Current Stem Cell Reports最新文献_第8页

Regulation of Stem Cell Therapy Travel 干细胞治疗旅行的调控

IF 1.4

Current Stem Cell Reports Pub Date : 2018-07-14 DOI: 10.1007/s40778-018-0134-8

I. Glenn Cohen, Shelly Simana

引用次数: 6

The Ethics of Chimera Creation in Stem Cell Research 干细胞研究中嵌合体产生的伦理问题

IF 1.4

Current Stem Cell Reports Pub Date : 2018-07-09 DOI: 10.1007/s40778-018-0136-6

I. Hyun

引用次数: 10

Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation. 母体和胎儿对子宫内干细胞移植的免疫反应。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-05-03 DOI: 10.1007/s40778-018-0129-5

Amir Alhajjat, Aimen Shaaban

{"title":"Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation.","authors":"Amir Alhajjat, Aimen Shaaban","doi":"10.1007/s40778-018-0129-5","DOIUrl":"https://doi.org/10.1007/s40778-018-0129-5","url":null,"abstract":"Purpose of review: In Utero Hematopoietic Cellular Transplantation (IUHCT) is a promising intervention for the non-toxic treatment of congenital disease that hinges on the assumption of fetal immunologic immaturity and an inability to reject a hematopoietic allograft. However, clinical IUCHT has failed except in cases where the fetus is severely immunocompromised. The current review examines recent studies of engraftment barriers stemming from either the fetal or maternal immune system.Recent findings: New reports have illuminated roles for maternal humoral and cellular immunity and fetal innate cellular immunity in the resistance to allogeneic IUHCT. These experimental findings have inspired new approaches to overcome these barriers. Despite these advances, postulates regarding a maternal immune barrier to IUHCT provide an inadequate explanation for the well-documented clinical success only in the treatment of fetal immunodeficiency with normal maternal immunity.Summary: Characterization of the maternal and fetal immune response to allogeneic IUHCT provides new insight into the complexity of prenatal tolerance. Future work in this area should aim to provide a unifying explanation for the observed patterns of success and failure with clinical IUHCT.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"4 2","pages":"182-187"},"PeriodicalIF":1.4,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0129-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37057229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate. 分子生物学:长链非编码RNA介导HSC命运。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-04-16 DOI: 10.1007/s40778-018-0130-z

Nathaniel Magilnick, Mark P Boldin

{"title":"Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate.","authors":"Nathaniel Magilnick, Mark P Boldin","doi":"10.1007/s40778-018-0130-z","DOIUrl":"https://doi.org/10.1007/s40778-018-0130-z","url":null,"abstract":"Purpose of review: Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as key, multi-faceted regulators of gene expression. This review explores the function of lncRNAs in the control of HSC homeostasis and hematopoietic differentiation.Recent findings: Multiple lncRNAs have been implicated in maintaining HSC stemness and enabling progenitors to carry out the correct programs of lineage differentiation. Specific lncRNAs have been identified that regulate the differentiation of multipotent progenitors into terminally differentiated blood cells. These lncRNAs predominantly act by assisting master regulators that drive specific differentiation programs, either by enhancing or repressing the transcription of particular genomic loci.Summary: Long noncoding RNAs contribute to the correct differentiation and maturation of various hematopoietic lineages by assisting with the activation of transcriptional programs in a time- and cell-dependent manner.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"4 2","pages":"158-165"},"PeriodicalIF":1.4,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0130-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36665758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil. 干细胞调控中的缺氧信号通路:好与坏。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-04-30 DOI: 10.1007/s40778-018-0127-7

Xinxin Huang, Thao Trinh, Arafat Aljoufi, Hal E Broxmeyer

{"title":"Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil.","authors":"Xinxin Huang, Thao Trinh, Arafat Aljoufi, Hal E Broxmeyer","doi":"10.1007/s40778-018-0127-7","DOIUrl":"https://doi.org/10.1007/s40778-018-0127-7","url":null,"abstract":"Purpose of review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell systems. Stem cells for different lineages/tissues reside in distinct niches, and are exposed to diverse oxygen concentrations. Recent studies have revealed the importance of the hypoxia signaling pathway for stem cell functions.Recent findings: Hypoxia and HIFs contribute to maintenance of embryonic stem cells, generation of induced pluripotent stem cells, functionality of hematopoietic stem cells, and survival of leukemia stem cells. Harvest and collection of mouse bone marrow and human cord blood cells in ambient air results in fewer hematopoietic stem cells recovered due to the phenomenon of Extra PHysiologic Oxygen Shock/Stress (EPHOSS).Summary: Oxygen is an important factor in the stem cell microenvironment. Hypoxia signaling and HIFs play important roles in modeling cellular metabolism in both stem cells and niches to regulate stem cell biology, and represent an additional dimension that allows stem cells to maintain an undifferentiated status and multilineage differentiation potential.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"4 2","pages":"149-157"},"PeriodicalIF":1.4,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0127-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37397569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

Personalizing Cancer Treatments Empirically in the Laboratory: Patient-Specific Tumor Organoids for Optimizing Precision Medicine 实验室经验个性化癌症治疗:优化精准医疗的患者特异性肿瘤类器官

IF 1.4

Current Stem Cell Reports Pub Date : 2018-04-14 DOI: 10.1007/s40778-018-0122-z

Andrea Mazzocchi, K. Votanopoulos, A. Skardal

引用次数: 4

Epigenetic and Epitranscriptomic Factors Make a Mark on Hematopoietic Stem Cell Development. 表观遗传和表转录组学因素在造血干细胞发育中的作用

IF 1.4

Current Stem Cell Reports Pub Date : 2018-03-01

Dionna M Kasper, Stefania Nicoli

{"title":"Epigenetic and Epitranscriptomic Factors Make a Mark on Hematopoietic Stem Cell Development.","authors":"Dionna M Kasper, Stefania Nicoli","doi":"","DOIUrl":"","url":null,"abstract":"Purpose of the review: Blood specification is a highly dynamic process, whereby committed hemogenic endothelial cells (ECs) progressively transdifferentiate into multipotent, self-renewing hematopoietic stem cells (HSCs). Massive changes in gene expression must occur to switch cell identity, however the factors that mediate such an effect were a mystery until recently. This review summarizes the higher-order mechanisms involved in endothelial to hematopoietic reprogramming identified thus far.Recent findings: Accumulating evidence from mouse and zebrafish studies reveal that numerous chromatin-modifying (epigenetic) and RNA-modifying (epitranscriptomic) factors are required for the formation of HSCs from hemogenic endothelium. These genes function throughout the endothelial-hematopoietic transition, suggesting a dynamic interplay between 'epi'-machineries.Summary: Epigenetic and epitranscriptomic regulation are key mechanisms for reshaping global EC gene expression patterns to those that support HSC production. Future studies that capture modification dynamics should bring us closer to a complete understanding of how HSCs transition from hemogenic endothelium at the molecular level.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"4 1","pages":"22-32"},"PeriodicalIF":1.4,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999335/pdf/nihms939941.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10441003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury 更正:肠干细胞在辐射诱导的肠道损伤后上皮再生中的作用

IF 1.4

Current Stem Cell Reports Pub Date : 2018-02-19 DOI: 10.1007/s40778-018-0121-0

Chang-Kyung Kim, V. Yang, A. Bialkowska

引用次数: 1

Development of the Artificial Womb 人工子宫的发展

IF 1.4

Current Stem Cell Reports Pub Date : 2018-02-05 DOI: 10.1007/s40778-018-0120-1

E. Partridge, M. Davey, A. Flake

引用次数: 5

How and Why to Replace the 14-Day Rule. 如何以及为什么要替换14天规则。