Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation.

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-05-03 DOI:10.1007/s40778-018-0129-5

Amir Alhajjat, Aimen Shaaban

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引用次数: 2

Abstract

Purpose of review: In Utero Hematopoietic Cellular Transplantation (IUHCT) is a promising intervention for the non-toxic treatment of congenital disease that hinges on the assumption of fetal immunologic immaturity and an inability to reject a hematopoietic allograft. However, clinical IUCHT has failed except in cases where the fetus is severely immunocompromised. The current review examines recent studies of engraftment barriers stemming from either the fetal or maternal immune system.

Recent findings: New reports have illuminated roles for maternal humoral and cellular immunity and fetal innate cellular immunity in the resistance to allogeneic IUHCT. These experimental findings have inspired new approaches to overcome these barriers. Despite these advances, postulates regarding a maternal immune barrier to IUHCT provide an inadequate explanation for the well-documented clinical success only in the treatment of fetal immunodeficiency with normal maternal immunity.

Summary: Characterization of the maternal and fetal immune response to allogeneic IUHCT provides new insight into the complexity of prenatal tolerance. Future work in this area should aim to provide a unifying explanation for the observed patterns of success and failure with clinical IUHCT.

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母体和胎儿对子宫内干细胞移植的免疫反应。

回顾目的:子宫内造血细胞移植(IUHCT)是一种很有前途的无毒性治疗先天性疾病的干预措施，这取决于胎儿免疫不成熟和无法排斥造血异体移植物的假设。然而，除了胎儿免疫功能严重受损的情况外，临床IUCHT失败了。目前的综述检查了来自胎儿或母体免疫系统的植入障碍的最新研究。最新发现:新的报告阐明了母体体液免疫和细胞免疫以及胎儿先天细胞免疫在抵抗异体IUHCT中的作用。这些实验发现激发了克服这些障碍的新方法。尽管取得了这些进展，但关于母体免疫屏障的假设并不能充分解释为什么只有在正常母体免疫治疗胎儿免疫缺陷方面取得了充分的临床成功。摘要:母体和胎儿对同种异体IUHCT免疫反应的表征为产前耐受的复杂性提供了新的见解。该领域未来的工作应旨在为临床IUHCT观察到的成功和失败模式提供统一的解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.