Journal of Mid-life Health最新文献

{"title":"Message from the President, Indian Menopause Society, 2025-2026.","authors":"","doi":"10.4103/jmh.jmh_22_26","DOIUrl":"https://doi.org/10.4103/jmh.jmh_22_26","url":null,"abstract":"","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 Suppl 1","pages":"S8"},"PeriodicalIF":1.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause Medicine Comes of Age: A Founder's Message.","authors":"Wulf Utian","doi":"10.4103/jmh.jmh_45_26","DOIUrl":"10.4103/jmh.jmh_45_26","url":null,"abstract":"","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 Suppl 1","pages":"S119-S120"},"PeriodicalIF":1.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Lifestyle Factors to Reduce the Incidence of Endometrial Cancer.","authors":"Saurabh RamBihariLal Shrivastava, Prateek Sudhakar Bobhate, Rajasi Sengupta, Smita Parate","doi":"10.4103/jmh.jmh_111_25","DOIUrl":"10.4103/jmh.jmh_111_25","url":null,"abstract":"<p><p>Endometrial cancer has been regarded as one of the most common gynecological malignancies in high-income nations. A wide range of genetic, environmental, and lifestyle-related factors has been identified in the causation of endometrial cancers among women. Acknowledging the rising incidence, associated mortality, and the presence of multiple lifestyle-related factors in the causation of endometrial cancer, we must adopt targeted public health interventions to minimize the impact of these attributes. In conclusion, multiple lifestyle-related factors interact synergistically and significantly contribute to the incidence of endometrial cancer. The need of the hour is to adopt a multisectoral approach to effectively mitigate the consequences of lifestyle-related factors.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"188-190"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Vesicles Mislead: A Rare Case of Massive Lymphangioma Circumscriptum of the Vulva.","authors":"Lajya Devi Goyal, Yukta Dhingra, Neelima Chelluru","doi":"10.4103/jmh.jmh_164_25","DOIUrl":"10.4103/jmh.jmh_164_25","url":null,"abstract":"<p><strong>Background: </strong>Lymphangioma circumscriptum (LC) is a benign lymphatic malformation resulting from dilated lymphatic vessels in the skin and subcutaneous tissue. It commonly affects the chest, tongue, axilla, and oral cavity. Vulvar involvement is exceptionally rare.</p><p><strong>Case report: </strong>We report the case of a 45-year-old multiparous female with a 4-year history of vulvar lesions along with discharge. There was no history of associated burning, pain, or itching. She underwent abdominal hysterectomy 10 months back (it was after the appearance of vulvar lesions). Local examination revealed grouped vesicles over the mons pubis and labia majora. Histopathology confirmed LC, showing dilated lymphatic spaces in the dermis.</p><p><strong>Management and outcome: </strong>The patient underwent surgical excision followed by daily dressings. Postoperative period was uneventful, with excellent cosmetic and symptomatic improvement.</p><p><strong>Conclusion: </strong>Vulvar LC, although rare, should be kept in the differential diagnosis of vesicular or wart-like vulvar lesions. Early diagnosis and surgical intervention offer favorable cosmetic and psychosocial outcomes. This case highlights the importance of histopathological confirmation to distinguish LC from other similar presentations like genital warts or molluscum contagiosum.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"174-177"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Menopausal Symptoms and Demographic Variables among Perimenopausal and Postmenopausal Women: A Community-based Cross-sectional Survey.","authors":"Agatha Nneka Obayi, Olive Oluchukwu Ilo, Uchenna Cosmas Ugwu","doi":"10.4103/jmh.jmh_74_25","DOIUrl":"10.4103/jmh.jmh_74_25","url":null,"abstract":"<p><strong>Background: </strong>Menopausal symptoms (MS) present painful experiences that have adverse effects on the overall health of women. The purpose of this study is to determine the prevalence of MS and its association with demographic variables among perimenopausal and postmenopausal women in Nsukka communities.</p><p><strong>Subjects and methods: </strong>It was a community-based cross-sectional survey adopting a multistage sampling technique, conducted from September 2024 to February 2025 in 30 communities. A total of 850 women of perimenopausal and postmenopausal status were investigated using an adapted menopause symptoms assessment questionnaire, demonstrating a 0.86 reliability index. The IBM-SPSS version 22 was used for data computation, whereas all statistical analysis was performed using frequency, percentage, and Chi-square statistics at <i>P</i> ≤ 0.05.</p><p><strong>Results: </strong>Out of 850 eligible participants, only 26 (30.1%) declined, whereas 824 (96.9%) complied accordingly; 523 (63.5%) were perimenopausal, whereas 301 (36.5%) were postmenopausal women, respectively. Overall, MS prevalence was 76.1% for perimenopausal; and 82.4% for postmenopausal women. Specifically, the prevalence of somatic (57%) and (55.5%); psychological (68.3%) and (67.7%); and urogenital symptoms (58.2%) and (65.6%) for perimenopausal and postmenopausal women was found. Statistically, MS was significantly associated with education (<i>P</i> = 0.021), marital status (<i>P</i> = 0.010), and tobacco intake (<i>P</i> = 0.002), whereas no significant associations existed on denomination (<i>P</i> = 0.662) and age (<i>P</i> = 0.091), respectively.</p><p><strong>Conclusion: </strong>The prevalence of MS was higher among postmenopausal women. The perimenopausal women had higher prevalence of somatic and psychological symptoms. MS was significantly associated with variables, suggesting the need for a community-based health program to reducing MS in women.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"87-92"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Various Kinds of Exercise on Metabolic Parameters in Healthy Post-Menopausal Women: A Systematic Review of Randomized Control Trials.","authors":"Uma Phalswal, Priyanshi Dixit, Rohit Kumar, Nipin Kalal, Raman Kalia","doi":"10.4103/jmh.jmh_226_25","DOIUrl":"10.4103/jmh.jmh_226_25","url":null,"abstract":"<p><p>Changes in hormonal patterns transitioning into menopause put women at risk for developing metabolic syndrome (MetS). Sedentary behavior and low levels of physical activity can both contribute to this risk factor. There are plausible pathways through which physical activity might provide these important health-enhancing attributes, especially regarding MetS risk factors. Nevertheless, it is not clear yet if different intensities or modalities of exercise affect MetS risk factors and their subsequent development in postmenopausal women. This systematic review was conducted to investigate the effects of exercise training on the parameters of MetS in postmenopausal women. This systematic review utilized PubMed, Scopus, Web of Science, and Cochrane as electronic databases to gather evidence using the Preferred Reporting Items for Systematic Reviews and Meta-analyses methodology. We searched for the articles using the selected keywords and Boolean terms. This review incorporated randomized controlled trials that met specific, predefined inclusion criteria. The search yielded 12,217 titles and abstracts, subsequently narrowing down to 48 potentially relevant publications. Sixteen of those studies satisfied the inclusion criteria. Quality assessment of articles was performed via the Risk of Bias 2.0 Cochrane tool. All studies examined the effect of different forms of exercise on metabolic factors, including blood pressure (BP), blood sugar, lipid profile, and waist circumference (WC) in postmenopausal women. In particular, the interventional groups had significantly better scores than the control group for all these measures. Concerning metabolic outcome results, in nine studies, the intervention group had a significant change in BP, and lipid profiles in 10 studies, blood sugar in 3 studies, and WC in 5 studies included the findings. Exercise may improve plasma lipid profile, BP, and cardiovascular risk factors in postmenopausal women. Healthcare practitioners should advise regular exercise to postmenopausal women for maintaining well-being and avoiding illness.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"60-70"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive Health Consequences of Per- and Polyfluoroalkyl Substances and Microplastics in Mid-life Women: A Systematic Review of Emerging Evidence.","authors":"Nani Gopal Das, Amitava Baidya, Nirmalendu Das, Satabdi Saha","doi":"10.4103/jmh.jmh_93_25","DOIUrl":"10.4103/jmh.jmh_93_25","url":null,"abstract":"<p><strong>Background: </strong>Mid-life women are increasingly recognized as a vulnerable population for endocrine disruption due to chronic environmental exposures. Among emerging contaminants, per- and polyfluoroalkyl substances (PFAS) and microplastics have been implicated in reproductive health risks, yet focused evaluations in mid-life populations remain limited.</p><p><strong>Objective: </strong>The to systematically review human studies assessing the association between chronic exposure to PFAS and microplastics with reproductive health outcomes in mid-life women.</p><p><strong>Methods: </strong>We conducted a systematic review adhering to PRISMA 2020 guidelines. Databases searched included PubMed, Scopus, Web of Science, and EMBASE up to April 2025. Inclusion criteria were original human studies evaluating PFAS or microplastics in association with at least one reproductive health outcome (e.g., menopause, hormone levels, fertility metrics, and gynecologic conditions) in mid-life women. Study quality was appraised using the Newcastle-Ottawa Scale. Publication bias was qualitatively assessed. PROSPERO Registration ID: CRD42025446217.</p><p><strong>Results: </strong>Eighteen human studies were included (16 PFAS-related, 2 microplastic-related). PFAS exposure was consistently linked with earlier menopause, elevated FSH, reduced fertility, and higher odds of endometriosis and polycystic ovarian syndrome. Limited studies on microplastics demonstrated their presence in human ovarian follicular fluid and placental tissues, with preliminary evidence of altered ovarian reserve. However, no large-scale epidemiological outcomes for microplastics were available.</p><p><strong>Conclusion: </strong>PFAS are significantly associated with adverse reproductive outcomes in mid-life women. Although microplastics have been detected in reproductive tissues, outcome-based evidence is insufficient. Further longitudinal studies are warranted to clarify these emerging environmental risks.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"5-15"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesitogenic Hypothyroidism: Diagnostic Challenges and Therapeutic Implications in Modern Endocrinology.","authors":"Prabhat Kumar Agrawal, Siddhant Dev, Ruchika Garg","doi":"10.4103/jmh.jmh_32_26","DOIUrl":"10.4103/jmh.jmh_32_26","url":null,"abstract":"<p><p>Obesity and hypothyroidism frequently coexist in clinical practice, yet the nature of their relationship remains incompletely understood. While traditional teaching attributes weight gain to thyroid hormone deficiency, growing evidence suggests that excess adiposity itself can alter thyroid physiology. Obesity is associated with mild elevations in thyroid-stimulating hormone, often with normal free thyroxine levels, raising diagnostic uncertainty regarding true hypothyroidism versus a reversible, adaptive response. Adipokine imbalance, chronic low-grade inflammation, altered deiodinase activity, and immune dysregulation appear to mediate this interaction. This narrative review synthesizes current evidence on the epidemiology, pathophysiology, diagnostic challenges, and clinical implications of obesity-associated thyroid dysfunction, for which the term obesitogenic hypothyroidism is proposed. Emphasis is placed on distinguishing adaptive hyperthyrotropinemia from primary autoimmune thyroid disease to avoid unnecessary lifelong levothyroxine therapy. Recognizing this phenotype has important implications for rational investigation, individualized treatment decisions, and long-term metabolic outcomes.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"55-59"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Study to Assess the Utility of Artificial Intelligence-driven Cervical Screening Using Smart Scope versus Conventional Method.","authors":"Sukanya Dhar, Mriganka Mouli Saha, Sourav Sarkar, Nayan Chandra Sarkar, Subir Kumar Das, Sayanica Dutta","doi":"10.4103/jmh.jmh_170_25","DOIUrl":"10.4103/jmh.jmh_170_25","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer, the fourth most common cancer among women worldwide, often proves fatal and stems from high-risk human papillomavirus infection. Approximately 90% of cervical cancers can be prevented due to the disease's slow progression, which allows for a 10-year window for the detection and treatment of precancerous lesions. The World Health Organization called for global action toward the elimination of cervical cancer. One of the main strategies for cervical cancer elimination is to achieve screening coverage of at least 70% of women aged 35-45 years and to ensure that 90% of women diagnosed with precancerous lesions or invasive cervical cancer receive appropriate treatment by 2030. One of the main strategies for cervical cancer elimination is to achieve screening coverage of at least 70% of women aged 35-45 years and to ensure that 90% of women diagnosed with precancerous lesions or invasive cervical cancer receive appropriate treatment by 2030.</p><p><strong>Aims and objectives: </strong>The aims of the study were a comparative analysis of conventional Pap smear cytology and artificial intelligence (AI)-based analysis using Smart Scope for screening of cervical cancer.</p><p><strong>Materials and methods: </strong>A prospective, cross-sectional study was conducted among 128 women at a tertiary care center. Participants underwent cervical screening using Smart Scope imaging, followed by AI-based analysis. The findings were compared with conventional methods using appropriate statistical tests.</p><p><strong>Results: </strong>In this prospective cross-sectional pilot study involving 128 samples, AI-assisted screening demonstrated a high specificity (96.0%) and negative predictive value (99.2%) for cervical cancer detection, effectively identifying 89.8% of cases as negative for intraepithelial lesion or malignancy. AI enabled rapid image analysis and gynecologist-dependent diagnostic variability and minimized the subjectivity inherent in human interpretation. AI enabled rapid image analysis, reduced gynecologist-dependent diagnostic variability, and minimized the subjectivity inherent in human interpretation.</p><p><strong>Conclusions: </strong>AI-based image analysis shows promise as an adjunct tool in cervical cancer screening but lacks the reliability to function as a standalone modality. Further refinement and integration with the clinical context are warranted to improve its screening effectiveness.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"160-166"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual Reality and Digital Interventions in Cancer Pain Relief: A New Frontier in Supportive Oncology Care.","authors":"Ram Kumar Garg","doi":"10.4103/jmh.jmh_186_25","DOIUrl":"10.4103/jmh.jmh_186_25","url":null,"abstract":"<p><p>Cancer-related pain remains a complex challenge, often resistant to pharmacological treatment due to drug side effects and the multidimensional nature of pain. Emerging technologies, particularly virtual reality (VR) and digital health tools, offer innovative, non-invasive approaches that target both sensory and cognitive pain pathways. This review evaluates current evidence on VR and digital interventions - including mobile apps, wearables, and artificial intelligence-driven platforms - for managing acute and chronic cancer pain. VR has shown efficacy in reducing pain intensity and distress during chemotherapy, radiotherapy, and procedures through mechanisms such as immersive distraction and neuroplasticity modulation. Digital tools support self-management and real-time symptom tracking but face barriers related to access, standardization, and regulation. VR and digital health represent a promising shift toward multimodal, personalized pain management in oncology, warranting further large-scale trials and clinical integration.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"17 1","pages":"16-22"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}