嗜酸性筋膜炎与igg4相关疾病相关

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2025-07-01 DOI:10.1016/j.rcreu.2024.06.003

Jesica Gallo , Alejandro Varizat , Sergio Paira

{"title":"嗜酸性筋膜炎与igg4相关疾病相关","authors":"Jesica Gallo , Alejandro Varizat , Sergio Paira","doi":"10.1016/j.rcreu.2024.06.003","DOIUrl":null,"url":null,"abstract":"<div><div>A 52-year-old male presented with pain and induration of the skin and muscles. Physical examination revealed swelling and induration of the skin and muscles of the arms, forearms, hands, thorax, abdomen, and legs, accompanied by the characteristic orange peel appearance. In addition to bilateral hearing impairment, there was enlargement of both lacrimal glands. Laboratory results revealed hyper-eosinophilia, elevated C-reactive protein, and erythrocyte sedimentation rate, hypocomplementaemia, polyclonal hypergammaglobulinaemia, elevated IgE, IgG, and increased IgG1 and IgG4. MRI of the lower limbs reported enhanced contrast in the muscles of both thighs with thickening of the semimembranosus vastus lateralis fascia and arms. A skin and fascia biopsy indicated lymphoplasmacytic infiltrate, eosinophils, and non-storiform fibrosis. Immunohistochemistry showed IgG4 positivity in less than 10%, with an IgG4/lgG range of less than 40%. The patient meets the criteria for eosinophilic fasciitis and ACR/EULAR criteria for IgG4-RD. For this reason, we would like to report the first case found of eosinophilic fasciitis associated with IgG4-RD.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 3","pages":"Pages 294-297"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eosinophilic fasciitis associated with IgG4-related disease\",\"authors\":\"Jesica Gallo , Alejandro Varizat , Sergio Paira\",\"doi\":\"10.1016/j.rcreu.2024.06.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A 52-year-old male presented with pain and induration of the skin and muscles. Physical examination revealed swelling and induration of the skin and muscles of the arms, forearms, hands, thorax, abdomen, and legs, accompanied by the characteristic orange peel appearance. In addition to bilateral hearing impairment, there was enlargement of both lacrimal glands. Laboratory results revealed hyper-eosinophilia, elevated C-reactive protein, and erythrocyte sedimentation rate, hypocomplementaemia, polyclonal hypergammaglobulinaemia, elevated IgE, IgG, and increased IgG1 and IgG4. MRI of the lower limbs reported enhanced contrast in the muscles of both thighs with thickening of the semimembranosus vastus lateralis fascia and arms. A skin and fascia biopsy indicated lymphoplasmacytic infiltrate, eosinophils, and non-storiform fibrosis. Immunohistochemistry showed IgG4 positivity in less than 10%, with an IgG4/lgG range of less than 40%. The patient meets the criteria for eosinophilic fasciitis and ACR/EULAR criteria for IgG4-RD. For this reason, we would like to report the first case found of eosinophilic fasciitis associated with IgG4-RD.</div></div>\",\"PeriodicalId\":37643,\"journal\":{\"name\":\"Revista Colombiana de Reumatologia\",\"volume\":\"32 3\",\"pages\":\"Pages 294-297\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Colombiana de Reumatologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0121812324000744\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Health Professions\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Colombiana de Reumatologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0121812324000744","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Health Professions","Score":null,"Total":0}

引用次数: 0

摘要

一名52岁男性，表现为皮肤和肌肉疼痛和硬化。体格检查发现手臂、前臂、手部、胸部、腹部和腿部皮肤和肌肉肿胀和硬化，并伴有特征性橙皮样外观。除双侧听力障碍外，双侧泪腺肿大。实验室结果显示嗜酸性粒细胞增多、c反应蛋白升高、红细胞沉降率升高、补体不足、多克隆高γ球蛋白血症、IgE、IgG升高、IgG1和IgG4升高。下肢MRI显示双大腿肌肉造影剂增强，股外侧半膜肌筋膜增厚。皮肤和筋膜活检显示淋巴浆细胞浸润、嗜酸性粒细胞和非层状纤维化。免疫组化显示IgG4阳性小于10%，IgG4/lgG范围小于40%。患者符合嗜酸性筋膜炎的标准和IgG4-RD的ACR/EULAR标准。因此，我们报告第一例发现的与IgG4-RD相关的嗜酸性筋膜炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Eosinophilic fasciitis associated with IgG4-related disease

A 52-year-old male presented with pain and induration of the skin and muscles. Physical examination revealed swelling and induration of the skin and muscles of the arms, forearms, hands, thorax, abdomen, and legs, accompanied by the characteristic orange peel appearance. In addition to bilateral hearing impairment, there was enlargement of both lacrimal glands. Laboratory results revealed hyper-eosinophilia, elevated C-reactive protein, and erythrocyte sedimentation rate, hypocomplementaemia, polyclonal hypergammaglobulinaemia, elevated IgE, IgG, and increased IgG1 and IgG4. MRI of the lower limbs reported enhanced contrast in the muscles of both thighs with thickening of the semimembranosus vastus lateralis fascia and arms. A skin and fascia biopsy indicated lymphoplasmacytic infiltrate, eosinophils, and non-storiform fibrosis. Immunohistochemistry showed IgG4 positivity in less than 10%, with an IgG4/lgG range of less than 40%. The patient meets the criteria for eosinophilic fasciitis and ACR/EULAR criteria for IgG4-RD. For this reason, we would like to report the first case found of eosinophilic fasciitis associated with IgG4-RD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.