Evaluación de las características clínicas, gammagráficas e histopatológicas en pacientes con diagnóstico presuntivo de síndrome de Sjögren

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2025-07-01 DOI:10.1016/j.rcreu.2024.10.001

Lina María Franco González , Leonor Victoria González Pérez , Mónica Vanessa Posso Zapata , Vanessa Andrea Flórez Arango

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引用次数: 0

Abstract

Introduction

Sicca syndrome is characterized by the presence of dry eye (xerophthalmia - keratoconjunctivitis sicca), dry mouth (xerostomia), and dry skin (xeroderma), this triad may be related to Sjögren's syndrome.

Objective

To associate the clinical, scintigraphic, and histopathological characteristics of patients with xerostomia and diagnosis of SS and presumptive diagnosis of Sjögren's syndrome in Medellín-Colombia, 2018-2020.

Materials and methods

The study was a quantitative approach, with cross-sectional analysis. The participants were grouped into two groups: diagnosis of Sicca syndrome and presumptive diagnosis of Sjögren's syndrome, and a survey of sociodemographic data was applied. For each group, salivary flow measurements, Schirmer's test, salivary gland scintigraphic study, and histological evaluation were performed. Statistical analysis was performed using measures of central tendency (median) and dispersion (interquartile range), Fisher's exact test, and the Mann-Whitney U test.

Results

The sample consisted of 24 women. The most frequent systemic clinical sign was joint pain which was present in 90% of cases of Sicca syndrome and in 92.9% of cases of diagnosis presumptive Sjogren's syndrome, while the clinical signs of tongue depapillation were present in 100% of cases of Sicca syndrome and in 92.9% of cases of Sjögren's syndrome. Functional tests, unstimulated salivary flow rate, and salivary gland scintigraphy showed greater involvement in the group of presumptive diagnosis of Sjögren's syndrome. Histopathological analysis showed atrophic changes, fibrosis, and fatty changes in both categories.

Conclusion

The findings suggest that patients with a presumptive diagnosis of Sicca syndrome may be in an early phase of Sjögren's syndrome progression, so this study aims to establish an association of signs, symptoms, and diagnostic aids to define an accurate diagnosis and therapy.

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评估疑似Sjogren综合征患者的临床特征、伽马图和组织病理学

干燥综合征以干眼（干眼症-干燥性角膜结膜炎）、口干（口干症）和皮肤干燥（干皮病）为特征，这三种症状可能与Sjögren综合征有关。目的探讨2018-2020年Medellín-Colombia地区口干症患者的临床、影像学和组织病理学特征与SS诊断和Sjögren综合征推定诊断的相关性。材料与方法本研究采用定量方法，采用横断面分析。参与者被分为两组：诊断为Sicca综合征和推定诊断为Sjögren综合征，并采用社会人口学数据调查。对各组进行唾液流量测量、Schirmer试验、唾液腺显影研究和组织学评价。统计分析采用集中趋势（中位数）和离散度（四分位数范围）、Fisher精确检验和Mann-Whitney U检验进行。结果本组共24名女性。最常见的全身性临床症状是关节疼痛，在90%的Sicca综合征病例和92.9%的推定干燥综合征病例中出现关节疼痛，而100%的Sicca综合征病例和92.9%的Sjögren综合征病例中出现舌脱毛的临床症状。功能测试、非刺激唾液流速和唾液腺闪烁成像显示，在推定诊断Sjögren综合征的组中，参与程度更高。组织病理学分析显示两类患者均出现萎缩、纤维化和脂肪变化。结论推定为Sicca综合征的患者可能处于Sjögren综合征进展的早期阶段，因此本研究旨在建立体征、症状和诊断辅助工具的关联，以确定准确的诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.