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Current Stem Cell Reports最新文献

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Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE). 造血急性辐射综合征 (H-ARS) 和急性辐射照射延迟效应 (DEARE) 小鼠模型中年龄、性别和遗传多样性的影响。
IF 1.4
Current Stem Cell Reports Pub Date : 2022-09-01 Epub Date: 2022-07-14 DOI: 10.1007/s40778-022-00214-z
Christie M Orschell, Tong Wu, Andrea M Patterson
{"title":"Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE).","authors":"Christie M Orschell, Tong Wu, Andrea M Patterson","doi":"10.1007/s40778-022-00214-z","DOIUrl":"10.1007/s40778-022-00214-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Radiation medical countermeasure (MCM) development relies on robust animal models reflective of all age groups and both sexes. This review details critical considerations in murine H-ARS and DEARE model development including divergent radiation responses dependent on age, sex, and genetic diversity.</p><p><strong>Recent findings: </strong>Radioresistance increases with murine age from pediatrics through geriatrics. Between sexes, radioresistance is higher in male weanlings, pubescent females, and aged males, corresponding with accelerated myelopoiesis. Jackson diversity outbred (JDO) mice resemble non-human primates in radiation response for modeling human diversity. Weanlings and JDO models exhibit less DEARE than other models.</p><p><strong>Summary: </strong>Highly characterized age-, sex- and diversity-conscious murine models of H-ARS and DEARE provide powerful and essential tools in MCM development for all radiation victims.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9928166/pdf/nihms-1825962.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10134801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine 心血管成像数据库：为再生医学构建机器学习算法
IF 1.4
Current Stem Cell Reports Pub Date : 2022-08-09 DOI: 10.1007/s40778-022-00216-x
Chirag Mehta, Rohan M. Shah, N. Yanamala, P. Sengupta
{"title":"Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine","authors":"Chirag Mehta, Rohan M. Shah, N. Yanamala, P. Sengupta","doi":"10.1007/s40778-022-00216-x","DOIUrl":"https://doi.org/10.1007/s40778-022-00216-x","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49470148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview 放射治疗和热疗与免疫系统的相互作用:当前简要综述
IF 1.4
Current Stem Cell Reports Pub Date : 2022-07-20 DOI: 10.1007/s40778-022-00215-y
A. Sengedorj, M. Hader, B. Frey, R. Fietkau, O. Ott, U. Gaipl, M. Rückert
{"title":"Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview","authors":"A. Sengedorj, M. Hader, B. Frey, R. Fietkau, O. Ott, U. Gaipl, M. Rückert","doi":"10.1007/s40778-022-00215-y","DOIUrl":"https://doi.org/10.1007/s40778-022-00215-y","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47265721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis 利用碳离子治疗嗜铬性髓母细胞瘤
IF 1.4
Current Stem Cell Reports Pub Date : 2022-05-10 DOI: 10.1007/s40778-022-00213-0
Hannah Sophia Schreiber, M. Simovic, Aurélie Ernst
{"title":"Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis","authors":"Hannah Sophia Schreiber, M. Simovic, Aurélie Ernst","doi":"10.1007/s40778-022-00213-0","DOIUrl":"https://doi.org/10.1007/s40778-022-00213-0","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44039680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding Human Hematopoietic Stem Cell Self-Renewal 解码人类造血干细胞自我更新
IF 1.4
Current Stem Cell Reports Pub Date : 2022-04-18 DOI: 10.1007/s40778-022-00209-w
I. Fares, V. Calvanese, H. Mikkola
{"title":"Decoding Human Hematopoietic Stem Cell Self-Renewal","authors":"I. Fares, V. Calvanese, H. Mikkola","doi":"10.1007/s40778-022-00209-w","DOIUrl":"https://doi.org/10.1007/s40778-022-00209-w","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47928999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of the hematopoietic stem cells in immunological memory. 造血干细胞在免疫记忆中的作用。
IF 1.4
Current Stem Cell Reports Pub Date : 2022-03-01 DOI: 10.1007/s40778-021-00204-7
Vinothini Govindarajah, Damien Reynaud
{"title":"Role of the hematopoietic stem cells in immunological memory.","authors":"Vinothini Govindarajah,&nbsp;Damien Reynaud","doi":"10.1007/s40778-021-00204-7","DOIUrl":"https://doi.org/10.1007/s40778-021-00204-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune system, the concept of memory has recently been broadened to the innate immune system. This review summarizes recent studies that highlight the contribution of the hematopoietic stem cells (HSCs) in supporting immunological memory.</p><p><strong>Recent findings: </strong>Short-lived innate immune cells can build a long-lasting memory of infection to improve their response to secondary challenges. Studies show that these unexpected properties of the innate immune system are sustained by epigenetic and metabolic changes in the HSC compartment.</p><p><strong>Summary: </strong>HSCs are durably altered in response to pathogens and serve as long-term support for innate immune memory. Many questions remain regarding the mechanisms contributing to the induction and the maintenance of this immune memory in HSCs. Answering these questions will open new perspectives to understand how environmental factors shape the HSC activity over time.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007548/pdf/nihms-1771315.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Are Mesenchymal Stem Cells Fibroblasts with Benefits? 间充质干细胞成纤维细胞有益处吗？
IF 1.4
Current Stem Cell Reports Pub Date : 2022-02-19 DOI: 10.1007/s40778-022-00210-3
D. Mönch, J. Koch, M. Dahlke
{"title":"Are Mesenchymal Stem Cells Fibroblasts with Benefits?","authors":"D. Mönch, J. Koch, M. Dahlke","doi":"10.1007/s40778-022-00210-3","DOIUrl":"https://doi.org/10.1007/s40778-022-00210-3","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47391496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical Manufacturing of Human Mesenchymal Stromal Cells using a Potency-Driven Paradigm 利用潜能驱动模式临床制造人间充质间质细胞
IF 1.4
Current Stem Cell Reports Pub Date : 2022-02-07 DOI: 10.1007/s40778-022-00208-x
Matthew Teryek, Aneesha Doshi, L. Sherman, P. Rameshwar, Sunghoon Jung, B. Parekkadan
{"title":"Clinical Manufacturing of Human Mesenchymal Stromal Cells using a Potency-Driven Paradigm","authors":"Matthew Teryek, Aneesha Doshi, L. Sherman, P. Rameshwar, Sunghoon Jung, B. Parekkadan","doi":"10.1007/s40778-022-00208-x","DOIUrl":"https://doi.org/10.1007/s40778-022-00208-x","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48954770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Hypoxia and Hematopoiesis 缺氧与造血
IF 1.4
Current Stem Cell Reports Pub Date : 2022-01-28 DOI: 10.1007/s40778-021-00203-8
Paige Dausinas Ni, Christopher Basile, Chase Junge, M. Hartman, H. O’Leary
{"title":"Hypoxia and Hematopoiesis","authors":"Paige Dausinas Ni, Christopher Basile, Chase Junge, M. Hartman, H. O’Leary","doi":"10.1007/s40778-021-00203-8","DOIUrl":"https://doi.org/10.1007/s40778-021-00203-8","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48890981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel 间充质间质细胞在太空中的应用:间充质间质细胞治疗作为长距离载人太空旅行的使能技术
IF 1.4
Current Stem Cell Reports Pub Date : 2022-01-22 DOI: 10.1007/s40778-022-00207-y
J. Giri, Guido Moll
{"title":"MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel","authors":"J. Giri, Guido Moll","doi":"10.1007/s40778-022-00207-y","DOIUrl":"https://doi.org/10.1007/s40778-022-00207-y","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52903073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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