Obstetrics and Gynecology Science最新文献

Correlation of VEGF, HIF-1α, and MMP2 expression in placental villi among patients with recurrent spontaneous abortion. 复发性自然流产患者胎盘绒毛中VEGF、HIF-1α和MMP2表达的相关性

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-07-03 DOI: 10.5468/ogs.24176

Yaru Ju, Xiaolin Hou, Yage Wang, Xiaofeng Zhang, Yan Feng

{"title":"Correlation of VEGF, HIF-1α, and MMP2 expression in placental villi among patients with recurrent spontaneous abortion.","authors":"Yaru Ju, Xiaolin Hou, Yage Wang, Xiaofeng Zhang, Yan Feng","doi":"10.5468/ogs.24176","DOIUrl":"https://doi.org/10.5468/ogs.24176","url":null,"abstract":"Objective: In this study, the expression and clinical significance of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α), and matrix metalloproteinase-2 (MMP2) in the placental villi of patients experiencing recurrent spontaneous abortion were investigated.Methods: Fifty-one patients with recurrent spontaneous abortion (RSA) and 50 control individuals were enrolled (between January 2022 and December 2023). The mRNA and protein levels of VEGF, HIF-1α, and MMP2 in the placental villi of all enrolled patients were assessed using quantitative real-time polymerase chain reaction and western blot techniques. Additionally, the correlation between VEGF, HIF-1α, and MMP2 expression was analyzed using Pearson correlation coefficient.Results: The results revealed that the levels of VEGF mRNA and protein in the placental villi of patients with RSA were significantly lower than those in the control group, and this difference was statistically significant. Conversely, the mRNA and protein levels of HIF-1α and MMP2 were significantly higher in the RSA patient group than in the control group. Furthermore, the study revealed a negative correlation between the expression of VEGF and MMP2 in the placental villi of patients with RSA, and a positive correlation was observed between the expression of HIF-1α and MMP2.Conclusion: The downregulated expression of VEGF and upregulated expression of HIF-1α and MMP2 in the placental villi of patients with RSA may contribute to the pathogenesis of RSA. However, further investigation is required to elucidate the specific molecular regulatory mechanisms.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of adopting vaginal natural orifice transluminal endoscopic surgery for risk-reducing salpingo-oophorectomy for women with germline BRCA1/2 pathogenic variants analysis from conventional procedure. 采用阴道自然口腔内内窥镜手术降低风险的输卵管卵巢切除术妇女生殖系BRCA1/2致病变异分析从传统程序。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-07-03 DOI: 10.5468/ogs.25044

Hidetaka Nomura, Akiko Abe, Atsushi Fusegi, Mayumi Kamata, Arisa Ueki, Hiroyuki Kanao

{"title":"Validation of adopting vaginal natural orifice transluminal endoscopic surgery for risk-reducing salpingo-oophorectomy for women with germline BRCA1/2 pathogenic variants analysis from conventional procedure.","authors":"Hidetaka Nomura, Akiko Abe, Atsushi Fusegi, Mayumi Kamata, Arisa Ueki, Hiroyuki Kanao","doi":"10.5468/ogs.25044","DOIUrl":"https://doi.org/10.5468/ogs.25044","url":null,"abstract":"Objective: Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is less invasive than conventional transabdominal laparoscopic surgery for benign gynecological indications. When adopting this procedure for risk-reducing salpingo-oophorectomy (RRSO) in women with hereditary breast and ovarian cancer (HBOC), the ventral side of the uterus becomes a blind area, which is a challenge. To clarify the effects of this blind area on the treatment outcome of HBOC, we examined the clinical data of RRSO using conventional procedures for women with germline BRCA1/2 pathogenic variants who were treated at our institution.Methods: A retrospective chart review was performed. The clinical data of patients who underwent RRSO using the conventional procedure between 2011 and July 2024 were extracted. All included patients were preoperatively examined using vaginal ultrasonography, contrast-enhanced pelvic magnetic resonance imaging, and carcinoma antigen-125 level measurements to exclude ovarian cancer development.Results: A total of 267 patients underwent RRSO at our institution. The mean age at RRSO was 50.1 years. Five cases of occult invasive cancer (1.9%) and 10 cases of serous tubal intraepithelial carcinoma (3.7%) were identified postoperatively. One patient (0.37%) showed macroscopic peritoneal dissemination in the omentum. None of the 252 patients without occult cancer developed peritoneal cancer during the mean observational time of 62.4 months No patient presented with peritoneal lesions ventral to the uterus.Conclusion: Macroscopic tumors on the peritoneum ventral to the uterus were rare when strict preoperative screening for ovarian cancer was performed. vNOTES can be safely adopted for RRSO in patients with HBOC, without evident disadvantages.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of time elapsed since diagnosis on neuropathic symptoms, sexual function, lymphedema, and overall quality of life in ovarian cancer survivors (KGOG 3068). 诊断后时间对卵巢癌幸存者神经病变症状、性功能、淋巴水肿和整体生活质量的影响（KGOG 3068）。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-07-02 DOI: 10.5468/ogs.24338

Maitreyee Parulekar, Su Min Hyun, Kidong Kim, Hee Seung Kim, Yong-Man Kim, Sang Yoon Park, Chel Hun Choi, Jae-Hoon Kim

{"title":"Impact of time elapsed since diagnosis on neuropathic symptoms, sexual function, lymphedema, and overall quality of life in ovarian cancer survivors (KGOG 3068).","authors":"Maitreyee Parulekar, Su Min Hyun, Kidong Kim, Hee Seung Kim, Yong-Man Kim, Sang Yoon Park, Chel Hun Choi, Jae-Hoon Kim","doi":"10.5468/ogs.24338","DOIUrl":"https://doi.org/10.5468/ogs.24338","url":null,"abstract":"Objective: To assess the impact of time since treatment on the quality of life (QOL), neurotoxicity, sexual function, lymphedema, and utility in ovarian cancer survivors.Methods: This secondary analysis of a cross-sectional study examined the QOL, neurotoxicity, sexual function, lymphedema, and utility in 172 epithelial ovarian cancer survivors treated with first-line platinum-based chemotherapy without recurrence. Associations between time since treatment and overall QOL (National Comprehensive Cancer Network/functional assessment of cancer therapy ovarian symptom index-18 [NFOSI 18]), neurotoxicity (neurotoxicity subscale, version 4 [NTX4]), sexual function (female sexual function index, 6-item Korean version [FSFI-6K]), lymphedema (gynecologic cancer lymphedema questionnaire [GCLQ]), and utility (EuroQol 5-dimension [EQ-5D]) were visualized using jittered box plots.Results: Overall QOL (NFOSI 18) improved up to 3 years post-treatment (scores: 29.3 at 1 year, 28.6 at 2 years, 26.6 and 3 years), followed by minor fluctuations over time. NTX4 scores improved until 5 years (8.2, 7.7, 6.2, and 5.8), but remained above normal (score 0). Sexual function (FSFI-6K) increased until 3 years of age (4.6, 6.9, and 10 years), stabilizing at a level indicative of dysfunction (score <21). The lymphedema (GCLQ) scores fluctuated over time (4.9, 5.6, 3.3, 4.3, 5.2, and 3.8). Utility (EQ-5D index) improved up to 3 years (0.8250, 0.885, and 0.925), whereas the EQ-5D visual analog scale score increased gradually up to 5 years (71.5, 72, 73, 76, and 74), indicating ongoing recovery.Conclusion: In ovarian cancer survivors, QOL, symptom burden, and utility gradually improved over time post-treatment but did not fully return to pre-treatment levels.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of volatile organic compound (VOC) as a novel modality for cervical cancer detection. 挥发性有机化合物（VOC）的鉴定作为宫颈癌检测的新方法。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-07-01 DOI: 10.5468/ogs.25038

Muhammad Ary Zucha, Dian Kesumapramudya Nurputra, Ardhanu Kusumanto, Shidiq Nur Hidayat, Kuwat Triyana, Widha Apriani Priadi, Nadia Yasmine, Ova Emilia

{"title":"Identification of volatile organic compound (VOC) as a novel modality for cervical cancer detection.","authors":"Muhammad Ary Zucha, Dian Kesumapramudya Nurputra, Ardhanu Kusumanto, Shidiq Nur Hidayat, Kuwat Triyana, Widha Apriani Priadi, Nadia Yasmine, Ova Emilia","doi":"10.5468/ogs.25038","DOIUrl":"https://doi.org/10.5468/ogs.25038","url":null,"abstract":"Objective: In this study, we developed a novel detection strategy based on volatile organic compound (VOC) sensing. Persistent infection by human papillomavirus (HPV) may cause biological changes in the cervical epithelium, leading to VOC production.Methods: This study included 200 urine samples from cervical cancer patients and controls that were HPV-negative. Urine samples were collected and measured using a gas sensor array composed of a matrix of 10 sensors. For each analyzed sample, the instrument produced a vector signal encoding the VOC emitted from the urine (urine prints). The urine prints of cervical cancer patients were differentiated from those of healthy controls.Results: Compared with healthy controls and cervical cancer patients, women had reliable accuracy (91% sensitivity, 85% specificity, and 89% accuracy).Conclusion: Our results demonstrated the applicability of VOC sensing for cervical cancer detection and its potential application in treatment monitoring.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social egg freezing among single females: Middle Eastern point of view. 单身女性的社会卵子冷冻：中东观点。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-07-01 DOI: 10.5468/ogs.24327

Rawia Sharaydih, Amal Akour, Haneen Al-Sabbah, Suha A AlMuhaissen

{"title":"Social egg freezing among single females: Middle Eastern point of view.","authors":"Rawia Sharaydih, Amal Akour, Haneen Al-Sabbah, Suha A AlMuhaissen","doi":"10.5468/ogs.24327","DOIUrl":"https://doi.org/10.5468/ogs.24327","url":null,"abstract":"Objective: This study aimed to assess the beliefs, barriers, and attitudes towards oocyte cryopreservation in Jordanian females. Understanding these aspects in our region can help healthcare providers identify similarities and differences compared to other geographic areas, which could facilitate a proper approach and informed counseling.Methods: We conducted a cross-sectional online survey using Google® forms (COMPANY, CITY, STATE, COUNTRY). The questions were designed to target a convenience sample of single women (never married, divorced, or widowed) aged 18-64 years in Jordan. Of the 400 women approached, 345 completed the questionnaire voluntarily. Responses were collected and analyzed using the software program SPSS® 23.0 (IBM, Armonk, NY, USA).Results: The results highlight notable deficiencies in women's understanding of the expenses, procedures, and success rates of oocyte freezing as a feasible method for fertility preservation. Most participants stated that the main barriers to oocyte cryopreservation were cost (87.5%), future husband rejection (76.8%), and social exclusion (72.2%). However, a significant number of participants admitted that this procedure would encourage late marriage and increase the chance of pregnancy in cases of late marriage and fertility problems.Conclusion: Women in this study had poor knowledge, but generally had positive attitudes toward oocyte cryopreservation. Educational campaigns are warranted to enhance knowledge and positive attitudes.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cauda equina syndrome following vaginal delivery. 阴道分娩后的马尾综合征。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-06-30 DOI: 10.5468/ogs.25166

Seung Jun Lee, So-Young Lee, Jun-Hwan Choi, Hyun Jung Lee, Hyun Jung Lee

引用次数: 0

Role of random blood glucose and HbA1c levels in optimizing glucose tolerance screening in early pregnancy: a retrospective cohort study. 随机血糖和糖化血红蛋白水平在优化妊娠早期糖耐量筛查中的作用：一项回顾性队列研究

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-06-27 DOI: 10.5468/ogs.25052

Yoshitsugu Chigusa, Yoshikazu Ikeda, Akitoshi Yamamura, Haruta Mogami, Akiko Nishimura, Satoshi Morita, Masaki Mandai, Shin-Ichi Harashima

{"title":"Role of random blood glucose and HbA1c levels in optimizing glucose tolerance screening in early pregnancy: a retrospective cohort study.","authors":"Yoshitsugu Chigusa, Yoshikazu Ikeda, Akitoshi Yamamura, Haruta Mogami, Akiko Nishimura, Satoshi Morita, Masaki Mandai, Shin-Ichi Harashima","doi":"10.5468/ogs.25052","DOIUrl":"https://doi.org/10.5468/ogs.25052","url":null,"abstract":"Objective: Random blood glucose (rBG) levels are commonly measured in Japan; however, no standardized cutoff values exist for glucose tolerance screening in early pregnancy. The contribution of glycated hemoglobin (HbA1c) and glycated albumin (GA) measurements to the diagnosis of gestational diabetes mellitus (GDM) remains unclear. Therefore, we aimed to evaluate the significance of these glycemic indicators in early pregnancy for predicting GDM.Methods: This observational cohort study enrolled pregnant women who underwent initial prenatal examinations to determine their rBG, HbA1c, and GA levels at a rural maternity facility. Clinical data were retrospectively reviewed.Results: A total of 449 patients were analyzed, comprising 394 with normal glucose tolerance (NGT) and 55 with GDM. The rBG, HbA1c, and GA levels were significantly higher during early pregnancy in women who developed GDM than in those with NGT. Receiver operating characteristic curve analysis revealed that the areas under the curve (AUC) for rBG, HbA1c, and GA were 0.733, 0.591, and 0.608, respectively, with cutoff values of 100 mg/dL, 5.2%, and 14.6%, respectively. These cutoff values had sensitivities of 52.7%, 70.9%, and 36.4% and specificities of 87.6%, 43.4%, and 82.5%, respectively. The product of rBG and HbA1c levels demonstrated improved performance, with an AUC of 0.750, cutoff value of 509, 63.6% sensitivity, and 83.5% specificity.Conclusion: Glucose tolerance screening in early pregnancy using an rBG level of 100 mg/dL and an HbA1c level of 5.2% as cutoff values may help identify high-risk cases and enable early diagnosis of GDM.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bleeding control and posterior vaginal fornix approach for cesarean hysterectomy in placenta accreta spectrum. 胎盘增生谱剖宫产子宫切除术的出血控制及阴道后穹窿入路。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-06-27 DOI: 10.5468/ogs.24216

Thiti Atjimakul, Kulisara Nanthamongkolkul, Ingporn Jiamset, Yuthasak Suphasynth, Aroontorn Pichatechaiyoot, Ekasak Thiangphak, Chayut Pongpanich, Athithan Ratttanaburi

{"title":"Bleeding control and posterior vaginal fornix approach for cesarean hysterectomy in placenta accreta spectrum.","authors":"Thiti Atjimakul, Kulisara Nanthamongkolkul, Ingporn Jiamset, Yuthasak Suphasynth, Aroontorn Pichatechaiyoot, Ekasak Thiangphak, Chayut Pongpanich, Athithan Ratttanaburi","doi":"10.5468/ogs.24216","DOIUrl":"https://doi.org/10.5468/ogs.24216","url":null,"abstract":"Objective: Placenta accreta spectrum (PAS) is a leading cause of massive obstetric hemorrhage, particularly when the placenta is removed or unintentionally disrupted during cesarean hysterectomy. In this video, we demonstrate an alternative surgical approach via the posterior vaginal fornix for performing cesarean hysterectomy in patients with PAS.Methods: A cesarean hysterectomy for a case of placenta percreta was performed using the posterior vaginal fornix approach. This technique focuses on avoiding bleeding due to placental disruption and preventing urinary bladder injury.Results: We summarize the steps of the procedure, including ligation of the vascular pedicles, entry into the retroperitoneal space to identify vital structures and control bleeding, dissection along avascular plane to delineate organ borders, and posterior culdotomy followed by en bloc uterine amputation to avoid urinary bladder injury and minimize blood loss.Conclusion: The posterior vaginal fornix approach for cesarean hysterectomy in patients with PAS is an effective technique for minimizing bleeding from the highly vascular placental area. Additionally, it offers the advantage of reducing the risk of unintentional urinary bladder injury, thereby improving surgical outcomes in these challenging cases.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overall survival after progression in patients with uterine carcinosarcoma: a single-center retrospective cohort study. 子宫癌肉瘤患者进展后的总生存率：一项单中心回顾性队列研究

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-06-23 DOI: 10.5468/ogs.24201

Rakchai Buhachat, Kanakarn Wangrangsimakul, Ekasak Thiangphak, Ingporn Jiamset

{"title":"Overall survival after progression in patients with uterine carcinosarcoma: a single-center retrospective cohort study.","authors":"Rakchai Buhachat, Kanakarn Wangrangsimakul, Ekasak Thiangphak, Ingporn Jiamset","doi":"10.5468/ogs.24201","DOIUrl":"https://doi.org/10.5468/ogs.24201","url":null,"abstract":"Objective: To investigate 2-year overall survival (OS) after progression in patients with uterine carcinosarcoma (UCS).Methods: This retrospective descriptive cohort study included patients diagnosed with progressive UCS at all stages, who underwent surgical staging with or without adjuvant therapy between January 2002 and December 2022. Clinicopathological characteristics, including recurrence patterns, were assessed using descriptive statistics, Fisher's exact test, and the chi-squared test. Prognostic factors and OS after progression were analyzed using the Cox proportional hazards model and Kaplan-Meier method, respectively.Results: Fifty-four patients (mean age, 61 years) were eligible for analysis. During primary treatment, 40 patients underwent optimal surgery, 44 received adjuvant chemotherapy with or without radiotherapy, and 43 developed progressive disease within the first 2 years (median progression-free interval: 10.5 months). Overall, 74.07% of patients developed distant or combined metastases. During salvage treatment, 22 patients received chemotherapy, 11 received a combination of chemotherapy and radiotherapy, and five underwent radiotherapy alone. The median follow-up period was 18 months, with a 2-year OS rate of 20% post-progression. Multivariate analysis revealed that leukocytosis at progression was associated with decreased survival (hazard ratio [HR], 5.98; 95% confidence interval [CI], 2.33-15.3; P<0.001). Notably, optimal primary surgery (HR, 0.31; 95% CI, 0.13-0.72; P=0.006) and chemoradiotherapy as salvage treatment (HR, 0.23; 95% CI, 0.08-0.7; P=0.009) significantly improved survival.Conclusion: Patients with progressive UCS have poor OS. Optimal surgery as primary treatment combined with salvage chemoradiotherapy improves post-progression survival. Leukocytosis during disease progression significantly affects survival outcomes.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of ultraviolet radiation on bone density and muscle strength in postmenopausal women: a randomized controlled study. 紫外线辐射对绝经后妇女骨密度和肌肉力量的影响：一项随机对照研究。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-06-19 DOI: 10.5468/ogs.25077

Wafaa M Kamal, Ahmed M Maged, Noha Salah, Nour A El-Goly, Wael El-Sherbiny, Elham S Hassan

{"title":"Impact of ultraviolet radiation on bone density and muscle strength in postmenopausal women: a randomized controlled study.","authors":"Wafaa M Kamal, Ahmed M Maged, Noha Salah, Nour A El-Goly, Wael El-Sherbiny, Elham S Hassan","doi":"10.5468/ogs.25077","DOIUrl":"https://doi.org/10.5468/ogs.25077","url":null,"abstract":"Objective: This study aimed to evaluate the effects of narrowband ultraviolet-B (UV-B) irradiation on bone and muscle health in postmenopausal women.Methods: A randomized controlled trial was conducted involving 70 postmenopausal women with vitamin D deficiency (<20 ng/mL) and osteopenia. Participants were randomly assigned to two groups. For 6 months, 35 postmenopausal women in study group (A) received three weekly sessions of narrowband UV-B therapy and vitamin D supplements in the form of 100,000 IU cholecalciferol weekly as loading therapy for 8 weeks. This was followed by the daily administration of cholecalciferol 3,000 IU as maintenance therapy for 16 weeks. The control group (B) consisted of thirty-five postmenopausal women who were administered vitamin D supplements alone for 6 months. ELISA kits were used to test the serum levels of 25-hydroxyvitamin D (25(OH)D), DEXA (COMPANY, CITY, STATE, COUNTRY) was used to test the bone mineral density of the lumbar spine and right femur, and a Biodex System 3 (COMPANY, CITY, STATE, COUNTRY) isokinetic dynamometer was used to assess the peak torque of the extensors and flexors of the dominant knee.Results: Serum 25(OH)D levels (P=0.000*), Lumbar T-score (P=0.008*), femoral T-score (P=0.002*), and knee extensor peak torque (P=0.030*) significantly increased in both groups after 6 months of treatment, favoring study group (A) over the control group (B).Conclusion: Narrowband UV-B combined with vitamin D3 supplementation is more effective than vitamin D supplementation alone.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0