趾间超声引导下浸润肉毒杆菌毒素治疗雷诺现象有效性的回顾性研究。

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2025-07-01 DOI:10.1016/j.rcreu.2024.02.005

Ángel Estuardo Plasencia Ezaine , Marco Aurelio Ramírez Huaranga , Rocío Arenal López , David Castro Corredor , Verónica Salas Manzanedo , María Dolores Mínguez Sánchez , Elisa Sánchez Rodríguez

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引用次数: 0

摘要

雷诺氏现象（RP）是一种血管痉挛性疾病，引起疼痛和残疾。当常规治疗不足够有效时，需要探索其他治疗方案，如指间肉毒杆菌毒素（BT）注射。目的探讨RP患者的临床改善情况（每日发作次数、发作期间视觉模拟评分（VAS）、发作持续时间和雷诺病情评分）。材料和方法对接受超声引导下指间注射A型BT的RP患者进行观察性、描述性、回顾性研究，获得术后对照（1、3和6个月）数据，并通过StatPlus程序使用Wilcoxon检验进行分析。结果8例患者（100%为女性），平均年龄48.5岁，均为继发于全身性疾病的RP（87.5%为系统性硬化症）。观察到第一个月RP发作次数的显著差异（中位数和四分位数范围）（P = 0.043）。每次发作的疼痛VAS评分在第一个月（P = 0.027）和第三个月（P = 0.043）下降。第1个月和第3个月的雷诺状态评分差异有统计学意义（P = 0.027）。结论超声引导下指间注射A型BT可作为RP患者的辅助治疗方法。

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查看原文本刊更多论文

Estudio retrospectivo sobre la efectividad de la infiltración ecoguiada interdigital de toxina botulínica para el tratamiento del fenómeno de Raynaud

Introduction

Raynaud's phenomenon (RP) is a vasospastic condition that carries a significant burden of pain and disability. When conventional therapies are not sufficiently effective, the need arises to explore other therapeutic alternatives such as interdigital botulinum toxin (BT) injection.

Objective

To determine clinical improvement in patients with RP (number of daily episodes, Visual Analogue Scale (VAS) during episodes, duration of episodes, and Raynaud Condition Score).

Materials and methods

Observational, descriptive, retrospective study of patients with RP who received ultrasound-guided interdigital injection of type A BT. Data from post-procedure controls (months 1, 3, and 6) were obtained, and analysis was performed using the Wilcoxon test through the StatPlus programme.

Results

The study was conducted on 8 patients (100% female) with a mean age of 48.5 years, all of whom had RP secondary to a systemic disease (87.5% systemic sclerosis). Significant differences were observed (median and interquartile range) in the number of RP episodes in the first month (P = .043). The pain VAS for each episode decreased in the first month (P = .027) and in the third month (P = .043). Differences were found in the Raynaud condition score in the first month (P = .027) and the third month (P = .043).

Conclusions

Ultrasound-guided interdigital injection of type A BT could be an adjuvant treatment for patients with RP.

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.