Revista Colombiana de Reumatologia最新文献

{"title":"Utility of musculoskeletal ultrasound (MSK-US) in the diagnosis of COVID-19 related arthritis","authors":"Amarilis J. Pérez De Jesús,&nbsp;Andrea C. Vincenti Pérez","doi":"10.1016/j.rcreu.2026.504910","DOIUrl":"10.1016/j.rcreu.2026.504910","url":null,"abstract":"<div><div>Since the emergence of COVID-19 in December 2019, a wide array of musculoskeletal and rheumatic manifestations has been observed in affected patients, with inflammatory arthritis emerging as a notable complication. This article explores the radiographic and musculoskeletal ultrasound (MSK-US) findings in COVID-19-related arthritis, which often resembles seronegative rheumatoid arthritis. A literature review was conducted to identify studies on post-viral inflammatory arthritis, particularly COVID-19-related cases and their distinction from seronegative RA. The role of imaging, particularly musculoskeletal ultrasound, is emphasized as an effective diagnostic tool for assessing inflammation, joint effusions, and enthesopathy in COVID-19-related arthritis. Studies have shown that musculoskeletal ultrasound can help distinguish COVID-19-related arthritis from rheumatoid arthritis by detecting synovitis and the absence of erosions. Further research is needed to refine diagnostic criteria and improve treatment approaches for patients with persistent arthritis following SARS-CoV-2 infection.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504910"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comite Editorial online","authors":"","doi":"10.1016/S0121-8123(26)00096-4","DOIUrl":"10.1016/S0121-8123(26)00096-4","url":null,"abstract":"","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504957"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin ultrasound in the evaluation of rheumatic diseases: Systemic sclerosis and psoriatic disease","authors":"Alejandro Correa Giraldo,&nbsp;Eybar Diaz,&nbsp;Edwin Castillo","doi":"10.1016/j.rcreu.2026.504937","DOIUrl":"10.1016/j.rcreu.2026.504937","url":null,"abstract":"<div><div>The clinical relevance of skin ultrasound evaluation in systemic sclerosis (SSc) and psoriasis (PsO) is significant, as it provides a non-invasive, objective, and reproducible method for assessing skin involvement, which is crucial for diagnosis, monitoring disease progression, and evaluating treatment efficacy. High-frequency ultrasound (HFUS) and shear wave elastography (SWE) are particularly useful in quantifying skin thickness and stiffness, parameters that correlate with disease activity and severity. This approach offers a more sensitive alternative to traditional methods such as the modified Rodnan skin score (mRSS), which can be subjective and variable. This article details the specific clinical applications and benefits of skin ultrasound (US) in SSc and PsO. Although the reviewed studies primarily focus on SSc, the principles of using US for skin evaluation can be extended to PsO. In PsO, US can help assess the extent of skin involvement, monitor treatment response, and potentially differentiate between active and inactive lesions, although specific studies on PsO were not detailed in the analyzed contexts. In contrast to advancements in SSc, the application of skin US in PsO requires further exploration to establish standardized protocols and validate its clinical utility. The potential of US to provide detailed insights into PsO-related skin pathology remains promising, warranting further research to fully understand its benefits. This document presents different US techniques, imaging windows, and technical aspects of performing skin US in SSc and PsO with skin involvement, covering the advantages and limitations of each method in both diseases.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504937"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glomerulonefritis «full house» con inclusiones túbulo-reticulares en una endocarditis bacteriana, un simulador de nefritis lúpica: reporte de caso","authors":"Diego Niño-Torres,&nbsp;Julia Recalde-Reyes,&nbsp;Johanna Álvarez,&nbsp;Luis Javier Cajas-Santana","doi":"10.1016/j.rcreu.2026.504912","DOIUrl":"10.1016/j.rcreu.2026.504912","url":null,"abstract":"<div><h3>Introduction</h3><div>Immune complex-associated membranoproliferative glomerulonephritis and tubuloreticular inclusions have been strongly linked to systemic lupus erythematosus (SLE). However, other etiologies have been associated with these findings.</div></div><div><h3>Case presentation</h3><div>A 72-year-old male presented with a fever of unknown origin and these histopathological findings in the kidney biopsy. An extensive diagnostic workup established an infective endocarditis as the etiology.</div></div><div><h3>Conclusions</h3><div>Even in the presence of a highly suggestive kidney biopsy of a potential lupus nephritis, alternative differential diagnosis should be considered, as these findings are characteristic but not pathognomonic.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504912"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound in vasculitis and other vessel pathologies","authors":"Juan Molina-Collada,&nbsp;Edward-Camilo Vera-Parra,&nbsp;Luis Javier Cajas,&nbsp;Josué Guillermo López-Velandia","doi":"10.1016/j.rcreu.2026.504929","DOIUrl":"10.1016/j.rcreu.2026.504929","url":null,"abstract":"<div><div>Ultrasound as a tool in rheumatology has an increasingly wide range of applications. Its harmless nature, low cost, and the possibility of use in the consultation itself have made it gain increasing strength in its indications. With training, it is possible to identify findings that can contribute to diagnosis, monitoring, and risk stratification in inflammatory and non-inflammatory vascular diseases. We propose a review of the literature on the different vascular pathologies in which rheumatologists can receive support with this imaging technique, which is also considered a semiological prolongation.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504929"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colirios elaborados con suero autólogo vs. colirios elaborados a partir de plasma rico en plaquetas en el tratamiento del ojo seco. Una revisión de alcance","authors":"Melissa Barros,&nbsp;Karol Araque,&nbsp;Lina Andrea Gómez","doi":"10.1016/j.rcreu.2026.504922","DOIUrl":"10.1016/j.rcreu.2026.504922","url":null,"abstract":"<div><div>Dry eye syndrome is characterized by an alteration in the production and stability of the tear film, leading to debilitating symptoms that affect quality of life. Its incidence increases with age, the presence of systemic diseases such as autoimmune disorders and diabetes, as well as environmental factors and lifestyle habits, including prolonged use of electronic devices and exposure to adverse climates. Conventional treatments include artificial tears and topical anti-inflammatory agents, which provide symptomatic relief, although clinical variability makes standardization of management difficult. In this context, biological therapies such as autologous serum (AS) eye drops and platelet-rich plasma (PRP) eye drops have emerged, showing efficacy in moderate and severe cases, highlighting the need for personalized approaches and further clinical research. To assess their usefulness, a scoping review was conducted following PRISMA-ScR guidelines, with searches carried out in PubMed, Google Scholar, and Scopus. Experimental and analytical observational studies in English and Spanish were included, while theoretical works, animal studies, narrative or systematic reviews, and non-analytical studies were excluded. Out of 951 identified records, five met the inclusion criteria and were analyzed both quantitatively and qualitatively. The results confirmed that both autologous serum and PRP are safe and effective treatments in moderate to severe stages. Both improved clinical parameters, although PRP may offer additional advantages in epithelial regeneration and tear film stability. However, methodological heterogeneity prevented establishing their definitive superiority.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504922"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of response to the high dose intravenous cyclophosphamide in Egyptian lupus nephritis patients: A retrospective cohort study","authors":"Doaa Attia,&nbsp;Nessma Abdel-Malik,&nbsp;Dina Effat","doi":"10.1016/j.rcreu.2024.12.003","DOIUrl":"10.1016/j.rcreu.2024.12.003","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify the predictors of response to the high dose intravenous cyclophosphamide (IV CYC) in Egyptian patients with lupus nephritis using the commonly used laboratory tests.</div></div><div><h3>Materials and methods</h3><div>Data were collected retrospectively at baseline (T₀), and after 3 (T₁), and 6 (T₂) cycles of CYC. The percentages of laboratory values at T₁ relative to T₀ [(T₁/T₀)<!--> <!-->×<!--> <!-->100] were calculated to detect the potential predictors of response. ROC curves and Youden index were used to determine the cut-off values that best predict complete, partial, and global responses [CR, PR, GR (CR<!--> <!-->+<!--> <!-->PR), respectively].</div></div><div><h3>Results</h3><div>One hundred eighteen patients were included. At T₂<span>, 40 (33.9%) patients had achieved CR, 28 (23.7%) patients had PR, and 50 (42.4%) patients were resistant to treatment. The percent changes of platelet count, complement 3 (C3) level, and 24-h proteinuria were significantly different between the three groups (</span><em>p</em> <!-->=<!--> <span>.042, .029, &lt;.001, respectively). Concerning CR, the AUC for proteinuria was the greatest (AUC</span> <!-->=<!--> <!-->.763, <em>p</em> <!-->=<!--> <span><span>&lt;.001). Accordingly, the cut-off value of the percent change of proteinuria for CR prediction was 72.3% with 87.5% sensitivity and 55.1% specificity. Concerning GR, the AUC for </span>C3 (AUC</span> <!-->=<!--> <!-->.788, <em>p</em> <!-->=<!--> <!-->.011) and proteinuria (AUC<!--> <!-->=<!--> <!-->.810, <em>p</em> <!-->=<!--> <span>&lt;.001) were the highest. Accordingly, the cut-off value of the percent change of C3 for GR prediction was 145.11% with 76.9% sensitivity and 85.7% specificity, while that of proteinuria was 78.34% with 86.8% sensitivity and 66% specificity.</span></div></div><div><h3>Conclusions</h3><div>The magnitude of change in proteinuria and C3 levels during the early course of IV CYC could predict the final response to the drug.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 102170"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of fibrinogen, fibrinogen to albumin ratio, and blood cell-derived inflammatory indices in patients with systemic sclerosis: A case–control study","authors":"Fatma M. Helbawi,&nbsp;Maha S.I. Abdelrahman,&nbsp;Aml A. Rayan","doi":"10.1016/j.rcreu.2025.03.002","DOIUrl":"10.1016/j.rcreu.2025.03.002","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div><span>Systemic sclerosis (SSc) is a rare autoimmune systemic disorder characterized by inflammation and fibrosis. Fibrinogen and C-reactive protein (CRP) are raised during inflammation. Blood cell-derived inflammatory indices are helpful for monitoring disease activity in several autoimmune diseases. In this study, we aimed to evaluate the levels of fibrinogen, fibrinogen to albumin ratio (FAR), </span>CRP<span>, CRP to albumin ratio (CAR), and blood cell-derived inflammatory indices in SSc patients.</span></div></div><div><h3>Patients and methods</h3><div>This observational case–control study included 31 SSc patients and 20 age- and sex-matched healthy participants. Clinical assessment was performed for SSc patients. Complete blood count, CRP, fibrinogen, and albumin were done for all study subjects with calculation of the following: CAR, FAR, lymphocyte to CRP ratio, neutrophil to lymphocyte ratio (NLR), systemic inflammation response index (SIRI), systemic immune inflammation index (SII), and prognostic nutritional index (PNI).</div></div><div><h3>Results</h3><div><span>We detected significant differences between SSc patients and healthy subjects regarding all studied variables except for albumin and PNI. Both fibrinogen and FAR were positively correlated with disease activity (</span><em>p</em>-value<!--> <!-->=<!--> <span>0.006 and 0.009, respectively), while NLR, SIRI, and SII were positively correlated with the modified Rodnan Skin Score (</span><em>p</em>-value<!--> <!-->=<!--> <!-->0.04, 0.034, and 0.005, respectively). ROC curve analysis for active disease cutoff point detection revealed that fibrinogen had an area under the curve of 0.75 (<em>p</em>-value<!--> <!-->=<!--> <!-->0.04) at a criterion of 3.2 with 70% sensitivity and 62% specificity.</div></div><div><h3>Conclusions</h3><div>Fibrinogen and FAR are reliable indicators of inflammation and disease activity in SSc patients.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 102177"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manifestaciones renales y cardiopulmonares en pacientes con lupus eritematoso sistémico juvenil, experiencia clínica en Cali, Colombia","authors":"María Paula Rengifo Mosquera,&nbsp;Robinson Pacheco,&nbsp;María del Pilar Gómez Mora","doi":"10.1016/j.rcreu.2026.504909","DOIUrl":"10.1016/j.rcreu.2026.504909","url":null,"abstract":"<div><h3>Introduction</h3><div>Juvenile systemic lupus erythematosus (jSLE) is a chronic, multisystemic autoimmune disease with a variable course and prognosis. The pediatric population accounts for 20% of total SLE cases. Renal and cardiopulmonary manifestations contribute significantly to morbidity and mortality.</div></div><div><h3>Objective</h3><div>To clinically and demographically characterize the renal and cardiopulmonary manifestations of jSLE in the study population.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional observational study was conducted in patients with jSLE (EULAR/ACR-2019 criteria) at a Pediatric Rheumatology clinic in Cali, Colombia, between 2012 and 2024. Data were collected from medical records and analyzed using the IBM SPSS v29 statistical program.</div></div><div><h3>Results</h3><div>Among 98 patients with JSLE, 30.6% had renal involvement, 10.2% had cardiopulmonary involvement, and 6.1% had both. Regarding renal involvement, 83.3% were female, with a mean age of 11.4<!--> <!-->years; 76.6% presented at disease onset, while 13.3% developed renal involvement more than two years after diagnosis. Most patients presented with proteinuria, hypertension, and nephrotic syndrome. Renal biopsy was performed in 73.3% of cases, revealing nephritis types<!--> <!-->2, 3, and<!--> <!-->4 (ISN/RPS classification) in 13.3%, 10%, and 50% of patients, respectively. The mean activity index was 9/24, and the chronicity index was 2/12. Regarding cardiopulmonary involvement, 90% of patients were female, with a mean age of 12.5<!--> <!-->years; 90% presented at diagnosis. The most common clinical manifestations were chest pain, pleuritis, and pericarditis. Laboratory findings in renal involvement included anemia, elevated erythrocyte sedimentation rate (ESR), decreased complement levels (C3 and C4), and positive Anti-DNA and Anti-SM antibodies. In cardiopulmonary involvement, findings included elevated C-reactive protein and ESR, decreased C3 and C4 levels, and positive Anti-DNA, Anti-SM, and Anti-RNP antibodies. Additionally, 40% of patients with renal involvement and 60% of those with cardiopulmonary involvement had other autoimmune diseases. Mortality occurred in one patient with mixed involvement.</div></div><div><h3>Conclusion</h3><div>In jSLE, renal involvement is a common presentation at disease onset, while cardiopulmonary involvement is less prevalent. Despite the severity of these manifestations, mortality was low. However, the high inflammatory activity and significant percentage of autoimmune comorbidities highlight the complexity of this condition and underscore the importance of early identification and treatment to improve the quality of life of this population.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 504909"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent autoimmunity in healthcare workers with natural, vaccine-induced or hybrid immunity to SARS-CoV-2","authors":"Diana M. Monsalve,&nbsp;Yeny Acosta-Ampudia,&nbsp;Manuel Rojas,&nbsp;Nohemi Caballero,&nbsp;Juliana Quintero,&nbsp;Carolina Ramírez-Santana","doi":"10.1016/j.rcreu.2025.03.007","DOIUrl":"10.1016/j.rcreu.2025.03.007","url":null,"abstract":"<div><h3>Introduction</h3><div>SARS-CoV-2 infection and COVID-19 vaccination have prompted extensive research into the potential of this virus to induce autoimmunity and, in certain cases, contribute to the development of autoimmune diseases. However, the presence of latent autoimmunity and their role in the transition to overt autoimmune conditions remain poorly understood.</div></div><div><h3>Objective</h3><div>To evaluate the prevalence of latent autoimmunity among healthcare workers (HCWs) with natural, vaccine-induced, and hybrid immunity to SARS-CoV-2.</div></div><div><h3>Materials and methods</h3><div>We conducted a prospective observational study with 50 HCWs to assess the presence of latent rheumatic, thyroid, and phospholipid autoimmunity. Participants comprised HCWs with no previous exposure to SARS-CoV-2 or those who had undergone natural infection and subsequently received a COVID-19 booster vaccination.</div></div><div><h3>Results</h3><div>The evaluation of 25 autoantibodies associated with latent rheumatic, thyroid, and phospholipid autoimmunity revealed no statistically significant differences among the studied groups.</div></div><div><h3>Conclusions</h3><div>Natural infection with SARS-CoV-2, vaccination, or hybrid immunity against this virus was not associated with the development of new-onset latent autoimmunity.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 3","pages":"Article 102183"},"PeriodicalIF":0.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}