Obstetrics and Gynecology Science最新文献

Red blood cell indices as predictor for severity of endometriosis. 红细胞指标作为子宫内膜异位症严重程度的预测指标。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-24 DOI: 10.5468/ogs.25080

Josua Simanjuntak, Edy Priyanto, M Alamsyah Azis

{"title":"Red blood cell indices as predictor for severity of endometriosis.","authors":"Josua Simanjuntak, Edy Priyanto, M Alamsyah Azis","doi":"10.5468/ogs.25080","DOIUrl":"https://doi.org/10.5468/ogs.25080","url":null,"abstract":"Objective: Endometriosis is the presence of endometrial tissue outside of the uterine cavity. Certain markers have been used to evaluate the severity of endometriosis. This study aimed to explore the correlation between red blood cell (RBC) indices and the severity of endometriosis.Methods: This was a cross-sectional study including 200 patients with endometriosis (stage I-II and stage III-IV groups) and 100 patients with other benign ovarian tumors who underwent laparotomy at the Department of Obstetrics and Gynaecology, Margono Regional Public Hospital, between 2021 and 2024. Blood tests were evaluated before surgery, and the severity of endometriosis was determined during surgery using the revised American Society for Reproductive Medicine classification.Results: Among the obtained RBC indices, mean hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) values were significantly lower in subjects with stage III-IV endometriosis than in those with stage I-II endometriosis and the control group (P=0.000, P =0.000, P=0.006, and P=0.010, respectively). The mean red cell distribution width (RDW) was significantly higher in the stage III-IV group than in the stage I-II and control groups (P=0.000). In addition, univariate analysis indicated that lower preoperative RBC indices (Hb ≤11.9 g/dL, Hct ≤37.1%, MCV ≤82.6 fL, MCH ≤26.6 pg) and higher RDW (≥14.9%) were independent risk factors for stage III/IV endometriosis.Conclusion: Lower RBC indices, including pre-operative Hb, Hct, MCV, and MCH, were significantly associated with the severity of endometriosis, which is potentially caused by dysregulation of iron metabolism and inflammation.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining the AJCC TNM staging system for vulvar melanomas: role of mucosal and cutaneous differentiation. 完善外阴黑素瘤的AJCC TNM分期系统：粘膜和皮肤分化的作用。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-24 DOI: 10.5468/ogs.25288

Wiebren Tjalma

引用次数: 0

Laparoscopic mesh sacr ocolpopexy versus lateral vaginal vault suspension in prevention of post hysterectomy vault prolapse: a randomized trial. 腹腔镜网状骶骨固定与阴道外侧拱顶悬吊预防子宫切除术后拱顶脱垂：一项随机试验。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-19 DOI: 10.5468/ogs.25092

Mostafa Hussein Haider, Ahmed Salah Abo Elagha

{"title":"Laparoscopic mesh sacr ocolpopexy versus lateral vaginal vault suspension in prevention of post hysterectomy vault prolapse: a randomized trial.","authors":"Mostafa Hussein Haider, Ahmed Salah Abo Elagha","doi":"10.5468/ogs.25092","DOIUrl":"https://doi.org/10.5468/ogs.25092","url":null,"abstract":"Objective: To compare laparoscopic mesh sacrocolpopexy (LSC) and laparoscopic lateral suspension (LLS) for preventing post hysterectomy vault prolapse.Methods: This randomized trial included 40 women who were scheduled for a hysterectomy. The patients were randomly assigned to two groups in a 1:1 ratio: group I underwent LSC immediately after hysterectomy, and group II (n=20) underwent LLS immediately after hysterectomy.Results: Postoperative pelvic organ prolapse quantification measurements (anterior vaginal points Aa and Ba, vaginal apex point C, and posterior vaginal points AP and BP) were significantly better in the LSC group, with a lower rate of postoperative vault prolapse beyond the introitus (P=0.047). Both groups showed similar estimated blood loss, urinary tract infection, wound infection, and urinary retention rates. However, LSC was associated with significantly higher postoperative pain scores at 24 hours and 48 hours and a longer hospital stay (P<0.05).Conclusion: Although LSC demonstrated more favorable anatomical outcomes and a lower incidence of postoperative vault prolapse beyond the introitus than LLS, these findings should be interpreted with caution because of the limited sample size. Both procedures showed comparable safety profiles, although the LSC was associated with greater postoperative pain and longer hospitalization times. Given the study's exploratory design, small cohort, and short follow-up period, further large-scale multicenter studies are needed to confirm these preliminary observations and to better inform clinical practice regarding the optimal surgical approach for preventing post hysterectomy vault prolapse.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaginal microbiome and its implications in preterm birth. 阴道微生物组及其对早产的影响。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-17 DOI: 10.5468/ogs.25085

Sunwha Park, Young-Ah You, Gain Lee, Young Min Hur, Yoon-Young Go, Suenie Park, Young Ju Kim

{"title":"Vaginal microbiome and its implications in preterm birth.","authors":"Sunwha Park, Young-Ah You, Gain Lee, Young Min Hur, Yoon-Young Go, Suenie Park, Young Ju Kim","doi":"10.5468/ogs.25085","DOIUrl":"https://doi.org/10.5468/ogs.25085","url":null,"abstract":"Preterm birth (PTB), defined as birth occurring before 37 weeks of gestation, remains a major global public health challenge, affecting approximately 10% of pregnancies worldwide and contributing significantly to neonatal morbidity and mortality. Despite extensive research, the etiology of PTB is multifactorial and not yet fully understood, with ongoing debates regarding the contributions of inflammation, hormonal dysregulation, genetic predisposition, and environmental factors such as microbial dysbiosis. Recent studies have highlighted the role of the vaginal microbiome in pregnancy outcomes, particularly its association with PTB. This review consolidates current findings on the vaginal microbiome's influence on PTB, addressing microbial dysbiosis as a key risk factor. Despite differences in ethnicity, gestational age at sample collection, and analytical methodologies, a common observation is that a decrease in Lactobacillus species is associated with an increased risk of PTB. These differences influence study outcomes by affecting variations in microbial composition, host immune regulation, genetic predisposition, and environmental influences. However, a consistently observed trend is that a Lactobacillus-dominant vaginal microbiome is generally associated with a lower risk of PTB across diverse populations. This review also discusses the limitations of existing research and suggests directions for future microbiome studies.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative outcomes of excision and active surveillance for cervical intraepithelial neoplasia 2 in women under 35: a single institutional retrospective study. 35岁以下女性宫颈上皮内瘤2切除与主动监测的比较结果：一项单一机构回顾性研究

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-08 DOI: 10.5468/ogs.25100

Jihyun Lee, Mi Song Kim, Ju-Won Roh, Kyung Hee Han

{"title":"Comparative outcomes of excision and active surveillance for cervical intraepithelial neoplasia 2 in women under 35: a single institutional retrospective study.","authors":"Jihyun Lee, Mi Song Kim, Ju-Won Roh, Kyung Hee Han","doi":"10.5468/ogs.25100","DOIUrl":"https://doi.org/10.5468/ogs.25100","url":null,"abstract":"Objective: This study aimed to compare the outcomes of excision (conization) and active surveillance in women under 35 years of age diagnosed with cervical intraepithelial neoplasia 2 (CIN 2) on disease regression to normal cervical cytology and the effectiveness of nonsurgical management.Methods: This retrospective cohort study was conducted at OOO. Women under 35 diagnosed with CIN 2 were included and divided into two groups based on the management strategy: excisional treatment or active surveillance. Data on patient outcomes, including the regression time to normal cytology, were retrospectively collected and analyzed.Results: The follow-up period ranged from 2.73 months to 42.6 months, with a median follow-up period of 6.8 months. Management strategies between the excisional procedure and active surveillance were not associated with the cytological normalization from CIN 2 (P=0.32). The median time to achieve normal cytology was 7.4 months (95% confidence interval [CI], 6.08-8.77) in the excision group and 12.8 months (95% CI, 10.34-15.22) in the active surveillance group (P=0.22). This trend was observed across the following age groups: 20-24, 25-29, and 30-34 years (20-24, P=0.96; 25-29, P=0.67; and 30-34, P=0.99).Conclusions: There was no significant difference between the excisional procedure and active surveillance in terms of achieving normalized cytology from CIN 2. Active surveillance is a feasible option for managing CIN 2 in women under 35 years of age.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review. E-cadherin和N-cadherin在子宫内膜异位症及其他妇科疾病靶向治疗中的表达谱：系统综述

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.5468/ogs.25123

Leila Adamyan, Laura Pivazyan, Lilia Obosyan, Kristina Kurbatova, Elizaveta Platonova, Karina Mailova, Assia Stepanian

{"title":"Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review.","authors":"Leila Adamyan, Laura Pivazyan, Lilia Obosyan, Kristina Kurbatova, Elizaveta Platonova, Karina Mailova, Assia Stepanian","doi":"10.5468/ogs.25123","DOIUrl":"10.5468/ogs.25123","url":null,"abstract":"This systematic review aimed to summarize all available data and evaluate the roles of E-cadherin, N-cadherin, associated molecules, and signaling pathways in the pathogenesis of endometriosis. The search was conducted on PubMed, Cochrane Library, ClinicalTrials.gov, Scopus, Embase, and Google Scholar electronic databases. Twenty-two studies were included in the qualitative analyses. Several studies reported reduced E-cadherin expression in the ectopic and eutopic endometrium of patients with endometriosis, compared with that in the endometrium of patients without endometriosis (healthy comparison group and patients with non-malignant gynecological diseases). Moreover, some of the included studies reported higher E-cadherin concentration in endometriotic lesions than in the eutopic endometrium of patients with endometriosis. Similar results were obtained for β-catenin concentration. Some studies found that the expression levels of N-cadherin, ZEB1, ZEB2, TWIST, vimentin, SNAIL, SLUG, matrix metalloproteinases-9, and hypoxia-inducible factor-1α were higher in patients with endometriosis and that the E-cadherin levels were lower in ovarian and endometrial carcinomas than in endometriosis. These findings support the transplantation theory of endometriosis pathogenesis and highlight the potential therapeutic value of modulating E-cadherin and N-cadherin expression. Further research should be conducted to explore targeted treatment strategies for endometriosis.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"349-371"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical time in gynecologic surgery using laparoscopic articulated instruments (KGOG 4002). 妇科手术中使用腹腔镜关节器械的手术时间（kgog4002）。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.5468/ogs.25076

Hyunjoon Im, Soyeon Ahn, Kidong Kim, Min Kyung Kim, Jeong-Yeol Park, Ha Kyun Chang, Seok Ju Seong, Jong Ha Hwang

{"title":"Surgical time in gynecologic surgery using laparoscopic articulated instruments (KGOG 4002).","authors":"Hyunjoon Im, Soyeon Ahn, Kidong Kim, Min Kyung Kim, Jeong-Yeol Park, Ha Kyun Chang, Seok Ju Seong, Jong Ha Hwang","doi":"10.5468/ogs.25076","DOIUrl":"10.5468/ogs.25076","url":null,"abstract":"Objective: To estimate the learning curve of laparoscopic articulated instrument (LAI) surgery by analyzing data from a multi-institutional gynecologic surgery cohort using surgical time as the primary metric for evaluation.Methods: A total of 400 patients scheduled to undergo gynecologic surgery (adnexal surgery, myomectomy, hysterectomy, and cancer surgery) using LAI were prospectively enrolled at 14 institutes in the Republic of Korea between November 2021 and April 2022 (KGOG 4002). After excluding patients who did not undergo surgery with LAI (n=43), those in whom LAI was rarely used (n=11), and those operated on by surgeons with prior LAI experience (n=147), 199 patients were included in the analysis. Changes in surgical time according to the surgery index were evaluated using linear regression analysis.Results: Fifty-four adnexal surgeries, 40 myomectomies, 68 hysterectomies, and 37 cancer surgeries were performed by 24 surgeons. Each surgeon performed between one and 24 surgeries. Surgical time did not decrease as the surgery index increased for any type of surgery. Among surgeons who performed ≥10 surgeries, surgical time similarly showed no decrease with increasing surgery index.Conclusion: In gynecologic surgery using LAI, surgical time did not decrease despite accumulating surgical experience.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"401-407"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cauda equina syndrome following vaginal delivery. 阴道分娩后的马尾综合征。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-06-30 DOI: 10.5468/ogs.25166

Seung Jun Lee, So-Young Lee, Jun-Hwan Choi, Hyun Jung Lee

引用次数: 0

Postnatal outcomes of referred cases with abnormal ultrasound findings of fetal gall bladder and cyst in the fetal liver. 超声异常发现胎儿胆囊和胎儿肝脏囊肿的转诊病例的产后结局。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-08-19 DOI: 10.5468/ogs.25114

Soo Ran Choi, Hye-Sung Won, Jin Hoon Chung, Mi-Young Lee, Jihye Koh, Yoo Jin Lee

{"title":"Postnatal outcomes of referred cases with abnormal ultrasound findings of fetal gall bladder and cyst in the fetal liver.","authors":"Soo Ran Choi, Hye-Sung Won, Jin Hoon Chung, Mi-Young Lee, Jihye Koh, Yoo Jin Lee","doi":"10.5468/ogs.25114","DOIUrl":"10.5468/ogs.25114","url":null,"abstract":"Objective: To evaluate the postnatal outcomes of referred cases with abnormal findings in the fetal gallbladder (GB) or cysts in the fetal liver.Methods: This retrospective study included pregnant women referred to a tertiary referral unit, the fetal therapy center at Ulsan Asan Medical Center in Korea, between June 2005 and October 2022. Persistent non-visualization of the fetal gallbladder (NVFGB) was defined as non-visualization at least twice using an ultrasound scan. Antenatal ultrasound findings were obtained from the medical records, and the clinical, radiological, and surgical findings of the babies were reviewed.Results: A total of 113 referred patients were evaluated. Most enlarged and small GBs were identified as normal or GB stones, sludge, septate GB, or choledochal cysts (CDC). NVFGB was identified postnatally in 77.5% of cases. Persistent NVFGB was identified postnatally as biliary atresia (3/14; 21.4%), hepatic parenchymal disease with cholestasis (2/14; 14.2%), or isolated GB agenesis (6/14; 42.8%). The majority of cysts in the fetal liver cases with visualization of the fetal GB were identified as CDC. Half of the patients (2/4) with CDC who underwent NVFGB were confirmed to have biliary atresia.Conclusion: Except for persistent NVFGB, most abnormal ultrasound findings in fetal GB were associated with good postnatal outcomes. Cysts in the fetal liver with visualization of the fetal GB did not result in serious adverse outcomes. NVFGB, especially persistent NVFGB with or without cysts in the fetal liver, should be followed up closely prenatally and postnatally.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"382-389"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of VEGF, HIF-1α, and MMP2 expression in placental villi among patients with recurrent spontaneous abortion. 复发性自然流产患者胎盘绒毛中VEGF、HIF-1α和MMP2表达的相关性

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-09-01 Epub Date: 2025-07-03 DOI: 10.5468/ogs.24176

Yaru Ju, Xiaolin Hou, Yage Wang, Xiaofeng Zhang, Yan Feng

{"title":"Correlation of VEGF, HIF-1α, and MMP2 expression in placental villi among patients with recurrent spontaneous abortion.","authors":"Yaru Ju, Xiaolin Hou, Yage Wang, Xiaofeng Zhang, Yan Feng","doi":"10.5468/ogs.24176","DOIUrl":"10.5468/ogs.24176","url":null,"abstract":"Objective: In this study, the expression and clinical significance of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α), and matrix metalloproteinase-2 (MMP2) in the placental villi of patients experiencing recurrent spontaneous abortion were investigated.Methods: Fifty-one patients with recurrent spontaneous abortion (RSA) and 50 control individuals were enrolled (between January 2022 and December 2023). The messenger RNA (mRNA) and protein levels of VEGF, HIF-1α, and MMP2 in the placental villi of all enrolled patients were assessed using quantitative real-time polymerase chain reaction and western blot techniques. Additionally, the correlation between VEGF, HIF-1α, and MMP2 expression was analyzed using Pearson correlation coefficient.Results: The results revealed that the levels of VEGF mRNA and protein in the placental villi of patients with RSA were significantly lower than those in the control group, and this difference was statistically significant. Conversely, the mRNA and protein levels of HIF-1α and MMP2 were significantly higher in the RSA patient group than in the control group. Furthermore, the study revealed a negative correlation between the expression of VEGF and MMP2 in the placental villi of patients with RSA, and a positive correlation was observed between the expression of HIF-1α and MMP2.Conclusion: The downregulated expression of VEGF and upregulated expression of HIF-1α and MMP2 in the placental villi of patients with RSA may contribute to the pathogenesis of RSA. However, further investigation is required to elucidate the specific molecular regulatory mechanisms.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"408-417"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0