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Current Stem Cell Reports最新文献

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Human Hematopoietic Stem Cells: Concepts and Perspectives on the Biology and Use of Fresh Versus In Vitro–Generated Cells for Therapeutic Applications 人造血干细胞:生物学的概念和观点，以及新鲜细胞与体外细胞在治疗应用中的应用
IF 1.4
Current Stem Cell Reports Pub Date : 2019-07-20 DOI: 10.1007/s40778-019-00162-1
H. Mayani
{"title":"Human Hematopoietic Stem Cells: Concepts and Perspectives on the Biology and Use of Fresh Versus In Vitro–Generated Cells for Therapeutic Applications","authors":"H. Mayani","doi":"10.1007/s40778-019-00162-1","DOIUrl":"https://doi.org/10.1007/s40778-019-00162-1","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-00162-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43911859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
How to Characterize Stem Cells? Contributions from Mathematical Modeling 如何描述干细胞?数学建模的贡献
IF 1.4
Current Stem Cell Reports Pub Date : 2019-05-23 DOI: 10.1007/s40778-019-00155-0
T. Stiehl, A. Marciniak-Czochra
{"title":"How to Characterize Stem Cells? Contributions from Mathematical Modeling","authors":"T. Stiehl, A. Marciniak-Czochra","doi":"10.1007/s40778-019-00155-0","DOIUrl":"https://doi.org/10.1007/s40778-019-00155-0","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2019-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-00155-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52902437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Translating HSC Niche Biology for Clinical Applications 转化造血干细胞生态位生物学用于临床应用
IF 1.4
Current Stem Cell Reports Pub Date : 2019-02-21 DOI: 10.1007/s40778-019-0152-1
T. Olson
{"title":"Translating HSC Niche Biology for Clinical Applications","authors":"T. Olson","doi":"10.1007/s40778-019-0152-1","DOIUrl":"https://doi.org/10.1007/s40778-019-0152-1","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2019-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-0152-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52902713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Non-apoptotic Roles of Caspases in Stem Cell Biology, Carcinogenesis, and Radiotherapy 半胱天冬酶在干细胞生物学、癌变和放疗中的非凋亡作用
IF 1.4
Current Stem Cell Reports Pub Date : 2019-01-30 DOI: 10.1007/s40778-019-0151-2
R. Kaakati, Ruya Zhao, Xuhui Bao, Andrew K. Lee, Xinjian Liu, Fang Li, Chuan-Yuan Li
{"title":"Non-apoptotic Roles of Caspases in Stem Cell Biology, Carcinogenesis, and Radiotherapy","authors":"R. Kaakati, Ruya Zhao, Xuhui Bao, Andrew K. Lee, Xinjian Liu, Fang Li, Chuan-Yuan Li","doi":"10.1007/s40778-019-0151-2","DOIUrl":"https://doi.org/10.1007/s40778-019-0151-2","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-0151-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52902636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Engineered Biomimetic Neural Stem Cell Niche. 工程仿生神经干细胞。
IF 1.4
Current Stem Cell Reports Pub Date : 2019-01-01 Epub Date: 2019-05-20 DOI: 10.1007/s40778-019-00161-2
Rita Matta, Anjelica L Gonzalez
{"title":"Engineered Biomimetic Neural Stem Cell Niche.","authors":"Rita Matta, Anjelica L Gonzalez","doi":"10.1007/s40778-019-00161-2","DOIUrl":"10.1007/s40778-019-00161-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Neural stem cells (NSCs) have the potential to proliferate and differentiate into functional neurons, heightening their potential use for therapeutic applications. This review explores bioengineered systems which recapitulate NSC niche cell-cell and cell-matrix interactions.</p><p><strong>Recent findings: </strong>Delivery of NSCs to the cytotoxic injured brain is limited by low cell survival rates post-transplantation and poor maintenance of native niche bioactive components. The use of biomaterial platforms can mimic <i>in vivo</i> the environment of the two germinal areas of the adult brain in which NSCs thrive. An environmental mimic that includes extracellular proteins and moieties, along with appropriate biomechanical cues has recently demonstrated promising results in enhancing neurogenesis, aiding the production of a bioengineered niche.</p><p><strong>Summary: </strong>Biocomposition, biomechanics, and biostructure can be manipulated through engineered platforms to re-create the biofunctionality of an NSC niche. Upon transplantation and delivery with biomimetic scaffolds, NSCs show potential to promote functional recovery and rebuild neural circuitry post neurological trauma.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451115/pdf/nihms-1529882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38325612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral blood stem cell mobilization; a look ahead. 外周血干细胞动员；展望未来。
IF 2.3
Current Stem Cell Reports Pub Date : 2018-12-01 Epub Date: 2018-10-23 DOI: 10.1007/s40778-018-0141-9
Louis M Pelus, Hal E Broxmeyer
{"title":"Peripheral blood stem cell mobilization; a look ahead.","authors":"Louis M Pelus, Hal E Broxmeyer","doi":"10.1007/s40778-018-0141-9","DOIUrl":"10.1007/s40778-018-0141-9","url":null,"abstract":"<p><strong>The purpose of review: </strong>Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers are difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remains an area of interest.This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment.</p><p><strong>Recent findings: </strong>Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress, identify strategies to collect more potent competing HSC and new methods to optimize stem cell collection and engraftment are being evaluated.</p><p><strong>Summary: </strong>Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532982/pdf/nihms-1510358.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37274005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini Review: Application of Human Mesenchymal Stem Cells in Gene and Stem Cells Therapy Era 人间充质干细胞在基因和干细胞治疗时代的应用综述
IF 1.4
Current Stem Cell Reports Pub Date : 2018-11-09 DOI: 10.1007/s40778-018-0147-3
R. Deng, A. H. Law, Jia-Juan Shen, G. C. Chan
{"title":"Mini Review: Application of Human Mesenchymal Stem Cells in Gene and Stem Cells Therapy Era","authors":"R. Deng, A. H. Law, Jia-Juan Shen, G. C. Chan","doi":"10.1007/s40778-018-0147-3","DOIUrl":"https://doi.org/10.1007/s40778-018-0147-3","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0147-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52902191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Novel Cellular Therapeutic Approaches for the Prevention and Management of Graft-Versus-Host Disease 预防和治疗移植物抗宿主病的新细胞治疗方法
IF 1.4
Current Stem Cell Reports Pub Date : 2018-10-31 DOI: 10.1007/s40778-018-0146-4
S. Jauhari, N. Chao
{"title":"Novel Cellular Therapeutic Approaches for the Prevention and Management of Graft-Versus-Host Disease","authors":"S. Jauhari, N. Chao","doi":"10.1007/s40778-018-0146-4","DOIUrl":"https://doi.org/10.1007/s40778-018-0146-4","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0146-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52902053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editing the Genome Ex Vivo Stem Cell Therapy 编辑基因组的体外干细胞治疗
IF 1.4
Current Stem Cell Reports Pub Date : 2018-10-16 DOI: 10.1007/s40778-018-0148-2
Yiping Fan, J. Chan
{"title":"Editing the Genome Ex Vivo Stem Cell Therapy","authors":"Yiping Fan, J. Chan","doi":"10.1007/s40778-018-0148-2","DOIUrl":"https://doi.org/10.1007/s40778-018-0148-2","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0148-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52902302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges 诱导多能干细胞衍生的红细胞、巨核细胞和血小板:进展和挑战
IF 1.4
Current Stem Cell Reports Pub Date : 2018-10-12 DOI: 10.1007/s40778-018-0144-6
H. An, M. Poncz, S. Chou
{"title":"Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges","authors":"H. An, M. Poncz, S. Chou","doi":"10.1007/s40778-018-0144-6","DOIUrl":"https://doi.org/10.1007/s40778-018-0144-6","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0144-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44699553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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