Current Stem Cell Reports最新文献_第3页

IF 1.4

Current Stem Cell Reports Pub Date : 2022-01-28 DOI: 10.1007/s40778-021-00203-8

Paige Dausinas Ni, Christopher Basile, Chase Junge, M. Hartman, H. O’Leary

引用次数: 2

MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel 间充质间质细胞在太空中的应用:间充质间质细胞治疗作为长距离载人太空旅行的使能技术

IF 1.4

Current Stem Cell Reports Pub Date : 2022-01-22 DOI: 10.1007/s40778-022-00207-y

J. Giri, Guido Moll

引用次数: 3

Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics. 冷冻保存和冻融对间充质基质/干细胞治疗特性的影响及其他常见细胞疗法。

IF 1.4

Current Stem Cell Reports Pub Date : 2022-01-01 DOI: 10.1007/s40778-022-00212-1

Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai

{"title":"Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics.","authors":"Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai","doi":"10.1007/s40778-022-00212-1","DOIUrl":"https://doi.org/10.1007/s40778-022-00212-1","url":null,"abstract":"Purpose of review: Cryopreservation and its associated freezing and thawing procedures-short \"freeze-thawing\"-are among the final steps in economically viable manufacturing and clinical application of diverse cellular therapeutics. Translation from preclinical proof-of-concept studies to larger clinical trials has indicated that these processes may potentially present an Achilles heel to optimal cell product safety and particularly efficacy in clinical trials and routine use.Recent findings: We review the current state of the literature on how cryopreservation of cellular therapies has evolved and how the application of this technique to different cell types is interlinked with their ability to engraft and function upon transfer in vivo, in particular for hematopoietic stem and progenitor cells (HSPCs), their progeny, and therapeutic cell products derived thereof. We also discuss pros and cons how this may differ for non-hematopoietic mesenchymal stromal/stem cell (MSC) therapeutics. We present different avenues that may be crucial for cell therapy optimization, both, for hematopoietic (e.g., effector, regulatory, and chimeric antigen receptor (CAR)-modified T and NK cell based products) and for non-hematopoietic products, such as MSCs and induced pluripotent stem cells (iPSCs), to achieve optimal viability, recovery, effective cell dose, and functionality of the cryorecovered cells.Summary: Targeted research into optimizing the cryopreservation and freeze-thawing routines and the adjunct manufacturing process design may provide crucial advantages to increase both the safety and efficacy of cellular therapeutics in clinical use and to enable effective market deployment strategies to become economically viable and sustainable medicines.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"8 2","pages":"72-92"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility. 细胞中心原理在再生医学中的应用。

IF 1.4

Current Stem Cell Reports Pub Date : 2022-01-01 DOI: 10.1007/s40778-022-00219-8

Alicia D Henn, Kunal Mitra, Joshua Hunsberger, Xiuzhi Susan Sun, Mark Nardone, Ramon Montero, Sita Somara, Gary Green, Alan Blanchard, Yu Shrike Zhang, Carl G Simon, Randy Yerden

{"title":"Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility.","authors":"Alicia D Henn, Kunal Mitra, Joshua Hunsberger, Xiuzhi Susan Sun, Mark Nardone, Ramon Montero, Sita Somara, Gary Green, Alan Blanchard, Yu Shrike Zhang, Carl G Simon, Randy Yerden","doi":"10.1007/s40778-022-00219-8","DOIUrl":"https://doi.org/10.1007/s40778-022-00219-8","url":null,"abstract":"Purpose of review: Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encountered over time. Currently, routine cell culture practices subject cell and tissue products to highly variable and non-physiologic conditions. This article defines five cytocentric principles that place the conditions for cells at the core of what we do for better reproducibility in Regenerative Medicine.Recent findings: There is a rising awareness of the cell environment as a neglected, but critical variable. Recent publications have called for controlling culture conditions for better, more reproducible cell products.Summary: Every industry has basic quality principles for reproducibility. Cytocentric principles focus on the fundamental needs of cells: protection from contamination, physiologic simulation, and full-time conditions for cultures that are optimal, individualized, and dynamic. Here, we outline the physiologic needs, the technologies, the education, and the regulatory support for the cytocentric principles in regenerative medicine.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"8 4","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088063/pdf/nihms-1874876.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9364102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer Stem Cell Division: Mathematical Models and Insights 癌症干细胞分裂:数学模型和见解

IF 1.4

Current Stem Cell Reports Pub Date : 2021-09-30 DOI: 10.1007/s40778-021-00199-1

Ellen R. Swanson, Samantha L. Elliott, Elizabeth Zollinger, Emek Kose

引用次数: 0

Approaches to Optimize Stem Cell-Derived Cardiomyocyte Maturation and Function 优化干细胞来源的心肌细胞成熟度和功能的方法

IF 1.4

Current Stem Cell Reports Pub Date : 2021-09-30 DOI: 10.1007/s40778-021-00197-3

G. Gilbert

引用次数: 0

Bioreactor Technology for Cell Therapy Manufacturing in Regenerative Medicine 再生医学中用于细胞治疗制造的生物反应器技术

IF 1.4

Current Stem Cell Reports Pub Date : 2021-09-30 DOI: 10.1007/s40778-021-00200-x

Hu Zhang, D. Kent, M. Albanna, Lexan Lhu, X. Sun, S. Eaker, S. Somara

引用次数: 1

Liquid Ventilation in the Management of Preterm Infants 液体通气在早产儿管理中的应用

IF 1.4

Current Stem Cell Reports Pub Date : 2021-08-28 DOI: 10.1007/s40778-021-00192-8

Travis Kotzur, Samantha Tilden, E. Partridge

引用次数: 0

Lessons from Biology: Engineering Design Considerations for Modeling Human Hematopoiesis 生物学的经验教训：人类造血系统建模的工程设计考虑因素

IF 1.4

Current Stem Cell Reports Pub Date : 2021-08-20 DOI: 10.1007/s40778-021-00195-5

D. Tavakol, Jocelyn S. Chen, Nicholas W. Chavkin, Tara N. Tavakol, K. Hirschi, G. Vunjak‐Novakovic

引用次数: 3

Understanding Normal and Pathological Hematopoietic Stem Cell Biology Using Mathematical Modelling 用数学模型理解正常和病理造血干细胞生物学

IF 1.4

Current Stem Cell Reports Pub Date : 2021-06-09 DOI: 10.1007/s40778-021-00191-9

M. Brunetti, M. Mackey, M. Craig

引用次数: 4