Obstetrics and Gynecology Science最新文献

{"title":"Isobaric NOTES hysterectomy: an alternative to transvaginal NOTES hysterectomy.","authors":"Yun Seok Yang, Chul Kwon Lim, Jae Young Kwack, Jun-Hyeok Kang, Seong Hee Kim, Kwan Young Oh","doi":"10.5468/ogs.25036","DOIUrl":"10.5468/ogs.25036","url":null,"abstract":"<p><strong>Objective: </strong>Natural orifice transluminal endoscopic surgery (NOTES) for hysterectomy conventionally requires CO2 pneumoperitoneum via a transvaginal port, presenting challenges such as gas leakage and increased procedural complexity. We introduced isobaric NOTES hysterectomy (iNH) as an alternative to transvaginal NOTES hysterectomy (vNH) to eliminate the need for CO2 pneumoperitoneum.</p><p><strong>Methods: </strong>Between December 2014 and July 2018, 137 patients with benign uterine conditions underwent iNH or single-port laparoscopy-assisted vaginal hysterectomies (SP-LAVH). Clinical outcomes were retrospectively compared.</p><p><strong>Results: </strong>Of 137 patients, 59 underwent iNH and 78 underwent SP-LAVH. All iNH procedures were completed without conversion, except for one hybrid NOTES case, with no intraoperative complications reported in the iNH group. While the median operative times and uterine weights were comparable between the groups, iNH demonstrated significantly lower median blood loss, reduced hemoglobin changes on postoperative day 1, and shorter hospital stay than SP-LAVH.</p><p><strong>Conclusion: </strong>Using a single-hole vaginal platform without pneumoperitoneum, iNH combines the simplicity of vaginal hysterectomy with the visual advantages of vNH. Therefore, it is a distinct method within the transvaginal hysterectomy spectrum. Further studies are warranted to delineate the specific iNH advantages over conventional pneumoperitoneum-based vNOTES.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"433-441"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond vitamin D: the potential role of ultraviolet B-induced photoproducts (solar metabolome) in bone and muscle health.","authors":"Berkay Yalçınkaya, Ahmet Furkan Çolak, Hilmi Berkan Abacıoğlu, Murat Kara","doi":"10.5468/ogs.25208","DOIUrl":"10.5468/ogs.25208","url":null,"abstract":"","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"446-447"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of adopting vaginal natural orifice transluminal endoscopic surgery for risk-reducing salpingo-oophorectomy for women with germline BRCA1/2 pathogenic variants analysis from conventional procedure.","authors":"Hidetaka Nomura, Akiko Abe, Atsushi Fusegi, Mayumi Kamata, Arisa Ueki, Hiroyuki Kanao","doi":"10.5468/ogs.25044","DOIUrl":"10.5468/ogs.25044","url":null,"abstract":"<p><strong>Objective: </strong>Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is less invasive than conventional transabdominal laparoscopic surgery for benign gynecological indications. When adopting this procedure for risk-reducing salpingo-oophorectomy (RRSO) in women with hereditary breast and ovarian cancer (HBOC), the ventral side of the uterus becomes a blind area, which is a challenge. To clarify the effects of this blind area on the treatment outcome of HBOC, we examined the clinical data of RRSO using conventional procedures for women with germline BRCA1/2 pathogenic variants who were treated at our institution.</p><p><strong>Methods: </strong>A retrospective chart review was performed. The clinical data of patients who underwent RRSO using the conventional procedure between September 2011 and July 2024 were extracted. All included patients were preoperatively examined using vaginal ultrasonography, contrast-enhanced pelvic magnetic resonance imaging, and carcinoma antigen-125 level measurements to exclude ovarian cancer development.</p><p><strong>Results: </strong>A total of 267 patients underwent RRSO at our institution. The mean age at RRSO was 50.1 years. Five cases of occult invasive cancer (1.9%) and 10 cases of serous tubal intraepithelial carcinoma (3.7%) were identified postoperatively. One patient (0.37%) showed macroscopic peritoneal dissemination in the omentum. None of the 252 patients without occult cancer developed peritoneal cancer during the mean observational time of 62.4 months. No patient presented with peritoneal lesions ventral to the uterus.</p><p><strong>Conclusion: </strong>Macroscopic tumors on the peritoneum ventral to the uterus were rare when strict preoperative screening for ovarian cancer was performed. vNOTES can be safely adopted for RRSO in patients with HBOC, without evident disadvantages.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"418-423"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal outcomes after radiofrequency ablation for selective fetal reduction in complicated monochorionic pregnancies: a single-center experience.","authors":"K Aparna Sharma, Vatsla Dadhwal, Tanisha Gupta, Deepti Dahiya, Anubhuti Rana, Akash Singhal, Anu Thukral, Shivam Pandey","doi":"10.5468/ogs.25049","DOIUrl":"10.5468/ogs.25049","url":null,"abstract":"<p><strong>Objective: </strong>Monochorionic (MC) pregnancies are often complicated by shared placental and circulatory structures, resulting in conditions such as twin-twin transfusion syndrome (TTTS), selective fetal growth restriction (sFGR), and a twin-reversed arterial perfusion (TRAP) sequence. This study aimed to evaluate perinatal outcomes following radiofrequency ablation (RFA) for selective fetal reduction in complicated MC pregnancies at a tertiary care center in India.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 100 MC pregnancies that underwent RFA for selective fetal reduction between January 2016 and December 2023. The indications included TTTS, sFGR (stages II and III), discordant anomalies, TRAP, and elective reduction. The key outcomes assessed were live birth rates, procedural success, and complications, including preterm prelabor rupture of membranes (PPROM) and co-twin survival. Data were compared between the two intervention periods to evaluate improvements over time.</p><p><strong>Results: </strong>Procedural success was achieved in all patients with no intraoperative complications. The median gestational age at the time of the procedure was 22 weeks. The overall live birth rate was 85% and the discharge survival rate was 79%. PPROM occurred in 18% of patients, whereas fetal death was observed in 15%, predominantly in patients with TTTS. Post-procedure magnetic resonance imaging detected cerebral injury in 2% of surviving twins. Logistic regression analysis did not identify any significant predictors of co-twin death.</p><p><strong>Conclusion: </strong>RFA is an effective technique for selective fetal reduction in MC pregnancies, offering favorable survival outcomes, even in a resource-limited setting.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"372-381"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality for pain relief during office hysteroscopy: a randomized controlled trial.","authors":"Rania Gamal, Ahmed Zidan, Waleed Shawky, Joseph Ibrahim, Yassin Mostafa, Tarek Sabry, Amro Elhusseiny, Radwa Ali","doi":"10.5468/ogs.24334","DOIUrl":"10.5468/ogs.24334","url":null,"abstract":"<p><strong>Objective: </strong>Office hysteroscopy (OH) is widely used to diagnose and manage intrauterine pathologies. However, pain remains the primary factor that contributes to OH failure. This study aimed to assess the effect of virtual reality (VR) on pain reduction during OH.</p><p><strong>Methods: </strong>A prospective randomized controlled clinical trial was conducted at a university hospital between July and November 2024. The study involved 50 women undergoing OH randomly allocated to receive immersive VR videos during the procedure or standard care. The main outcome measure was self-reported intraoperative pain evaluated using a numerical rating scale. Other measures included satisfaction, duration, and success of the procedure.</p><p><strong>Results: </strong>Mean pain scores were 6.16±1.86 in standard care group and 4.88±1.69 in VR group (difference, 1.28; 95% confidence interval [CI], 0.27 to 2.29; P=0.014). After adjusting for other variables, no statistically significant relationship was found between VR and severe pain (odds ratio, 0.75; 95% CI, 0.15 to 3.87; P=0.73); only severe anxiety in women and procedure duration were associated with severe pain.</p><p><strong>Conclusion: </strong>Virtual reality did not significantly reduce pain severity during hysteroscopy. However, severe pain was associated with high anxiety and a longer procedure duration. These findings suggest that VR may not effectively mitigate severe pain, whereas managing anxiety and minimizing procedure time could be more effective strategies.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":"68 5","pages":"424-432"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A knowledge, attitudes, and practices study on BRCA mutations among family members of women diagnosed with epithelial ovarian or fallopian tube cancer.","authors":"Sopita Prasertpakdi, Prapaporn Suprasert","doi":"10.5468/ogs.25088","DOIUrl":"10.5468/ogs.25088","url":null,"abstract":"<p><strong>Objective: </strong>BReast CAncer (BRCA) gene mutations increase the risk of epithelial ovarian and fallopian tube cancers. Genetic counseling and screening play a crucial role in identifying individuals at risk. Assessing knowledge, attitudes, and practices (KAP) related to BRCA mutations among family members of affected individuals can assist in early detection and preventive strategies. This study aims to evaluate KAP among family members of patients with these cancers to identify gaps and improve awareness.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted between March and November 2024, involving 215 participants with a family history of epithelial ovarian or fallopian tube cancer. Data were collected through structured interviews.</p><p><strong>Results: </strong>The mean age of participants was 47.3 years; 42.8% were single and 44.2% were nulliparous. Most participants (65.6%) had one affected relative, with 86.5% being first-degree relatives. Only 16.3% had heard of BRCA mutations and 18.2% were aware of their association with ovarian cancer. The most commonly recognized ovarian cancer symptom was abdominal swelling. The highest mean KAP score was associated with the belief that regular pelvic examinations should be performed. Multivariate analysis identified independent factors influencing the desire for BRCA screening, including an attitude score of ≥25 (adjusted odds ratio [AOR], 12.638; P<0.001), follow-up duration of >5 years (AOR, 2.504; P=0.016), and ongoing or ineffective treatment (AOR, 4.303; P<0.001).</p><p><strong>Conclusion: </strong>Substantial gaps in KAP regarding BRCA mutations persist among family members of affected individuals. Targeted educational interventions and healthcare initiatives are essential to enhance awareness and support informed decision-making in high-risk populations.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"390-400"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical analysis using ChatGPT in medical research.","authors":"Soo-Nyung Kim","doi":"10.5468/ogs.25232","DOIUrl":"10.5468/ogs.25232","url":null,"abstract":"<p><p>This study aimed to explore the utility of chat generative pre-trained transformer (ChatGPT) in streamlining statistical analyses within medical research, evaluating its capabilities in data management, exploratory data analysis (EDA), statistical test selection, and result interpretation. It also addresses the critical need for appropriate disclosures and ethical considerations when integrating artificial intelligence (AI) tools into a scientific workflow. We review the current landscape of AI adoption in medical research, focusing on the role of ChatGPT in statistical analysis. Practical examples from lecture materials demonstrate its application in generating virtual datasets, performing data cleaning, conducting EDA, and assisting in the selection of appropriate statistical tests. Furthermore, guidelines for transparently disclosing AI tool usage in scientific manuscripts in accordance with the International Committee of Medical Journal Editors recommendations are discussed. ChatGPT demonstrates significant potential for accelerating various stages of statistical analysis, from initial data preparation to the interpretation of results. Its ability to rapidly generate virtual data for practice, assist in comprehensive data cleaning, and provide immediate insights through EDA can substantially enhance research efficiency. Although capable of suggesting statistical methods and interpreting outputs, human intervention remains crucial for verifying assumptions and ensuring calculation accuracy. ChatGPT can serve as a powerful assistant in medical statistical analyses, enabling researchers to conduct analyses more efficiently. However, its use requires careful data preprocessing, human verification of results, and transparent reporting to maintain scientific rigor and reproducibility. Adherence to ethical guidelines and journal policies regarding AI tool disclosure is paramount.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing evidence on isoflavones for menopausal vaginal health.","authors":"Noshaba Majeed, Shoaib Majeed, Jie Tu","doi":"10.5468/ogs.25147","DOIUrl":"https://doi.org/10.5468/ogs.25147","url":null,"abstract":"","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in applications of machine learning in cervical cancer research: a focus on prediction models.","authors":"Syed S Abrar, Seoparjoo Azmel Mohd Isa, Suhaily Mohd Hairon, Mohd Pazudin Ismail, Mohd Nasrullah Bin Nik Ab Kadir","doi":"10.5468/ogs.25041","DOIUrl":"10.5468/ogs.25041","url":null,"abstract":"<p><p>Artificial intelligence (AI) and machine learning (ML) are transforming cervical cancer research and offering advancements in diagnosis, prognosis, screening, and treatment. This review explores ML applications with particular emphasis on prediction models. A comprehensive literature search identified studies using ML for survival prediction, risk assessment, and treatment optimization. ML-driven prognostic models integrate clinical, histopathological, and genomic data to improve survival prediction and patient stratification. Screening methods, including deep-learning-based cytology analysis and human papillomavirus detection, enhance accuracy and efficiency. ML-driven imaging techniques facilitate early and precise cancer diagnosis, while risk prediction models assess susceptibility based on demographic and genetic factors. AI also optimizes treatment planning by predicting therapeutic responses and guiding personalized interventions. Despite significant progress, challenges remain regarding data availability, model interpretability, and clinical implementation. Standardized datasets, external validation, and cross-disciplinary collaborations are crucial for implementing ML innovations in clinical settings. Subsequent investigations should prioritize joint initiatives among data scientists, healthcare providers, and health authorities to translate AI innovations into real-world applications and to enhance the impact of ML on cervical cancer care. By synthesizing recent developments, this review highlights the potential of ML to improve clinical outcomes and shaping the future of cervical cancer management.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"247-259"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of random blood glucose and HbA1c levels in optimizing glucose tolerance screening in early pregnancy: a retrospective cohort study.","authors":"Yoshitsugu Chigusa, Yoshikazu Ikeda, Akitoshi Yamamura, Haruta Mogami, Akiko Nishimura, Satoshi Morita, Masaki Mandai, Shin-Ichi Harashima","doi":"10.5468/ogs.25052","DOIUrl":"10.5468/ogs.25052","url":null,"abstract":"<p><strong>Objective: </strong>Random blood glucose (rBG) levels are commonly measured in Japan; however, no standardized cutoff values exist for glucose tolerance screening in early pregnancy. The contribution of glycated hemoglobin (HbA1c) and glycated albumin (GA) measurements to the diagnosis of gestational diabetes mellitus (GDM) remains unclear. Therefore, we aimed to evaluate the significance of these glycemic indicators in early pregnancy for predicting GDM.</p><p><strong>Methods: </strong>This observational cohort study enrolled pregnant women who underwent initial prenatal examinations to determine their rBG, HbA1c, and GA levels at a rural maternity facility. Clinical data were retrospectively reviewed.</p><p><strong>Results: </strong>A total of 449 patients were analyzed, comprising 394 with normal glucose tolerance (NGT) and 55 with GDM. The rBG, HbA1c, and GA levels were significantly higher during early pregnancy in women who developed GDM than in those with NGT. Receiver operating characteristic curve analysis revealed that the areas under the curve (AUC) for rBG, HbA1c, and GA were 0.733, 0.591, and 0.608, respectively, with cutoff values of 100 mg/dL, 5.2%, and 14.6%, respectively. These cutoff values had sensitivities of 52.7%, 70.9%, and 36.4% and specificities of 87.6%, 43.4%, and 82.5%, respectively. The product of rBG and HbA1c levels demonstrated improved performance, with an AUC of 0.750, cutoff value of 509, 63.6% sensitivity, and 83.5% specificity.</p><p><strong>Conclusion: </strong>Glucose tolerance screening in early pregnancy using an rBG level of 100 mg/dL and an HbA1c level of 5.2% as cutoff values may help identify high-risk cases and enable early diagnosis of GDM.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"273-282"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}