Correlation of simple hematological parameters with disease activity and damage indices among Egyptian patients with systemic lupus erythematosus

Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2025-04-01 DOI:10.1016/j.rcreu.2024.01.006

Hanan H. Ahmed , Hebatallah S. Farag , Nesreen Sobhy

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引用次数: 0

Abstract

Objective

To evaluate the correlation of different hematological parameters in lupus patients with SLE disease activity index (SLEDAI), the Systemic Lupus International Collaboration Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI), and some laboratory data related to kidney functions in active patients with nephritis.

Material and methods

80 inactive SLE patients (SLEDAI score < 10 points), and 80 active patients (SLEDAI ≥ 10 points) were enrolled in this study. All patients underwent full medical history taking, clinical evaluation including calculation of SLEDAI and SLICC/ACR DI scores, and laboratory investigations including complete blood count. The two groups were compared regarding different disease parameters. Correlations of some hematological parameters with SLEDAI, SLICC/ACR DI scores and some laboratory data related to kidney function in patients with nephritis were made.

Results

The active group showed statistically significantly higher mean NLR (P = 0.000), NC3R (P = 0.000), MLR (P = 0.000), PLR (P = 0.000), and RDW (P = 0.001), and statistically significantly lower mean MPV (P = 0.002). The mean MLR (P = 0.018) and PLR (P = 0.005) were statistically significantly higher in the active patients with nephritis. For both groups, there were no significant correlations between studied parameters and SLEDAI or SLICC/ACR DI, except with NC3R values in the active group which were associated with SLEDAI (r = .221, P = 0.049).

Conclusion

The hematological parameters in SLE have promising potential clinical application as a novel activity marker, especially in patients with nephritis.

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.