Obstetrics and Gynecology Science最新文献_第3页

Genetic landscape of thrombophilia in recurrent miscarriages. 复发性流产中血栓性疾病的遗传情况。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.5468/ogs.22084

Alina Athar, Poonam Kashyap, Shagufta Khan, Real Sumayya Abdul Sattar, Suhail Ahmed Khan, Sudha Prasad, Syed Akhtar Husain, Farah Parveen

{"title":"Genetic landscape of thrombophilia in recurrent miscarriages.","authors":"Alina Athar, Poonam Kashyap, Shagufta Khan, Real Sumayya Abdul Sattar, Suhail Ahmed Khan, Sudha Prasad, Syed Akhtar Husain, Farah Parveen","doi":"10.5468/ogs.22084","DOIUrl":"10.5468/ogs.22084","url":null,"abstract":"The etiology of recurrent miscarriage (RM) is extremely heterogeneous, encompassing genetic, immunological, anatomical, endocrine, thrombophilic, infectious, and uterine abnormalities. Thrombophilia is a major contributor to pregnancy complications, potentially harming the fetus and jeopardizing the continuation of pregnancy. Therefore, successful pregnancy outcomes depend on maintaining a delicate balance between coagulation and fibrinolytic factors, crucial for ensuring the adjustment of the basal plate to facilitate adequate placental perfusion. Despite numerous studies shedding light on the role of thrombophilic factors and genetic variations in RM, the exact pathogenesis remains unclear. It is imperative to systematically rule out thrombophilia and other related factors responsible for pregnancy disorders and RMs to guide appropriate and active management strategies. Addressing thrombophilia continues to present challenges in terms of effective treatment. The current review aims to address the heterogeneity of RM as a therapeutic challenge, emphasizing the need for standardized diagnostic tests and welldesigned multicenter research trials to gather robust, evidence-based data on thrombophilic causes of RM and provide effective treatment. The goal is to enhance the understanding of thrombophilic factors and genetic landscapes associated with RM through various approaches, including candidate gene studies, genome-wide association studies, and high-throughput sequencing. Meta-analyses have underscored the significance of genetic aberrations in RM, highlighting the necessity for identifying critical mutations implicated in the etiopathogenesis of miscarriages to pave the way for implementation of targeted clinical therapies.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"435-448"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phospholipase C zeta: a hidden face of sperm for oocyte activation and early embryonic development. 磷脂酶 C zeta：精子激活卵母细胞和早期胚胎发育的隐藏面孔。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI: 10.5468/ogs.24019

Soukaina Azil, Modou Mamoune Mbaye, Noureddine Louanjli, Bouchra Ghazi, Moncef Benkhalifa

引用次数: 0

The evolving landscape of immunohistochemistry in cervical and uterine carcinoma in gynecologic oncology: current status and future directions. 妇科肿瘤学中宫颈癌和子宫癌免疫组化的演变：现状和未来方向。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-09-04 DOI: 10.5468/ogs.24120

Sumedha Gupta, Sana Ahuja, Dheer Singh Kalwaniya

{"title":"The evolving landscape of immunohistochemistry in cervical and uterine carcinoma in gynecologic oncology: current status and future directions.","authors":"Sumedha Gupta, Sana Ahuja, Dheer Singh Kalwaniya","doi":"10.5468/ogs.24120","DOIUrl":"10.5468/ogs.24120","url":null,"abstract":"Immunohistochemistry (IHC) has become an indispensable tool in routine gynecological pathology, particularly with the advancements in molecular understanding and histological classification of gynecological cancers. This evolution has led to new immunostainings for diagnostic and classification purposes. This review describes the diagnostic utility of IHC in gynecological neoplasms, drawing insights from literature reviews, personal experiences, and research findings. It delves into the application of IHC in resolving morphologically equivocal cases, emphasizing its role in achieving an accurate diagnosis. The selection of appropriate immunomarkers for common scenarios encountered in gynecological pathology aids pathologists in navigating complex cases. Specifically, we focus on cervical and endometrial malignancies, elucidating the molecular rationale behind the use of specific immunohistochemical markers. An updated overview of essential immunohistochemical markers provides knowledge for precise diagnosis and classification of gynecological cancers. This review serves as a valuable resource for clinicians and researchers involved in the management and study of gynecological malignancies, facilitating improved patient care and outcomes.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"449-466"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and risk factors of urinary incontinence in pregnant Korean women. 韩国孕妇尿失禁的患病率和风险因素。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI: 10.5468/ogs.24156

Hwisu Jung, Dong Won Hwang, Kyoung-Chul Chun, Young Ah Kim, Jae Whoan Koh, Jung Yeol Han, Hae Do Jung, Dal Soo Hong, Jeong Sup Yun

{"title":"Prevalence and risk factors of urinary incontinence in pregnant Korean women.","authors":"Hwisu Jung, Dong Won Hwang, Kyoung-Chul Chun, Young Ah Kim, Jae Whoan Koh, Jung Yeol Han, Hae Do Jung, Dal Soo Hong, Jeong Sup Yun","doi":"10.5468/ogs.24156","DOIUrl":"10.5468/ogs.24156","url":null,"abstract":"Objective: This study aimed to evaluate the prevalence of urinary incontinence (UI) and its associated risk factors among pregnant Korean women, as UI significantly impacts their quality of life.Methods: A cross-sectional study involving singleton pregnant women was conducted between April and December 2023. Data were collected using a questionnaire assessing demographic information and UI symptoms. The International Consultation on Incontinence Questionnaire-UI short form was used to diagnose UI.Results: A total of 824 pregnant women from three centers participated, with an overall prenatal UI prevalence of 40.2% (331/824). Stress UI was most common (77.1%), followed by mixed UI (16.9%), and urgency UI (6.0%). Risk factors for UI included prior delivery mode, specifically vaginal delivery (adjusted odds ratio [aOR], 5.61; 95% confidence interval [CI], 1.40-22.50; P=0.015) and combined vaginal and cesarean delivery (aOR, 23.14; 95% CI, 1.77-302.74; P=0.017). Additionally, second trimester (aOR, 1.99; 95% CI, 1.19-3.32; P=0.009) and third trimester (aOR, 4.44; 95% CI, 2.65-7.40; P<0.001) were associated with increased UI risk. Conversely, drinking alcohol before pregnancy was a protective factor (aOR, 0.72; 95% CI, 0.53-0.99; P=0.046).Conclusion: Approximately 40% of Korean pregnant women experience prenatal UI. Prior delivery mode and advanced gastrointestinal age are significant risk factors. Further research with postpartum and long-term follow-ups is needed.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"481-488"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of trisomy 9 mosaicism in the second trimester screening by abnormal level of biochemical markers. 通过生化标记物的异常水平在第二孕期筛查中发现 9 三体嵌合。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI: 10.5468/ogs.24062

Zohre Salari, Arman Moradi, Mahdiyeh Moudi, Zohre Mousavi

引用次数: 0

Does it affect the live birth rates to have a maximum endometrial thickness of 7, 8, or 9 mm in in-vitro fertilization-embryo transfer cycles? 在体外受精-胚胎移植周期中，子宫内膜最大厚度为 7、8 或 9 毫米是否会影响活产率？

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-09-01 Epub Date: 2024-08-02 DOI: 10.5468/ogs.22316

Einav Kadour-Peero, Ido Feferkorn, Shirel Hadad-Liven, Michael H Dahan

{"title":"Does it affect the live birth rates to have a maximum endometrial thickness of 7, 8, or 9 mm in in-vitro fertilization-embryo transfer cycles?","authors":"Einav Kadour-Peero, Ido Feferkorn, Shirel Hadad-Liven, Michael H Dahan","doi":"10.5468/ogs.22316","DOIUrl":"10.5468/ogs.22316","url":null,"abstract":"Objective: To assess the effect of endometrial thickness (EMT) on live birth rates (LBR) in women with endometrial lining between 7.0-9.9 mm.Methods: This retrospective cohort study included women who underwent fresh and frozen embryo transfers between 2008 and 2018, grouped according to their maximum EMT; group 1, 7.0-7.9 mm; group 2, 8.0-8.9 mm; and group 3, 9.0-9.9 mm and underwent blastocyst transfer.Results: The study included 7,091 in-vitro fertilization cycles: 1,385 in group 1, 3,000 in group 2, and 2,706 in group 3. The combined LBR was 22.2%. The mean age of women at oocyte retrieval day was 36.7±4.5 years. There was no difference in female age at oocyte retrieval or in the quality of embryos transferred between the three groups. Group 1 had more diagnoses of diminished ovarian reserve (25.8% vs. 19.5% and 19.1%; p<0.001) and less male factor infertility compared with group 2 and 3, respectively (25.0% vs. 28.8% and 28.5%; P=0.024). LBR was higher with increasing endometrial thickness, group 2 vs. group 1 (22.0% vs. 17.4%; P=0.0004), group 3 vs. group 1 (25.0% vs. 17.2%; p<0.001), and group 3 vs. group 2 (25.0% vs. 22.0%; P=0.008). After controlling for confounding factors, these three groups did not differ in LBR (group 1 vs. group 2, odds ratio [OR], 1.08; 95% confidence interval [CI], 0.83-1.4; P=0.54 and group 1 vs. group 3, OR, 1.16; 95% CI, 0.90-1.51; P=0.24).Conclusion: Live birth rates in women with endometrial thickness between 7.0-9.9 mm were not affected by different cut-offs when blastocyst transfer was performed.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"497-505"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WITHDRAWN: Embarking on life's blueprint: investigating the crucial involvement of extracellular vesicles in embryo development. 踏上生命的蓝图：研究细胞外囊泡在胚胎发育中的关键作用。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-08-09 DOI: 10.5468/ogs.24084

Seok Hee Lee

引用次数: 0

Development of an endometriosis self-assessment tool for patient. 为患者开发子宫内膜异位症自我评估工具。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI: 10.5468/ogs.21252.e1

Hyun-Hee Cho, Young-Sub Yoon

引用次数: 0

Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome. 评估多囊卵巢综合征患者的氧化应激和炎症。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-17 DOI: 10.5468/ogs.24031

Berra Sen, Senem Gonultas, Ceren Albayrak, Sevval Temur, Ilgar Acar, Beyza Nur Ozkan, Havva Sevde Islek, Muserref Banu Yilmaz, Ebru Kale, Eray Metin Guler

{"title":"Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome.","authors":"Berra Sen, Senem Gonultas, Ceren Albayrak, Sevval Temur, Ilgar Acar, Beyza Nur Ozkan, Havva Sevde Islek, Muserref Banu Yilmaz, Ebru Kale, Eray Metin Guler","doi":"10.5468/ogs.24031","DOIUrl":"10.5468/ogs.24031","url":null,"abstract":"Objective: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder characterized by hyperandrogenism, hyperinsulinemia, and insulin resistance. The prevalence of PCOS is increasing worldwide. Although the etiology of this disease is currently unknown, it is thought to be closely related to inflammation and oxidative stress. Our study aimed to compare patients have PCOS to healthy volunteers and assess the changes in oxidative stress and inflammatory parameters in these patients.Methods: Thirty patients between the ages of 18-45 diagnosed with PCOS and 30 healthy volunteers with the same demographic characteristics were included in this study. Clinical parameters were measured using immunoassays. Oxidative stress biomarkers, total oxidant (TOS), total antioxidant (TAS), total thiol (TT), and native thiol (NT) levels were measured using photometric methods according to Erel's method. The dynamic disulfide level (DIS) and oxidative stress index (OSI) were calculated using mathematical equations. Among the inflammatory parameters, values for interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured photometrically using commercially purchased kits.Results: Moreover, TT and NT levels were lower in patients with PCOS compared to those in the healthy group statistically significantly (P<0.001). In addition, TAS, TOS, OSI, DIS, IL-1β, IL-6, and TNF-α levels were identified to be significantly higher in the patients with PCOS than those in the healthy group (P<0.001).Conclusion: Evaluation of oxidative stress and clinical parameters used in the follow-up may be beneficial for the disease.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"414-420"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxychloroquine in obstetrics: potential implications of the prophylactic use of hydroxychloroquine for placental insufficiency during pregnancy. 产科中的羟氯喹：预防性使用羟氯喹治疗妊娠期胎盘功能不全的潜在影响。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.5468/ogs.23252.e1

Yoo-Min Kim, Ji-Hee Sung, Hyun-Hwa Cha, Soo-Young Oh

引用次数: 0