Design and construction of a low-cost compressive loading and perfusion flow bioreactor

IF 2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC

HardwareX Pub Date : 2024-07-25 DOI:10.1016/j.ohx.2024.e00565

Alexis Graham , Charlotte Thompson , Darrock Flynn , Honor Elchos , Jaydon Gibson , Lauren B. Priddy , Matthew W. Priddy

引用次数: 0

Abstract

This article reports the design and construction of an open-source compressive loading and perfusion flow bioreactor for under $4000, as well as validation of the device and an example use-application. The bioreactor is capable of recording applied force and displacement as well as regulating media flow rate. This bioreactor was built to be user friendly, widely adaptable for modular changes, and made of readily available materials.

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设计和建造低成本压缩加载和灌注流生物反应器

本文报告了一个不到 4000 美元的开源压缩加载和灌注流生物反应器的设计和建造，以及设备的验证和一个使用应用实例。该生物反应器能够记录作用力和位移，并调节介质流速。该生物反应器使用方便，可进行广泛的模块化改装，并由现成材料制成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HardwareX Engineering-Industrial and Manufacturing Engineering

CiteScore

4.10

自引率

18.20%

发文量

124

审稿时长

24 weeks

期刊介绍： HardwareX is an open access journal established to promote free and open source designing, building and customizing of scientific infrastructure (hardware). HardwareX aims to recognize researchers for the time and effort in developing scientific infrastructure while providing end-users with sufficient information to replicate and validate the advances presented. HardwareX is open to input from all scientific, technological and medical disciplines. Scientific infrastructure will be interpreted in the broadest sense. Including hardware modifications to existing infrastructure, sensors and tools that perform measurements and other functions outside of the traditional lab setting (such as wearables, air/water quality sensors, and low cost alternatives to existing tools), and the creation of wholly new tools for either standard or novel laboratory tasks. Authors are encouraged to submit hardware developments that address all aspects of science, not only the final measurement, for example, enhancements in sample preparation and handling, user safety, and quality control. The use of distributed digital manufacturing strategies (e.g. 3-D printing) is encouraged. All designs must be submitted under an open hardware license.