Obstetrics and Gynecology Science最新文献

{"title":"The role of uterine arteries Doppler indices in assisting decision-making for intramural fibroid removal in patients with infertility before in vitro fertilization.","authors":"Sedigheh Hantoushzadeh, Maasoumeh Saleh, Kamran Hessami, Nikan Zargarzadeh","doi":"10.5468/ogs.23056","DOIUrl":"10.5468/ogs.23056","url":null,"abstract":"The role of uterine arteries Doppler indices in assisting decision-making for intramural fibroid removal in patients with infertility before in vitro fertilization Sedigheh Hantoushzadeh, DEGREE, Maasoumeh Saleh, DEGREE, Kamran Hessami, DEGREE, Nikan Zargarzadeh, DEGREE Maternal-Fetal Neonatal Research Center, Valiasr Hospital, Shariati Hospital, Tehran University of Medical Sciences, Department of Obstetrics & Gynecology, Boston Children Hospital, Boston, MA, USA, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"457-458"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/6c/ogs-23056.PMC10514594.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial.","authors":"Zinat Sarebani, Venus Chegini, Hui Chen, Ehsan Aali, Monirsadat Mirzadeh, Mohammadreza Abbaspour, Mark D Griffiths, Zainab Alimoradi","doi":"10.5468/ogs.22038.e1","DOIUrl":"https://doi.org/10.5468/ogs.22038.e1","url":null,"abstract":"","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":"66 5","pages":"462"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/9f/ogs-22038-e1.PMC10514591.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial ablation and resection versus hysterectomy for heavy menstrual bleeding: an updated systematic review and meta-analysis of effectiveness and complications.","authors":"Clare Deehan,&nbsp;Iliana Georganta,&nbsp;Anna Strachan,&nbsp;Marysia Thomson,&nbsp;Miriam McDonald,&nbsp;Kerrie McNulty,&nbsp;Elizabeth Anderson,&nbsp;Alyaa Mostafa","doi":"10.5468/ogs.22308","DOIUrl":"10.5468/ogs.22308","url":null,"abstract":"<p><p>To evaluate the clinical efficacy, safety, and cost-effectiveness of endometrial ablation or resection (E:A/R) compared to hysterectomy for the treatment of heavy menstrual bleeding. Literature search was conducted, and randomized control trials (RCTs) comparing (E:A/R) versus hysterectomy were reviewed. The search was last updated in November 2022. Twelve RCTs with 2,028 women (hysterectomy: n=977 vs. [E:A/R]: n=1,051) were included in the analyzis. The meta-analysis revealed that the hysterectomy group showed improved patient-reported and objective bleeding symptoms more than those of the (E:A/R) group, with risk ratios of (mean difference [MD], 0.75; 95% confidence intervals [CI], 0.71 to 0.79) and (MD, 44.00; 95% CI, 36.09 to 51.91), respectively. Patient satisfaction was higher post-hysterectomy than (E:A/R) at 2 years of follow-up, but this effect was absent with long-term follow-up. (E:A/R) is considered an alternative to hysterectomy as a surgical management for heavy menstrual bleeding. Although both procedures are highly effective, safe, and improve the quality of life, hysterectomy is significantly superior at improving bleeding symptoms and patient satisfaction for up to 2 years. However, it is associated with longer operating and recovery times and a higher rate of postoperative complications. The initial cost of (E:A/R) is less than the cost of hysterectomy, but further surgical requirements are common; therefore, there is no difference in the cost for long-term follow-up.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"364-384"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/ac/ogs-22308.PMC10514595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment total lymphocyte count as a prognostic factor of survival in patients with recurrent cervical cancer after definitive radiation-based therapy: a retrospective study.","authors":"Ekasak Thiangphak,&nbsp;Kittinun Leetanaporn,&nbsp;Rakchai Buhachat","doi":"10.5468/ogs.23119","DOIUrl":"10.5468/ogs.23119","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the association between pretreatment total lymphocyte count (TLC) and overall survival (OS) in patients with recurrent cervical cancer.</p><p><strong>Methods: </strong>We retrospectively reviewed 290 patients with recurrent cervical cancer with definite complete responses to either definitive radiotherapy or concurrent chemoradiotherapy between January 2009 and December 2022. The associations between pretreatment TLC and progression-free survival (PFS) and OS rates were evaluated.</p><p><strong>Results: </strong>Ninety-three patients (32%) had a pretreatment TLC <1,000 cells/mm3. Patients with a pretreatment TLC <1,000 cells/mm3 had lower treatment response rates than their counterparts (P=0.045). The OS and PFS rates were significantly higher in patients with pretreatment TLC ≥1,000 cells/mm3 than in those with pretreatment TLC <1,000 cells/mm3 (10.74 vs. 3.89 months, P<0.0001; 8.32 vs. 4.97 months, P=0.042; respectively). Moreover, pretreatment TLC ≥1,000 cells/mm3 was identified as an independent prognostic factor for OS in both univariate analysis (hazard ratio [HR], 0.57; 95% conficence interval [CI], 0.44-0.74; P<0.001) and multivariate analysis (HR, 0.64; 95% CI, 0.47-0.86; P=0.003). However, TLC ≥1,000 cells/mm3 was identified as a prognostic factor for PFS only in univariate analysis (HR, 0.71; 95% CI, 0.51-0.99; P=0.043) but not in the multivariate analysis (HR, 0.81; 95% CI, 0.55-1.18; P=0.3).</p><p><strong>Conclusion: </strong>Pretreatment TLC was associated with treatment response and was identified as an independent prognostic factor associated with the survival outcomes of patients with recurrent cervical cancer.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"407-416"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/3b/ogs-23119.PMC10514585.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9828925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomograms to predict overall survival for patients with endometrial carcinosarcoma.","authors":"Christos Iavazzo,&nbsp;Alexandros Fotiou,&nbsp;Kalliopi Kokkali,&nbsp;Nikolaos Vrachnis","doi":"10.5468/ogs.23145","DOIUrl":"10.5468/ogs.23145","url":null,"abstract":"455 Dear editor, we read a very interesting article entitled “a personalized nomogram for predicting 3-year overall survival of patients with uterine carcinosarcoma in a tertiary care hospital in Southern Thailand” by Nanthamongkolkul et al. [1]. The authors presented their retrospective study analyzing a cohort of patients with uterine carcinosarcoma and how body mass index (BMI), International Federation of Gynecology and Obstetrics (FIGO) stage, and adjuvant chemotherapy can affect the 3-year overall survival. The authors combined three parameters to form their nomogram; one presenting the individual’s performance status (BMI), one presenting the tumor’s aggressiveness (FIGO stage), and one presenting the medical approach (adjuvant chemotherapy). They aimed to form a nomogram in which these parameters could predict the 3-year overall survival of patients with uterine carcinosarcoma. Recently, Chen et al. [2] in their multivariate analysis showed that age, race, year of diagnosis, FIGO stage, and treatment type can also be associated with survival and formed a similar nomogram with a good predictive capacity. Another study formed a nomogram predicting the overall survival of patients with ovarian carcinosarcoma including the following parameters: age, grade, tumor site, surgery, and chemotherapy [3]. We would like to ask the authors whether the addition of patients’ age and surgery might improve the prognostic performance of their nomogram. Moreover, Gao et al. [4] revealed in their study that log odds of metastatic lymph nodes (LODDS) has a better predicting accuracy compared to the number of positive lymph nodes and lymph node ratio. They suggest that a nomogram based on LODDS can offer an accurate predictive model of the overall survival of patients with uterine carcinosarcoma [4]. A possible modification of the nomogram by the team from Thailand might include such parameters (age, surgery, and LODDS). Would such additions improve their predictive model? Once again, we would like to thank the authors for their study.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"455-456"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/dd/ogs-23145.PMC10514590.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delta neutrophil index in obese and non-obese polycystic ovary syndrome patients.","authors":"Özlem Kayacık Günday,&nbsp;Mehmet Yılmazer","doi":"10.5468/ogs.22310","DOIUrl":"10.5468/ogs.22310","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate the usefulness of delta neutrophil index (DNI), a new inflammatory marker, in polycystic ovary syndrome (PCOS).</p><p><strong>Methods: </strong>This retrospective case-control study was conducted at a tertiary health center. The DNI and other blood parameters obtained from the complete blood count examination of 227 individuals, consisting of 72 PCOS patients and 155 controls, were compared between the two groups. A receiver operating characteristic analysis was performed to examine the relationship between DNI and PCOS.</p><p><strong>Results: </strong>DNI, white blood cell (WBC) count, and neutrophil count were significantly higher in the PCOS group than in the control group (P=0.028, 0.011, and 0.037; respectively). DNI and WBC counts were significantly higher in nonobese-PCOS patients (P=0.018 and 0.041; respectively). When the obese-PCOS and obese-control groups were compared, only neutrophil count was significantly higher in obese-PCOS patients (P=0.016). Significance was observed at cut-off values of 0.015 (area under the curve [AUC]=0.588) (P=0.034; sensitivity, 78%; specificity, 35%; Youden's index=0.133) for DNI: 9.35 (AUC=0.594) (P=0.022) for WBC; and 5.38 (AUC=0.628) (P=0.002) for neutrophils.</p><p><strong>Conclusion: </strong>Higher DNI in PCOS patients and similar results in the non-obese-PCOS group were observed when obese and non-obese-PCOS patients were considered separately. However, the lack of difference in the obese-PCOS group strengthens the hypothesis that there is obesity-independent inflammation in PCOS.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"441-448"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/65/ogs-22310.PMC10514584.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10259399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible cognition changes in women with polycystic ovary syndrome: a narrative review.","authors":"Marzieh Saei Ghare Naz,&nbsp;Fatemeh Alsadat Rahnemaei,&nbsp;Fahimeh Ramezani Tehrani,&nbsp;Fatemeh Sayehmiri,&nbsp;Vida Ghasemi,&nbsp;Mojde Banaei,&nbsp;Giti Ozgoli","doi":"10.5468/ogs.22165","DOIUrl":"10.5468/ogs.22165","url":null,"abstract":"<p><p>Nowadays, polycystic ovary syndrome (PCOS) and cognitive dysfunction are major health problems among female. This narrative review aimed to investigate cognitive dysfunction in female with PCOS. English and Persian articles published in PubMed, Scopus, Web of Science, Google Scholar, PsycINFO, Scientific Information Database, and Cochrane Database of Systematic Reviews until May 2022 were searched. Sixteen studies involving 850 female with PCOS and 974 controls were assessed. In these studies, the association between biochemical factors and symptoms of PCOS and memory, attention, executive functioning, information processing speed, and visuospatial skills was evaluated. The literature review revealed the possible cognitive changes in female with PCOS. This study summarized the different aspects of cognitive function in female with PCOS due to medication, psychological problems (mood disorders caused by disease symptoms and complications), and biochemical markers, such as metabolic and sex hormone abnormalities. Considering the existing scientific gap regarding the possibility of cognitive complications in female with PCOS, further biological studies should be conducted to evaluate the potential mechanisms involved.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"347-363"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/4b/ogs-22165.PMC10514592.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9692132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to screen the cervix and reduce the risk of spontaneous preterm birth in asymptomatic women without a prior preterm birth.","authors":"Seon Ui Lee,&nbsp;Gyul Jung,&nbsp;Han Wool Kim,&nbsp;Hyun Sun Ko","doi":"10.5468/ogs.23022","DOIUrl":"10.5468/ogs.23022","url":null,"abstract":"<p><p>Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality globally. PTB rates have increased in South Korea despite reduction in birth rates. A history of PTB is a strong predictor of subsequent PTB and screening of cervical length between 16 0/7 weeks and 24 0/7 weeks of gestation is recommended in women with a singleton pregnancy and a prior spontaneous PTB. However, the prediction and prevention of spontaneous PTBs in women without a prior PTB remain a matter of debate. The scope of this review article comprises cervical screening and prevention strategies for PTB in asymptomatic women without a prior PTB, based on recent evidence and guidelines.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"337-346"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/9a/ogs-23022.PMC10514583.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10150223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of pringle manoeuvre, type three liver mobilisation, full thickness diaphragmatic resection with primary closure technique and peritonectomy in the management of advanced ovarian malignancy.","authors":"Sarah Louise Smyth,&nbsp;Hooman Soleymani Majd","doi":"10.5468/ogs.23029","DOIUrl":"10.5468/ogs.23029","url":null,"abstract":"<p><strong>Objective: </strong>We present an educational technique for the safe completion of complete cytoreduction of diaphragmatic disease for the management of advanced ovarian malignancy.</p><p><strong>Methods: </strong>We demonstrated these steps with attention to anatomical landmarks and surgical approaches, considering intraoperative and postoperative morbidity and mortality.</p><p><strong>Results: </strong>We present the case of a 49-year-old female patient diagnosed with suspected stage 3C ovarian malignancy following diagnostic laparoscopy. We demonstrate the surgical application of the Pringle manoeuvre, type 3 liver mobilisation, and full-thickness diaphragmatic resection. This was completed with a primary closure technique, with integrity ensured through the performance of an air test and Valsalva manoeuvre. Final histology confirmed a serous borderline tumour with invasive implants within a port site nodule (stage 4A).</p><p><strong>Conclusion: </strong>This technique affirms the essential skills in gynaecological oncology training and details a challenging case requiring advanced surgical skills and knowledge, with specific consideration for intraoperative multidisciplinary decision-making.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"459-461"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/48/ogs-23029.PMC10514588.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before in vitro fertilization and embryo transfer.","authors":"Sung Pil Choo,&nbsp;Inha Lee,&nbsp;Jae-Hoon Lee,&nbsp;Dowon Lee,&nbsp;Hyemin Park,&nbsp;Joo Hyun Park,&nbsp;SiHyun Cho,&nbsp;Young Sik Choi","doi":"10.5468/ogs.22315","DOIUrl":"10.5468/ogs.22315","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the endometrial transcriptomic patterns in the early secretory phase (ESP) and mid-secretory phase (MSP) of the natural menstrual cycle before in vitro fertilization and embryo transfer (IVF-ET).</p><p><strong>Methods: </strong>Thirty patients whose endometrial tissues were obtained from the ESP or MSP of a natural menstrual cycle immediately before IVF-ET were included. Endometrial dating was histologically confirmed as ESP (cycle days 16-18) or MSP (cycle days 19-21), according to the noyes criteria. The patients were divided into two groups depending on the IVF-ET outcome: pregnant (n=14; 7 in ESP and 7 in MSP) or non-pregnant (n=16; 8 in ESP and 8 in MSP). Differentially expressed genes (DEGs) in the MSP, compared to the ESP, were identified using NanoString nCounter (NanoString Technologies, Seattle, WA, USA) data for both the pregnant and non-pregnant groups.</p><p><strong>Results: </strong>Thirteen DEGs in the pregnant group and 11 DEGs in the non-pregnant group were identified in the MSP compared to those in the ESP. In both groups, adrenoceptor alpha 2A, interleukin 1 receptor-associated kinase 2, a disintegrin and metalloproteinase with thrombospondin repeats 15 (ADAMTS15), serpin family E member 1, integrin subunit beta 3, transmembrane protein 252 (TMEM252), huntingtin associated protein 1, C2 calcium-dependent domain containing 4A, and integrin subunit alpha 2 were upregulated in the MSP, compared to the ESP. TMEM37, galactosidase beta 1 like 2, Rho family GTPase 3, and cytochrome P450 family 24 subfamily A member 1 were upregulated in the MSP only in the pregnant group. ADAMTS8 was downregulated and monoamine oxidase A was upregulated in the MSP only in the non-pregnant group.</p><p><strong>Conclusion: </strong>Transcriptomic patterns in the endometrium immediately before IVF-ET appear to differ according to the IVF-ET outcome. These novel DEGs, which have not been previously studied, may have functional significance during the window of implantation and serve as potential biomarkers of endometrial receptivity.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"417-429"},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/68/ogs-22315.PMC10514596.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}