{"title":"红细胞指标作为子宫内膜异位症严重程度的预测指标。","authors":"Josua Simanjuntak, Edy Priyanto, M Alamsyah Azis","doi":"10.5468/ogs.25080","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Endometriosis is the presence of endometrial tissue outside of the uterine cavity. Certain markers have been used to evaluate the severity of endometriosis. This study aimed to explore the correlation between red blood cell (RBC) indices and the severity of endometriosis.</p><p><strong>Methods: </strong>This was a cross-sectional study including 200 patients with endometriosis (stage I-II and stage III-IV groups) and 100 patients with other benign ovarian tumors who underwent laparotomy at the Department of Obstetrics and Gynaecology, Margono Regional Public Hospital, between 2021 and 2024. Blood tests were evaluated before surgery, and the severity of endometriosis was determined during surgery using the revised American Society for Reproductive Medicine classification.</p><p><strong>Results: </strong>Among the obtained RBC indices, mean hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) values were significantly lower in subjects with stage III-IV endometriosis than in those with stage I-II endometriosis and the control group (P=0.000, P =0.000, P=0.006, and P=0.010, respectively). The mean red cell distribution width (RDW) was significantly higher in the stage III-IV group than in the stage I-II and control groups (P=0.000). In addition, univariate analysis indicated that lower preoperative RBC indices (Hb ≤11.9 g/dL, Hct ≤37.1%, MCV ≤82.6 fL, MCH ≤26.6 pg) and higher RDW (≥14.9%) were independent risk factors for stage III/IV endometriosis.</p><p><strong>Conclusion: </strong>Lower RBC indices, including pre-operative Hb, Hct, MCV, and MCH, were significantly associated with the severity of endometriosis, which is potentially caused by dysregulation of iron metabolism and inflammation.</p>","PeriodicalId":37602,"journal":{"name":"Obstetrics and Gynecology Science","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Red blood cell indices as predictor for severity of endometriosis.\",\"authors\":\"Josua Simanjuntak, Edy Priyanto, M Alamsyah Azis\",\"doi\":\"10.5468/ogs.25080\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Endometriosis is the presence of endometrial tissue outside of the uterine cavity. Certain markers have been used to evaluate the severity of endometriosis. This study aimed to explore the correlation between red blood cell (RBC) indices and the severity of endometriosis.</p><p><strong>Methods: </strong>This was a cross-sectional study including 200 patients with endometriosis (stage I-II and stage III-IV groups) and 100 patients with other benign ovarian tumors who underwent laparotomy at the Department of Obstetrics and Gynaecology, Margono Regional Public Hospital, between 2021 and 2024. Blood tests were evaluated before surgery, and the severity of endometriosis was determined during surgery using the revised American Society for Reproductive Medicine classification.</p><p><strong>Results: </strong>Among the obtained RBC indices, mean hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) values were significantly lower in subjects with stage III-IV endometriosis than in those with stage I-II endometriosis and the control group (P=0.000, P =0.000, P=0.006, and P=0.010, respectively). The mean red cell distribution width (RDW) was significantly higher in the stage III-IV group than in the stage I-II and control groups (P=0.000). In addition, univariate analysis indicated that lower preoperative RBC indices (Hb ≤11.9 g/dL, Hct ≤37.1%, MCV ≤82.6 fL, MCH ≤26.6 pg) and higher RDW (≥14.9%) were independent risk factors for stage III/IV endometriosis.</p><p><strong>Conclusion: </strong>Lower RBC indices, including pre-operative Hb, Hct, MCV, and MCH, were significantly associated with the severity of endometriosis, which is potentially caused by dysregulation of iron metabolism and inflammation.</p>\",\"PeriodicalId\":37602,\"journal\":{\"name\":\"Obstetrics and Gynecology Science\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obstetrics and Gynecology Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5468/ogs.25080\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obstetrics and Gynecology Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5468/ogs.25080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Red blood cell indices as predictor for severity of endometriosis.
Objective: Endometriosis is the presence of endometrial tissue outside of the uterine cavity. Certain markers have been used to evaluate the severity of endometriosis. This study aimed to explore the correlation between red blood cell (RBC) indices and the severity of endometriosis.
Methods: This was a cross-sectional study including 200 patients with endometriosis (stage I-II and stage III-IV groups) and 100 patients with other benign ovarian tumors who underwent laparotomy at the Department of Obstetrics and Gynaecology, Margono Regional Public Hospital, between 2021 and 2024. Blood tests were evaluated before surgery, and the severity of endometriosis was determined during surgery using the revised American Society for Reproductive Medicine classification.
Results: Among the obtained RBC indices, mean hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) values were significantly lower in subjects with stage III-IV endometriosis than in those with stage I-II endometriosis and the control group (P=0.000, P =0.000, P=0.006, and P=0.010, respectively). The mean red cell distribution width (RDW) was significantly higher in the stage III-IV group than in the stage I-II and control groups (P=0.000). In addition, univariate analysis indicated that lower preoperative RBC indices (Hb ≤11.9 g/dL, Hct ≤37.1%, MCV ≤82.6 fL, MCH ≤26.6 pg) and higher RDW (≥14.9%) were independent risk factors for stage III/IV endometriosis.
Conclusion: Lower RBC indices, including pre-operative Hb, Hct, MCV, and MCH, were significantly associated with the severity of endometriosis, which is potentially caused by dysregulation of iron metabolism and inflammation.
期刊介绍：
Obstetrics & Gynecology Science (NLM title: Obstet Gynecol Sci) is an international peer-review journal that published basic, translational, clinical research, and clinical practice guideline to promote women’s health and prevent obstetric and gynecologic disorders. The journal has an international editorial board and is published in English on the 15th day of every other month. Submitted manuscripts should not contain previously published material and should not be under consideration for publication elsewhere. The journal has been publishing articles since 1958. The aim of the journal is to publish original articles, reviews, case reports, short communications, letters to the editor, and video articles that have the potential to change the practices in women''s health care. The journal’s main focus is the diagnosis, treatment, prediction, and prevention of obstetric and gynecologic disorders. Because the life expectancy of Korean and Asian women is increasing, the journal''s editors are particularly interested in the health of elderly women in these population groups. The journal also publishes articles about reproductive biology, stem cell research, and artificial intelligence research for women; additionally, it provides insights into the physiology and mechanisms of obstetric and gynecologic diseases.
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