Obstetrics and Gynecology Science最新文献

Correlation of VEGF, HIF-1α, and MMP2 expression in placental villi among patients with recurrent spontaneous abortion. 复发性自然流产患者胎盘绒毛中VEGF、HIF-1α和MMP2表达的相关性

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-07-03 DOI: 10.5468/ogs.24176

Yaru Ju, Xiaolin Hou, Yage Wang, Xiaofeng Zhang, Yan Feng

{"title":"Correlation of VEGF, HIF-1α, and MMP2 expression in placental villi among patients with recurrent spontaneous abortion.","authors":"Yaru Ju, Xiaolin Hou, Yage Wang, Xiaofeng Zhang, Yan Feng","doi":"10.5468/ogs.24176","DOIUrl":"https://doi.org/10.5468/ogs.24176","url":null,"abstract":"Objective: In this study, the expression and clinical significance of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α), and matrix metalloproteinase-2 (MMP2) in the placental villi of patients experiencing recurrent spontaneous abortion were investigated.Methods: Fifty-one patients with recurrent spontaneous abortion (RSA) and 50 control individuals were enrolled (between January 2022 and December 2023). The mRNA and protein levels of VEGF, HIF-1α, and MMP2 in the placental villi of all enrolled patients were assessed using quantitative real-time polymerase chain reaction and western blot techniques. Additionally, the correlation between VEGF, HIF-1α, and MMP2 expression was analyzed using Pearson correlation coefficient.Results: The results revealed that the levels of VEGF mRNA and protein in the placental villi of patients with RSA were significantly lower than those in the control group, and this difference was statistically significant. Conversely, the mRNA and protein levels of HIF-1α and MMP2 were significantly higher in the RSA patient group than in the control group. Furthermore, the study revealed a negative correlation between the expression of VEGF and MMP2 in the placental villi of patients with RSA, and a positive correlation was observed between the expression of HIF-1α and MMP2.Conclusion: The downregulated expression of VEGF and upregulated expression of HIF-1α and MMP2 in the placental villi of patients with RSA may contribute to the pathogenesis of RSA. However, further investigation is required to elucidate the specific molecular regulatory mechanisms.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of adopting vaginal natural orifice transluminal endoscopic surgery for risk-reducing salpingo-oophorectomy for women with germline BRCA1/2 pathogenic variants analysis from conventional procedure. 采用阴道自然口腔内内窥镜手术降低风险的输卵管卵巢切除术妇女生殖系BRCA1/2致病变异分析从传统程序。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-07-03 DOI: 10.5468/ogs.25044

Hidetaka Nomura, Akiko Abe, Atsushi Fusegi, Mayumi Kamata, Arisa Ueki, Hiroyuki Kanao

{"title":"Validation of adopting vaginal natural orifice transluminal endoscopic surgery for risk-reducing salpingo-oophorectomy for women with germline BRCA1/2 pathogenic variants analysis from conventional procedure.","authors":"Hidetaka Nomura, Akiko Abe, Atsushi Fusegi, Mayumi Kamata, Arisa Ueki, Hiroyuki Kanao","doi":"10.5468/ogs.25044","DOIUrl":"https://doi.org/10.5468/ogs.25044","url":null,"abstract":"Objective: Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is less invasive than conventional transabdominal laparoscopic surgery for benign gynecological indications. When adopting this procedure for risk-reducing salpingo-oophorectomy (RRSO) in women with hereditary breast and ovarian cancer (HBOC), the ventral side of the uterus becomes a blind area, which is a challenge. To clarify the effects of this blind area on the treatment outcome of HBOC, we examined the clinical data of RRSO using conventional procedures for women with germline BRCA1/2 pathogenic variants who were treated at our institution.Methods: A retrospective chart review was performed. The clinical data of patients who underwent RRSO using the conventional procedure between 2011 and July 2024 were extracted. All included patients were preoperatively examined using vaginal ultrasonography, contrast-enhanced pelvic magnetic resonance imaging, and carcinoma antigen-125 level measurements to exclude ovarian cancer development.Results: A total of 267 patients underwent RRSO at our institution. The mean age at RRSO was 50.1 years. Five cases of occult invasive cancer (1.9%) and 10 cases of serous tubal intraepithelial carcinoma (3.7%) were identified postoperatively. One patient (0.37%) showed macroscopic peritoneal dissemination in the omentum. None of the 252 patients without occult cancer developed peritoneal cancer during the mean observational time of 62.4 months No patient presented with peritoneal lesions ventral to the uterus.Conclusion: Macroscopic tumors on the peritoneum ventral to the uterus were rare when strict preoperative screening for ovarian cancer was performed. vNOTES can be safely adopted for RRSO in patients with HBOC, without evident disadvantages.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in applications of machine learning in cervical cancer research: a focus on prediction models. 机器学习在宫颈癌研究中的应用进展：以预测模型为重点。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 Epub Date: 2025-05-29 DOI: 10.5468/ogs.25041

Syed S Abrar, Seoparjoo Azmel Mohd Isa, Suhaily Mohd Hairon, Mohd Pazudin Ismail, Mohd Nasrullah Bin Nik Ab Kadir

{"title":"Recent advances in applications of machine learning in cervical cancer research: a focus on prediction models.","authors":"Syed S Abrar, Seoparjoo Azmel Mohd Isa, Suhaily Mohd Hairon, Mohd Pazudin Ismail, Mohd Nasrullah Bin Nik Ab Kadir","doi":"10.5468/ogs.25041","DOIUrl":"10.5468/ogs.25041","url":null,"abstract":"Artificial intelligence (AI) and machine learning (ML) are transforming cervical cancer research and offering advancements in diagnosis, prognosis, screening, and treatment. This review explores ML applications with particular emphasis on prediction models. A comprehensive literature search identified studies using ML for survival prediction, risk assessment, and treatment optimization. ML-driven prognostic models integrate clinical, histopathological, and genomic data to improve survival prediction and patient stratification. Screening methods, including deep-learning-based cytology analysis and human papillomavirus detection, enhance accuracy and efficiency. ML-driven imaging techniques facilitate early and precise cancer diagnosis, while risk prediction models assess susceptibility based on demographic and genetic factors. AI also optimizes treatment planning by predicting therapeutic responses and guiding personalized interventions. Despite significant progress, challenges remain regarding data availability, model interpretability, and clinical implementation. Standardized datasets, external validation, and cross-disciplinary collaborations are crucial for implementing ML innovations in clinical settings. Subsequent investigations should prioritize joint initiatives among data scientists, healthcare providers, and health authorities to translate AI innovations into real-world applications and to enhance the impact of ML on cervical cancer care. By synthesizing recent developments, this review highlights the potential of ML to improve clinical outcomes and shaping the future of cervical cancer management.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"247-259"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of random blood glucose and HbA1c levels in optimizing glucose tolerance screening in early pregnancy: a retrospective cohort study. 随机血糖和糖化血红蛋白水平在优化妊娠早期糖耐量筛查中的作用：一项回顾性队列研究

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 Epub Date: 2025-06-27 DOI: 10.5468/ogs.25052

Yoshitsugu Chigusa, Yoshikazu Ikeda, Akitoshi Yamamura, Haruta Mogami, Akiko Nishimura, Satoshi Morita, Masaki Mandai, Shin-Ichi Harashima

{"title":"Role of random blood glucose and HbA1c levels in optimizing glucose tolerance screening in early pregnancy: a retrospective cohort study.","authors":"Yoshitsugu Chigusa, Yoshikazu Ikeda, Akitoshi Yamamura, Haruta Mogami, Akiko Nishimura, Satoshi Morita, Masaki Mandai, Shin-Ichi Harashima","doi":"10.5468/ogs.25052","DOIUrl":"10.5468/ogs.25052","url":null,"abstract":"Objective: Random blood glucose (rBG) levels are commonly measured in Japan; however, no standardized cutoff values exist for glucose tolerance screening in early pregnancy. The contribution of glycated hemoglobin (HbA1c) and glycated albumin (GA) measurements to the diagnosis of gestational diabetes mellitus (GDM) remains unclear. Therefore, we aimed to evaluate the significance of these glycemic indicators in early pregnancy for predicting GDM.Methods: This observational cohort study enrolled pregnant women who underwent initial prenatal examinations to determine their rBG, HbA1c, and GA levels at a rural maternity facility. Clinical data were retrospectively reviewed.Results: A total of 449 patients were analyzed, comprising 394 with normal glucose tolerance (NGT) and 55 with GDM. The rBG, HbA1c, and GA levels were significantly higher during early pregnancy in women who developed GDM than in those with NGT. Receiver operating characteristic curve analysis revealed that the areas under the curve (AUC) for rBG, HbA1c, and GA were 0.733, 0.591, and 0.608, respectively, with cutoff values of 100 mg/dL, 5.2%, and 14.6%, respectively. These cutoff values had sensitivities of 52.7%, 70.9%, and 36.4% and specificities of 87.6%, 43.4%, and 82.5%, respectively. The product of rBG and HbA1c levels demonstrated improved performance, with an AUC of 0.750, cutoff value of 509, 63.6% sensitivity, and 83.5% specificity.Conclusion: Glucose tolerance screening in early pregnancy using an rBG level of 100 mg/dL and an HbA1c level of 5.2% as cutoff values may help identify high-risk cases and enable early diagnosis of GDM.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"273-282"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does a specific age group impact sperm cryobanking efficiency among adolescent and young adult cancer patients? 特定年龄组是否会影响青少年和年轻成年癌症患者的精子冷冻库效率？

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 Epub Date: 2025-06-11 DOI: 10.5468/ogs.25009

Soo Jin Park, Sung Woo Kim, Sung Ah Kim, Hee Sun Kim, Jung-Won Choi, Moon-Joo Kang, Jung Yoon Choi, Hyoung Jin Kang, Hee Jin Son, Ji Yeon Han, Hoon Kim, Seung-Yup Ku

{"title":"Does a specific age group impact sperm cryobanking efficiency among adolescent and young adult cancer patients?","authors":"Soo Jin Park, Sung Woo Kim, Sung Ah Kim, Hee Sun Kim, Jung-Won Choi, Moon-Joo Kang, Jung Yoon Choi, Hyoung Jin Kang, Hee Jin Son, Ji Yeon Han, Hoon Kim, Seung-Yup Ku","doi":"10.5468/ogs.25009","DOIUrl":"10.5468/ogs.25009","url":null,"abstract":"Objective: Fertility preservation is vital for adolescent and young adult (AYA) cancer patients. Sperm cryobanking is a key option, but age-related factors influencing its efficiency remain unclear. This study evaluated the impact of age on cryobanking attempts, success rates, and disposition outcomes among AYA patients with cancer aged 11-25 years.Methods: We retrospectively analyzed 298 AYA patients with cancer referred for fertility preservation counseling over 9 years. Data on cryobanking attempts, success rates, and disposition outcomes were stratified by age group (11-15, 16-20, and 21-25 years). Logistic regression was used to assess factors influencing these outcomes.Results: The mean age was 16.0 years, with leukemia (22.5%), sarcoma (22.1%), and lymphoma (17.1%) being the most common diagnoses. Among the cohort, 72.1% attempted cryobanking, with lower attempt rates in the youngest group (59.6%) compared to 82.2% and 88.2% in the older groups, respectively. Younger age was a significant predictor of not attempting cryobanking (adjusted odds ratio, 5.059; P=0.001); however, age did not affect the success of sperm cryobanking among patients who attempted it. Disposition analysis showed that 77.2% of samples remained in storage, while 16.2% were discarded; although disposal was often influenced by family decisions, no significant predictors of disposal were identified.Conclusion: Younger patients are less likely to attempt sperm cryobanking, although success rates among those who do are comparable across age groups. While most patients continued storage, higher disposal rates in younger groups highlight the need for strategies to increase participation and support informed decision-making.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"323-333"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of volatile organic compound as a novel modality for cervical cancer detection. 挥发性有机化合物（VOC）的鉴定作为宫颈癌检测的新方法。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 DOI: 10.5468/ogs.25038

Muhammad Ary Zucha, Dian Kesumapramudya Nurputra, Ardhanu Kusumanto, Shidiq Nur Hidayat, Kuwat Triyana, Widha Apriani Priadi, Nadia Yasmine, Ova Emilia

{"title":"Identification of volatile organic compound as a novel modality for cervical cancer detection.","authors":"Muhammad Ary Zucha, Dian Kesumapramudya Nurputra, Ardhanu Kusumanto, Shidiq Nur Hidayat, Kuwat Triyana, Widha Apriani Priadi, Nadia Yasmine, Ova Emilia","doi":"10.5468/ogs.25038","DOIUrl":"10.5468/ogs.25038","url":null,"abstract":"Objective: In this study, we developed a novel detection strategy based on volatile organic compound (VOC) sensing. Persistent infection by human papillomavirus (HPV) may cause biological changes in the cervical epithelium, leading to VOC production.Methods: This study included 200 urine samples from cervical cancer patients and controls that were HPV-negative. Urine samples were collected and measured using a gas sensor array composed of a matrix of 10 sensors. For each analyzed sample, the instrument produced a vector signal encoding the VOC emitted from the urine (urine prints). The urine prints of cervical cancer patients were differentiated from those of healthy controls.Results: Identification of VOC for cervical cancer detection showed reliable accuracy (91% sensitivity, 85% specificity, and 89% accuracy).Conclusion: Our.Results: demonstrated the applicability of VOC sensing for cervical cancer detection and its potential application in treatment monitoring.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"293-303"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of L-carnitine supplementation on fertility outcomes among patients with polycystic ovary syndrome: a systematic review and dose-response meta-analysis of randomized clinical trials. 补充左旋肉碱对多囊卵巢综合征患者生育结局的影响：随机临床试验的系统评价和剂量反应荟萃分析

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 Epub Date: 2025-05-28 DOI: 10.5468/ogs.24272

Ahmed Abu-Zaid, Ghadeer Adel Alghamdi, Alaa Saleh Alharbi, Saeed Baradwan, Saleh A K Saleh, Heba M Adly, Mooza M Alzayed, Mohammed Abuzaid, Raghad Sindi, Mohannad Alsabban, Osama Alomar

{"title":"Effect of L-carnitine supplementation on fertility outcomes among patients with polycystic ovary syndrome: a systematic review and dose-response meta-analysis of randomized clinical trials.","authors":"Ahmed Abu-Zaid, Ghadeer Adel Alghamdi, Alaa Saleh Alharbi, Saeed Baradwan, Saleh A K Saleh, Heba M Adly, Mooza M Alzayed, Mohammed Abuzaid, Raghad Sindi, Mohannad Alsabban, Osama Alomar","doi":"10.5468/ogs.24272","DOIUrl":"10.5468/ogs.24272","url":null,"abstract":"This systematic review and meta-analysis of randomized controlled trials (RCTs) assessed the effect of L-carnitine (LC) supplementation on the fertility outcomes of patients with polycystic ovary syndrome (PCOS). Online databases (Scopus, Web of Science, Cochrane Library, EMBASE, and PubMed) were searched to identify eligible RCTs published until March 2024. A dose-response meta-analysis was performed using a random-effects model. Meta-regression was also performed to investigate the source of heterogeneity based on the LC dose and duration of treatment. The pooled analysis included eight RCTs with 1,046 participants. The LC-treated group had significantly increased chemical and clinical pregnancy rates, ovulation rate, progesterone levels, number of preovulatory follicles >17 mm in diameter, and endometrial thickness compared to the untreated groups. The meta-analysis model indicated that LC supplementation did not change the serum levels of estrogen and testosterone; however, the dose-response meta-analysis indicated that prolonged LC intake significantly increased estrogen levels. LC supplementation has significant effects on fertility outcomes of women with PCOS. Additional large-scale longer RCTs are required to confirm the findings of this study.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"260-272"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bleeding control and posterior vaginal fornix approach for cesarean hysterectomy in placenta accreta spectrum. 胎盘增生谱剖宫产子宫切除术的出血控制及阴道后穹窿入路。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 Epub Date: 2025-06-27 DOI: 10.5468/ogs.24216

Thiti Atjimakul, Kulisara Nanthamongkolkul, Ingporn Jiamset, Yuthasak Suphasynth, Aroontorn Pichatechaiyoot, Ekasak Thiangphak, Chayut Pongpanich, Athithan Rattanaburi

{"title":"Bleeding control and posterior vaginal fornix approach for cesarean hysterectomy in placenta accreta spectrum.","authors":"Thiti Atjimakul, Kulisara Nanthamongkolkul, Ingporn Jiamset, Yuthasak Suphasynth, Aroontorn Pichatechaiyoot, Ekasak Thiangphak, Chayut Pongpanich, Athithan Rattanaburi","doi":"10.5468/ogs.24216","DOIUrl":"10.5468/ogs.24216","url":null,"abstract":"Objective: Placenta accreta spectrum (PAS) is a leading cause of massive obstetric hemorrhage, particularly when the placenta is removed or unintentionally disrupted during cesarean hysterectomy. In this video, we demonstrate an alternative surgical approach via the posterior vaginal fornix for performing cesarean hysterectomy in patients with PAS.Methods: A cesarean hysterectomy for a case of placenta percreta was performed using the posterior vaginal fornix approach. This technique focuses on avoiding bleeding due to placental disruption and preventing urinary bladder injury.Results: We summarize the steps of the procedure, including ligation of the vascular pedicles, entry into the retroperitoneal space to identify vital structures and control bleeding, dissection along avascular plane to delineate organ borders, and posterior culdotomy followed by en bloc uterine amputation to avoid urinary bladder injury and minimize blood loss.Conclusion: The posterior vaginal fornix approach for cesarean hysterectomy in patients with PAS is an effective technique for minimizing bleeding from the highly vascular placental area. Additionally, it offers the advantage of reducing the risk of unintentional urinary bladder injury, thereby improving surgical outcomes in these challenging cases.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"346-348"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological considerations and future directions for research on COVID-19 vaccination and menstrual changes. COVID-19疫苗接种与月经变化研究的方法学思考及未来方向

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 Epub Date: 2025-05-29 DOI: 10.5468/ogs.25127

Noshaba Majeed, Shoaib Majeed, Jie Tu

引用次数: 0

Impact of ultraviolet radiation on bone density and muscle strength in postmenopausal women: a randomized controlled study. 紫外线辐射对绝经后妇女骨密度和肌肉力量的影响：一项随机对照研究。

IF 1.9

Obstetrics and Gynecology Science Pub Date : 2025-07-01 Epub Date: 2025-06-19 DOI: 10.5468/ogs.25077

Wafaa M Kamal, Ahmed M Maged, Noha Salah, Nour A El-Goly, Wael El-Sherbiny, Elham S Hassan

{"title":"Impact of ultraviolet radiation on bone density and muscle strength in postmenopausal women: a randomized controlled study.","authors":"Wafaa M Kamal, Ahmed M Maged, Noha Salah, Nour A El-Goly, Wael El-Sherbiny, Elham S Hassan","doi":"10.5468/ogs.25077","DOIUrl":"10.5468/ogs.25077","url":null,"abstract":"Objective: This study aimed to evaluate the effects of narrowband ultraviolet B (UVB) irradiation on bone and muscle health in postmenopausal women.Methods: A randomized controlled trial was conducted involving 70 postmenopausal women with vitamin D deficiency (<20 ng/mL) and osteopenia. Participants were randomly assigned to two groups. For 6 months, 35 postmenopausal women in study group A received three weekly sessions of narrowband UVB therapy and vitamin D supplements in the form of 100,000 international unit (IU) cholecalciferol weekly as loading therapy for 8 weeks. This was followed by the daily administration of cholecalciferol 3,000 IU as maintenance therapy for 16 weeks. The control group B consisted of 35 postmenopausal women who were administered vitamin D supplements alone for 6 months. Enzyme-linked immuno sorbent assay kits were used to test the serum levels of 25-hydroxyvitamin D (25(OH)D), dual-energy X-ray absorptiometry (DEXA) (DMS, Occitanie, France) was used to test the bone mineral density of the lumbar spine and right femur, and a Biodex System 3 (Biodex Medical Systems Inc., Shirley, NY, USA) isokinetic dynamometer was used to assess the peak torque of the extensors and flexors of the dominant knee.Results: Serum 25(OH)D levels (P=0.000), Lumbar T-score (P=0.008), femoral T-score (P=0.002), and knee extensor peak torque (P=0.030) significantly increased in both groups after 6 months of treatment, favoring study group A over the control group B.Conclusion: Narrowband UVB combined with vitamin D3 supplementation is more effective than vitamin D supplementation alone.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"334-343"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0