Obstetrics and Gynecology Science最新文献

Recent Advances in Applications of Machine Learning in Cervical Cancer Research: A Focus on Prediction Models. 机器学习在宫颈癌研究中的应用进展：以预测模型为重点。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-29 DOI: 10.5468/ogs.25041

Syed S Abrar, Seoparjoo Azmel Mohd Isa, Suhaily Mohd Hairon, Mohd Pazudin Ismail, Mohd Nasrullah Bin Nik Ab Kadir

{"title":"Recent Advances in Applications of Machine Learning in Cervical Cancer Research: A Focus on Prediction Models.","authors":"Syed S Abrar, Seoparjoo Azmel Mohd Isa, Suhaily Mohd Hairon, Mohd Pazudin Ismail, Mohd Nasrullah Bin Nik Ab Kadir","doi":"10.5468/ogs.25041","DOIUrl":"https://doi.org/10.5468/ogs.25041","url":null,"abstract":"Artificial intelligence (AI) and machine learning (ML) are transforming cervical cancer research and offering advancements in diagnosis, prognosis, screening, and treatment. This review explores ML applications with particular emphasis on prediction models. A comprehensive literature search identified studies using ML for survival prediction, risk assessment, and treatment optimization. ML-driven prognostic models integrate clinical, histopathological, and genomic data to improve survival prediction and patient stratification. Screening methods, including deep-learning-based cytology analysis and HPV detection, enhance accuracy and efficiency. ML-driven imaging techniques facilitate early and precise cancer diagnosis, whereas risk prediction models assess susceptibility based on demographic and genetic factors. AI also optimizes treatment planning by predicting therapeutic responses and guiding personalized interventions. Despite significant progress, challenges remain regarding data availability, model interpretability, and clinical implementation. Standardized datasets, external validation, and cross-disciplinary collaborations are crucial for implementing ML innovations in clinical settings. Subsequent investigations should prioritize joint initiatives among data scientists, healthcare providers, and health authorities to translate AI innovations into real-world applications and to enhance the impact of ML on cervical cancer care. By synthesizing recent developments, this review highlights the potential of ML to improve clinical outcomes and shaping the future of cervical cancer management.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological considerations and future directions for research on COVID-19 vaccination and menstrual changes. COVID-19疫苗接种与月经变化研究的方法学思考及未来方向

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-29 DOI: 10.5468/ogs.25127

Noshaba Majeed, Shoaib Majeed, Jie Tu

引用次数: 0

Effect of L-carnitine supplementation on fertility outcomes among patients with polycystic ovary syndrome: a systematic review and dose-response meta-analysis of randomized clinical trials. 补充左旋肉碱对多囊卵巢综合征患者生育结局的影响：随机临床试验的系统评价和剂量反应荟萃分析

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-28 DOI: 10.5468/ogs.24272

Ahmed Abu-Zaid, Ghadeer Adel Alghamdi, Alaa Saleh Alharbi, Saeed Baradwan, Saleh A K Saleh, Heba M Adly, Mooza M Alzayed, Mohammed Abuzaid, Raghad Sindi, Mohannad Alsabban, Osama Alomar

{"title":"Effect of L-carnitine supplementation on fertility outcomes among patients with polycystic ovary syndrome: a systematic review and dose-response meta-analysis of randomized clinical trials.","authors":"Ahmed Abu-Zaid, Ghadeer Adel Alghamdi, Alaa Saleh Alharbi, Saeed Baradwan, Saleh A K Saleh, Heba M Adly, Mooza M Alzayed, Mohammed Abuzaid, Raghad Sindi, Mohannad Alsabban, Osama Alomar","doi":"10.5468/ogs.24272","DOIUrl":"https://doi.org/10.5468/ogs.24272","url":null,"abstract":"This systematic review and meta-analysis of randomized controlled trials (RCTs) assessed the effect of L-carnitine (LC) supplementation on the fertility outcomes of patients with polycystic ovary syndrome (PCOS). Online databases (Scopus, Web of Science, Cochrane Library, EMBASE, and PubMed) were searched to identify eligible RCTs published until March 2024. A dose-response meta-analysis was performed using a random-effects model. Meta-regression was also performed to investigate the source of heterogeneity based on the LC dose and duration of treatment. The pooled analysis included eight RCTs with 1,046 participants. The LC-treated group had significantly increased chemical and clinical pregnancy rates, ovulation rate, progesterone levels, number of preovulatory follicles >17 mm in diameter, and endometrial thickness compared to the untreated groups. The meta-analysis model indicated that LC supplementation did not change the serum levels of estrogen and testosterone; however, the dose-response meta-analysis indicated that prolonged LC intake significantly increased estrogen levels. LC supplementation has significant effects on fertility outcomes of women with PCOS. Additional large-scale longer RCTs are required to confirm the findings of this study.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Executive summary: indonesian guidelines on polycystic ovary syndrome management. 执行摘要：印度尼西亚多囊卵巢综合征管理指南。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.5468/ogs.24288

Mila Maidarti, Achmad Kemal Harzif, Amalia Shadrina, Nafi'atul Ummah, Wiryawan Permadi

{"title":"Executive summary: indonesian guidelines on polycystic ovary syndrome management.","authors":"Mila Maidarti, Achmad Kemal Harzif, Amalia Shadrina, Nafi'atul Ummah, Wiryawan Permadi","doi":"10.5468/ogs.24288","DOIUrl":"10.5468/ogs.24288","url":null,"abstract":"Objective: Polycystic ovary syndrome (PCOS) is a gynecological, endocrine condition characterized by ovulatory disorders, clinical or biochemical hyperandrogenism, and polycystic ovarian morphology. PCOS has significant metabolic and reproductive implications that affect the quality of life of women. This PCOS guideline summary is based on the Indonesian Reproductive Endocrinology and Fertility Association guidelines for PCOS. This guideline is expected to guide the diagnosis and long-term management of PCOS.Methods: We searched scientific evidence on the Cochrane and PubMed databases using the keyword \"polycystic ovary syndrome\". This evidence was reviewed by experts in the field of obstetrics and gynecology, and recommendations were made based on scientific evidence while considering patient values, costs, and resources.Results: A total of 127 recommendations and practice points were made regarding the diagnosis and management of PCOS. The levels of available health services and management algorithms for PCOS in Indonesia are also included.Conclusion: The first-line treatment for managing hyperandrogenism and menstrual disorders in patients with PCOS is combined oral contraceptives. The first-line treatment for ovulation induction is letrozole, while clomiphene citrate, metformin, gonadotropins, and ovarian surgery serve as the second-line treatment. The third-line treatments included in vitro fertilization, with or without in vitro maturation.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"221-236"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sentinel lymph node biopsy in low- and intermediaterisk endometrial carcinoma. 低、中危子宫内膜癌前哨淋巴结活检。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.5468/ogs.25050

Christos Iavazzo, Ioannis D Gkegkes

引用次数: 0

Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis. 组织蛋白酶与女性不孕症的因果关系：双向孟德尔随机分析。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.5468/ogs.24254

Lidan Liu, Ming Liao, Bo Liu, Qianyi Huang, Huimei Wu, Mujun Li

{"title":"Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis.","authors":"Lidan Liu, Ming Liao, Bo Liu, Qianyi Huang, Huimei Wu, Mujun Li","doi":"10.5468/ogs.24254","DOIUrl":"10.5468/ogs.24254","url":null,"abstract":"Objective: This study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR).Methods: .Methods: A bidirectional MR analysis was conducted utilizing single nucleotide polymorphisms as instrumental variables to investigate the potential causal effects between nine cathepsins and female infertility. Genetic data on female infertility were sourced from the FinnGen study, and cathepsin-related data were obtained from genome-wide association studies datasets of European ancestry.Results: Elevated levels of cathepsin E were significantly and inversely associated with the risk of female infertility, suggesting a potential protective role. This finding was further supported by multivariable MR analysis. However, no significant associations were observed between the other eight cathepsins and female infertility.Conclusion: This study represents the first systematic MR analysis to identify a potential protective effect of cathepsin E on female infertility.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"237-243"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journey of infertile couples: scoping the barriers for infertility care among infertile women in Morocco. 不孕夫妇之旅：确定摩洛哥不孕妇女不孕护理的障碍。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.5468/ogs.24259

Meriem Ouadrhiri, Chaymae Rochdi, Rachida Archou, Mounia Amazian, Mustapha Boucetta, Nawal Mouhoute, Nisrine Mamouni, Kamelia Amazian

{"title":"Journey of infertile couples: scoping the barriers for infertility care among infertile women in Morocco.","authors":"Meriem Ouadrhiri, Chaymae Rochdi, Rachida Archou, Mounia Amazian, Mustapha Boucetta, Nawal Mouhoute, Nisrine Mamouni, Kamelia Amazian","doi":"10.5468/ogs.24259","DOIUrl":"10.5468/ogs.24259","url":null,"abstract":"Objective: The World Health Organization recognized infertility as a disease and emphasized universal access to high-quality treatment. Nevertheless, inequality and inequity in infertility care are pervasive in Morocco, access to care is hindered by multiple potential barriers delaying treatment seeking and management. This study aimed to explore factors and barriers to assisted reproductive technology (ART) among infertile women in Morocco.Methods: This is a cross-sectional analytical study relies on prospective data collected through a standardized questionnaire, was carried out in January-June 2023. The target population concerned 110 infertile women attending a private clinic in Morocco.Results: Women who experienced infertility in Morrocco have demonstrated several barriers including: cost and lack of financial means (90%) and distance from fertility care (80%). On bivariate analysis findings suggest there are multifactorial factors that influence access to ART: the age, marriage span, monthly household income, duration of infertility, and education level and profession. On multivariable logistic analysis, age over 35 years old (odds ratio [OR], 3.36; 95% confidence interval [CI], 1.07-10.65; P=0.004) and the duration of infertility over 10 years (OR, 5.59; 95% CI, 1.24-25.24; P=0.003) remained significantly associated with women who had undergone ART.Conclusion: This study has demonstrated that infertile women confront economic barriers, social pressure, and constraints related to health systems. Women over the age of 35 with the duration of infertility exceeding 10 years are certainly making more considerable economic efforts to access ART. Policy-makers must to take into account these barriers and factors to ensure efficient access to ART.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"186-197"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation between pelvic organ prolapse and menopausal hormone therapy: nationwide cohort study. 盆腔器官脱垂与绝经期激素治疗的关系：全国性队列研究。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.5468/ogs.24071

Hee-Yeong Jung, Tae-Ran Kim, Gwan Hee Han, Jin-Sung Yuk

{"title":"Relation between pelvic organ prolapse and menopausal hormone therapy: nationwide cohort study.","authors":"Hee-Yeong Jung, Tae-Ran Kim, Gwan Hee Han, Jin-Sung Yuk","doi":"10.5468/ogs.24071","DOIUrl":"10.5468/ogs.24071","url":null,"abstract":"Objective: To analyze the relationship between pelvic organ prolapse (POP) and menopausal hormone therapy (MHT).Methods: This retrospective cohort study used Korean National Health checkup and insurance data from 2002 to 2019. Women who used MHT for more than 6 months between 2002 and 2011 were included in the MHT group; postmenopausal women with no MHT use comprised the non-MHT group.Results: In the non-MHT group, there were 1,001,350 women, while the MHT group had 353,206 women. Tibolone (adjusted hazard ratio [aHR], 0.87; 99% confidence interval [CI], 0.818-0.926) and combined estrogen plus progestin by the manufacturer (CEPM) (aHR, 0.821; 99% CI, 0.758-0.89) were associated with reduced POP risk. The other oral MHT groups and the transdermal estrogen group showed no significant difference in POP risk compared with the non-MHT group (other oral MHT: aHR, 1.045; 99% CI, 0.941-1.161) (transdermal estrogen: aHR, 1.252; 99% CI, 0.731-2.145). Lower body mass index (BMI) (<18.5) was associated with reduced POP risk (aHR, 0.822; 99% CI, 0.698-0.968), while a BMI between 23 and 29.9 was associated with increased risk (BMI 23-24.9: aHR, 1.143; 99% CI, 1.088-1.2) (BMI 25-29.9: aHR, 1.173; 99% CI, 1.12-1.228). All parities had a higher POP risk than parity 1 (parity 0 or no response: aHR, 1.785; 99% CI, 1.589-2.005; parity 2: aHR, 1.434; 99% CI, 1.292-1.592; parity ≥3: aHR, 1.916; 99% CI, 1.712-2.144).Conclusion: Tibolone and CEPM use were associated with reduced POP risk in postmenopausal women. Other MHT types showed no significant association with POP.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"210-220"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical practice in office hysteroscopy. 宫腔镜的临床应用。

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-01 Epub Date: 2025-04-04 DOI: 10.5468/ogs.24234

Namkung Jeong, Angela Cho, Yu-Jin Koo, Jun-Woo Ahn, Hyuntae Park, Eun Sil Lee, Sang Wook Yi, Won Duk Joo, Sang-Hoon Lee, Jae Kwan Lee, Sa Ra Lee

{"title":"Clinical practice in office hysteroscopy.","authors":"Namkung Jeong, Angela Cho, Yu-Jin Koo, Jun-Woo Ahn, Hyuntae Park, Eun Sil Lee, Sang Wook Yi, Won Duk Joo, Sang-Hoon Lee, Jae Kwan Lee, Sa Ra Lee","doi":"10.5468/ogs.24234","DOIUrl":"10.5468/ogs.24234","url":null,"abstract":"Hysteroscopy is particularly valuable for the diagnosis of uterine cavity abnormalities through direct visualization. The development of office hysteroscopy has expanded the range of diagnostic and surgical procedures available. These detailed guidelines include patient counseling and the selection and setting of office hysteroscopy, including room, equipment, and medical staff. Analgesia or local anesthesia is often required in selective office hysteroscopy cases. Cervical dilation and preparation using medical or mechanical methods are required for most diagnostic hysteroscopic procedures. Methods for optimizing visualization and choosing suitable distension media are important for a successful office hysteroscopy. It is crucial to adhere to guidelines to prevent complications, such as vasovagal syncope, cervical trauma, uterine perforation, fluid overload, and embolism. Vaginoscopy can be a good alternative option for alleviating pain, especially in cases where the insertion of a vaginal speculum is expected to be challenging.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"175-185"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and occupational risk factors of male infertility based on 3,025 patients in Eastern Morocco during 2021-2023: a cohort study. 2021-2023年摩洛哥东部3025例男性不育症的流行病学和职业危险因素：一项队列研究

IF 2

Obstetrics and Gynecology Science Pub Date : 2025-05-01 Epub Date: 2025-03-17 DOI: 10.5468/ogs.24297

Chaymae Rochdi, Meriem Ouadrhiri, Ibtissam Bellajdel, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni, Mohammed Choukri

{"title":"Epidemiology and occupational risk factors of male infertility based on 3,025 patients in Eastern Morocco during 2021-2023: a cohort study.","authors":"Chaymae Rochdi, Meriem Ouadrhiri, Ibtissam Bellajdel, Hafsa Taheri, Hanane Saadi, Ahmed Mimouni, Mohammed Choukri","doi":"10.5468/ogs.24297","DOIUrl":"10.5468/ogs.24297","url":null,"abstract":"Objective: The objective of our study was to characterize the sperm parameters of men consulting for infertility in our fertility center.Methods: The study included 3,025 patients investigated from September 2021 to July 2023. Demographic data, infertility risk factors, and the primary or secondary nature of infertility were recorded for each patient. The sperm parameters were analyzed according to World Health Organization (WHO) criteria (2021).Results: The average age of the patients was 40 years. The average duration of infertility was 5.5 years. Primary infertility was noted in 2,736 patients (88.97%). The most common risk factors for infertility were occupational exposure, followed by varicocele. Lifestyle factors associated with male infertility included smoking (24.29%), alcohol consumption (12.49%), and high temperature exposure (30.08%). Spermogram abnormalities were observed in 78.71% of cases. Spermocytogram abnormalities were found in 63.1% of cases. Sperm count, morphology, total motility, and vitality below WHO (2021) reference values were found in 25.60%, 34.13%, 32.29%, and 62.46% of the analyzed samples, respectively. Seminal fluid analysis revealed oligozoospermia in 29.07% of cases, asthenozoospermia in 24.68%, and azoospermia in 17.56%. Oligo-astheno-necrospermia was the most frequently observed combined abnormality (10.0%).Conclusion: This study showed a high rate of abnormal semen quality in male partners of infertile couples. Male infertility is often multifactorial and results in quantitative and/or qualitative sperm abnormalities.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"198-209"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0