挥发性有机化合物（VOC）的鉴定作为宫颈癌检测的新方法。

IF 2 Q2 OBSTETRICS & GYNECOLOGY

Obstetrics and Gynecology Science Pub Date : 2025-07-01 DOI:10.5468/ogs.25038

Muhammad Ary Zucha, Dian Kesumapramudya Nurputra, Ardhanu Kusumanto, Shidiq Nur Hidayat, Kuwat Triyana, Widha Apriani Priadi, Nadia Yasmine, Ova Emilia

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引用次数: 0

摘要

目的：在本研究中，我们开发了一种基于挥发性有机化合物（VOC）传感的新型检测策略。人乳头瘤病毒（HPV）的持续感染可能引起宫颈上皮的生物学变化，导致挥发性有机化合物的产生。方法：本研究包括200例宫颈癌患者和hpv阴性对照组的尿液样本。尿液样本的收集和测量使用由10个传感器矩阵组成的气体传感器阵列。对于每个分析样本，仪器产生一个矢量信号，编码从尿液（尿液指纹）释放的挥发性有机化合物。宫颈癌患者的尿纹与健康对照有明显的区别。结果：与健康对照组和宫颈癌患者相比，女性具有可靠的准确性（灵敏度91%，特异性85%，准确性89%）。结论：挥发性有机化合物检测在宫颈癌检测中的适用性及其在治疗监测中的潜在应用前景。

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Identification of volatile organic compound (VOC) as a novel modality for cervical cancer detection.

Objective: In this study, we developed a novel detection strategy based on volatile organic compound (VOC) sensing. Persistent infection by human papillomavirus (HPV) may cause biological changes in the cervical epithelium, leading to VOC production.

Methods: This study included 200 urine samples from cervical cancer patients and controls that were HPV-negative. Urine samples were collected and measured using a gas sensor array composed of a matrix of 10 sensors. For each analyzed sample, the instrument produced a vector signal encoding the VOC emitted from the urine (urine prints). The urine prints of cervical cancer patients were differentiated from those of healthy controls.

Results: Compared with healthy controls and cervical cancer patients, women had reliable accuracy (91% sensitivity, 85% specificity, and 89% accuracy).

Conclusion: Our results demonstrated the applicability of VOC sensing for cervical cancer detection and its potential application in treatment monitoring.

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来源期刊

Obstetrics and Gynecology Science Medicine-Obstetrics and Gynecology

CiteScore

3.80

自引率

15.80%

发文量

审稿时长

16 weeks

期刊介绍： Obstetrics & Gynecology Science (NLM title: Obstet Gynecol Sci) is an international peer-review journal that published basic, translational, clinical research, and clinical practice guideline to promote women’s health and prevent obstetric and gynecologic disorders. The journal has an international editorial board and is published in English on the 15th day of every other month. Submitted manuscripts should not contain previously published material and should not be under consideration for publication elsewhere. The journal has been publishing articles since 1958. The aim of the journal is to publish original articles, reviews, case reports, short communications, letters to the editor, and video articles that have the potential to change the practices in women''s health care. The journal’s main focus is the diagnosis, treatment, prediction, and prevention of obstetric and gynecologic disorders. Because the life expectancy of Korean and Asian women is increasing, the journal''s editors are particularly interested in the health of elderly women in these population groups. The journal also publishes articles about reproductive biology, stem cell research, and artificial intelligence research for women; additionally, it provides insights into the physiology and mechanisms of obstetric and gynecologic diseases.