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Current Stem Cell Reports最新文献

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First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies 利用预处理方法改进间充质干细胞疗法的首次临床经验
IF 1.4
Current Stem Cell Reports Pub Date : 2024-01-05 DOI: 10.1007/s40778-023-00232-5
Bryan Le, Amin Cressman, David Morales, Fernando A Fierro
{"title":"First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies","authors":"Bryan Le, Amin Cressman, David Morales, Fernando A Fierro","doi":"10.1007/s40778-023-00232-5","DOIUrl":"https://doi.org/10.1007/s40778-023-00232-5","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"5 4","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139383907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It 干细胞生物学及其他领域的定量建模：如何充分利用它
IF 1.4
Current Stem Cell Reports Pub Date : 2023-12-11 DOI: 10.1007/s40778-023-00230-7
P. Greulich
{"title":"Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It","authors":"P. Greulich","doi":"10.1007/s40778-023-00230-7","DOIUrl":"https://doi.org/10.1007/s40778-023-00230-7","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"19 3","pages":"67 - 76"},"PeriodicalIF":1.4,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138979191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives 基于间充质干细胞的细胞疗法治疗 COVID-19 相关性 ARDS 和经典 ARDS：比较视角
IF 1.4
Current Stem Cell Reports Pub Date : 2023-12-06 DOI: 10.1007/s40778-023-00231-6
Daniel J. Weiss, S. Rolandsson Enes
{"title":"MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives","authors":"Daniel J. Weiss, S. Rolandsson Enes","doi":"10.1007/s40778-023-00231-6","DOIUrl":"https://doi.org/10.1007/s40778-023-00231-6","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"37 7","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning Approaches for Stem Cells 干细胞的机器学习方法
Current Stem Cell Reports Pub Date : 2023-09-22 DOI: 10.1007/s40778-023-00228-1
Mazlee Mazalan, Tien-Dung Do, Wan Safwani Wan Kamarul Zaman, Effirul I. Ramlan
{"title":"Machine Learning Approaches for Stem Cells","authors":"Mazlee Mazalan, Tien-Dung Do, Wan Safwani Wan Kamarul Zaman, Effirul I. Ramlan","doi":"10.1007/s40778-023-00228-1","DOIUrl":"https://doi.org/10.1007/s40778-023-00228-1","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136060178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription factors and splice factors - interconnected regulators of stem cell differentiation. 转录因子和剪接因子——干细胞分化的相关调控因子
IF 2.3
Current Stem Cell Reports Pub Date : 2023-06-01 Epub Date: 2023-06-29 DOI: 10.1007/s40778-023-00227-2
Madison M Mehlferber, Muge Kuyumcu-Martinez, Clint L Miller, Gloria M Sheynkman
{"title":"Transcription factors and splice factors - interconnected regulators of stem cell differentiation.","authors":"Madison M Mehlferber, Muge Kuyumcu-Martinez, Clint L Miller, Gloria M Sheynkman","doi":"10.1007/s40778-023-00227-2","DOIUrl":"10.1007/s40778-023-00227-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>The underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an area of ongoing investigation. Cell state is the product of the combinatorial effect of individual factors operating within a coordinated regulatory network. Here, we discuss the contribution of both gene regulatory and splicing regulatory networks in defining stem cell fate during differentiation and the critical role of protein isoforms in this process.</p><p><strong>Recent findings: </strong>We review recent experimental and computational approaches that characterize gene regulatory networks, splice regulatory networks, and the resulting transcriptome and proteome they mediate during differentiation. Such approaches include long-read RNA sequencing, which has demonstrated high-resolution profiling of mRNA isoforms, and Cas13-based CRISPR, which could make possible high-throughput isoform screening. Collectively, these developments enable systems-level profiling of factors contributing to cell state.</p><p><strong>Summary: </strong>Overall, gene and splice regulatory networks are important in defining cell state. The emerging high-throughput systems-level approaches will characterize the gene regulatory network components necessary in driving stem cell differentiation.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"9 1","pages":"31-41"},"PeriodicalIF":2.3,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49477765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling 理解造血干细胞动力学——从数学建模的角度看
IF 1.4
Current Stem Cell Reports Pub Date : 2023-02-13 DOI: 10.1007/s40778-023-00224-5
R. K. Pedersen, Morten Andersen, T. Stiehl, J. Ottesen
{"title":"Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling","authors":"R. K. Pedersen, Morten Andersen, T. Stiehl, J. Ottesen","doi":"10.1007/s40778-023-00224-5","DOIUrl":"https://doi.org/10.1007/s40778-023-00224-5","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"9 1","pages":"9-16"},"PeriodicalIF":1.4,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47871520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review 关节内脐带间充质干细胞注射治疗膝关节骨性关节炎的疗效:一项系统综述
IF 1.4
Current Stem Cell Reports Pub Date : 2023-02-10 DOI: 10.1007/s40778-023-00223-6
I. H. Dilogo, A. Lubis, Natasena Galar Perwida, Safinah Aulia Sani, R. A. Rasyidah, Bernadus Riyan Hartanto
{"title":"The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review","authors":"I. H. Dilogo, A. Lubis, Natasena Galar Perwida, Safinah Aulia Sani, R. A. Rasyidah, Bernadus Riyan Hartanto","doi":"10.1007/s40778-023-00223-6","DOIUrl":"https://doi.org/10.1007/s40778-023-00223-6","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"9 1","pages":"17-29"},"PeriodicalIF":1.4,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43538896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics 干细胞动力学的随机和确定性建模综述
IF 1.4
Current Stem Cell Reports Pub Date : 2023-01-26 DOI: 10.1007/s40778-023-00225-4
Shaojun Gong, Leili Shahriyari
{"title":"A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics","authors":"Shaojun Gong, Leili Shahriyari","doi":"10.1007/s40778-023-00225-4","DOIUrl":"https://doi.org/10.1007/s40778-023-00225-4","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"9 1","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47223375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling. 人类干细胞用于眼科：诊断图像分析和计算建模的最新进展》。
IF 2.3
Current Stem Cell Reports Pub Date : 2023-01-01 Epub Date: 2023-11-18 DOI: 10.1007/s40778-023-00229-0
L E Wadkin, I Makarenko, N G Parker, A Shukurov, F C Figueiredo, M Lako
{"title":"Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling.","authors":"L E Wadkin, I Makarenko, N G Parker, A Shukurov, F C Figueiredo, M Lako","doi":"10.1007/s40778-023-00229-0","DOIUrl":"10.1007/s40778-023-00229-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>To explore the advances and future research directions in image analysis and computational modelling of human stem cells (hSCs) for ophthalmological applications.</p><p><strong>Recent findings: </strong>hSCs hold great potential in ocular regenerative medicine due to their application in cell-based therapies and in disease modelling and drug discovery using state-of-the-art 2D and 3D organoid models. However, a deeper characterisation of their complex, multi-scale properties is required to optimise their translation to clinical practice. Image analysis combined with computational modelling is a powerful tool to explore mechanisms of hSC behaviour and aid clinical diagnosis and therapy.</p><p><strong>Summary: </strong>Many computational models draw on a variety of techniques, often blending continuum and discrete approaches, and have been used to describe cell differentiation and self-organisation. Machine learning tools are having a significant impact in model development and improving image classification processes for clinical diagnosis and treatment and will be the focus of much future research.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"9 4","pages":"57-66"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem Cell Banking of Adipose Tissue 脂肪组织的干细胞库
IF 1.4
Current Stem Cell Reports Pub Date : 2022-11-08 DOI: 10.1007/s40778-022-00222-z
Mahmood S Choudhery, Ruhma Mahmood, D. Harris
{"title":"Stem Cell Banking of Adipose Tissue","authors":"Mahmood S Choudhery, Ruhma Mahmood, D. Harris","doi":"10.1007/s40778-022-00222-z","DOIUrl":"https://doi.org/10.1007/s40778-022-00222-z","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"8 1","pages":"174 - 183"},"PeriodicalIF":1.4,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49274285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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