or ASB in pregnant women and included those that fulfilled the eligibility criteria. The results showed that single-dose fosfomycin was comparable with other antibiotic agents in clinical resolution of uncomplicated UTI (odds ratio [OR]: 1.11, 95% confidence interval [CI] 0.88-1.41, <i>I</i> ² = 0%, <i>P</i> = 0.37, moderate certainty). Moreover, single-dose fosfomycin was equal to other antibiotics in the microbiological resolution of uncomplicated UTI (OR: 1.02, 95% CI: 0.83-1.25, <i>I</i> ² = 34%, <i>P</i> = 0.88, moderate certainty) and ASB among nonpregnant women (OR: 0.76, 95% CI: 0.45-1.28, <i>I</i> ² = 0%, <i>P</i> = 0.30, moderate certainty). The incidence of adverse events too was similar in patients receiving fosfomycin or other antibiotics (OR: 0.97, 95% CI: 0.77-1.23, <i>I</i> ² = 41%, <i>P</i> = 0.82, moderate certainty). Administering a single dose of fosfomycin is just as safe and effective as other antibiotics in treating uncomplicated UTIs in women. Prescribing a single dose of fosfomycin (3 g) as a regular practice may result in higher compliance rates and a reduced likelihood of antibiotic resistance.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"124-136"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroadenomatoid Hyperplasia of the Breast with Prominent Smooth Muscle Component: An Uncommon Histopathological Encounter.","authors":"Seetu Palo, Divya Donepudi, Shrinivas Bheemrao Somalwar","doi":"10.4103/jmh.jmh_35_25","DOIUrl":"10.4103/jmh.jmh_35_25","url":null,"abstract":"","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"226-227"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forgotten Intrauterine Contraceptive Device Presenting as Vesicouterine Fistula - Migration or Misadventure.","authors":"Vidhyalakshmi Ramadoss Kabilan, J Karthiga Prabhu, Senthilkumar Thiagarajan, Divyabharathi Muthulingam, N Yashwanthini Priyankaa","doi":"10.4103/jmh.jmh_84_25","DOIUrl":"10.4103/jmh.jmh_84_25","url":null,"abstract":"<p><p>Intrauterine contraceptive device (IUD) is one of the most commonly used long-term contraceptive methods worldwide. Migration of IUD is one of the rare complications of IUD insertion. Migrated IUD with calculus formation is a rarer long-term complication of IUD. A 55-year-old postmenopausal woman attended the outpatient clinic with complaints of continuous dribbling of urine. On examination, there was pooling of urine in the posterior fornix of the vagina, and the calcified vertical stem of the IUD was visualized through the cervical os. On evaluation, a giant calculus was noted within the bladder arising from the perforated IUD arm with vesicouterine fistula. Vesical lithotripsy followed by fistulous tract excision with repair of bladder wall was done.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"221-223"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Subjective Stress and its Association with 5-min Electrocardiogram-based Heart Rate Variability in Middle-aged Women of an Urban Area of West India.","authors":"Jayesh Dalpatbhai Solanki, Krina Ashish Atodaria, Divyang Rajeshkumar Joshi, Chhaya Maheshbhai Ghodadara, Jinesh Parmar","doi":"10.4103/jmh.jmh_207_24","DOIUrl":"10.4103/jmh.jmh_207_24","url":null,"abstract":"<p><strong>Background: </strong>Midlife health poses stress to women. Perceived Stress Scale (PSS) score allows subjective assessment of perceived stress whereas heart rate variability (HRV) gives electrocardiogram (ECG)-based quantification of cardiac autonomic function, but the relation between these two is scarcely studied. Hence, the association between PSS and HRV was studied in middle-aged women.</p><p><strong>Methodology: </strong>A cross-sectional study was done in midlife premenopausal (<i>n</i> = 51), perimenopausal (<i>n</i> = 59), and postmenopausal (<i>n</i> = 82) women. Perceived stress was interviewed by PSS score. ECG-based 5 min HRV was done by Variowin HR Software for frequency domain, time domain, and geometric HRV parameters. PSS and HRV were further compared or associated in subgroups, taking <i>P</i> < 0.05 as statistically significant.</p><p><strong>Results: </strong>HRV was reduced in all three groups which had a prevalence of PSS grade 0, 1, 2 44%, 53%, and 3%, respectively, without intergroup difference. Diabetic and/or hypertensive subgroups exhibited reduced HRV than nondiabetic nonhypertensive subgroups. No significant correlation was found between PSS score and HRV parameters in either group. HRV did not associate with PSS grade-based subgroups in pre-, peri-, or postmenopausal stage.</p><p><strong>Conclusion: </strong>Lack of HRV to perceived subjective stress association was observed in 40-55-year-old women with mild confounding by diabetes and/or hypertension. We suggest HRV total power and low-frequency: high-frequency ratio as best HRV parameters and consideration of age, reproductive health stage, and presence of comorbidities as a weak confounder for both HRV and PSS studies of middle-aged women. Further studies are warranted to consolidate the utility of HRV and PSS for the assessment of these two different types of stress.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"192-200"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}