{"title":"Naturalight: A controlled illuminated environment to study light exposure impact on behavior and cognition in freely moving rats","authors":"Christophe Hecquet , Maylis Etcheberry , Nadine Ravel , Philippe Litaudon , Frédéric Pain","doi":"10.1016/j.ohx.2025.e00662","DOIUrl":"10.1016/j.ohx.2025.e00662","url":null,"abstract":"<div><div>In humans, scientific studies have shown that the increased use of screens at night and prolonged exposure to artificial light, particularly blue light, can significantly disrupt the organization of sleep-wake cycles and the functions that depend on them like memory. In rodents, moderate and even weak exposures to light have been shown to have various and either detrimental or beneficial effects on circadian rhythms, behavior, cognition. Yet, scattered and sometimes opposite effects are reported in the literature, which is largely attributed to differences in experimental conditions, especially on the definition and evaluation of the actual dose of light received. To address this issue, we have built an enclosure with controlled and characterized illumination. It can be used as a standalone experimental environment or eventually connected to naturalistic environment where several animals live constantly and interact freely within several housing modules, including the controlled illumination one.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00662"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-06-21DOI: 10.1016/j.ohx.2025.e00666
Matthias Quintelier, Joke Hadermann
{"title":"MDT: A simple tool to facilitate dropcasting on in situ TEM MEMS chips","authors":"Matthias Quintelier, Joke Hadermann","doi":"10.1016/j.ohx.2025.e00666","DOIUrl":"10.1016/j.ohx.2025.e00666","url":null,"abstract":"<div><div><em>In situ</em> transmission electron microscopy with holders based on the use of micro-electromechanical systems provides valuable insights into material kinetics, yet sample preparation remains complex due to fragile silicon nitride (Si<sub>3</sub>N<sub>4</sub>) windows and the risk of leaks and contamination during dropcasting. This results in failed experiments and increases experimental costs. This paper introduces the MEMS Dropcasting Tool (MDT), a cost-effective, in-house 3D-printable solution that confines the droplet to a specific area, preventing particle migration under the O-ring and reducing contamination risks at the inlet and outlet ports of closed cell chip holders.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00666"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-07-13DOI: 10.1016/j.ohx.2025.e00678
Floriberto Díaz-Díaz , Prisciliano Felipe de Jesús Cano-Barrita
{"title":"Design and construction of a small embeddable nuclear magnetic resonance sensor utilizing 3D-printed components","authors":"Floriberto Díaz-Díaz , Prisciliano Felipe de Jesús Cano-Barrita","doi":"10.1016/j.ohx.2025.e00678","DOIUrl":"10.1016/j.ohx.2025.e00678","url":null,"abstract":"<div><div>This paper presents the design and construction of a cost-effective embeddable nuclear magnetic resonance sensor using 3D printing to improve the construction process. The sensor comprises two 25.4 mm diameter x 3 mm thick neodymium-iron-boron disk magnets and an elliptical radio frequency coil. Magnetic field simulations were employed to determine the optimal separation between magnets, achieving a relatively homogeneous B<sub>0</sub> field of 180 mT at the center of the array. Custom 3D-printed parts ensured precise magnet alignment and facilitated coil fabrication. The sensor was encased within a Faraday cage constructed from a printed circuit board to mitigate external electromagnetic interference. A remote tuning circuit was developed to tune the coil to 7.66 MHz. Initial testing involved using an eraser sample to determine the required 90° and 180° pulse amplitudes and duration. The sensor’s performance was further validated under immersion conditions in milk, yogurt, and fresh cement paste, using the Carr-Purcell-Meiboom-Gill technique. The signals obtained were processed by fitting the data to an exponential decay function to obtain the T<sub>2</sub> lifetimes and their corresponding signal intensities, and by Inverse Laplace Transformation to obtain the T<sub>2</sub> lifetime distribution. Results indicate the sensoŕs capability to detect variations in samples having different compositions.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00678"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-08-19DOI: 10.1016/j.ohx.2025.e00692
Daniel Soto Rodriguez , Andres Eduardo Rivera Gomez , Ruthber Rodriguez Serrezuela
{"title":"Development of an embedded diagnostic tool for visual misalignment screening","authors":"Daniel Soto Rodriguez , Andres Eduardo Rivera Gomez , Ruthber Rodriguez Serrezuela","doi":"10.1016/j.ohx.2025.e00692","DOIUrl":"10.1016/j.ohx.2025.e00692","url":null,"abstract":"<div><div>This article presents the design, implementation, and validation of a low-cost embedded system for preliminary strabismus screening, based on computer vision and deep learning. The hardware integrates a Raspberry Pi 4, a USB camera, and a 3D-printed chin rest to ensure consistent facial positioning. The software, developed in Python using PyQt5 and OpenCV, incorporates a NASNetLarge convolutional neural network converted to TensorFlow Lite for real-time inference. The graphical interface allows users to capture or upload images, perform automated analysis, generate diagnostic PDF reports, and access a gamified treatment module. Functional validation included a proprietary dataset of 27 images, achieving a 96.30 % classification accuracy. Additionally, a stratified 10-fold cross-validation on a balanced dataset of 1000 images yielded an average accuracy of 95.6 % with strong generalization metrics (F1-score, precision, and recall above 94 %). A novel treatment validation mechanism was implemented by analyzing pupil-to-stimulus distance frame-by-frame, confirming reliable eye tracking and the system’s potential for detecting microstrabismus. This open-source, portable prototype is suitable for community health screening and educational use, particularly in low-resource settings.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00692"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-07-28DOI: 10.1016/j.ohx.2025.e00681
James P. Verheyden , Bryce Huffaker , Max J. Sevcik , Isaac Snyder , Finnegan Wilson , Grace I. Rabinowitz , Carter Watkins , Elbert Caravaca , Edward G. Tersine , Veronica Eliasson
{"title":"Tool changing and tool sharing system for interconnected multi-material direct ink write 3D printers","authors":"James P. Verheyden , Bryce Huffaker , Max J. Sevcik , Isaac Snyder , Finnegan Wilson , Grace I. Rabinowitz , Carter Watkins , Elbert Caravaca , Edward G. Tersine , Veronica Eliasson","doi":"10.1016/j.ohx.2025.e00681","DOIUrl":"10.1016/j.ohx.2025.e00681","url":null,"abstract":"<div><div>Direct ink write (DIW) is a material extrusion additive manufacturing technique where a flowable liquid or semi-solid ink is selectively deposited through a nozzle onto a build surface. DIW can be leveraged to print a wide range of multi-material components with unique geometries, which would otherwise be challenging to produce with traditional manufacturing techniques. However, despite their unique capabilities, DIW extruders are costly to purchase and labor intensive to clean, limiting widespread adoption. To address these challenges, an automatic tool changer with tool sharing system was developed to reduce printer capital costs, minimize operator interactions, and increase extruder utilization. Unlike conventional tool changers popular with fused filament fabrication (FFF) printers, which allows a single printer to swap between multiple tools, this novel tool sharing system enables tool sharing and coordination between two adjacent printers. By effectively halving the total number of extruders and associated cleaning operations, DIW capabilities are greatly improved, increasing production, lowering system cost, and minimizing operator involvement. The hardware consists of a tool changing mechanism, post processor to insert tool exchange G-code, and software to coordinate tool sharing between printers, enabling tool changing and tool sharing between two adjacent printers.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00681"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-07-05DOI: 10.1016/j.ohx.2025.e00675
Hoai Phong Nguyen , Thuan Thanh Nguyen , Minh Phuong Le , Minh Tan Tran , Cong Duy Pham
{"title":"Design and implementation of three-phases energy storage system using DSP F28379D for laboratory research","authors":"Hoai Phong Nguyen , Thuan Thanh Nguyen , Minh Phuong Le , Minh Tan Tran , Cong Duy Pham","doi":"10.1016/j.ohx.2025.e00675","DOIUrl":"10.1016/j.ohx.2025.e00675","url":null,"abstract":"<div><div>This paper presents the hardware design for a three-phases energy storage system connected to the grid through a safe isolation transformer, suitable for use in university laboratory experiments. The power hardware configuration includes a bidirectional DC/DC buck-boost converter and a bidirectional 3-phase 6-switch DC/AC converter. Additionally, the control board uses the Texas Instruments DSP F28379D with a charging-discharging control program written in C programming language and compiled with Code Composer Studio (CCS v12). The current and voltage sensing circuits use Hall-effect sensors to isolate the power circuit from the control circuit. A unique aspect of this research is the modular design, allowing for quick and easy upgrades and changes to the configuration and power capacity, facilitating the testing of control algorithms for the storage system. Experiments were conducted on a 3-phase 380(V) power grid through an isolation transformer and a simulated battery bank powered by the APS1000 amplifier, with a 100(V) output voltage controlled in charging mode from the grid and discharging mode to the grid at a controlled power of 230(W). The results show that the hardware model can be used effectively in laboratory settings to serve educational needs.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00675"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-07-02DOI: 10.1016/j.ohx.2025.e00668
Lasse Alexander Nissen Pedersen , Jeppe Don , Claus Melvad , Søren Rysgaard
{"title":"Temperature string device (TSD): A new low-cost instrument for sea ice observations in remote areas","authors":"Lasse Alexander Nissen Pedersen , Jeppe Don , Claus Melvad , Søren Rysgaard","doi":"10.1016/j.ohx.2025.e00668","DOIUrl":"10.1016/j.ohx.2025.e00668","url":null,"abstract":"<div><div>Warmer conditions in the Arctic regions are causing sea ice to melt. Sea ice plays critical roles in reflecting solar radiation, mitigating heat absorption and slowing temperature rise. However, the reduction in annual sea ice formation, driven by rising temperatures, contributes to a positive feedback loop that accelerates further warming. This underscores the importance of monitoring seasonal sea ice growth. To address this need, a Temperature String Device has been developed. This innovative, low-cost, compact, and customizable solution is designed for easy deployment, requiring just one person or even a robot for non-human deployment. The device measures temperature throughout the sea ice and transmits data in real-time to the cloud, enabling immediate analysis to estimate sea ice thickness. Its default configuration collects 30 data points over a 3-meter depth at 30-minute intervals and remains operational for up to one year. Its affordability allows production of multiple units, enabling widespread deployment and enhancing spatial resolution. Furthermore, its suitability for robotic deployments makes it ideal for remote, inaccessible locations, facilitating simultaneous monitoring.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00668"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-07-17DOI: 10.1016/j.ohx.2025.e00679
Minh Nhat Huynh , Quoc Minh Lam , Cong Toai Truong , Huy Hung Nguyen , Van Tu Duong
{"title":"Low-cost electronic DC load module design for battery capacity evaluation","authors":"Minh Nhat Huynh , Quoc Minh Lam , Cong Toai Truong , Huy Hung Nguyen , Van Tu Duong","doi":"10.1016/j.ohx.2025.e00679","DOIUrl":"10.1016/j.ohx.2025.e00679","url":null,"abstract":"<div><div>Rapid advancements in energy storage technology spurred by the use of electricity in a variety of applications have brought attention to the critical need for precise battery capacity evaluation. The electronic DC load devices play an important role in those tests by replicating real-world discharge conditions. However, commercial DC load systems are often prohibitively expensive and remain largely inaccessible to small enterprises, academic laboratories, and independent researchers. While open-source alternatives offer cost advantages, many existing designs lack scalability, flexibility, and ease of use. This study proposes a low-cost, modular electronic DC load capable of continuous operation at up to <span><math><mrow><mn>50</mn><mi>W</mi></mrow></math></span> per module. With its user-friendly interface and support for numerous other tests, including constant current, constant resistor, constant power, battery evaluation, and high-power pulse charge (HPPC) the proposed electronic DC load is robust and simple to use for battery research and evaluation.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00679"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HardwareXPub Date : 2025-09-01Epub Date: 2025-08-19DOI: 10.1016/j.ohx.2025.e00684
Pablo S. Rivadeneira, Alejandro Mira
{"title":"Real-time converter of intermittent-scanned glucose sensors to continuous glucose monitors with potential future applications for insulin delivery","authors":"Pablo S. Rivadeneira, Alejandro Mira","doi":"10.1016/j.ohx.2025.e00684","DOIUrl":"10.1016/j.ohx.2025.e00684","url":null,"abstract":"<div><div>This paper presents the development of a transmitter that transforms intermittent glucose sensors (isCGM) into a continuous and real-time glucose monitoring system (c-rtCGM), a key component in automated insulin delivery systems. The transmitter enhances the capabilities of conventional intermittent sensors by leveraging Near Field Communication (NFC) technology to capture raw glucose value and automatically transmit it via Bluetooth Low Energy (BLE-Bluetooth 4.2 Dual-Mode) to a smart device every five minutes. A specialized glucose monitoring application converts the raw values to blood glucose by applying a calibration based on a static linear model and a capillary blood glucose measurement. The accuracy and performance of the c-rtCGM were validated through a study involving 37 participants with type 1 diabetes, demonstrating its reliability compared to commercial transmitters. Values reported by the c-rtCGM system compared with the isCGM monitor system resulted in an overall mean average relative difference (MARD) around 9%. During the trial, the c-rtCGM system achieved a data transmission success rate of 96%, and only 2316 connection failures were recorded from the 66525 total connection attempts, indicating a high level of communication stability. The transmitter battery life lasted an average of 6.5 days, showing that it is necessary to recharge only once for the duration of the sensor (14 days). The main advantages of this customized transmitter, in contrast with the commercial versions, are reliability, cost, and the flexibility of its software, since its processor (an ESP32) can be easily programmed to fulfill other helpful tasks in managing glucose levels with automated insulin delivery systems.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00684"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design and implementation of a low-cost gimbal-based angular ultrasound gantry for optimal tissue slice selection using deep learning","authors":"Abhishek Kumar, Akshay S. Menon, Divyansh Sharma, Raviteja Sista, Debdoot Sheet","doi":"10.1016/j.ohx.2025.e00676","DOIUrl":"10.1016/j.ohx.2025.e00676","url":null,"abstract":"<div><div>Ultrasound (US) is a widely popular imaging technique for the diagnosis of tumors and associated soft tissue pathology. Traditionally, excised tumor masses are manually sliced for microscopic examination, which is a resource-intensive, time-consuming process, and prone to human error. The proposed work addresses these challenges by developing a cost-effective US gantry system integrated with a deep learning algorithm to automate the tissue slice selection process. This system scans the entire tumor and by integrating a deep learning algorithm predicts the optimal slice to assist its preparation for microscopic analysis. Automating this process reduces the time and resources required while minimizing the risk of human error. Optimal tissue slice reduces sampling associated uncertainty in diagnosis and treatment planning. Thereby determining tumor grade and type, and helping to reduce the treatment risks. The initial development focused on a linear US gantry that moves in one direction to acquire B-mode images. However, this design is limited, as it cannot fully capture the tumor’s structural complexity. In order to overcome this, we developed an angular US gantry that can maneuver along multiple angles, acquiring a broader range of images for comprehensive geometric analysis. The angular gantry demonstrated significant improvement, achieving 98% accuracy in selecting the optimal tissue slice.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"23 ","pages":"Article e00676"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}