Obstetrics and Gynecology Science最新文献_第3页

Development of an endometriosis self-assessment tool for patient. 为患者开发子宫内膜异位症自我评估工具。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI: 10.5468/ogs.21252.e1

Hyun-Hee Cho, Young-Sub Yoon

引用次数: 0

Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome. 评估多囊卵巢综合征患者的氧化应激和炎症。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-17 DOI: 10.5468/ogs.24031

Berra Sen, Senem Gonultas, Ceren Albayrak, Sevval Temur, Ilgar Acar, Beyza Nur Ozkan, Havva Sevde Islek, Muserref Banu Yilmaz, Ebru Kale, Eray Metin Guler

{"title":"Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome.","authors":"Berra Sen, Senem Gonultas, Ceren Albayrak, Sevval Temur, Ilgar Acar, Beyza Nur Ozkan, Havva Sevde Islek, Muserref Banu Yilmaz, Ebru Kale, Eray Metin Guler","doi":"10.5468/ogs.24031","DOIUrl":"10.5468/ogs.24031","url":null,"abstract":"Objective: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder characterized by hyperandrogenism, hyperinsulinemia, and insulin resistance. The prevalence of PCOS is increasing worldwide. Although the etiology of this disease is currently unknown, it is thought to be closely related to inflammation and oxidative stress. Our study aimed to compare patients have PCOS to healthy volunteers and assess the changes in oxidative stress and inflammatory parameters in these patients.Methods: Thirty patients between the ages of 18-45 diagnosed with PCOS and 30 healthy volunteers with the same demographic characteristics were included in this study. Clinical parameters were measured using immunoassays. Oxidative stress biomarkers, total oxidant (TOS), total antioxidant (TAS), total thiol (TT), and native thiol (NT) levels were measured using photometric methods according to Erel's method. The dynamic disulfide level (DIS) and oxidative stress index (OSI) were calculated using mathematical equations. Among the inflammatory parameters, values for interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured photometrically using commercially purchased kits.Results: Moreover, TT and NT levels were lower in patients with PCOS compared to those in the healthy group statistically significantly (P<0.001). In addition, TAS, TOS, OSI, DIS, IL-1β, IL-6, and TNF-α levels were identified to be significantly higher in the patients with PCOS than those in the healthy group (P<0.001).Conclusion: Evaluation of oxidative stress and clinical parameters used in the follow-up may be beneficial for the disease.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"414-420"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxychloroquine in obstetrics: potential implications of the prophylactic use of hydroxychloroquine for placental insufficiency during pregnancy. 产科中的羟氯喹：预防性使用羟氯喹治疗妊娠期胎盘功能不全的潜在影响。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.5468/ogs.23252.e1

Yoo-Min Kim, Ji-Hee Sung, Hyun-Hwa Cha, Soo-Young Oh

引用次数: 0

Efficacy and safety of drospirenone 2 mg/17β-estradiol 1 mg hormone therapy in Korean postmenopausal women. 韩国绝经后妇女接受屈螺酮 2 毫克/17β-雌二醇 1 毫克激素疗法的有效性和安全性。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.5468/ogs.2017.60.2.213.e1

Bo Ra Park, Hye Na Park, Ji Back Jung, Eun Sil Lee, Jeong Sig Kim, Gyu Yeon Choi, Jeong Jae Lee, Im Soon Lee

引用次数: 0

Chitinase-3-like protein 1, matrix metalloproteinase-9, and monocyte chemoattractant protein-1 as potential biomarkers and treatment targets of adenomyosis. 几丁质酶-3样蛋白1、基质金属蛋白酶-9和单核细胞趋化蛋白-1是子宫腺肌病的潜在生物标记物和治疗靶标。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-06-11 DOI: 10.5468/ogs.24021

Alvin Setiawan, Hanom Husni Syam, Wiryawan Permadi, Ruswana Anwar, Tita Husnitawati Madjid, Dian Tjahyadi, Putu Doster Mahayasa

{"title":"Chitinase-3-like protein 1, matrix metalloproteinase-9, and monocyte chemoattractant protein-1 as potential biomarkers and treatment targets of adenomyosis.","authors":"Alvin Setiawan, Hanom Husni Syam, Wiryawan Permadi, Ruswana Anwar, Tita Husnitawati Madjid, Dian Tjahyadi, Putu Doster Mahayasa","doi":"10.5468/ogs.24021","DOIUrl":"10.5468/ogs.24021","url":null,"abstract":"Objective: This study aimed to investigate the levels of chitinase-3-like protein-1 (CHI3L1), matrix metalloproteinase-9 (MMP-9), and monocyte chemoattractant protein-1 (MCP-1) in adenomyosis, as compared to normal myometrial tissue. These biomarkers may be useful for determining potential treatment targets.Methods: This was a correlative, analytical, and observational study with a cross-sectional design. Participants with a diagnosis of moderate-to-severe adenomyosis, as determined through transvaginal ultrasonography and histological examination, and who underwent laparotomy or laparoscopic surgery for the treatment of adenomyosis, were enrolled in the study. Unlike other studies that recruited healthy women as controls, our study used adenomyotic and healthy nonadenomyotic myometria obtained from the same individual. The levels of CHI3L1, MMP-9, and MCP-1 in the biopsy samples were determined using enzyme-linked immunoassay kits, according to the manufacturer's protocol.Results: A highly significant increase in the levels of CHI3L1, MMP-9, and MCP-1 was found in adenomyotic tissues compared to non-adenomyotic tissues (P<0.001). A significant positive correlation was found between CHI3L1 and MMP-9 levels (r=0.463; P=0.008), CHI3L1 and MCP-1 levels (r=0.594; P<0.001), and MCP-1 and MMP-9 levels (r=0.680; P<0.001) in adenomyotic tissues.Conclusion: CHI3L1 may play a role in the pathogenesis of adenomyosis via the regulation of the MCP-1 and MMP-9 pathways. Therefore, these molecules may serve as biomarkers and potential therapeutic targets for adenomyosis.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"421-429"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living lab modelling as a pilot study assessing the potential psychological health benefits of forest environment for cancer survivors. 将生活实验室模型作为一项试点研究，评估森林环境对癌症幸存者心理健康的潜在益处。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-06-12 DOI: 10.5468/ogs.24035

Mi-Kyung Kim, Hyo Jin Park, Kyung Ju Lee

{"title":"Living lab modelling as a pilot study assessing the potential psychological health benefits of forest environment for cancer survivors.","authors":"Mi-Kyung Kim, Hyo Jin Park, Kyung Ju Lee","doi":"10.5468/ogs.24035","DOIUrl":"10.5468/ogs.24035","url":null,"abstract":"Objective: To evaluate the physiological and psychological changes in cancer survivors who engage in repeated forest therapy in a living environment.Methods: This study included stay-based forest therapy for female cancer survivors aged ≥40 years. The program was conducted in two cycles, each spanning 3 weeks and consisting of a 2-night, 3-day stay, followed by daily life integration. The cycles were repeated from July 2, 2022, to August 18, 2022. Participant assessment included standard physical health parameters and a questionnaire on general characteristics, lifestyle habits, stress levels, and health status.Results: Thirty-seven female cancer survivors participated in the forest healing program, 56.8% of whom had a history of breast cancer. The median body mass index (BMI) was 23.80 kg/m2 (range, 21.00-25.60). More than half of the patients reported mild-to-moderate fatigue, chronic pain, and mild-to-moderate depression (81%, 65%, and 73%, respectively). After two cycles of forest therapy, no significant differences were observed in terms of fatigue, pain, or BMI levels. However, significant improvements were found in quality of life measures, particularly the psychological quality of life (mean score 12.54 at baseline vs. 13.48 after cycle 2; P=0.007). Positive improvements were also observed in terms of stress (mean score 17.03 vs. 13.76; P=0.002) and depression (mean score 8.35 vs. 6.11; P=0.002) levels.Conclusion: Our forest-healing program demonstrated that nature-based therapies improve the mental health and quality of life of female cancer survivors, suggesting the need for further research on nature-based interventions to better support cancer survivors.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"404-413"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida: a Korean National Cohort Study over 15 years. 高龄产妇对无效妊娠后代先天性畸形、短期和长期预后的影响：一项历时 15 年的韩国全国队列研究。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-04-26 DOI: 10.5468/ogs.24005

Su Jin You, Danbee Kang, Ji-Hee Sung, Hyejeong Park, Juhee Cho, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh

{"title":"The influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida: a Korean National Cohort Study over 15 years.","authors":"Su Jin You, Danbee Kang, Ji-Hee Sung, Hyejeong Park, Juhee Cho, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh","doi":"10.5468/ogs.24005","DOIUrl":"10.5468/ogs.24005","url":null,"abstract":"Objective: To assess the influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida.Methods: A retrospective study was conducted using the Korean National Health Insurance Service database spanning from January 2005 to December 2019. All live-born offspring of nulligravida (n=3,685,817) were included. The maternal age was subdivided into the following subgroups: <25 years (n=153,818), 25-29 years (n=845,355), 30-34 years (n=1,738,299), 35-39 years (n=787,530), 40-44 years (n=151,519), and >44 years (n=9,296). Outcomes were assessed based on International Classification of Diseases-10 codes. Adjusted odds ratios (aOR) were calculated with the group of 25-29 years as a reference.Result: Most congenital malformations showed an age dependent increase, but cleft lip and abdominal wall defect exhibited a U-shape curve, indicating an increase even in those <25 years old. Similarly, various disorders included in the neonatal composite outcomes from short-term outcomes showed aged dependent escalation. However, the preterm birth from the short-term outcome and most of the long-term developmental outcomes, except for motor developmental delay and Tics, showed a U-shaped pattern. The aOR of autism and cerebral palsy, showing the most obvious U-shaped curved in the long-term outcomes, was 1.50 (95% confidence interval [CI], 1.24-1.82) and 1.54 (95% CI, 1.17-2.03), respectively in the group >44 years old and 1.18 (95% CI, 1.11-1.25) and 1.19 (95% CI, 1.09-1.30) in <25 years old group.Conclusion: Overall, an advanced maternal age has an age-dependent correlation with most congenital malformations and shortand long-term outcomes of neonates.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"380-392"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basic knowledge for counseling patients undergoing risk-reducing salpingo-oophorectomy. 为接受降低风险的输卵管切除术的患者提供咨询的基本知识。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.5468/ogs.24054

Jihye Kim, Chel Hun Choi

{"title":"Basic knowledge for counseling patients undergoing risk-reducing salpingo-oophorectomy.","authors":"Jihye Kim, Chel Hun Choi","doi":"10.5468/ogs.24054","DOIUrl":"10.5468/ogs.24054","url":null,"abstract":"Significant progress has been made in the molecular diagnosis of cancer. It provides personalized medicine, including cancer diagnosis, prognosis, targeted therapy, and risk detection. These advances allow physicians to identify patients at risk for cancer before it develops and offer them an opportunity to prevent its development. Mutations in breast cancer susceptibility genes 1 and 2 (BRCA1 and 2) are one of the most well-known cancer-related gene mutations since actor Angelina Jolie shared her experience with genetic mutations and risk-reducing surgery in the media. In Korea, tests for germline BRCA1/2 mutations have been covered by insurance since May 2012 and the number of women of BRCA1/2 mutations has continued to increase over the past decade. Most carriers of BRCA1/2 mutations consider risk-reducing salpingo-oophorectomy (RRSO) resulting in early menopause and want to know the lifetime risks and benefits of RRSO. However, despite the increasing number of carriers of BRCA1/2 mutations, the counseling and management of patients requiring RRSO varies among physicians. This article provides basic knowledge on RRSO to help physicians comprehensively assess its risks and benefits and manage at-risk women.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"343-355"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis. 不同年龄患者非整倍体植入前基因检测：系统综述和荟萃分析。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.5468/ogs.24028

Leila Adamyan, Laura Pivazyan, Lilia Obosyan, Ekaterina Krylova, Sapiyat Isaeva

{"title":"Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis.","authors":"Leila Adamyan, Laura Pivazyan, Lilia Obosyan, Ekaterina Krylova, Sapiyat Isaeva","doi":"10.5468/ogs.24028","DOIUrl":"10.5468/ogs.24028","url":null,"abstract":"This study aimed to summarize the current knowledge on the benefits of in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic testing for aneuploidy (PGT-A) and to discuss the role of PGT-A in patients of different ages undergoing assisted reproduction. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 checklist. Registration number: CRD42022354697. Studies were identified by searching the PubMed, Cochrane Library, Google Scholar, Scopus, Embase, and ClinicalTrials databases. Seven meta-analyses were performed with additional stratification of age and prognosis of the women studied. Clinical pregnancy rate per embryo transfer in patients aged >35 years was higher in the PGT-A group (P=0.0002) than in controls. Live birth rate (LBR) per embryo transfer in women 35 years old or younger (P=0.002) was higher in the PGT-A group. The LBR per patient in women aged >35 years was higher in the PGT-A group (P=0.004). The effects of PGT-A on LBR in patients with poor prognosis showed a statistically significant increase (P=0.003). There was no significant difference in the rate between the two groups. PGT-A is effective and can be recommended for patients aged >35 years undergoing assisted reproduction to improve their reproductive outcomes. Moreover, our study showed the possible benefits of PGT-A in patients with a poor prognosis. Overall, our findings suggest that PGT-A is a valuable tool for improving the reproductive outcomes of assisted reproductive procedures in older women and those with a history of pregnancy complications.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"356-379"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage: a single-center experience. 胎儿颅内出血的产前诊断和产后结果：单中心经验。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-06-20 DOI: 10.5468/ogs.24097

Suhra Kim, Yun Ji Jung, Jiwon Baik, Hayan Kwon, JoonHo Lee, Ja-Young Kwon, Young-Han Kim

{"title":"Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage: a single-center experience.","authors":"Suhra Kim, Yun Ji Jung, Jiwon Baik, Hayan Kwon, JoonHo Lee, Ja-Young Kwon, Young-Han Kim","doi":"10.5468/ogs.24097","DOIUrl":"10.5468/ogs.24097","url":null,"abstract":"Objective: To assess prenatal ultrasonographic findings and postnatal outcomes in fetuses with intracranial hemorrhage (ICH).Methods: This retrospective study included fetuses prenatally diagnosed with ICH between December 2012 and August 2023. Maternal characteristics, prenatal ultrasonographic findings, and postnatal outcomes were reviewed.Results: Twenty-seven fetuses with ICH were reviewed. Intracranial hemorrhage was classified as grade 3 and 4 in 24 fetuses. Twenty-two fetuses had ICH, four had ICH with subdural hemorrhage, and one had ICH with subarachnoid hemorrhage. Ventriculomegaly was the most common ultrasonographic finding, and was observed in 22 of the 27 (81.5%) fetuses. Seven fetuses were lost to follow-up, and four intrauterine fetal deaths occurred. The remaining 16 fetuses were delivered at a median gestational age of 35+2 weeks. The infants were followed-up for 40.1 months (range, 4-88). Nine of the 16 infants underwent ventriculoperitoneal placement. One infant underwent brain surgery for severe epilepsy. Motor impairment, including cerebral palsy, was observed in 13 infants (81.2%). Neurologic impairment occurred in six infants (37.5%), developmental delay in nine (56.2%), and epilepsy in 11 (68.7%).Conclusion: Fetal ICH is a rare complication diagnosed during pregnancy, which results in subsequent fetal neurological sequelae or death. This study demonstrated that the common ultrasonographic findings in fetal ICH were progressive ventriculomegaly and increased periventricular echogenicity. Fetuses diagnosed with prenatal ICH, especially those affected by higher-grade ICH, may be at an increased risk of long-term neurodevelopmental problems.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"393-403"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0