Obstetrics and Gynecology Science最新文献_第2页

The effect of antioxidant supplementation on dysmenorrhea and endometriosis-associated painful symptoms: a systematic review and meta-analysis of randomized clinical trials. 抗氧化剂补充剂对痛经和子宫内膜异位症相关疼痛症状的影响：随机临床试验的系统回顾和荟萃分析。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.5468/ogs.24228

Sedighe Esmaeilzadeh, Parvaneh Mirabi

引用次数: 0

Lenvatinib and pembrolizumab versus platinum doublet chemotherapy as second-line therapy for advanced or recurrent endometrial cancer. 作为晚期或复发性子宫内膜癌的二线疗法，乐伐替尼和pembrolizumab与铂类双联化疗的比较。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI: 10.5468/ogs.24075

Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Hiroki Nishimura, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami

{"title":"Lenvatinib and pembrolizumab versus platinum doublet chemotherapy as second-line therapy for advanced or recurrent endometrial cancer.","authors":"Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Hiroki Nishimura, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami","doi":"10.5468/ogs.24075","DOIUrl":"10.5468/ogs.24075","url":null,"abstract":"Objective: There is no consensus on whether platinum doublet chemotherapy or lenvatinib and pembrolizumab (LEN/PEM) is superior for advanced or recurrent endometrial cancer. Thus, this study aimed to compare the prognosis and adverse events in patients with advanced or recurrent endometrial cancer treated with platinum doublet chemotherapy or LEN/PEM.Methods: We retrospectively reviewed the medical records of patients who received platinum doublet chemotherapy or LEN/PEM at our institution for advanced or recurrent endometrial cancer and had a history of platinum-based chemotherapy between January 2013 and August 2023.Results: During the study period, 11 regimens were identified in the platinum doublet chemotherapy group, and 11 regimens were identified in the LEN/PEM group. The objective response rates of the platinum doublet chemotherapy and LEN/ PEM groups were 36.4% and 54.5% (P=0.67), respectively. The 6-month progression-free survival (PFS) rates of the platinum doublet chemotherapy and LEN/PEM groups were 27.3% (95% confidence interval [CI], 13.8%-40.7%) and 70.0% (95% CI, 55.5%-84.5%), respectively. The differences were significant between the two groups. Multivariate analyses of histology, prior lines of chemotherapy, platinum-free intervals, and regimens revealed that the LEN/PEM group had significantly better PFS rates.Conclusion: Treatment with LEN/PEM resulted in significantly longer PFS than that of treatment with platinum doublet chemotherapy in patients with advanced and recurrent endometrial cancer. However, further large-scale studies are required to validate these findings.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"534-540"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of excessive gestational weight gain among overweight and obese women. 超重和肥胖妇女妊娠体重增加过多的发生率。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI: 10.5468/ogs.24122

Suphisara Maimaen, Kusol Russameecharoen, Dittakarn Boriboonhirunsarn

{"title":"Incidence of excessive gestational weight gain among overweight and obese women.","authors":"Suphisara Maimaen, Kusol Russameecharoen, Dittakarn Boriboonhirunsarn","doi":"10.5468/ogs.24122","DOIUrl":"10.5468/ogs.24122","url":null,"abstract":"Objective: To determine the incidence of excessive gestational weight gain (GWG) among overweight and obese pregnant women, its associated factors, and pregnancy outcomes.Methods: A total of 355 overweight or obese singleton pregnant women who were included. Obstetric characteristics, weight gain, and pregnancy outcomes, were extracted from medical records. GWG was categorized according to the Institute of Medicine recommendation. Comparisons were made between individuals with inadequate, normal, and excessive GWG. Logistic regression analysis was performed to determine independent associated factors for excessive GWG.Results: Majority of the women were overweight (68.7%), 38.9% were nulliparous, and mean pre-pregnancy body mass index was 28.9 kg/m2. Excessive GWG was observed in 53% of the women. Women with excessive GWG had significantly higher weight gain in every trimester. Risk of excessive GWG increased in women ≤30 years, while gestational diabetes (GDM) significantly decreased the risk. Women with excessive GWG had a significantly higher primary cesarean section rate. Both women with normal and excessive GWG showed higher rate of having large for gestational age (LGA) infants (P=0.003). Maternal age of ≤30 years significantly increased the risk of excessive GWG (adjusted odds ratio [aOR], 1.91; 95% confidence interval [CI], 1.11-3.27) and GDM significantly decreased this risk (aOR, 0.40; 95% CI, 0.24-0.67).Conclusion: The incidence of excessive GWG among overweight and obese women was 53%. Maternal age of ≤30 years significantly increased this risk while women with GDM were significantly decreased risk. Primary cesarean section and fetal LGA significantly increased in women with excessive GWG.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"489-496"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic landscape of thrombophilia in recurrent miscarriages. 复发性流产中血栓性疾病的遗传情况。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.5468/ogs.22084

Alina Athar, Poonam Kashyap, Shagufta Khan, Real Sumayya Abdul Sattar, Suhail Ahmed Khan, Sudha Prasad, Syed Akhtar Husain, Farah Parveen

{"title":"Genetic landscape of thrombophilia in recurrent miscarriages.","authors":"Alina Athar, Poonam Kashyap, Shagufta Khan, Real Sumayya Abdul Sattar, Suhail Ahmed Khan, Sudha Prasad, Syed Akhtar Husain, Farah Parveen","doi":"10.5468/ogs.22084","DOIUrl":"10.5468/ogs.22084","url":null,"abstract":"The etiology of recurrent miscarriage (RM) is extremely heterogeneous, encompassing genetic, immunological, anatomical, endocrine, thrombophilic, infectious, and uterine abnormalities. Thrombophilia is a major contributor to pregnancy complications, potentially harming the fetus and jeopardizing the continuation of pregnancy. Therefore, successful pregnancy outcomes depend on maintaining a delicate balance between coagulation and fibrinolytic factors, crucial for ensuring the adjustment of the basal plate to facilitate adequate placental perfusion. Despite numerous studies shedding light on the role of thrombophilic factors and genetic variations in RM, the exact pathogenesis remains unclear. It is imperative to systematically rule out thrombophilia and other related factors responsible for pregnancy disorders and RMs to guide appropriate and active management strategies. Addressing thrombophilia continues to present challenges in terms of effective treatment. The current review aims to address the heterogeneity of RM as a therapeutic challenge, emphasizing the need for standardized diagnostic tests and welldesigned multicenter research trials to gather robust, evidence-based data on thrombophilic causes of RM and provide effective treatment. The goal is to enhance the understanding of thrombophilic factors and genetic landscapes associated with RM through various approaches, including candidate gene studies, genome-wide association studies, and high-throughput sequencing. Meta-analyses have underscored the significance of genetic aberrations in RM, highlighting the necessity for identifying critical mutations implicated in the etiopathogenesis of miscarriages to pave the way for implementation of targeted clinical therapies.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"435-448"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phospholipase C zeta: a hidden face of sperm for oocyte activation and early embryonic development. 磷脂酶 C zeta：精子激活卵母细胞和早期胚胎发育的隐藏面孔。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI: 10.5468/ogs.24019

Soukaina Azil, Modou Mamoune Mbaye, Noureddine Louanjli, Bouchra Ghazi, Moncef Benkhalifa

引用次数: 0

The evolving landscape of immunohistochemistry in cervical and uterine carcinoma in gynecologic oncology: current status and future directions. 妇科肿瘤学中宫颈癌和子宫癌免疫组化的演变：现状和未来方向。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-09-04 DOI: 10.5468/ogs.24120

Sumedha Gupta, Sana Ahuja, Dheer Singh Kalwaniya

{"title":"The evolving landscape of immunohistochemistry in cervical and uterine carcinoma in gynecologic oncology: current status and future directions.","authors":"Sumedha Gupta, Sana Ahuja, Dheer Singh Kalwaniya","doi":"10.5468/ogs.24120","DOIUrl":"10.5468/ogs.24120","url":null,"abstract":"Immunohistochemistry (IHC) has become an indispensable tool in routine gynecological pathology, particularly with the advancements in molecular understanding and histological classification of gynecological cancers. This evolution has led to new immunostainings for diagnostic and classification purposes. This review describes the diagnostic utility of IHC in gynecological neoplasms, drawing insights from literature reviews, personal experiences, and research findings. It delves into the application of IHC in resolving morphologically equivocal cases, emphasizing its role in achieving an accurate diagnosis. The selection of appropriate immunomarkers for common scenarios encountered in gynecological pathology aids pathologists in navigating complex cases. Specifically, we focus on cervical and endometrial malignancies, elucidating the molecular rationale behind the use of specific immunohistochemical markers. An updated overview of essential immunohistochemical markers provides knowledge for precise diagnosis and classification of gynecological cancers. This review serves as a valuable resource for clinicians and researchers involved in the management and study of gynecological malignancies, facilitating improved patient care and outcomes.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"449-466"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and risk factors of urinary incontinence in pregnant Korean women. 韩国孕妇尿失禁的患病率和风险因素。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI: 10.5468/ogs.24156

Hwisu Jung, Dong Won Hwang, Kyoung-Chul Chun, Young Ah Kim, Jae Whoan Koh, Jung Yeol Han, Hae Do Jung, Dal Soo Hong, Jeong Sup Yun

{"title":"Prevalence and risk factors of urinary incontinence in pregnant Korean women.","authors":"Hwisu Jung, Dong Won Hwang, Kyoung-Chul Chun, Young Ah Kim, Jae Whoan Koh, Jung Yeol Han, Hae Do Jung, Dal Soo Hong, Jeong Sup Yun","doi":"10.5468/ogs.24156","DOIUrl":"10.5468/ogs.24156","url":null,"abstract":"Objective: This study aimed to evaluate the prevalence of urinary incontinence (UI) and its associated risk factors among pregnant Korean women, as UI significantly impacts their quality of life.Methods: A cross-sectional study involving singleton pregnant women was conducted between April and December 2023. Data were collected using a questionnaire assessing demographic information and UI symptoms. The International Consultation on Incontinence Questionnaire-UI short form was used to diagnose UI.Results: A total of 824 pregnant women from three centers participated, with an overall prenatal UI prevalence of 40.2% (331/824). Stress UI was most common (77.1%), followed by mixed UI (16.9%), and urgency UI (6.0%). Risk factors for UI included prior delivery mode, specifically vaginal delivery (adjusted odds ratio [aOR], 5.61; 95% confidence interval [CI], 1.40-22.50; P=0.015) and combined vaginal and cesarean delivery (aOR, 23.14; 95% CI, 1.77-302.74; P=0.017). Additionally, second trimester (aOR, 1.99; 95% CI, 1.19-3.32; P=0.009) and third trimester (aOR, 4.44; 95% CI, 2.65-7.40; P<0.001) were associated with increased UI risk. Conversely, drinking alcohol before pregnancy was a protective factor (aOR, 0.72; 95% CI, 0.53-0.99; P=0.046).Conclusion: Approximately 40% of Korean pregnant women experience prenatal UI. Prior delivery mode and advanced gastrointestinal age are significant risk factors. Further research with postpartum and long-term follow-ups is needed.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"481-488"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of trisomy 9 mosaicism in the second trimester screening by abnormal level of biochemical markers. 通过生化标记物的异常水平在第二孕期筛查中发现 9 三体嵌合。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI: 10.5468/ogs.24062

Zohre Salari, Arman Moradi, Mahdiyeh Moudi, Zohre Mousavi

引用次数: 0

Does it affect the live birth rates to have a maximum endometrial thickness of 7, 8, or 9 mm in in-vitro fertilization-embryo transfer cycles? 在体外受精-胚胎移植周期中，子宫内膜最大厚度为 7、8 或 9 毫米是否会影响活产率？

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-02 DOI: 10.5468/ogs.22316

Einav Kadour-Peero, Ido Feferkorn, Shirel Hadad-Liven, Michael H Dahan

{"title":"Does it affect the live birth rates to have a maximum endometrial thickness of 7, 8, or 9 mm in in-vitro fertilization-embryo transfer cycles?","authors":"Einav Kadour-Peero, Ido Feferkorn, Shirel Hadad-Liven, Michael H Dahan","doi":"10.5468/ogs.22316","DOIUrl":"10.5468/ogs.22316","url":null,"abstract":"Objective: To assess the effect of endometrial thickness (EMT) on live birth rates (LBR) in women with endometrial lining between 7.0-9.9 mm.Methods: This retrospective cohort study included women who underwent fresh and frozen embryo transfers between 2008 and 2018, grouped according to their maximum EMT; group 1, 7.0-7.9 mm; group 2, 8.0-8.9 mm; and group 3, 9.0-9.9 mm and underwent blastocyst transfer.Results: The study included 7,091 in-vitro fertilization cycles: 1,385 in group 1, 3,000 in group 2, and 2,706 in group 3. The combined LBR was 22.2%. The mean age of women at oocyte retrieval day was 36.7±4.5 years. There was no difference in female age at oocyte retrieval or in the quality of embryos transferred between the three groups. Group 1 had more diagnoses of diminished ovarian reserve (25.8% vs. 19.5% and 19.1%; p<0.001) and less male factor infertility compared with group 2 and 3, respectively (25.0% vs. 28.8% and 28.5%; P=0.024). LBR was higher with increasing endometrial thickness, group 2 vs. group 1 (22.0% vs. 17.4%; P=0.0004), group 3 vs. group 1 (25.0% vs. 17.2%; p<0.001), and group 3 vs. group 2 (25.0% vs. 22.0%; P=0.008). After controlling for confounding factors, these three groups did not differ in LBR (group 1 vs. group 2, odds ratio [OR], 1.08; 95% confidence interval [CI], 0.83-1.4; P=0.54 and group 1 vs. group 3, OR, 1.16; 95% CI, 0.90-1.51; P=0.24).Conclusion: Live birth rates in women with endometrial thickness between 7.0-9.9 mm were not affected by different cut-offs when blastocyst transfer was performed.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"497-505"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WITHDRAWN: Embarking on life's blueprint: investigating the crucial involvement of extracellular vesicles in embryo development. 踏上生命的蓝图：研究细胞外囊泡在胚胎发育中的关键作用。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-08-09 DOI: 10.5468/ogs.24084

Seok Hee Lee

引用次数: 0