Maria Pía Izaguirre Germain , Paola Ávila , Nauan Fara , Julia Pretini , María Elena Gaona , Pia Pissani , Maira Arias Saavedra , Valeria Aquino , Mariana Espindola Echazu , Manuela Laffont , Magdalena Acevedo , Lucrecia Garcia Faura , Romina Hassan , Karen Roberts , Jorge Alejandro Brigante , Damaris Álvarez , Marina Laura Micelli , Vanesa Laura Cosentino , Sandra Fabiana Montoya , Gabriel Sequeira , Eduardo Mario Kerzberg
{"title":"Características de los pacientes reumáticos que consultan fuentes de información digitales","authors":"Maria Pía Izaguirre Germain , Paola Ávila , Nauan Fara , Julia Pretini , María Elena Gaona , Pia Pissani , Maira Arias Saavedra , Valeria Aquino , Mariana Espindola Echazu , Manuela Laffont , Magdalena Acevedo , Lucrecia Garcia Faura , Romina Hassan , Karen Roberts , Jorge Alejandro Brigante , Damaris Álvarez , Marina Laura Micelli , Vanesa Laura Cosentino , Sandra Fabiana Montoya , Gabriel Sequeira , Eduardo Mario Kerzberg","doi":"10.1016/j.rcreu.2023.11.007","DOIUrl":"10.1016/j.rcreu.2023.11.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Many patients use the Internet as a source of health information and to create and share content of diverse quality of evidence, complementing and even competing with traditional sources of information.</div></div><div><h3>Objectives</h3><div>To evaluate differences between rheumatic patients who consult digital information sources (DISs) and those who do not (Non-DISs), and their perception of the credibility attributed to these sources by both groups.</div></div><div><h3>Materials and methods</h3><div>An observational cross-sectional study was conducted through an anonymous survey of patients with rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and spondyloarthritis. Patients were asked about their search for information from different DISs or Non-DISs. Patients rated the credibility they assigned to the different sources on a scale of 0 to 10, where 0 was no credibility and 10 was the maximum possible credibility.</div></div><div><h3>Results</h3><div>A total of 402 patients (79% female) were surveyed. Two hundred and 7<!--> <!-->(51%) had consulted at least one DIS during the previous year (DISs group). The DISs group had consulted a total of 5 DISs and Non-DISs (First-Third Quartile: 3-7) vs. 2 (First-Third Quartile: 1-3) in the Non-DISs group (p<<!--> <!-->.001). The number of searches in DISs was higher at younger ages (OR .97 95% CI .95-.99) and at higher levels of education (secondary vs. primary OR 2.0; 95% CI 1.05-3.85). The DISs group assigned higher credibility to Facebook and YouTube than the other patients (median credibility of 6/10 and 6/10 vs. 2/10 and 1/10 respectively; <em>P</em><.001). However, they did not assign lower credibility to traditional sources.</div></div><div><h3>Conclusions</h3><div>DISs are more frequently consulted by a younger population with a higher level of education. These patients consult multiple sources, but do not assign lower credibility to traditional information sources.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 43-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luz Adriana Gómez-Ramírez , Laura Betancur-Gómez , Estefanía Tabares-Ramírez , Sofía Villada-Montoya , Libia María Rodríguez-Padilla , María Fernanda Álvarez-Barreneche , Carlos Jaime Velásquez-Franco , Miguel Antonio Mesa-Navas , Marcela Posada-Velásquez
{"title":"Hallazgos histológicos y complicaciones en pacientes con biopsia de glándula salival en dos instituciones de Medellín, Colombia: estudio descriptivo","authors":"Luz Adriana Gómez-Ramírez , Laura Betancur-Gómez , Estefanía Tabares-Ramírez , Sofía Villada-Montoya , Libia María Rodríguez-Padilla , María Fernanda Álvarez-Barreneche , Carlos Jaime Velásquez-Franco , Miguel Antonio Mesa-Navas , Marcela Posada-Velásquez","doi":"10.1016/j.rcreu.2023.10.005","DOIUrl":"10.1016/j.rcreu.2023.10.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Salivary gland biopsy is the gold standard for the diagnosis of Sjogren's syndrome. There are several approaches for the realization of the biopsy, being generally used an approach to the mucosa with the use of various instruments and incisions that vary in its length, passing through trucut biopsy to scraping with needle.</div></div><div><h3>Objective</h3><div>Evaluate the performance, complications and histological report systems of the minor salivary gland biopsy with a minimally invasive technique.</div></div><div><h3>Materials and methods</h3><div>We conducted a descriptive study that included adult patients undergoing salivary gland biopsy between 2017-2022. Medical records and salivary gland biopsy reports were used to collect information and registered in the Magpi platform. Sociodemographic, clinical, and histopathological variables were recorded. The qualitative variables were expressed in absolute and relative frequencies; the quantitative ones were by median and interquartile range. Seventy-two biopsies were included.</div></div><div><h3>Results</h3><div>Regarding demographic characteristics, 87,5% were women with a median age of 52 years. The biopsy characteristics showed that 70 (97,2%) corresponded to a representative sample. Twenty-seven (38,5%) biopsies showed lymphocytic infiltration and reported a classification system, of which the most used one was the Chisholm Mason used in 18 (66,6%) of such biopsies. Complications were present in four (5,7%) patients.</div></div><div><h3>Conclusions</h3><div>Despite the recommendation of using Focus Score for classification criteria, the Chisholm Mason system is still the most widely used. The present technique is a safe and effective for the realization of minor salivary gland biopsy.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 3-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Javier Cajas , María Carolina Torres , Mayelin Fernanda Ceballos
{"title":"Detection of latent tuberculosis by tuberculin booster in patients with immunosuppressive treatment","authors":"Luis Javier Cajas , María Carolina Torres , Mayelin Fernanda Ceballos","doi":"10.1016/j.rcreu.2023.10.006","DOIUrl":"10.1016/j.rcreu.2023.10.006","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>One-third of the world's population has latent tuberculosis. Because it can be reactivated by immunosuppressive treatments, screening is suggested. In Colombia, the tuberculin test with the booster is recommended in this population because of the risk of false negative results and anergy caused by treatments. Currently, the number of patients detected with this second test is unknown, so the primary objective is to determine the percentage of additional positive detections.</div></div><div><h3>Materials and methods</h3><div>From 2017 to 2022, a cross-sectional, analytical study was conducted on a group of patients from a rheumatology service who had a tuberculin test and a booster within a year to check for latent tuberculosis. Over the course of a year and three weeks, we looked at the number of patients whose booster tests showed new findings. A study was conducted to see if there were any differences in treatment based on the first tuberculin result.</div></div><div><h3>Results</h3><div>A tuberculin test was performed on 674 subjects, of whom 496 were immunosuppressed. From the 382 whose test was negative, 191 and 74 booster tests were performed within a year and three weeks; 8 (4.1%) and 3 (3.6%) were positive, respectively. When evaluating the differences in treatments between the groups with a positive and negative first tuberculin test, significant differences were found. Use of prednisolone at 5<!--> <!-->mg or more per day (<em>p</em> <!-->=<!--> <!-->.02) and three immunosuppressants (<em>p</em> <!-->=<!--> <!-->.005) was more frequent in negative tuberculin tests.</div></div><div><h3>Conclusions</h3><div>It can be said that the booster test raises the number of people with latent tuberculosis by 4%. More use of prednisolone at 5<!--> <!-->mg/day or three immunosuppressants in the group with the negative tuberculin test was found to be statistically significant.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 10-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandra Espinosa Trujillo , Francisco Brañas Fernández , Aitor Abuín Blanco , Robustiano Pego Reigosa , María Rodríguez Rodríguez
{"title":"Enfermedad de Erdheim-Chester, una histiocitosis de células no Langerhans infrecuente y su asociación con el síndrome de Sjögren","authors":"Alejandra Espinosa Trujillo , Francisco Brañas Fernández , Aitor Abuín Blanco , Robustiano Pego Reigosa , María Rodríguez Rodríguez","doi":"10.1016/j.rcreu.2024.01.003","DOIUrl":"10.1016/j.rcreu.2024.01.003","url":null,"abstract":"<div><div>Erdheim Chester disease (ECD) is a rare non-Langerhans cell histiocytosis. It is characterized by the infiltration of various organs and tissues by foamy histiocytes with a heterogeneous clinical course that varies from mild forms to disseminated forms with progressive and lethal behaviour. The case of a patient who presented with a cerebellar syndrome associated with autoimmune pathology is presented. In the course of the disease, refractoriness to glucocorticoids and clinical manifestation with bone involvement in the form of symmetrical osteosclerosis of long bones were determining factors for suspicion of this entity. We reviewed scientific articles through the PubMed metasearch engine with the keywords «erdheim chester disease», «erdheim chester and nervous system», and «autoimmunity and erdheim chester disease», selecting those with greater emphasis on clinical presentation with neurological involvement and associated autoimmune pathology. Advances in the pathogenesis of ECD have allowed us to understand the nature of the disease, as well as the use of targeted therapies. It is interesting to keep this entity in mind, as well as the pathologies with which it is frequently associated, with the objective of an early diagnosis and a better clinical approach.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 90-94"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sinem Yenil , Elif Gur Kabul , Bilge Basakci Calik , Gulsah Kilbas , Selcuk Yuksel
{"title":"Investigation of motor skill in patients with juvenile idiopathic arthritis: A cross sectional study","authors":"Sinem Yenil , Elif Gur Kabul , Bilge Basakci Calik , Gulsah Kilbas , Selcuk Yuksel","doi":"10.1016/j.rcreu.2023.11.005","DOIUrl":"10.1016/j.rcreu.2023.11.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The inflammatory process of Juvenile Idiopathic Arthritis (JIA) is associated comorbidities. The JIA patients can fall behind their healthy peers, and motor and functional skills can reduce.</div></div><div><h3>Objectives</h3><div>The primary aim is to compare the motor skills of JIA patients with healthy controls. The secondary aim is to determine whether disease activity affects patients with JIA.</div></div><div><h3>Materials and methods</h3><div><span><span>Fifteen patients with JIA and 15 healthy controls were included in the study. Motor skills were evaluated with Bruininks-Oseretsky Test of Motor Proficiency Second Edition Short Form (BOT-2 SF) in patients with JIA and healthy controls. BOT-2 SF measures four motor area composites with eight subtests. Disease activity was evaluated with Juvenile Arthritis Disease Activity Score-27 (JADAS-27), disability level with Childhood </span>Health Assessment Questionnaire Disability Index (CHAQ-DI), and disease-related quality of life with </span>Pediatric Quality of Life Inventory (PedsQL) 3.0 Arthritis Module for JIA. According to disease activity, patients with JIA were divided into two groups as remission and active.</div></div><div><h3>Results</h3><div>The patients with JIA had significantly lower scores in the total and four motor area of BOT-2 SF compared to healthy controls (<em>p</em> <!--><<!--> <!-->.05). When the remission and active groups were compared, there was no difference in the total and four motor area of BOT-2 SF, CHAQ-DI, or PedsQL (<em>p</em> <!-->><!--> <!-->.05).</div></div><div><h3>Conclusion</h3><div>The motor skills of patients with JIA are lower than their healthy peers, and their motor skills, quality of life, and disability did not make a difference between the remission and active period.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 36-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139687625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esther Casablanca Alarcón , Mabel de la Cruz Mendoza , María de los Ángeles Terán de Baudoin , Rolando Pastén Vargas , Manuel Montero Jauregui , Carlos Guachalla Castro , Luis Fernando Sosa Tordoya
{"title":"Niveles de expresión génica relativa del gen codificante de la proteína quimioatractante de monocitos-1 (MCP-1) como biomarcador urinario en nefropatía lúpica","authors":"Esther Casablanca Alarcón , Mabel de la Cruz Mendoza , María de los Ángeles Terán de Baudoin , Rolando Pastén Vargas , Manuel Montero Jauregui , Carlos Guachalla Castro , Luis Fernando Sosa Tordoya","doi":"10.1016/j.rcreu.2023.12.006","DOIUrl":"10.1016/j.rcreu.2023.12.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Lupus nephropathy (LN) is a chronic inflammatory process, characterized by the activation of T<!--> <!-->cells and high levels of various cytokines, such as MCP-1 at the level of the renal glomerulus and the interstitial tubule. MCP-1 is a chemoattractant of monocytes and lymphocytes, it is responsible for the infiltration of leukocytes in the kidney, which is why MCP-1 levels in urine of patients with LN correlate with the active form of the disease.</div></div><div><h3>Objective</h3><div>The present study aims to evaluate the expression levels of MCP-1 in patients with LN and to correlate their urinary levels with serum autoimmunity markers.</div></div><div><h3>Material and methods</h3><div>Our study is of the case-control type, where the groups were made up of 112 patients diagnosed with SLE or LN, and 28 apparently healthy people with no clinical or family history of autoimmune diseases, respectively. MCP-1 expression levels were estimated using qRT-PCR. In addition, clinical parameters and serum levels were evaluated (anti-ds-DNA, anti-nucleosome, anti-C1q antibodies, β2-microglobulin levels, and C3 and C4 complement fraction). Finally, clinical, and molecular data were correlated.</div></div><div><h3>Results</h3><div>Our study included 39 patients with active SLE (median 36<!--> <!-->years), 32 with active LN (median 32.5<!--> <!-->years), 28 with inactive SLE (median 41.5<!--> <!-->years), 13 with inactive LN (median 38<!--> <!-->years), and 28 control patients (median 28.5<!--> <!-->years). The comparison of MCP-1 expression levels between patients with active LN and active SLE did not show statistically significant values (<em>P</em> <!-->><!--> <!-->.05). Likewise, a statistically significant correlation was observed between the expression levels of MCP-1 with the levels of anti-C1q (r<!--> <!-->=<!--> <!-->.255; <em>P</em> <!--><<!--> <!-->.025); however, no correlation was found with the other markers.</div></div><div><h3>Conclusion</h3><div>The use of MCP-1 expression levels in the Bolivian population would not be a useful biomarker to evaluate lupus nephropathy. However, the anti-C1q biomarker is suggested as a serological marker for monitoring the disease.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 1","pages":"Pages 49-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140091889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diseño e implementación de centros de cuidado clínico en espondiloartritis. Un modelo de atención y de enfermedad referente en patologías crónicas","authors":"","doi":"10.1016/j.rcreu.2023.04.002","DOIUrl":"10.1016/j.rcreu.2023.04.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Spondyloarthritis (SpA) is a musculoskeletal disease presenting with phenotypic clinical manifestations, integrating a set of interrelated inflammatory conditions, which share immunogenetic, epidemiological, and therapeutic characteristics.</div></div><div><h3>Objective</h3><div>to do a reflection exercise through the experience of designing and implementing a clinical care center for spondyloarthropathies, from the administrative and clinical perspective to the implications in decision making and impact on the different indicators related to efficiencies and safety of the services included in the model.</div></div><div><h3>Results</h3><div>In clinical practice, the reality of the care process in patients diagnosed with SpA represents an area of opportunity in multiple aspects. The fragmentation of clinical care and the heterogeneous flow of the patient in the care pathway, are associated with suboptimal and undesired clinical outcomes. Several aspects highlight the reality of patients with SpA in the national scenario, which -to a certain extent- could reflect what is observed in other Latin American countries. SpA represents a very significant burden for society and for individuals affected by this condition. Comprehensive assessment of the burden of disease from the perspective of the clinician and the patient is important, in order to support decisions related to treatment and comprehensive management of this condition. The improvement in health outcomes and the reduction in the cost of chronic inflammatory diseases, such as SpA, are the main advantages of implementing a care model in specialized centres integrating a multidisciplinary team.</div></div><div><h3>Conclusion</h3><div>This is an opportunity to include the perspective of individuals affected by this condition, seeking integration between an informed patient and a highly qualified multidisciplinary care team in the comprehensive management of patients with SpA.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 511-516"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41323859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validación de la escala FACIT-fatiga en una muestra de población hispanohablante con artritis reumatoide","authors":"","doi":"10.1016/j.rcreu.2023.05.004","DOIUrl":"10.1016/j.rcreu.2023.05.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Fatigue is a frequent symptom in patients with rheumatoid arthritis (RA). The Functional Assessment of Chronic illnesses Therapy-Fatigue (FACIT-F) is an instrument that assesses self-reported fatigue and was validated for measuring fatigue in RA.</div></div><div><h3>Objective</h3><div>The aim of this study was to validate the FACIT-F for use in Spanish-speaking RA patients.</div></div><div><h3>Materials and methods</h3><div>Cross-sectional, multicentre study. We included patients (n = 192) with RA diagnosis from two hospitals. Exploratory and confirmatory analyses were conducted. Construct validity and internal consistency were evaluated.</div></div><div><h3>Results</h3><div>FACIT-F showed high internal consistency (alpha = .87, omega = .93). Analysis of the main components showed a single factor, which explained 62% of the variance. The confirmatory factor analysis showed a satisfactory fit of the model. We found a correlation between FACIT–F, VAS fatigue (-.72 <em>P</em> < .001), and BRAF-MDQ (-.81 <em>P</em> < .001).</div></div><div><h3>Conclusion</h3><div>FACIT-F is a valid instrument with a high internal consistency for measuring fatigue in clinical practice and research in Spanish-speaking patients with RA.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 435-441"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49523844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caracterización de los pacientes menores de 18 años con nefritis lúpica en el Hospital Pablo Tobón Uribe y en el Hospital San Vicente Fundación de la ciudad de Medellín, entre 2008 y 2017","authors":"","doi":"10.1016/j.rcreu.2023.09.005","DOIUrl":"10.1016/j.rcreu.2023.09.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The kidney is one of the organs frequently affected in systemic lupus erythematosus (40-60%); the manifestations are variable, from a silent pattern to the irreversible impairment of renal function.</div></div><div><h3>Objetives</h3><div><ul><li><span>•</span><span><div>To characterize patients under 18 years of age with a diagnosis of lupus nephritis treated at the Pablo Tobón Uribe Hospital and San Vicente Fundación Hospital during the years 2006 to 2017.</div></span></li><li><span>•</span><span><div>Establish the frequency of lupus nephritis in patients diagnosed with childhood systemic lupus erythematosus.</div></span></li><li><span>•</span><span><div>Describe the general, sociodemographic, clinical and paraclinical characteristics, as well as histopathological characteristics, immunosuppressive treatment and complications such as chronic kidney disease, high blood pressure, need for renal replacement therapy and death in patients diagnosed with lupus nephritis.</div></span></li><li><span>•</span><span><div>Explore the association between lupus nephritis with a histological pattern defined as moderate or severe and chronic kidney disease, arterial hypertension, need for renal replacement therapy and death.</div></span></li></ul></div></div><div><h3>Materials and methods</h3><div>Descriptive study with retrospective information in a group of patients under 18<!--> <!-->years of age with a diagnosis of lupus nephritis, attended in two referral centres of the city of Medellin between 2008 and 2017. Clinical records of patients who met the inclusion criteria were reviewed.</div></div><div><h3>Results</h3><div>The median age was 13 years, with predominance in females. The majority had renal involvement at the time of diagnosis of lupus. Histological class<!--> <!-->IV was the most frequent (48%). Age under 10<!--> <!-->years, absence of response to induction therapy, and histological class<!--> <!-->IV, were related to the development of chronic kidney disease (><!--> <!-->60<!--> <!-->ml/min/1.73<!--> <!-->m<sup>2</sup>).</div></div><div><h3>Conclusions</h3><div>Renal involvement was higher in this study. Age, class<!--> <!-->IV, and non-response to induction were associated with impaired renal function.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"31 4","pages":"Pages 463-472"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139293049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}