Obstetrics and Gynecology Science最新文献

Significance of sentinel lymph node biopsy in low- and intermediate- risk endometrial cancer: a study at tertiary care centre, India.

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-12-18 DOI: 10.5468/ogs.24182

Kanika Batra Modi, Arnika Kumari Kashyap, Manvika Chandel, Komal Agrawal, Harit Kumar Chaturvedi

{"title":"Significance of sentinel lymph node biopsy in low- and intermediate- risk endometrial cancer: a study at tertiary care centre, India.","authors":"Kanika Batra Modi, Arnika Kumari Kashyap, Manvika Chandel, Komal Agrawal, Harit Kumar Chaturvedi","doi":"10.5468/ogs.24182","DOIUrl":"https://doi.org/10.5468/ogs.24182","url":null,"abstract":"Objective: To evaluate the incidence of sentinel lymph node (SLN) metastasis observed in patients with presumed low- and intermediate-risk endometrial cancer (EC) and change in stage and adjuvant therapy resulting from SLN analysis. Secondary objectives include assessing the rates of detection of SLN using indocyanine green (ICG) dye and complication rates.Methods: Between March 2017 and December 2023, 210 patients were included in the study. A total of 412 SLNs were detected in 210 patients using intracervical ICG dye injections.Results: The pathologically confirmed detection rate was >95%. A total of 25 (11.9%) patients exhibited positive sentinel metastasis detected through pathological and immunohistochemical analysis, with isolated tumor cell in 5 (2.4%), micro-metastasis in 6 (2.9%), and macro-metastasis in 14 (6.7%) patients. SLN metastasis with micro- and macro-metastases changed to stage III; therefore, adjuvant therapy was administered in the form of chemotherapy and radiation therapy. Of the 210 patients, 186 (88.5%) remained at low and intermediate risk after the final histopathological analysis. The other 24 patients exhibited SLN metastasis, high-grade EC, higher-stage detection, or high risk on molecular profiling.Conclusion: A change in stage was observed in 11.9% of patients, and adjuvant therapy was administered to 20 patients, of whom 16 received adjuvant therapy based solely on SLN involvement (in the form of micro- and macro-metastasis), thus preventing undertreatment. Overtreatment was reduced in six patients who were classified as high-grade and non-endometrioid types with SLN metastases.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance and limitations of routine p16/Ki-67 immunohistochemistry as a diagnostic tool for high-grade squamous intraepithelial lesions of the uterine cervix. 常规 p16/Ki-67 免疫组化作为宫颈高级别鳞状上皮内病变诊断工具的意义和局限性。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-12-18 DOI: 10.5468/ogs.24236

Kazutaka Ozono, Fumi Kawakami, Yoshiki Mikami

{"title":"Significance and limitations of routine p16/Ki-67 immunohistochemistry as a diagnostic tool for high-grade squamous intraepithelial lesions of the uterine cervix.","authors":"Kazutaka Ozono, Fumi Kawakami, Yoshiki Mikami","doi":"10.5468/ogs.24236","DOIUrl":"https://doi.org/10.5468/ogs.24236","url":null,"abstract":"Objective: To evaluate the diagnostic utility and limitations of routine p16 and Ki-67 immunohistochemistry (IHC) in detecting high-grade squamous intraepithelial lesions (HSILs) in the uterine cervix.Methods: We reviewed 2,061 cervical biopsy records, including 271 morphologically indeterminate squamous lesions, evaluated using p16/Ki-67 IHC for HSIL detection or exclusion. HSIL was diagnosed based on p16 positivity and a high Ki-67 labeling index (Ki-LI). In cases that remained inconclusive after IHC, follow-up histological and/or cytological outcomes were assessed.Results: p16/Ki-67 IHC established a definitive diagnosis of either HSIL or non-HSIL in 74.2% (201/271) of morphologically indeterminate cases, whereas 25.8% (70/271) remained inconclusive. p16/Ki-67 IHC contributed to the diagnosis of HSIL in 120 cases, representing 11.9% (120/1,011) of all HSILs cases and 44.3% (120/271) of morphologically indeterminate cases. Among the 70 inconclusive cases, 58 had available follow-up data, of which 22 were subsequently diagnosed with HSIL, including 12 within 1 month of the initial biopsy. HSIL outcomes were more frequent in cases with suspicious HSIL on the initial biopsy (66.7 [12/18]). Based on the p16/Ki-LI status, patients with HSIL outcomes were categorized into three groups: p16-positive/low Ki-LI (54.2 [13/24]), p16-negative/high Ki-LI (50.0 [5/10]), and p16-negative/low Ki-LI (16.7 [4/24]). Multiple comparisons revealed a significant difference between the p16-positive/low Ki-LI and p16-negative/low Ki-LI groups (Benjamini-Yekutieli adjusted P=0.0435), whereas no significant difference was found between other groups.Conclusion: IHC using p16/Ki-67 significantly improved the diagnostic performance for HSIL. In cases that remain inconclusive after IHC, IHC-based risk stratification offers a valuable approach for surveillance, thus mitigating delays in HSIL diagnosis.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical evaluation and management of endometriosis: 2024 guideline for Korean patients from the Korean Society of Endometriosis.

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-12-11 DOI: 10.5468/ogs.24242

Hyun Joo Lee, Sang-Hee Yoon, Jae Hoon Lee, Youn-Jee Chung, So Yun Park, Sung Woo Kim, Yeon Hee Hong, Sung Eun Kim, Youjin Kim, Sungwook Chun, Yong Jin Na

引用次数: 0

The role of placenta Hofbauer cells during pregnancy and pregnancy complications.

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-12-11 DOI: 10.5468/ogs.24247

Seung-Woo Yang, Han-Sung Hwang, Young-Sun Kang

{"title":"The role of placenta Hofbauer cells during pregnancy and pregnancy complications.","authors":"Seung-Woo Yang, Han-Sung Hwang, Young-Sun Kang","doi":"10.5468/ogs.24247","DOIUrl":"https://doi.org/10.5468/ogs.24247","url":null,"abstract":"Placental Hofbauer cells (HBCs) are specialized macrophages present in the human placenta that play a crucial role in maintaining a healthy pregnancy. These cells are derived from the fetal mesoderm and are responsible for various functions, including immune regulation, angiogenesis, and nutrient transport. In normal pregnancies, HBCs primarily exhibit an M2 or immunomodulatory phenotype, which helps maintain a tolerant and anti-inflammatory environment at the maternal-fetal interface. However, in pregnancies complicated by conditions such as immunological disorders, inflammation, or infection, the phenotype and function of HBCs may be altered. Although emerging evidence has highlighted the vital role of HBCs in both normal pregnancies and those with complications, such as chorioamnionitis, gestational diabetes, preeclampsia, and viral infections, their role remains unclear. Recent research also suggests a relationship between HBCs and the development of diseases in offspring. Understanding the role of HBCs in pregnancy could provide insights into the pathophysiology of various pregnancy-related disorders and offer potential therapeutic targets for improving maternal and fetal outcomes. This review explores the functions of HBCs in normal pregnancy and their involvement in complications, emphasizing their potential as biomarkers or targets for interventions aimed at reducing the incidence of adverse pregnancy outcomes. Additionally, we reviewed their potential for perinatal research in recent studies.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal biometry measurements in diabetic pregnant women and neonatal outcomes.

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-29 DOI: 10.5468/ogs.24230

Aram Heo, Jinha Chung, Seula Lee, Hyunjin Cho

{"title":"Fetal biometry measurements in diabetic pregnant women and neonatal outcomes.","authors":"Aram Heo, Jinha Chung, Seula Lee, Hyunjin Cho","doi":"10.5468/ogs.24230","DOIUrl":"https://doi.org/10.5468/ogs.24230","url":null,"abstract":"Objective: In this study, we aimed to investigate how fetal head and abdominal circumferences are related to the incidence of neonatal complications in mothers with gestational mellitus (GDM) and pre-gestational diabetes mellitus (PGDM) compared to normal pregnancies.Methods: We retrospectively analyzed data of expectant mothers with GDM, PGDM, and normal pregnancies who delivered singleton full-term infants (≥37 weeks) at a tertiary center from January 2013 to December 2022. Ultrasonography-measured fetal weight, fetal head circumference, fetal abdominal circumference, difference between head and abdominal circumference, and head-to-abdominal circumference ratio were assessed. Neonatal outcomes were evaluated based on the rates of admission to the neonatal intensive care unit, intubation, and hypoglycemia. Statistical analyses, including univariate and multivariate analyses, were performed using the SPSS software (COMPANY, CITY, STATE, COUNTRY).Results: Among the 473 participants, 175 (37.0%) were mothers with diabetes (DM). A head-to-abdominal circumference ratio <0.95 and a difference of ≥2.5 cm were significantly associated with neonatal hypoglycemia in all mothers with DM, with statistical significance noted only in the PGDM group. No significant association was observed in normal pregnancies.Conclusion: Our findings indicate that a head-to-abdominal circumference ratio <0.95 and a ≥2.5 cm difference in circumferences are associated with neonatal hypoglycemia in mothers with DM.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends, statistics, and policy recommendations on maternal, fetal, and infant mortality before and after COVID-19: a review of the past decade (2012-2022) based on national health information data. COVID-19 前后的孕产妇、胎儿和婴儿死亡率趋势、统计数据和政策建议：基于国家健康信息数据的过去十年（2012-2022 年）回顾。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-27 DOI: 10.5468/ogs.24264

Kyung Ju Lee, Seokmin Lee

{"title":"Trends, statistics, and policy recommendations on maternal, fetal, and infant mortality before and after COVID-19: a review of the past decade (2012-2022) based on national health information data.","authors":"Kyung Ju Lee, Seokmin Lee","doi":"10.5468/ogs.24264","DOIUrl":"https://doi.org/10.5468/ogs.24264","url":null,"abstract":"Objective: To examine the impact of the coronavirus disease 2019 (COVID-19) pandemic on maternal, fetal, and infant mortality in South Korea using national statistics, in order to inform policy development and enhance maternal and child health outcomes with the provided data.Methods: Pregnancy-related mortality in women, as well as deaths of infants, in South Korea was identified using cause-of-death statistics from Statistics Korea. Records from death certificates, cremation reports on infant and fetal deaths, and the complementary cause-of-death investigation system were reviewed for the 2012-2022 period. The classification criteria for cause of death followed the recommendations of World Health Organization and the Korean standard classification of diseases and causes of death.Results: The maternal mortality rate decreased from 11.3 per 100,000 live births in 2018 to 9.9 in 2019, rose to 11.8 in 2020, and fell to 8.8 in 2021.The actual number of maternal deaths declined from 37 in 2018 to 23 in 2021 due to fewer births. The fetal death rate increased from 11.3 per 1,000 live births in 2018 to 11.6 in 2019, continuing to rise to 12.0 in 2021. The number of fetal deaths dropped from 3,743 in 2018 to 3,152 in 2021.Conclusion: Despite the COVID-19 pandemic, Korea experienced a sharp decline in births as well as in maternal, infant, and fetal deaths. However, maternal, infant, and fetal mortality rates remained at similar levels.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent development of nanotechnology-based approaches for gynecologic cancer therapy. 基于纳米技术的妇科癌症治疗方法的最新发展。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-26 DOI: 10.5468/ogs.24180

Gangaraju Gedda, Yoo-Jin Park, Myung-Geol Pang

引用次数: 0

Usefulness and limitations of ChatGPT in getting information on teratogenic drugs exposed in pregnancy. ChatGPT 在获取孕期接触的致畸药物信息方面的实用性和局限性。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-20 DOI: 10.5468/ogs.24231

Jung Yeol Han

{"title":"Usefulness and limitations of ChatGPT in getting information on teratogenic drugs exposed in pregnancy.","authors":"Jung Yeol Han","doi":"10.5468/ogs.24231","DOIUrl":"https://doi.org/10.5468/ogs.24231","url":null,"abstract":"There is a growing interest in using artificial intelligence (AI) technology to obtain information on the risk and safety of drugs in pregnancy. Inadvertent drug exposure in pregnant women is inevitable in acute or chronic diseases, especially in unplanned pregnancies. According to the Korean mother safe counselling center database (2010-2023), many Korean pregnant women and their families asked about the teratogenicity of their exposed drugs. The most frequently used drug was topiramate (n=2,018), followed by isotretinoin (n=1,972), dexamethasone (n=1,279), and doxycycline (n=1,119). Unexpectedly, thalidomide, a notorious teratogen that causes phocomelia, was included. It has been withdrawn from general prescriptions since 1961, except for the treatment of multiple myeloma. Her partner used it for the treatment of multiple myeloma. In this study, we evaluated the usefulness of AI Chat generative pretrained transformer (Chat GPT) by comparing information between AI and a literature review on isotretinoin, a well-known teratogen to which Korean pregnant women are frequently exposed. ChatGPT provides general information on teratogenicity for pregnant women and medical providers rather than on their exposure. Thus, AI can induce unnecessary termination of pregnancy due to misinformation and misperception in cases of notorious teratogens such as isotretinoin. Therefore, counseling on the teratogenicity of medication exposure in pregnancy must be performed with ChatGPT, as well as a literature review. Further studies are required to obtain more individualized information using AI in the field of teratology.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current approach of patients with Mayer-Rokitansky-Küster-Hauser syndrome. 梅尔-罗基坦斯基-鞠斯特-豪泽尔综合征患者的当前治疗方法。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-20 DOI: 10.5468/ogs.24099

Christos Iavazzo, Panagiotis Peitsidis, Ioannis D Gkegkes

引用次数: 0

Comparative analysis of ferric carboxymaltose and iron sucrose in treating iron deficiency anemia in perimenopausal women with heavy menstrual bleeding: a randomized controlled trial. 羧甲基铁和蔗糖铁治疗月经过多围绝经期妇女缺铁性贫血的比较分析：随机对照试验。

IF 2

Obstetrics and Gynecology Science Pub Date : 2024-11-01 Epub Date: 2024-11-04 DOI: 10.5468/ogs.24065

Jaya Chaturvedi, Rupendra K, Anupama Bahadur, Ayush Heda, Rajlaxmi Mundhra

{"title":"Comparative analysis of ferric carboxymaltose and iron sucrose in treating iron deficiency anemia in perimenopausal women with heavy menstrual bleeding: a randomized controlled trial.","authors":"Jaya Chaturvedi, Rupendra K, Anupama Bahadur, Ayush Heda, Rajlaxmi Mundhra","doi":"10.5468/ogs.24065","DOIUrl":"10.5468/ogs.24065","url":null,"abstract":"Objective: To evaluate the impact of intravenous ferric carboxymaltose (FCM) compared to iron sucrose (ISC) in perimenopausal women with heavy menstrual bleeding (HMB) and anemia.Methods: This prospective, open-label, randomized controlled trial enrolled perimenopausal women (40-50 years) with HMB and hemoglobin levels between 6-10 g/dL, intolerant or non-compliant to oral iron therapy. The study compared FCM and ISC by assessing hematological parameters, including hemoglobin, ferritin, and iron levels, over a 12-week period. The patients were followed up at 3, 6, and 12 weeks after initiation. The adverse effects were also evaluated.Results: The study included 60 perimenopausal women, with 30 in each group. The baseline patient characteristics were comparable. FCM demonstrated a statistically significant higher mean increase in hemoglobin (4.97 g/dL) than ISC (4.63 g/dL) over 12 weeks. The proportion of patients achieving correction of anemia (hemoglobin ≥12 g/dL) was higher in the FCM group (75.9% vs. 65.5%). Serum ferritin levels were significantly higher in the FCM group after 3 weeks. Adverse effects were minimal and comparable between the groups. Although the direct cost of FCM is high, its ability to be administered in larger doses may result in lower total costs.Conclusion: In perimenopausal women with heavy menstrual bleeding and iron deficiency anemia, FCM and ISC show comparable efficacy in increasing hemoglobin levels with similar side effect profiles. This study highlights the potential benefits of FCM and calls for further exploration of these therapies in diverse patient populations.","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":"565-573"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11581812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0