Journal of Mid-life Health最新文献

{"title":"Status of Diabetes Mellitus in Pre-, Peri-, and Postmenopausal Women Accessing Obstetrics and Gynecological Care Services in Nigerian Hospitals.","authors":"Uchenna Cosmas Ugwu, Lawretta Eyuche Ozoemena, Vivian Akah Pauluyonwu","doi":"10.4103/jmh.jmh_55_25","DOIUrl":"10.4103/jmh.jmh_55_25","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM) poses significant threats to overall health, contributing to increased morbidity and mortality. This study investigated DM prevalence, knowledge, attitude, and practice (PKAP) among premenopausal, perimenopausal, and postmenopausal women accessing obstetric and gynecological care services in Nigerian hospitals, and explored associations with demographic variables.</p><p><strong>Subjects and methods: </strong>A hospital-based, cross-sectional survey was conducted between August 2024 and January 2025 using a multistage sampling technique. A total of 1620 women were recruited. Data were collected using an adapted Diabetes Mellitus Assessment Questionnaire, which demonstrated 0.81 reliability index. Data analysis was performed using IBM SPSS version 22, with statistical significance set at <i>P</i> ≤ 0.05.</p><p><strong>Results: </strong>Of the 1620 women recruited (aged 40-65 years), 1538 (94.9%) provided valid responses, whereas 82 (5.1%) withdrew voluntarily. Among respondents, 586 (38.1%) were premenopausal, 316 (20.5%) perimenopausal, and 636 (41.4%) postmenopausal. DM prevalence was 21.3%, 64.2%, and 65.3% among premenopausal, perimenopausal, and postmenopausal women, respectively. Good DM knowledge was observed in 62.8%, 69.3%, and 68.9% of premenopausal, perimenopausal, and postmenopausal women, respectively. Attitudes and practices toward DM varied across groups. Statistically, significant association was found between DM knowledge and employment (<i>P</i> = 0.022), whereas none existed on education (<i>P</i> = 0.701), alcohol intake (<i>P</i> = 0.901), or marital status (<i>P</i> = 0.501).</p><p><strong>Conclusion: </strong>The prevalence of DM was notably high, particularly among perimenopausal and postmenopausal women. While DM knowledge was generally good, attitudes and practices varied. The significant association between DM knowledge and certain demographic factors underscores the need for targeted health interventions and gender-responsive DM education programs.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"284-292"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo-Broad Ligament Leiomyoma: A Rare Cause of Diagnostic Uncertainty.","authors":"Neelam Singh, Shikha Singh, Rekha Rani, Urvashi Verma, Shikha Arora","doi":"10.4103/jmh.jmh_49_26","DOIUrl":"10.4103/jmh.jmh_49_26","url":null,"abstract":"<p><p>Broad ligament fibroids are rare extrauterine leiomyomas that present diagnostic and surgical challenges due to their atypical location and distortion of pelvic anatomy. Large tumors may closely mimic adnexal masses, making accurate preoperative diagnosis difficult. A 44-year-old multiparous woman presented with progressive abdominal distension and a sensation of heaviness and pain in the lower abdomen for one year. Clinical examination and ultrasonography suggested a uterine fibroid, but the precise site of origin could not be determined. Intraoperatively, a large abdominopelvic mass measuring approximately 121 mm × 117 mm was identified arising from the uterine wall and extending into the broad ligament, consistent with a pseudo-broad ligament fibroid. The mass caused significant pelvic distortion with lateral displacement of the ureter. Tumor excision with total hysterectomy and bilateral salpingectomy was performed. Histopathology confirmed leiomyoma without malignancy. The postoperative course was uneventful. Pseudo-broad ligament fibroids are uncommon and often diagnosed only at surgery. Awareness and meticulous surgical technique are essential to prevent complications.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"305-308"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Obesity Drugs: The Rising Significance of GLP-1Agonist, Tirzepatide.","authors":"Prabhat Kumar Agrawal, Ruchika Garg","doi":"10.4103/jmh.jmh_259_25","DOIUrl":"10.4103/jmh.jmh_259_25","url":null,"abstract":"","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"206-207"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond its Rarity: A 10-year Study on Primary Adenoid Cystic Carcinoma of the Breast from a Tertiary Care Center.","authors":"Pavithra Ethirajan, Swetha Lakshmi Narla","doi":"10.4103/jmh.jmh_200_25","DOIUrl":"10.4103/jmh.jmh_200_25","url":null,"abstract":"<p><strong>Introduction: </strong>Adenoid cystic carcinoma (AdCC) of the breast is a rare malignancy (~0.1%), affecting women in their 50s-60s. It presents as a palpable mass with tubular, cribriform, and solid patterns and shows biphasic differentiation. C-Kit expression supports diagnosis. Despite its triple-negative status, AdCC has a favorable prognosis, except in solid-basaloid variants.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted in the Department of Histopathology, Apollo Cancer Center, Chennai, and included all cases of primary breast AdCC diagnosed between January 2014 and December 2024.</p><p><strong>Results: </strong>Twelve female patients were included, with a mean age of 55.5 years. All presented with a breast lump; right and left sides were equally involved, with the upper outer quadrant being the most common site (70%). Surgical management included wide local excision (WLE) (45.45%), modified radical mastectomy (36.36%), total mastectomy (9.09%), and chemotherapy/immunotherapy in one patient (9.09%). Multifocality was seen in 16.66% (2/12). Mean tumor size was 2.66 cm, and pT2 stage was most frequent (57.14%). One case showed local recurrence post-WLE; another developed lung metastasis. Histologically, 75% showed all three patterns with solid areas ranging from 10% to 90%. Perineural invasion was seen in 58.33% (7/12) and lymphovascular invasion in 16.66% (2/12). Most tumors were Nottingham Grade 2 (83.33%). All were progesterone receptor and HER2/neu negative; estrogen receptor positivity was seen in two cases. C-Kit was positive in all tested cases. Ki-67 index ranged from 6% to 80%.</p><p><strong>Conclusion: </strong>Breast AdCC shows favorable prognosis. Most cases were pT2, stage IIA, with rare recurrence or metastasis.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"241-247"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of Human Papilloma Virus in Carcinoma Cervix along with Screening of Risk Factors and their Regional Comparison.","authors":"Arti Agrawal, Astha, Parul Garg, Gargi Tyagi, Pooja Agrawal, Urvashi Verma, Ruchika Garg, Ayushi Gupta, Surabhi Gupta","doi":"10.4103/jmh.jmh_378_25","DOIUrl":"10.4103/jmh.jmh_378_25","url":null,"abstract":"<p><strong>Introduction background: </strong>The threat of cervical carcinoma is still a major public health challenge in low- and middle-income countries, including India. In this context, disparate findings about HPV genotypes are reported from different regions of India. Interestingly, although HPV-16 and HPV-18 have demonstrated global supremacy as risk factors for cervical cancer, recent observations from India indicate a rising trend of high-risk non-18 genotypes.</p><p><strong>Aim and objectives: </strong>To assess the prevalence, distribution of genotypes, and molecular profile of the human papillomavirus in women presenting with suspected cervical pathology in the Agra region of North India. In addition, the cytology-VIA correlation and epidemiological risk factors in the region were assessed.</p><p><strong>Material and methods: </strong>In this hospital-based cross-sectional study, the data were collected over a period of 18 months from April 2023 to January 2025. A total of 500 symptomatic women between the age group of 25 and 65 years were included from a tertiary care hospital in Agra. Cervical samples were obtained for the Pap smear, VIA, and HPV DNA. Genotyping for various types of HPV was done by real-time PCR for 28 types of HPV. Sociodemographic, reproductive, and behavioral factors of the subjects were taken into consideration.</p><p><strong>Results: </strong>The DNA of the human papillomavirus was detected in 13% of the 500 patients. There was no association between sociodemographic and behavioral factors. Abnormal cytology was found to be highly significantly associated with the presence of the human papillomavirus. Abnormal cytology was 74.7% associated with the presence of human papillomavirus (<i>p</i> < 0.001). Pap smear was found to be 95.6% specific and 86.2% sensitive. VIA was found to be 100% sensitive but 62.8% specific. In the present study, the human papillomavirus type 16 was the most prevalent. In addition to human papillomavirus type 16, human papillomavirus type 39.</p><p><strong>Conclusion: </strong>This study underlines marked regional diversity in HPV genotypes at high risk other than HPV-16/18 and confirms a strong concordance between infection with high-risk human papillomavirus and cytological abnormalities. These findings raise the demand for genotype-informed surveillance of human papillomavirus infection, expanded vaccine coverage, and integrated screening to advance the effort at cervical cancer prevention in north India.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"228-235"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Medicalization: Menopause Care with Empathy: An Editorial Review.","authors":"Seema Sharma, Reeti Mehra","doi":"10.4103/jmh.jmh_193_26","DOIUrl":"10.4103/jmh.jmh_193_26","url":null,"abstract":"","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"201-205"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations Regarding the Assessment of Quality of Life Using the Menopause-specific Quality of Life Questionnaire among Menopausal Women.","authors":"Anchal Gupta, Neha Reyalch, Aakanksha Bajpai","doi":"10.4103/jmh.jmh_30_26","DOIUrl":"10.4103/jmh.jmh_30_26","url":null,"abstract":"","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"323-324"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Difference in the Prolapse Quality-of-Life Questionnaire Score in Patients Undergoing Laparoscopic Sacrocolpopexy or Transvaginal Mesh Surgery for Pelvic Organ Prolapse Based on a Nearest-neighbor Propensity Score Matched Analysis.","authors":"Kenji Kuroda, Koetsu Hamamoto, Kazuki Kawamura, Ayako Masunaga, Hiroaki Kobayashi, Keiichi Ito","doi":"10.4103/jmh.jmh_227_25","DOIUrl":"10.4103/jmh.jmh_227_25","url":null,"abstract":"<p><strong>Objectives: </strong>Both laparoscopic sacrocolpopexy (LSC) and transvaginal mesh surgery (TVM) result in favorable outcomes for patients undergoing pelvic organ prolapse (POP) repair. However, their effects on postoperative quality of life (QOL) are yet unknown, particularly when performed on patient groups with similar backgrounds. This study aimed to compare the postoperative POP-related symptoms between patient groups without statistically significant preoperative differences.</p><p><strong>Materials and methods: </strong>We retrospectively evaluated 245 patients with POP who underwent LSC or TVM. In our hospital, 97 patients were treated by LSC, whereas 148 were treated by TVM. The postoperative QOL between the matched 68 LSC-treated patients and 68 TVM-treated patients were compared using the nearest-neighbor propensity score matching. The Japanese version of the prolapse QOL questionnaire (P-QOL) was administered to assess POP-related conditions. The rates of urinary incontinence (UI), mesh exposure, and prolapse recurrence were also calculated.</p><p><strong>Results: </strong>The nearest-neighbor propensity score matching showed no statistically significant differences between the matched LSC and TVM groups. In the matched patients, compared with the preoperative scores, the 3-12-month postoperative P-QOL component scores decreased significantly. When comparing the 1-year postoperative values with the preoperative values, differences in the presence of UI, mesh exposure, prolapse recurrence rates, and the P-QOL component scores were not statistically significant between the two matched groups.</p><p><strong>Conclusion: </strong>Using nearest-neighbor propensity score matched analysis, this study suggested TVM as a favorable option to treat POP, given the postoperative improvement in P-QOL scores in addition to the shorter operative time and lower complication rates.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"253-260"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early versus Delayed Removal of Urinary Catheter after Laparoscopic Hysterectomy: Insights from a Prospective Observational Study.","authors":"Suma Shet, Charu Sharma, Shashank Shekhar, Pratibha Singh, Manisha Jhirwal, Meenakshi Gothwal, Manoj Kumar Gupta","doi":"10.4103/jmh.jmh_204_25","DOIUrl":"10.4103/jmh.jmh_204_25","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the outcomes of early versus delayed removal of the urinary catheter after total laparoscopic hysterectomy (TLH), focusing on urinary retention, re-catheterization, urinary tract infection (UTI), and hospital stay duration.</p><p><strong>Subjects and methods: </strong>A prospective observational study was conducted, enrolling patients who underwent TLH. Participants were divided into two groups based on the timing of urinary catheter removal: early removal (immediately post-surgery) and delayed removal (≥18-24 h post-surgery). The primary outcomes included the incidence of temporary urinary retention (inability to void within 6 h of catheter removal requiring re-catheterization, the rate of UTI, and the duration of hospital stay). Statistical analyses were performed to compare outcomes between the two groups.</p><p><strong>Results: </strong>A total of 128 women were analyzed (early catheter removal [ECR]: 62, delayed catheter removal: 66). Early removal of the urinary catheter was associated with an increased risk of temporary urinary retention. The risk difference was 9.7% (95% confidence interval [CI] [2.3-17.0]); <i>P</i> = 0.028) and a higher rate of re-catheterization (10.9% [95% CI 3.23-18.30]; <i>P</i> = 0.01). The incidence of UTIs was lower in the early removal group (1.53% vs. 7.69%), although this difference was not statistically significant (<i>P</i> = 0.20). Patients in the early removal group had a significantly shorter hospital stay (2.91 ± 0.9 days vs. 2.97 ± 0.6 days, <i>P</i> = 0.05).</p><p><strong>Conclusion: </strong>ECR after laparoscopic hysterectomy increases the risk of transient urinary retention and re-catheterization, with a possible trend toward lower UTI rates and a modest reduction in hospital stay. A risk-stratified, individualized approach may be preferable.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"269-275"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross sectional Study to Assess the Prevalence of Periodontitis and its Association with Temporomandibular Joint Disorders among Pre and Postmenopausal Women.","authors":"Girish Suragimath, S R Ashwinirani, Disha Suragimath","doi":"10.4103/jmh.jmh_190_25","DOIUrl":"10.4103/jmh.jmh_190_25","url":null,"abstract":"<p><strong>Introduction: </strong>Midlife changes in the oral cavity of humans can involve both natural aging processes and hormonal fluctuations, especially in women. Common oral changes include increased dental caries, dry mouth, periodontitis, burning mouth syndrome, and temporomandibular joint disorders (TMDs). This study was designed to assess the prevalence of periodontitis and its association with TMDs among pre- and postmenopausal women.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted among 100 women (50 premenopausal and 50 postmenopausal). Demographic details and TMD symptoms were recorded using a structured proforma. Periodontal health was assessed using a mouth mirror and periodontal probe, and staging was determined according to standard case definitions. TMDs evaluation followed the diagnostic criteria for TMDs. Statistical analysis was conducted, and <i>P</i> < 0.05 was considered significant.</p><p><strong>Results: </strong>Periodontitis was present in 65% of participants, with significantly higher prevalence in postmenopausal women (84%) compared to premenopausal women (46%). The signs and symptoms of TMDs were observed in 68% of women. Among women with periodontitis, 86% suffered from TMDs. Clicking sounds, masseter and lateral pterygoid tenderness, and temporomandibular joint (TMJ) pain were significantly more common in postmenopausal women (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>This study demonstrated a significant association between menopause, periodontitis, and TMDs, with postmenopausal women showing a greater prevalence of both conditions. These findings suggest that hormonal changes and aging may influence TMJ function. Routine TMD screening in women with periodontitis, especially during menopause, is recommended for early management and improved quality of life.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 2","pages":"299-304"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}