Current Stem Cell Reports最新文献_第2页

Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling. 人类干细胞用于眼科：诊断图像分析和计算建模的最新进展》。

IF 2.3

Current Stem Cell Reports Pub Date : 2023-01-01 Epub Date: 2023-11-18 DOI: 10.1007/s40778-023-00229-0

L E Wadkin, I Makarenko, N G Parker, A Shukurov, F C Figueiredo, M Lako

{"title":"Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling.","authors":"L E Wadkin, I Makarenko, N G Parker, A Shukurov, F C Figueiredo, M Lako","doi":"10.1007/s40778-023-00229-0","DOIUrl":"10.1007/s40778-023-00229-0","url":null,"abstract":"Purpose of review: To explore the advances and future research directions in image analysis and computational modelling of human stem cells (hSCs) for ophthalmological applications.Recent findings: hSCs hold great potential in ocular regenerative medicine due to their application in cell-based therapies and in disease modelling and drug discovery using state-of-the-art 2D and 3D organoid models. However, a deeper characterisation of their complex, multi-scale properties is required to optimise their translation to clinical practice. Image analysis combined with computational modelling is a powerful tool to explore mechanisms of hSC behaviour and aid clinical diagnosis and therapy.Summary: Many computational models draw on a variety of techniques, often blending continuum and discrete approaches, and have been used to describe cell differentiation and self-organisation. Machine learning tools are having a significant impact in model development and improving image classification processes for clinical diagnosis and treatment and will be the focus of much future research.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"9 4","pages":"57-66"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem Cell Banking of Adipose Tissue 脂肪组织的干细胞库

IF 1.4

Current Stem Cell Reports Pub Date : 2022-11-08 DOI: 10.1007/s40778-022-00222-z

Mahmood S Choudhery, Ruhma Mahmood, D. Harris

引用次数: 1

The Effects of Different Regenerative Treatments after Tooth Avulsion 牙齿脱落后不同再生治疗的效果

IF 1.4

Current Stem Cell Reports Pub Date : 2022-09-24 DOI: 10.1007/s40778-022-00218-9

A. H. Kohsar, Mohammad Javad Yousefi, Haleh Hali

引用次数: 0

Advances in Biomaterials for Promoting Vascularization 促进血管形成的生物材料研究进展

IF 1.4

Current Stem Cell Reports Pub Date : 2022-09-07 DOI: 10.1007/s40778-022-00217-w

Ronald A. Nelson, E. Rhee, Mohamad Alaeddine, M. Nikkhah

引用次数: 3

Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE). 造血急性辐射综合征 (H-ARS) 和急性辐射照射延迟效应 (DEARE) 小鼠模型中年龄、性别和遗传多样性的影响。

IF 1.6

Current Stem Cell Reports Pub Date : 2022-09-01 Epub Date: 2022-07-14 DOI: 10.1007/s40778-022-00214-z

Christie M Orschell, Tong Wu, Andrea M Patterson

{"title":"Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE).","authors":"Christie M Orschell, Tong Wu, Andrea M Patterson","doi":"10.1007/s40778-022-00214-z","DOIUrl":"10.1007/s40778-022-00214-z","url":null,"abstract":"Purpose of review: Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Radiation medical countermeasure (MCM) development relies on robust animal models reflective of all age groups and both sexes. This review details critical considerations in murine H-ARS and DEARE model development including divergent radiation responses dependent on age, sex, and genetic diversity.Recent findings: Radioresistance increases with murine age from pediatrics through geriatrics. Between sexes, radioresistance is higher in male weanlings, pubescent females, and aged males, corresponding with accelerated myelopoiesis. Jackson diversity outbred (JDO) mice resemble non-human primates in radiation response for modeling human diversity. Weanlings and JDO models exhibit less DEARE than other models.Summary: Highly characterized age-, sex- and diversity-conscious murine models of H-ARS and DEARE provide powerful and essential tools in MCM development for all radiation victims.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"8 3","pages":"139-149"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928166/pdf/nihms-1825962.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10134801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine 心血管成像数据库：为再生医学构建机器学习算法

IF 1.4

Current Stem Cell Reports Pub Date : 2022-08-09 DOI: 10.1007/s40778-022-00216-x

Chirag Mehta, Rohan M. Shah, N. Yanamala, P. Sengupta

引用次数: 2

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview 放射治疗和热疗与免疫系统的相互作用:当前简要综述

IF 1.4

Current Stem Cell Reports Pub Date : 2022-07-20 DOI: 10.1007/s40778-022-00215-y

A. Sengedorj, M. Hader, B. Frey, R. Fietkau, O. Ott, U. Gaipl, M. Rückert

引用次数: 2

Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis 利用碳离子治疗嗜铬性髓母细胞瘤

IF 1.4

Current Stem Cell Reports Pub Date : 2022-05-10 DOI: 10.1007/s40778-022-00213-0

Hannah Sophia Schreiber, M. Simovic, Aurélie Ernst

引用次数: 0

Decoding Human Hematopoietic Stem Cell Self-Renewal 解码人类造血干细胞自我更新

IF 1.4

Current Stem Cell Reports Pub Date : 2022-04-18 DOI: 10.1007/s40778-022-00209-w

I. Fares, V. Calvanese, H. Mikkola

引用次数: 2

Role of the hematopoietic stem cells in immunological memory. 造血干细胞在免疫记忆中的作用。

IF 1.4

Current Stem Cell Reports Pub Date : 2022-03-01 DOI: 10.1007/s40778-021-00204-7

Vinothini Govindarajah, Damien Reynaud

{"title":"Role of the hematopoietic stem cells in immunological memory.","authors":"Vinothini Govindarajah, Damien Reynaud","doi":"10.1007/s40778-021-00204-7","DOIUrl":"https://doi.org/10.1007/s40778-021-00204-7","url":null,"abstract":"Purpose of review: Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune system, the concept of memory has recently been broadened to the innate immune system. This review summarizes recent studies that highlight the contribution of the hematopoietic stem cells (HSCs) in supporting immunological memory.Recent findings: Short-lived innate immune cells can build a long-lasting memory of infection to improve their response to secondary challenges. Studies show that these unexpected properties of the innate immune system are sustained by epigenetic and metabolic changes in the HSC compartment.Summary: HSCs are durably altered in response to pathogens and serve as long-term support for innate immune memory. Many questions remain regarding the mechanisms contributing to the induction and the maintenance of this immune memory in HSCs. Answering these questions will open new perspectives to understand how environmental factors shape the HSC activity over time.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"8 1","pages":"35-43"},"PeriodicalIF":1.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007548/pdf/nihms-1771315.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1