Obstetrics and Gynecology Science最新文献

{"title":"Does a specific age group impact sperm cryobanking efficiency among adolescent and young adult cancer patients?","authors":"Soo Jin Park, Sung Woo Kim, Sung Ah Kim, Hee Sun Kim, Jung-Won Choi, Moon-Joo Kang, Jung Yoon Choi, Hyoung Jin Kang, Hee Jin Son, Ji Yeon Han, Hoon Kim, Seung-Yup Ku","doi":"10.5468/ogs.25009","DOIUrl":"10.5468/ogs.25009","url":null,"abstract":"<p><strong>Objective: </strong>Fertility preservation is vital for adolescent and young adult (AYA) cancer patients. Sperm cryobanking is a key option, but age-related factors influencing its efficiency remain unclear. This study evaluated the impact of age on cryobanking attempts, success rates, and disposition outcomes among AYA patients with cancer aged 11-25 years.</p><p><strong>Methods: </strong>We retrospectively analyzed 298 AYA patients with cancer referred for fertility preservation counseling over 9 years. Data on cryobanking attempts, success rates, and disposition outcomes were stratified by age group (11-15, 16-20, and 21-25 years). Logistic regression was used to assess factors influencing these outcomes.</p><p><strong>Results: </strong>The mean age was 16.0 years, with leukemia (22.5%), sarcoma (22.1%), and lymphoma (17.1%) being the most common diagnoses. Among the cohort, 72.1% attempted cryobanking, with lower attempt rates in the youngest group (59.6%) compared to 82.2% and 88.2% in the older groups, respectively. Younger age was a significant predictor of not attempting cryobanking (adjusted odds ratio, 5.059; P=0.001); however, age did not affect the success of sperm cryobanking among patients who attempted it. Disposition analysis showed that 77.2% of samples remained in storage, while 16.2% were discarded; although disposal was often influenced by family decisions, no significant predictors of disposal were identified.</p><p><strong>Conclusion: </strong>Younger patients are less likely to attempt sperm cryobanking, although success rates among those who do are comparable across age groups. While most patients continued storage, higher disposal rates in younger groups highlight the need for strategies to increase participation and support informed decision-making.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"323-333"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of volatile organic compound as a novel modality for cervical cancer detection.","authors":"Muhammad Ary Zucha, Dian Kesumapramudya Nurputra, Ardhanu Kusumanto, Shidiq Nur Hidayat, Kuwat Triyana, Widha Apriani Priadi, Nadia Yasmine, Ova Emilia","doi":"10.5468/ogs.25038","DOIUrl":"10.5468/ogs.25038","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we developed a novel detection strategy based on volatile organic compound (VOC) sensing. Persistent infection by human papillomavirus (HPV) may cause biological changes in the cervical epithelium, leading to VOC production.</p><p><strong>Methods: </strong>This study included 200 urine samples from cervical cancer patients and controls that were HPV-negative. Urine samples were collected and measured using a gas sensor array composed of a matrix of 10 sensors. For each analyzed sample, the instrument produced a vector signal encoding the VOC emitted from the urine (urine prints). The urine prints of cervical cancer patients were differentiated from those of healthy controls.</p><p><strong>Results: </strong>Identification of VOC for cervical cancer detection showed reliable accuracy (91% sensitivity, 85% specificity, and 89% accuracy).</p><p><strong>Conclusion: </strong>Our.</p><p><strong>Results: </strong>demonstrated the applicability of VOC sensing for cervical cancer detection and its potential application in treatment monitoring.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"293-303"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of L-carnitine supplementation on fertility outcomes among patients with polycystic ovary syndrome: a systematic review and dose-response meta-analysis of randomized clinical trials.","authors":"Ahmed Abu-Zaid, Ghadeer Adel Alghamdi, Alaa Saleh Alharbi, Saeed Baradwan, Saleh A K Saleh, Heba M Adly, Mooza M Alzayed, Mohammed Abuzaid, Raghad Sindi, Mohannad Alsabban, Osama Alomar","doi":"10.5468/ogs.24272","DOIUrl":"10.5468/ogs.24272","url":null,"abstract":"<p><p>This systematic review and meta-analysis of randomized controlled trials (RCTs) assessed the effect of L-carnitine (LC) supplementation on the fertility outcomes of patients with polycystic ovary syndrome (PCOS). Online databases (Scopus, Web of Science, Cochrane Library, EMBASE, and PubMed) were searched to identify eligible RCTs published until March 2024. A dose-response meta-analysis was performed using a random-effects model. Meta-regression was also performed to investigate the source of heterogeneity based on the LC dose and duration of treatment. The pooled analysis included eight RCTs with 1,046 participants. The LC-treated group had significantly increased chemical and clinical pregnancy rates, ovulation rate, progesterone levels, number of preovulatory follicles >17 mm in diameter, and endometrial thickness compared to the untreated groups. The meta-analysis model indicated that LC supplementation did not change the serum levels of estrogen and testosterone; however, the dose-response meta-analysis indicated that prolonged LC intake significantly increased estrogen levels. LC supplementation has significant effects on fertility outcomes of women with PCOS. Additional large-scale longer RCTs are required to confirm the findings of this study.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"260-272"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding control and posterior vaginal fornix approach for cesarean hysterectomy in placenta accreta spectrum.","authors":"Thiti Atjimakul, Kulisara Nanthamongkolkul, Ingporn Jiamset, Yuthasak Suphasynth, Aroontorn Pichatechaiyoot, Ekasak Thiangphak, Chayut Pongpanich, Athithan Rattanaburi","doi":"10.5468/ogs.24216","DOIUrl":"10.5468/ogs.24216","url":null,"abstract":"<p><strong>Objective: </strong>Placenta accreta spectrum (PAS) is a leading cause of massive obstetric hemorrhage, particularly when the placenta is removed or unintentionally disrupted during cesarean hysterectomy. In this video, we demonstrate an alternative surgical approach via the posterior vaginal fornix for performing cesarean hysterectomy in patients with PAS.</p><p><strong>Methods: </strong>A cesarean hysterectomy for a case of placenta percreta was performed using the posterior vaginal fornix approach. This technique focuses on avoiding bleeding due to placental disruption and preventing urinary bladder injury.</p><p><strong>Results: </strong>We summarize the steps of the procedure, including ligation of the vascular pedicles, entry into the retroperitoneal space to identify vital structures and control bleeding, dissection along avascular plane to delineate organ borders, and posterior culdotomy followed by en bloc uterine amputation to avoid urinary bladder injury and minimize blood loss.</p><p><strong>Conclusion: </strong>The posterior vaginal fornix approach for cesarean hysterectomy in patients with PAS is an effective technique for minimizing bleeding from the highly vascular placental area. Additionally, it offers the advantage of reducing the risk of unintentional urinary bladder injury, thereby improving surgical outcomes in these challenging cases.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"346-348"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations and future directions for research on COVID-19 vaccination and menstrual changes.","authors":"Noshaba Majeed, Shoaib Majeed, Jie Tu","doi":"10.5468/ogs.25127","DOIUrl":"10.5468/ogs.25127","url":null,"abstract":"","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"344-345"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ultraviolet radiation on bone density and muscle strength in postmenopausal women: a randomized controlled study.","authors":"Wafaa M Kamal, Ahmed M Maged, Noha Salah, Nour A El-Goly, Wael El-Sherbiny, Elham S Hassan","doi":"10.5468/ogs.25077","DOIUrl":"10.5468/ogs.25077","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects of narrowband ultraviolet B (UVB) irradiation on bone and muscle health in postmenopausal women.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted involving 70 postmenopausal women with vitamin D deficiency (<20 ng/mL) and osteopenia. Participants were randomly assigned to two groups. For 6 months, 35 postmenopausal women in study group A received three weekly sessions of narrowband UVB therapy and vitamin D supplements in the form of 100,000 international unit (IU) cholecalciferol weekly as loading therapy for 8 weeks. This was followed by the daily administration of cholecalciferol 3,000 IU as maintenance therapy for 16 weeks. The control group B consisted of 35 postmenopausal women who were administered vitamin D supplements alone for 6 months. Enzyme-linked immuno sorbent assay kits were used to test the serum levels of 25-hydroxyvitamin D (25(OH)D), dual-energy X-ray absorptiometry (DEXA) (DMS, Occitanie, France) was used to test the bone mineral density of the lumbar spine and right femur, and a Biodex System 3 (Biodex Medical Systems Inc., Shirley, NY, USA) isokinetic dynamometer was used to assess the peak torque of the extensors and flexors of the dominant knee.</p><p><strong>Results: </strong>Serum 25(OH)D levels (P=0.000), Lumbar T-score (P=0.008), femoral T-score (P=0.002), and knee extensor peak torque (P=0.030) significantly increased in both groups after 6 months of treatment, favoring study group A over the control group B.</p><p><strong>Conclusion: </strong>Narrowband UVB combined with vitamin D3 supplementation is more effective than vitamin D supplementation alone.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"334-343"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall survival after progression in patients with uterine carcinosarcoma: a single-center retrospective cohort study.","authors":"Rakchai Buhachat, Kanakarn Wangrangsimakul, Ekasak Thiangphak, Ingporn Jiamset","doi":"10.5468/ogs.24201","DOIUrl":"10.5468/ogs.24201","url":null,"abstract":"<p><strong>Objective: </strong>To investigate 2-year overall survival (OS) after progression in patients with uterine carcinosarcoma (UCS).</p><p><strong>Methods: </strong>This retrospective descriptive cohort study included patients diagnosed with progressive UCS at all stages, who underwent surgical staging with or without adjuvant therapy between January 2002 and December 2022. Clinicopathological characteristics, including recurrence patterns, were assessed using descriptive statistics, Fisher's exact test, and the chi-squared test. Prognostic factors and OS after progression were analyzed using the Cox proportional hazards model and Kaplan-Meier method, respectively.</p><p><strong>Results: </strong>Fifty-four patients (mean age, 61 years) were eligible for analysis. During primary treatment, 40 patients underwent optimal surgery, 44 received adjuvant chemotherapy with or without radiotherapy, and 43 developed progressive disease within the first 2 years (median progression-free interval: 10.5 months). Overall, 74.07% of patients developed distant or combined metastases. During salvage treatment, 22 patients received chemotherapy, 11 received a combination of chemotherapy and radiotherapy, and five underwent radiotherapy alone. The median follow-up period was 18 months, with a 2-year OS rate of 20% post-progression. Multivariate analysis revealed that leukocytosis at progression was associated with decreased survival (hazard ratio [HR], 5.98; 95% confidence interval [CI], 2.33-15.3; P<0.001). Notably, optimal primary surgery (HR, 0.31; 95% CI, 0.13-0.72; P=0.006) and chemoradiotherapy as salvage treatment (HR, 0.23; 95% CI, 0.08-0.7; P=0.009) significantly improved survival.</p><p><strong>Conclusion: </strong>Patients with progressive UCS have poor OS. Optimal surgery as primary treatment combined with salvage chemoradiotherapy improves post-progression survival. Leukocytosis during disease progression significantly affects survival outcomes.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"283-292"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of time elapsed since diagnosis on neuropathic symptoms, sexual function, lymphedema, and overall quality of life in ovarian cancer survivors (KGOG 3068).","authors":"Maitreyee Parulekar, Su Min Hyun, Kidong Kim, Hee Seung Kim, Yong-Man Kim, Sang Yoon Park, Chel Hun Choi, Jae-Hoon Kim","doi":"10.5468/ogs.24338","DOIUrl":"10.5468/ogs.24338","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of time since treatment on the quality of life (QOL), neurotoxicity, sexual function, lymphedema, and utility in ovarian cancer survivors.</p><p><strong>Methods: </strong>This secondary analysis of a cross-sectional study examined the QOL, neurotoxicity, sexual function, lymphedema, and utility in 172 epithelial ovarian cancer survivors treated with first-line platinum-based chemotherapy without recurrence. Associations between time since treatment and overall QOL (National Comprehensive Cancer Network/functional assessment of cancer therapy ovarian symptom index-18 [NFOSI-18]), neurotoxicity (neurotoxicity subscale, version-4 [NTX-4]), sexual function (female sexual function index, 6-item Korean version [FSFI-6K]), lymphedema (gynecologic cancer lymphedema questionnaire [GCLQ]), and utility (EuroQol 5-dimension [EQ-5D]) were visualized using jittered box plots.</p><p><strong>Results: </strong>Overall QOL (NFOSI-18) improved up to 3 years post-treatment (scores: 29.3 at 1 year, 28.6 at 2 years, and 26.6 at 3 years), followed by minor fluctuations over time. NTX-4 scores improved until 5 years (8.2, 7.7, 6.2, and 5.8), but remained above normal (score 0). Sexual function (FSFI-6K) increased until 3 years of age (4.6, 6.9, and 10.4 years), stabilizing at a level indicative of dysfunction (score <21). The lymphedema (GCLQ) scores fluctuated over time (4.9, 5.6, 3.3, 4.3, 5.2, and 3.8). Utility (EQ-5D index) improved up to 3 years (0.8250, 0.885, and 0.925), whereas the EQ-5D visual analog scale score increased gradually up to 5 years (71.5, 72, 73, 76, and 74), indicating ongoing recovery.</p><p><strong>Conclusion: </strong>In ovarian cancer survivors, QOL, symptom burden, and utility gradually improved over time post-treatment but did not fully return to pre-treatment levels.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"304-312"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social egg freezing among single females: Middle Eastern point of view.","authors":"Rawia Sharaydih, Amal Akour, Haneen Al-Sabbah, Suha A AlMuhaissen","doi":"10.5468/ogs.24327","DOIUrl":"10.5468/ogs.24327","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the beliefs, barriers, and attitudes towards oocyte cryopreservation in Jordanian females. Understanding these aspects in our region can help healthcare providers identify similarities and differences compared to other geographic areas, which could facilitate a proper approach and informed counseling.</p><p><strong>Methods: </strong>We conducted a cross-sectional online survey using Google® forms (Google, Mountain View, CA, USA). The questions were designed to target a convenience sample of single women (never married, divorced, or widowed) aged 18-64 years in Jordan. Of the 400 women approached, 345 completed the questionnaire voluntarily. Responses were collected and analyzed using the software program SPSS® 23.0 (IBM, Armonk, NY, USA).</p><p><strong>Results: </strong>The.</p><p><strong>Results: </strong>highlight notable deficiencies in women's understanding of the expenses, procedures, and success rates of oocyte freezing as a feasible method for fertility preservation. Most participants stated that the main barriers to oocyte cryopreservation were cost (87.5%), future husband rejection (76.8%), and social exclusion (72.2%). However, a significant number of participants admitted that this procedure would encourage late marriage and increase the chance of pregnancy in cases of late marriage and fertility problems.</p><p><strong>Conclusion: </strong>Women in this study had poor knowledge, but generally had positive attitudes toward oocyte cryopreservation. Educational campaigns are warranted to enhance knowledge and positive attitudes.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"313-322"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive summary: indonesian guidelines on polycystic ovary syndrome management.","authors":"Mila Maidarti, Achmad Kemal Harzif, Amalia Shadrina, Nafi'atul Ummah, Wiryawan Permadi","doi":"10.5468/ogs.24288","DOIUrl":"10.5468/ogs.24288","url":null,"abstract":"<p><strong>Objective: </strong>Polycystic ovary syndrome (PCOS) is a gynecological, endocrine condition characterized by ovulatory disorders, clinical or biochemical hyperandrogenism, and polycystic ovarian morphology. PCOS has significant metabolic and reproductive implications that affect the quality of life of women. This PCOS guideline summary is based on the Indonesian Reproductive Endocrinology and Fertility Association guidelines for PCOS. This guideline is expected to guide the diagnosis and long-term management of PCOS.</p><p><strong>Methods: </strong>We searched scientific evidence on the Cochrane and PubMed databases using the keyword \"polycystic ovary syndrome\". This evidence was reviewed by experts in the field of obstetrics and gynecology, and recommendations were made based on scientific evidence while considering patient values, costs, and resources.</p><p><strong>Results: </strong>A total of 127 recommendations and practice points were made regarding the diagnosis and management of PCOS. The levels of available health services and management algorithms for PCOS in Indonesia are also included.</p><p><strong>Conclusion: </strong>The first-line treatment for managing hyperandrogenism and menstrual disorders in patients with PCOS is combined oral contraceptives. The first-line treatment for ovulation induction is letrozole, while clomiphene citrate, metformin, gonadotropins, and ovarian surgery serve as the second-line treatment. The third-line treatments included in vitro fertilization, with or without in vitro maturation.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"221-236"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}