Common variable immune deficiency complicating proliferative lupus nephropathy: A diagnostic and therapeutic challenge

Introduction

Common variable immunodeficiency (CVID) is a rare condition characterized by a constitutional humoral immune deficiency. Its association with systemic lupus is extremely rare.

Case presentation

In this case report, we present a 21-year-old woman with a history of Hashimoto's thyroiditis, who, following the onset of nephrotic syndrome revealing her lupus disease, subsequently developed clinical and laboratory features consistent with CVID, alongside recurrent lupus flares. Her initial therapeutic management was intricate, ultimately resulting in stable remission achieved through monthly immunoglobulin infusions.

Conclusion

This case illustrates the diagnostic and therapeutic difficulty of lupus disease and a common variable immune deficiency.