Obstetrics and Gynecology Science最新文献_第2页

Coronavirus disease vaccine linked menstrual changes: mobile application study. 冠状病毒疫苗与月经变化相关：移动应用研究

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.5468/ogs.24104

Sung Eun Kim, Joseph J Noh, Yoo-Young Lee

{"title":"Coronavirus disease vaccine linked menstrual changes: mobile application study.","authors":"Sung Eun Kim, Joseph J Noh, Yoo-Young Lee","doi":"10.5468/ogs.24104","DOIUrl":"10.5468/ogs.24104","url":null,"abstract":"Objective: Since coronavirus disease 2019 (COVID-19) vaccination began, abnormal uterine bleeding (AUB) has occurred at a high rate. This study assessed the association between COVID-19 vaccination and AUB.Methods: In this retrospective cohort study, we analyzed mobile application data on menstrual cycles to investigate differences in the prevalence, duration, and amount of intermenstrual bleeding (IMB) after COVID-19 vaccination. We also analyzed the duration of menstruation, menstrual cycle length, and associated symptoms after the COVID-19 vaccination. Additionally, we investigated the prevalence of IMB according to the vaccine type.Results: After vaccination, IMB prevalence increased to 3.35% (odds ratio [OR], 1.61; 95% confidence interval [CI], 1.46-1.76; p<0.0001) and IMB duration increased by 0.43 days (95% CI, 0.25-0.60; p<0.0001). The proportion of respondents whose amount of IMB was heavier than regular menstruation increased (OR, 2.96; 95% CI, 1.47-5.93; p=0.002). Menstrual duration decreased by -0.01 days (95% CI, -0.023 to 0.003; p=0.114), and menstrual cycle length increased by 1.39 days (95% CI, 1.30-1.48; p<0.0001). The proportion of participants who answered that there was a difference in menstruation amount increased (OR, 1.52; 95% CI, 1.41-1.64; p<0.0001). The prevalence of IMB increased regardless of the vaccine type.Conclusion: There were statistically significant differences in the prevalence, duration and amount of IMB, menstrual duration, menstrual cycle length, and menstrual amount after COVID-19 vaccination. However, these values were not clinically meaningful and could be regarded as within the normal menstruation range.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"155-162"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis. 异黄酮对绝经后阴道干燥和性交困难的影响：一项系统综述和荟萃分析。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI: 10.5468/ogs.24282

Tri Hastono Setyo Hadi, Budi Santoso, Gatut Hardianto, Eighty Mardiyan Kurniawati

{"title":"The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis.","authors":"Tri Hastono Setyo Hadi, Budi Santoso, Gatut Hardianto, Eighty Mardiyan Kurniawati","doi":"10.5468/ogs.24282","DOIUrl":"10.5468/ogs.24282","url":null,"abstract":"Vaginal dryness and dyspareunia are frequent complaints among postmenopausal women. Studies have shown that isoflavones reduce the severity of menopausal symptoms. This study aimed to evaluate the effects of isoflavones on vaginal dryness and dyspareunia in postmenopausal women. PubMed, ScienceDirect, and Cochrane Library electronic databases were searched until June 15, 2024. Revman 5.4 software (The Nordic Cochrane Centre, Copenhagen, Denmark) was used to analyze the data. Ten randomized controlled trials (RCTs), totaling 675 participants, were included in the isoflavone treatment, and the duration was between 4 and 48 weeks. For the meta-analysis, four and two RCTs were conducted to analyze vaginal dryness and dyspareunia in postmenopausal women before and after isoflavone treatment, respectively. The analysis results for vaginal dryness showed a significant change after isoflavone therapy, whereas those for dyspareunia did not show a significant change. The random-effects estimation of the mean difference was -1.29, and 95% confidence interval (CI) was -2.53 to -0.04 (p=0.04) for vaginal dryness, and -0.82, with a 95% CI of -3.51 to 1.87 (p=0.55) for dyspareunia. This meta-analysis concluded that isoflavones have a significant effect on relieving vaginal dryness but have no impact on dyspareunia in postmenopausal women. Numerous larger, long-term trials are needed to fully assess their effects and efficacy.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"131-138"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy outcomes after all modes of conception in patients with genital tuberculosis: a systematic review and meta-analysis. 生殖结核患者所有受孕方式后的妊娠结局：一项系统回顾和荟萃分析。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-03-01 Epub Date: 2025-01-03 DOI: 10.5468/ogs.24045

Dian Tjahjadi, Jenifer Kiem Aviani, Kevin Dominique Tjandraprawira, Ida Parwati, Wiryawan Permadi, Tono Djuwantono, Tin Chiu Li

{"title":"Pregnancy outcomes after all modes of conception in patients with genital tuberculosis: a systematic review and meta-analysis.","authors":"Dian Tjahjadi, Jenifer Kiem Aviani, Kevin Dominique Tjandraprawira, Ida Parwati, Wiryawan Permadi, Tono Djuwantono, Tin Chiu Li","doi":"10.5468/ogs.24045","DOIUrl":"10.5468/ogs.24045","url":null,"abstract":"This systematic review and meta-analysis aimed to summarize the pregnancy outcomes of women diagnosed with genital tuberculosis (GTB) who spontaneously conceived or underwent intrauterine insemination (IUI) or in vitro fertilization (IVF) after being treated with antitubercular therapy (ATT). Publications from the PubMed, Medline, Embase, Ovid, Scopus, Web of Science, and Google Scholar databases were searched from December 20, 2021 to March 5, 2022. The outcomes are presented as pooled averages with 95% confidence intervals. The inconsistency index (I2) test was used to measure the heterogeneity between studies. The certainty of the evidence was assessed using GRADEPro (https://www.gradepro.org/). Of the numerous articles identified, 33 met the inclusion criteria and were included in this systematic review. Generally, there was a significant increase in pregnancy rates among patients who underwent IVF compared with those who underwent ATT (37.9% vs. 23.8%; p=0.02). Conversely, there was no significant difference in pregnancy rates between patients who underwent IUI and those who conceived spontaneously (18.1% vs. 23.8%; p=0.65). In cases in which no abnormalities were found on hysterosalpingography or hysterolaparoscopy, pregnancy rates were comparable between spontaneous and IVF conceptions (48.4% vs. 49.2%). There were no significant differences in pregnancy or live birth rates between patients with GTB and those with other infertility factors undergoing IVF treatment (p>0.05). ATT, which is administered during the early stages of GTB is effective in achieving pregnancy outcomes comparable to IVF. However, in patients with advanced-stage disease, IVF is a superior treatment modality, resulting in increased pregnancy rates.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"109-130"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can activator protein-1 transcription factors be monitored in the maternal circulation to predict set on labor? 能否通过监测母体循环中的活化蛋白-1 转录因子来预测分娩过程？

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-03-01 Epub Date: 2025-02-12 DOI: 10.5468/ogs.23288

Toghrul Yahyayev, Tugce Senturk Kirmizitas, Ali Benian, Tuba Gunel

{"title":"Can activator protein-1 transcription factors be monitored in the maternal circulation to predict set on labor?","authors":"Toghrul Yahyayev, Tugce Senturk Kirmizitas, Ali Benian, Tuba Gunel","doi":"10.5468/ogs.23288","DOIUrl":"10.5468/ogs.23288","url":null,"abstract":"Objective: We aimed to compare gene expression levels in myometrial tissues and serum from pregnant women undergoing cesarean section (CS) with and without uterine contractions. The myometrial activator protein-1 (AP-1) transcription factor family (JUN, FOS, and fos-related antigen-2 [FOSL2]) was evaluated as a contraction-related marker in maternal circulation to predict labor timing.Methods: Samples were collected from pregnant women undergoing CS. Uterine contractions were observed in the experimental group (n=10) but not in the control group (n=10). Gene expression of JUN, FOS, and FOSL2 was analyzed in serum and myometrial samples using droplet digital polymerase chain reaction, and statistical analysis was performed using GraphPad software (GraphPad Software, San Diego, CA, USA).Results: Given the non-normal data distribution, JUN, FOS, and FOSL2 gene expression levels increased in the CS group with uterine contractions. However, this increase was not statistically significant in either tissue or serum samples. Nevertheless, the correlation of JUN messenger RNA expression between maternal circulation and myometrial tissue was statistically significant in the CS group with contractions (p<0.01).Conclusion: This is the first study to investigate AP-1 transcription factor expression in matched tissue and serum samples in relation to uterine contractility. The increased expression of JUN, FOS, and FOSL2 in the CS group with contractions suggests these genes may play a key role in initiating or propagating human labor, indicating that contractionassociated AP-1 could serve as a biomarker for labor timing.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"139-147"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Usefulness and limitations of Chat GPT in getting information on teratogenic drugs exposed in pregnancy. ChatGPT 在获取孕期接触的致畸药物信息方面的实用性和局限性。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.5468/ogs.24231

Jung Yeol Han

{"title":"Usefulness and limitations of Chat GPT in getting information on teratogenic drugs exposed in pregnancy.","authors":"Jung Yeol Han","doi":"10.5468/ogs.24231","DOIUrl":"10.5468/ogs.24231","url":null,"abstract":"There is a growing interest in using artificial intelligence (AI) technology to obtain information on the risk and safety of drugs in pregnancy. Inadvertent drug exposure in pregnant women is inevitable in acute or chronic diseases, especially in unplanned pregnancies. According to the Korean mother safe counselling center database (2010-2023), many Korean pregnant women and their families asked about the teratogenicity of their exposed drugs. The most frequently used drug was topiramate (n=2,018), followed by isotretinoin (n=1,972), dexamethasone (n=1,279), and doxycycline (n=1,119). Unexpectedly, thalidomide, a notorious teratogen that causes phocomelia, was included. It has been withdrawn from general prescriptions since 1961, except for the treatment of multiple myeloma. Her partner used it for the treatment of multiple myeloma. In this study, we evaluated the usefulness of AI Chat generative pretrained transformer (Chat GPT) by comparing information between AI and a literature review on isotretinoin, a well-known teratogen to which Korean pregnant women are frequently exposed. Chat GPT provides general information on teratogenicity for pregnant women and medical providers rather than on their exposure. Thus, AI can induce unnecessary termination of pregnancy due to misinformation and misperception in cases of notorious teratogens such as isotretinoin. Therefore, counseling on the teratogenicity of medication exposure in pregnancy must be performed with Chat GPT, as well as a literature review. Further studies are required to obtain more individualized information using AI in the field of teratology.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends, statistics, and policy recommendations on maternal, fetal, and infant mortality before and after COVID-19: a review of the past decade (2012-2022) based on national health information data. COVID-19 前后的孕产妇、胎儿和婴儿死亡率趋势、统计数据和政策建议：基于国家健康信息数据的过去十年（2012-2022 年）回顾。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI: 10.5468/ogs.24264

Kyung Ju Lee, Seokmin Lee

{"title":"Trends, statistics, and policy recommendations on maternal, fetal, and infant mortality before and after COVID-19: a review of the past decade (2012-2022) based on national health information data.","authors":"Kyung Ju Lee, Seokmin Lee","doi":"10.5468/ogs.24264","DOIUrl":"10.5468/ogs.24264","url":null,"abstract":"Objective: To examine the impact of the coronavirus disease 2019 (COVID-19) pandemic on maternal, fetal, and infant mortality in South Korea using national statistics, in order to inform policy development and enhance maternal and child health outcomes with the provided data.Methods: Pregnancy-related mortality in women, as well as deaths of infants, in South Korea was identified using cause-of-death statistics from Statistics Korea. Records from death certificates, cremation reports on infant and fetal deaths, and the complementary cause-of-death investigation system were reviewed for the 2012-2022 period. The classification criteria for cause of death followed the recommendations of World Health Organization and the Korean standard classification of diseases and causes of death.Results: The maternal mortality rate decreased from 11.3 per 100,000 live births in 2018 to 9.9 in 2019, rose to 11.8 in 2020, and fell to 8.8 in 2021. The actual number of maternal deaths declined from 37 in 2018 to 23 in 2021 due to fewer births. The fetal death rate increased from 11.3 per 1,000 live births in 2018 to 11.6 in 2019, continuing to rise to 12.0 in 2021. The number of fetal deaths dropped from 3,743 in 2018 to 3,152 in 2021.Conclusion: Despite the COVID-19 pandemic, Korea experienced a sharp decline in births as well as in maternal, infant, and fetal deaths. However, maternal, infant, and fetal mortality rates remained at similar levels.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"59-68"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical evaluation and management of endometriosis: 2024 guideline for Korean patients from the Korean Society of Endometriosis. 子宫内膜异位症的临床评估和管理：韩国子宫内膜异位症协会2024年韩国患者指南。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.5468/ogs.24242

Hyun Joo Lee, Sang-Hee Yoon, Jae Hoon Lee, Youn-Jee Chung, So Yun Park, Sung Woo Kim, Yeon Hee Hong, Sung Eun Kim, Youjin Kim, Sungwook Chun, Yong Jin Na

引用次数: 0

Decoding impact of human papillomavirus in gynecological oncology: a narrative review. 人乳头瘤病毒在妇科肿瘤学中的解码影响：综述。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI: 10.5468/ogs.24226

Md Safiullah Sarker, Mohammed Moshtaq Pervez

引用次数: 0

Fetal biometry measurements in diabetic pregnant women and neonatal outcomes. 糖尿病孕妇的胎儿生物测量和新生儿结局。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.5468/ogs.24230

Aram Heo, Jinha Chung, Seula Lee, Hyunjin Cho

{"title":"Fetal biometry measurements in diabetic pregnant women and neonatal outcomes.","authors":"Aram Heo, Jinha Chung, Seula Lee, Hyunjin Cho","doi":"10.5468/ogs.24230","DOIUrl":"10.5468/ogs.24230","url":null,"abstract":"Objective: In this study, we aimed to investigate how fetal head and abdominal circumferences are related to the incidence of neonatal complications in mothers with gestational diabetes mellitus (GDM) and pre-gestational diabetes mellitus (PGDM) compared to normal pregnancies.Methods: We retrospectively analyzed data of expectant mothers with GDM, PGDM, and normal pregnancies who delivered singleton full-term infants (≥37 weeks) at a tertiary center from January 2013 to December 2022. Ultrasonography-measured fetal weight, fetal head circumference, fetal abdominal circumference, difference between head and abdominal circumference, and head-to-abdominal circumference ratio were assessed. Neonatal outcomes were evaluated based on the rates of admission to the neonatal intensive care unit, intubation, and hypoglycemia. Statistical analyses, including univariate and multivariate analyses, were performed using the SPSS software (IBM Corp., Armonk, NY, USA).Results: Among the 473 participants, 175 (37.0%) were mothers with diabetes (DM). A head-to-abdominal circumference ratio <0.95 and a difference of ≥2.5 cm were significantly associated with neonatal hypoglycemia in all mothers with DM, with statistical significance noted only in the PGDM group. No significant association was observed in normal pregnancies.Conclusion: Our findings indicate that a head-to-abdominal circumference ratio <0.95 and a ≥2.5 cm difference in circumferences are associated with neonatal hypoglycemia in mothers with DM.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"69-78"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of placenta Hofbauer cells during pregnancy and pregnancy complications. 胎盘霍夫鲍尔细胞在妊娠和妊娠并发症中的作用。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.5468/ogs.24247

Seung-Woo Yang, Han-Sung Hwang, Young-Sun Kang

{"title":"The role of placenta Hofbauer cells during pregnancy and pregnancy complications.","authors":"Seung-Woo Yang, Han-Sung Hwang, Young-Sun Kang","doi":"10.5468/ogs.24247","DOIUrl":"10.5468/ogs.24247","url":null,"abstract":"Placental Hofbauer cells (HBCs) are specialized macrophages present in the human placenta that play a crucial role in maintaining a healthy pregnancy. These cells are derived from the fetal mesoderm and are responsible for various functions, including immune regulation, angiogenesis, and nutrient transport. In normal pregnancies, HBCs primarily exhibit an M2 or immunomodulatory phenotype, which helps maintain a tolerant and antiinflammatory environment at the maternal-fetal interface. However, in pregnancies complicated by conditions such as immunological disorders, inflammation, or infection, the phenotype and function of HBCs may be altered. Although emerging evidence has highlighted the vital role of HBCs in both normal pregnancies and those with complications, such as chorioamnionitis, gestational diabetes, preeclampsia, and viral infections, their role remains unclear. Recent research also suggests a relationship between HBCs and the development of diseases in offspring. Understanding the role of HBCs in pregnancy could provide insights into the pathophysiology of various pregnancy-related disorders and offer potential therapeutic targets for improving maternal and fetal outcomes. This review explores the functions of HBCs in normal pregnancy and their involvement in complications, emphasizing their potential as biomarkers or targets for interventions aimed at reducing the incidence of adverse pregnancy outcomes. Additionally, we reviewed their potential for perinatal research in recent studies.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"9-17"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0