Journal of Mid-life Health最新文献

{"title":"Tirzepatide-induced Weight Loss in Overweight or Obese Midlife Adults with and without Type 2 Diabetes: A Real-world Comparative Cohort Study.","authors":"Prabhat Kumar Agrawal, Shambo Samrat Samajdar, Ruchika Garg, Gaurav Gupta, Ashish Gautam, Noor Husain, Shatavisa Mukherjee, Sandipta Kumar Panda","doi":"10.4103/jmh.jmh_373_25","DOIUrl":"10.4103/jmh.jmh_373_25","url":null,"abstract":"<p><strong>Background: </strong>Tirzepatide, a dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist, has demonstrated robust weight loss and glycemic benefits in randomized controlled trials. However, real-world data comparing its effectiveness and tolerability in obese adults with and without type 2 diabetes (T2D) are limited. The present study aimed to evaluate the real-world short-term effectiveness and safety of tirzepatide in promoting weight loss among obese or overweight adults with and without T2D.</p><p><strong>Methods: </strong>This was a 12-week, prospective, observational cohort study involving 93 adults (70 individuals without diabetes and 23 individuals with T2D) receiving tirzepatide at a tertiary care center. The primary outcome was change in body weight. The secondary outcomes included changes in body mass index (BMI), waist circumference (WC), glycemic parameters (in individuals with T2D only), responder thresholds (≥5%, ≥10%, and ≥15% weight loss), and adverse events (AEs). Between-group comparisons were adjusted using multivariable regression and 1:3 propensity score matching.</p><p><strong>Results: </strong>Both the groups experienced significant reductions in weight, BMI, and WC (all <i>P</i> < 0.001). The mean weight loss was - 7.14 kg in individuals without diabetes and - 5.87 kg in individuals with T2D. Among individuals with T2D, HbA1c and fasting glucose decreased by - 1.16% and - 30.9 mg/dL, respectively. A ≥10% weight loss was achieved by 21.4% of individuals without diabetes compared with 0% of individuals with T2D (<i>P</i> = 0.018). Adjusted between-group differences in weight change were modest and not statistically significant after propensity matching. AEs were more common in the T2D group (78.3% vs. 50.0%, <i>P</i> = 0.033) and were primarily mild gastrointestinal symptoms.</p><p><strong>Conclusion: </strong>Tirzepatide produced meaningful weight loss in both T2D and non-T2D obese adults, with additional glycemic improvements in T2D. Individuals without diabetes were more likely to achieve ≥10% weight loss, while tolerability remained acceptable in both the groups. These real-world findings support tirzepatide's role in individualized obesity and metabolic disease management.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"167-173"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Meta-analysis of Risk Factors for Breast Cancer among Indian Women.","authors":"Jyothi G Seshadri, Ruchika Garg, Swetha Shivaram","doi":"10.4103/jmh.jmh_376_25","DOIUrl":"10.4103/jmh.jmh_376_25","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most common cancer diagnosed among Indian women due to change in life style, reproductive patterns and rapid urbanization.</p><p><strong>Methods: </strong>A systematic search was conducted for case control studies published between January 2010 and April 2025. Data were extracted from 19 studies. Pooled odds ratios (OR) with 95% confidence intervals (CI) ,heterogeneity was assessed with I² statistics, while publication bias was evaluated using funnel plots and Egger's test. Study quality was appraised using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Sociodemographic risks included unmarried status (OR=1.96; 95% CI: 1.09-3.54) and late age at marriage > 21 years (OR= 2.66; 95% CI: 1.90-3.73). Family history of breast cancer doubled the risk (OR=2.35; 95% CI: 1.73-3.18), and past benign breast disease showed a strong association (OR=4.28; 95% CI: 2.50-7.35). Central obesity (WHR > 0.85) significantly increased risk (OR=2.74; 95% CI: 1.85-4.07), although BMI > 25 kg/m² alone was not significant. Lifestyle factors such as non-vegetarian diet (OR = 1.62; 95% CI: 1.19-2.21), tobacco use (OR=1.67; 95% CI: 1.24-2.24), and high-fat diet (OR=4.20; 95% CI: 2.76-6.42) demonstrated strong associations. Reproductive risk factors-including early menarche (OR =1.95), late menopause (OR=1.92), OCP use (OR=2.01), low parity (OR=1.52), previous abortions (OR=2.48), and breastfeeding <6 months (OR= 4.12)-were all significantly linked to higher risk. Several subgroups exhibited notable heterogeneity and occasional publication bias.</p><p><strong>Conclusion: </strong>Modifiable risks present critical opportunities for prevention.Women with non-modifiable factors warrant targeted screening and risk stratification.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"130-140"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reimagining Aging: A Systematic Review and Meta-analysis of Virtual Reality on Cognitive, Physical, and Functional Outcomes in Older Adults.","authors":"Charu Chhabra, Sohrab Ahmad Khan, Varsha Chorsiya, Habiba Sundus, Harsirjan Kaur, Mohd Mazhar, Harpreet Singh, Archita Agarwal","doi":"10.4103/jmh.jmh_223_25","DOIUrl":"10.4103/jmh.jmh_223_25","url":null,"abstract":"<p><p>The diverse applications of virtual reality (VR) for older adults require a need for comprehensive, updated syntheses, and research to understand VR's effectiveness across cognitive, physical, and functional domains. This study aimed to assess the effects of VR training on cognition, physical, and functional parameters in older adults through a systematic review and meta-analysis of randomized controlled trials (RCTs). Online databases were searched for relevant articles, which were screened for eligibility and data extraction following bias risk assessment. A total of sixteen RCTs were included in this systematic literature review. A meta-analysis was conducted using data extracted from the included studies. Standardized mean differences were calculated for Time Up and Go test, which is a measure of functional fitness. The pooled standardized mean difference (SMD) using a random effects model was - 0.175 (95% confidence interval [CI]; -0.834-0.483; <i>P</i> = 0.600), indicating no statistically significant difference between intervention and control groups. There was substantial heterogeneity among the included studies (Q = 42.74, df = 6, <i>P</i> < 0.0001), with an I value of 85.96%, suggesting considerable inconsistency in effect sizes. Among included studies, two reported statistically significant effects: Zak <i>et al</i>. (2022), SMD = 0.812 (95% CI: 0.053-1.570), and Htut <i>et al</i>. (2018), SMD = -1.996 (95% Cl: -2.750 to - 1.242). Remaining studies showed non-significant SMDs. The current review concludes that VR-based interventions are helpful for geriatric rehabilitation, especially when it comes to improving older adults' functional, cognitive, and physical outcomes.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"42-54"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Acupressure on Menopausal Symptoms: A Randomized, Sham-Controlled Study.","authors":"Melek Yesil Bayülgen, Fatma Hikmet Yeşil, Yasemin Ateşeyan","doi":"10.4103/jmh.jmh_8_25","DOIUrl":"10.4103/jmh.jmh_8_25","url":null,"abstract":"<p><strong>Background: </strong>With the increase in women's life expectancy at birth, the time spent in menopause has also increased. This has led to longer exposure to menopausal symptoms. This study aims to determine the effect of acupressure on menopausal symptoms. The study has a prospective, randomized, sham-controlled, and single-blind design.</p><p><strong>Materials and methods: </strong>The research was conducted with 81 women (acupressure <i>n</i> = 40, sham acupressure <i>n</i> = 41) attending the \"Menopause School\" in a public hospital at in Turkey between July 5, 2022 and August 2, 2022. Both groups received acupressure application thrice a week for 4 weeks, 12 sessions in total. The data were obtained using a personal information form and a Menopause Rating Scale.</p><p><strong>Results: </strong>Acupressure application was determined to reduce the somatic and urogenital complaints of women (<i>P</i> < 0.001), whereas it did not make any difference in their psychological complaints (<i>P</i> = 0.281). In the sham acupressure group, on the other hand, the sham acupressure was determined not to make a significant statistical difference in the mean menopausal complaints score (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Acupressure application is effective in reducing the somatic and urogenital complaints experienced by menopausal women.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"79-86"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Surgical Menopause versus Physiological Menopause on Quality of Life and Mental Health: A Cross-sectional Study in Eastern Part of India.","authors":"Divya Mecheril Balachandran, Priyanka Rai, Vinayagamoorthy Venugopal, Vineeta Singh, Swati Priya, Manish Raj, Ruchika Garg","doi":"10.4103/jmh.jmh_166_25","DOIUrl":"10.4103/jmh.jmh_166_25","url":null,"abstract":"<p><strong>Background: </strong>Menopause is a condition where there is an absence of menstrual cycles with cessation of ovarian activity. When it occurs naturally, then it is physiological menopause, and when it occurs after the removal of uterus and ovaries, then it is surgical menopause. This study aims to compare the adverse impact on quality of life and mental health on women after physiological menopause and surgical menopause.</p><p><strong>Subjects and methods: </strong>This is a hospital-based cross-sectional study conducted over a period of 6 months at a tertiary care center in the Eastern part of India. A total of 126 postmenopausal women - 63 women after surgical menopause and 63 after physiological menopause. Quality of life was assessed using the menopause-specific quality of life questionnaire and mental health morbidity was assessed using the Hospital Anxiety Depression scale. Mann-Whitney <i>U</i> test and Chi-square tests were used for comparing the two groups.</p><p><strong>Results: </strong>The mean age of hysterectomy in surgical menopause was 35.44 years ± 8.67, and the mean age of menopause in physiological menopause was 49.84 years ± 2.24. Women in surgical menopause experienced more physical (median score of 7 vs. 2) and psychosocial domain impairment (median score of 17 vs. 14) than the physiological menopause group. Depression was more significant in the surgical menopause group than physiological menopause with a median score of 6 versus 2. Overall, a poor quality of life was more in the surgical menopause group than in the physiological menopause group.</p><p><strong>Conclusion: </strong>Surgical menopause results in higher psychosocial and physical morbidity, resulting in impaired quality of life than physiological menopause.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"106-110"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammaging and Midlife Women: Translating Geroscience into Clinical Practice.","authors":"Atul Munshi, Ruchika Garg","doi":"10.4103/jmh.jmh_77_26","DOIUrl":"10.4103/jmh.jmh_77_26","url":null,"abstract":"","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"1-4"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and Immunohistochemical Analysis of Recurrent Endometrial Carcinomas: A Retrospective Study from an Indian Cohort.","authors":"Padmavathi Kamath, Gayatri Ravikumar, Kiran Kulkarni","doi":"10.4103/jmh.jmh_59_25","DOIUrl":"10.4103/jmh.jmh_59_25","url":null,"abstract":"<p><strong>Objectives: </strong>A significant proportion of endometrial carcinomas (EC) recur, necessitating the identification of prognostic factors to refine treatment strategies. This study aims to identify predictors of recurrence.</p><p><strong>Materials and methods: </strong>This retrospective analysis examines clinicopathological and immunohistochemical features of recurrent EC in an Indian cohort, which were also categorized by ESMO-ESGO-ESTRO risk stratification.</p><p><strong>Results: </strong>Seventeen cases of recurrent EC (2012-2024) treated in our hospital were analyzed. Surgical resection was performed in 16 patients, with one managed palliatively. All except one recurrence was biopsied. The median age at recurrence was 62 years, with a median recurrence interval of 24 months. Endometrioid carcinoma (64.7%) was the most common histological type. Tumors were nearly evenly distributed between low- versus high grade (41.2% vs. 58.8%) and FIGO Stage I versus II-IV (56.3% vs. 43.8%). Superficial myometrial invasion and diffuse invasion patterns were seen in 62.5% of cases, with inflammatory stromal responses in 43.8%. None exhibited a MELF pattern. High- and high-intermediate-risk tumors comprised 56.3%. Vaginal recurrences (<i>n</i> = 8) often occurred in low-grade, superficially invasive tumors without lymph node involvement. Immunohistochemistry (IHC) revealed PgR loss in 56% of recurrent tumors. One high-grade EC demonstrated p53 mutation-type staining in recurrences despite wild-type staining in the primary tumor. Other types showed stable IHC profiles.</p><p><strong>Conclusion: </strong>Risk stratification is a more reliable predictor of recurrence than individual parameters. Vaginal recurrences may not indicate aggressive tumor biology. Loss of PgR expression may contribute to disease progression. Molecular studies and extended follow-up are critical for understanding tumor biology and improving outcomes.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"117-124"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Magnetic Resonance Imaging in Staging Endometrial Cancer: A Retrospective Single-center Observational Study.","authors":"Priyanka Goel, Vineet Mishra, Samta Bali Rathore, Swati Garg, Shagun Gupta, Anupriya Agarwal","doi":"10.4103/jmh.jmh_296_25","DOIUrl":"10.4103/jmh.jmh_296_25","url":null,"abstract":"<p><strong>Background: </strong>Cancer of endometrium is among the most common female malignancies in developed nations. Usually, because of awareness related to complaints of postmenopausal bleeding and availability of various diagnostic modalities, endometrial cancer has a favorable prognosis. The aim of this study is to determine how accurate the contrast-enhanced magnetic resonance imaging (MRI) is for preoperative staging of uterine cancer considering final histopathological report as gold standard.</p><p><strong>Materials and methods: </strong>In this retrospective study done in a tertiary care center, 50 patients with histopathological diagnosis of endometrial carcinoma were included, operated at our center between January 2024 and December 2024. Various prognostic factors such as invasion of myometrium and cervical stroma, metastasis to the lymph nodes (LNs), and extrauterine spread (EUS) were analyzed preoperatively with contrast-enhanced MRI reported by a single radiologist and then compared with final histopathology report. Statistical parameters such as accuracy (Ac), sensitivity (Sn), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of MRI were assessed for each factor.</p><p><strong>Results: </strong>The Sn, Sp, Ac, PPV, and NPV of myometrial invasion (MI) diagnosed with MRI were 62.5%, 80.77%, 72%, 75%, and 70%, and these values for cervical invasion were 40%, 100%, 94%, 100%, and 93.75%, respectively. Similar values for LN metastasis were 33.3%, 95.5%, 88%, 50%, and 91.3% and for EUS were 25%, 97.83%, 92%, 50%, and 93.75%, respectively.</p><p><strong>Conclusions: </strong>MRI is a sensitive tool for MI with good Ac and Sp for the diagnosis of cervical stromal invasion and LN metastasis before surgery and helps the clinician to plan the surgery accordingly.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"125-129"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of <i>Shankhapushpi</i> (<i>Convolvulus pluricaulis</i>) in Posthysterectomy Menopausal Syndrome - A Randomized Controlled Pilot Clinical Trial.","authors":"Dharthy S Budihal, Kashavva V Hiremath, Omkar D Ingale, Swarda Uppin","doi":"10.4103/jmh.jmh_37_25","DOIUrl":"10.4103/jmh.jmh_37_25","url":null,"abstract":"<p><strong>Background: </strong>Menopause, cessation of woman's reproduction otherwise can happen early by hysterectomy might need therapeutic attention, as it disturbs psychosomatic health by interruption in the hormonal physiology. Herbs rich in phytoestrogens like <i>Convolvulus pluricaulis</i> Choisy, known as <i>Shankhapushpi</i> in <i>Ayurveda</i>, are better nonhormonal alternatives to manage such conditions.</p><p><strong>Objective: </strong>The objective of the study was to evaluate the effect of <i>C. pluricaulis</i> in posthysterectomy menopausal syndrome.</p><p><strong>Materials and methods: </strong>In this randomized controlled pilot trial, 30 women who underwent hysterectomy (before attaining natural menopause) meeting the inclusion criteria with a minimum menopause rating scale (MRS) score of 5 and a Modified Kupperman's Index (MKI) score of 7, were randomized into two groups. 15 subjects of the control group received <i>Asparagus racemosus</i> Willd powder, and 15 subjects of the interventional group received <i>C. pluricaulis</i> powder, 6 g twice daily, respectively, after food with lukewarm water for a period of 45 days. Study outcome was evaluated through primary measures MRS, MKI, and Menopause-Specific Quality of Life (MS-QoL) on baseline, 15^th, 30^th, and 45^th day, whereas Serum estrogen and secondary measure Hamilton Anxiety Rating Scale (HARS) on baseline and 45^th day. Statistical results were expressed through Independent and Dependent <i>t</i>-tests.</p><p><strong>Results: </strong>Study results revealed that both interventions were comparable and each produced significant improvement (<i>P</i> < 0.001) in MRS, MKI, MS-QoL, and HARS. <i>C. pluricaulis</i> has shown nonsignificant results in improving the serum estrogen levels (<i>P</i> = 0.334) compared to <i>A. racemosus</i> (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong><i>C. pluricaulis</i> was beneficial in managing posthysterectomy menopausal syndrome, assessed through MRS, MKI, MS-QoL, and HARS. It was also helpful in maintaining stable estrogen levels, suggesting its possible efficacy as a nonhormonal herbal medicine.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"146-153"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silence that Breaks the Nite \"The Effects of Nocturia on Psychological Well being and Quality of Life in Menopausal Women\": A Case-control Study.","authors":"Meryem Vural Şahin, Derya Yüksel Koçak","doi":"10.4103/jmh.jmh_201_25","DOIUrl":"10.4103/jmh.jmh_201_25","url":null,"abstract":"<p><strong>Background: </strong>According to previous studies, urogenital symptoms, including nocturia, worsen with the menopause and depression and quality of life decrease in women experiencing nocturia.</p><p><strong>Objectives: </strong>This study aimed to determine the impact of nocturia on depressive symptoms and quality of life in menopausal women.</p><p><strong>Materials and methods: </strong>This case-control study was conducted 110 premenopausal and 141 postmenopausal, who attended a Family Health Center in Ankara, Turkey, between July and September 2021. A total 251 menopausal women were included through convenience sampling. We utilized the World Health Organization Quality of Life Scale (WHOQOL-BREF), the Beck Depression Inventory (BDI), and the Sociodemographic Information Form. This study complies with the STROBE guideline.</p><p><strong>Results: </strong>In this study, the incidence of nocturia was higher in postmenopausal women (%69, 5) compared to premenopausal women (%49, 1). Except for the general health and physical health sub-dimension mean scores of the WHOQOL-BREF scale, other sub-dimension scores were statistically significantly lower in women with nocturia than in women without (<i>p</i> < 0.05). The mean BDI scores were statistically significantly higher in women with nocturia (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>It was determined that nocturia negatively affects the quality of life and increases the depressive symptoms in menopausal women. Healthcare professionals should assess urologic symptoms and psychological symptoms, including depressive symptoms.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"154-159"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}