Correlation of Body Mass Index with Endometrial Pathology in Perimenopausal Women with AUB: A Prospective Study.

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Journal of Mid-life Health Pub Date : 2025-01-01 Epub Date: 2025-04-05 DOI:10.4103/jmh.jmh_254_23

Saumya Bajpai Kaur, Sunmeet Singh, Amarjot Singh

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引用次数: 0

Abstract

Background: Body mass index (BMI) rises in correlation with endometrial cancer incidence as obesity rates among women have risen in recent years. In this study, we sought to evaluate the relationship between BMI and the perimenopausal ladies' aberrant and normal endometrial pathology. We also evaluated the correlation of transvaginal ultrasonography findings with histopathological findings.

Methodology: A prospective analytical study was conducted in a Tertiary care centre of Northern India over a period of 12 months from June 2022-May 2023 on women aged 40-55 years with Abnormal Uterine Bleeding (AUB) according to PALM-COEIN criteria. Patients were divided into two groups according to endometrial biopsy findings; women in group 1 were diagnosed with endometrial hyperplasia or carcinoma, while women in group 2 had normal endometrium, according to WHO classification. BMI, Endometrial biopsy pathology and transvaginal ultrasonography findings were noted. Data was analysed using SPSS version 24.0.

Results: Out of 72 patients, 22 patients had histopathological findings of Adenocarcinoma (3, 13.6%) and endometrial hyperplasia (19, 86.4%) and rest 50 patients had normal proliferative (13, 26%). On the basis of BMI, 51.5% (32/72) were overweight, 31.9% (23/72) were of Normal BMI, 11.1% (15/72) were Obese. The mean age in Group A and B was 52.37 ± 2.68 and 48.74 ± 7.98 respectively (P value- 0.003). Significant association between obesity and endometrial hyperplasia or carcinoma (P value-0.033). Correlation of Transvaginal Ultrasound (TVS) findings with that of histopathology was statistically significant (P value-0.002). Adenomyosis and Polyp and 100% correlation percentage on TVS and Histopathology.

Conclusion: There is a direct link between a high body mass index and AUB due to endometrial hyperplasia. Importance of physical activity as a preventative factor against AUB, endometrial cancer, and hyperplasia should be promoted. TVS is also a suitable diagnostic technique for the assessment of AUB as an initial procedure.

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围绝经期AUB妇女体重指数与子宫内膜病理的相关性：一项前瞻性研究。

背景：近年来，随着女性肥胖率的上升，体重指数（BMI）与子宫内膜癌发病率的上升相关。在这项研究中，我们试图评估BMI与围绝经期妇女异常和正常子宫内膜病理之间的关系。我们还评估了经阴道超声检查结果与组织病理学结果的相关性。方法：一项前瞻性分析研究于2022年6月至2023年5月在印度北部的三级保健中心进行，为期12个月，根据PALM-COEIN标准，年龄在40-55岁的子宫异常出血（AUB）妇女。根据子宫内膜活检结果将患者分为两组；根据WHO的分类，第一组的女性被诊断为子宫内膜增生或癌，而第二组的女性子宫内膜正常。记录BMI、子宫内膜活检病理及经阴道超声检查结果。数据分析采用SPSS 24.0版本。结果：72例患者中，腺癌22例（3.13.6%），子宫内膜增生19例（86.4%），增生正常50例（13.26%）。体重指数方面，超重占51.5%(32/72)，正常占31.9%(23/72)，肥胖占11.1%（15/72）。A、B组平均年龄分别为52.37±2.68、48.74±7.98 （P值- 0.003）。肥胖与子宫内膜增生或癌有显著相关性（P值0.033）。经阴道超声（TVS）检查结果与组织病理学检查结果的相关性有统计学意义（P值0.002）。子宫腺肌症和Polyp在TVS和组织学上的相关性为100%。结论：高体重指数与子宫内膜增生所致AUB有直接关系。体育活动作为预防AUB、子宫内膜癌和增生的重要因素应得到推广。TVS也是评估AUB的一种合适的诊断技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Mid-life Health Social Sciences-Health (social science)

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

43 weeks

期刊介绍： Journal of mid-life health is the official journal of the Indian Menopause society published Quarterly in January, April, July and October. It is peer reviewed, scientific journal of mid-life health and its problems. It includes all aspects of mid-life health, preventive as well as curative. The journal publishes on subjects such as gynecology, neurology, geriatrics, psychiatry, endocrinology, urology, andrology, psychology, healthy ageing, cardiovascular health, bone health, quality of life etc. as relevant of men and women in their midlife. The Journal provides a visible platform to the researchers as well as clinicians to publish their experiences in this area thereby helping in the promotion of mid-life health leading to healthy ageing, growing need due to increasing life expectancy. The Editorial team has maintained high standards and published original research papers, case reports and review articles from the best of the best contributors both national & international, consistently so that now, it has become a great tool in the hands of menopause practitioners.