Current Stem Cell Reports最新文献

{"title":"Approaches to Optimize Stem Cell-Derived Cardiomyocyte Maturation and Function","authors":"G. Gilbert","doi":"10.1007/s40778-021-00197-3","DOIUrl":"https://doi.org/10.1007/s40778-021-00197-3","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"140 - 160"},"PeriodicalIF":1.4,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47879684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioreactor Technology for Cell Therapy Manufacturing in Regenerative Medicine","authors":"Hu Zhang, D. Kent, M. Albanna, Lexan Lhu, X. Sun, S. Eaker, S. Somara","doi":"10.1007/s40778-021-00200-x","DOIUrl":"https://doi.org/10.1007/s40778-021-00200-x","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"212 - 218"},"PeriodicalIF":1.4,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43299623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid Ventilation in the Management of Preterm Infants","authors":"Travis Kotzur, Samantha Tilden, E. Partridge","doi":"10.1007/s40778-021-00192-8","DOIUrl":"https://doi.org/10.1007/s40778-021-00192-8","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"121 - 127"},"PeriodicalIF":1.4,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00192-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43439814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons from Biology: Engineering Design Considerations for Modeling Human Hematopoiesis","authors":"D. Tavakol, Jocelyn S. Chen, Nicholas W. Chavkin, Tara N. Tavakol, K. Hirschi, G. Vunjak‐Novakovic","doi":"10.1007/s40778-021-00195-5","DOIUrl":"https://doi.org/10.1007/s40778-021-00195-5","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"174 - 184"},"PeriodicalIF":1.4,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00195-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49397735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Normal and Pathological Hematopoietic Stem Cell Biology Using Mathematical Modelling","authors":"M. Brunetti, M. Mackey, M. Craig","doi":"10.1007/s40778-021-00191-9","DOIUrl":"https://doi.org/10.1007/s40778-021-00191-9","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"109 - 120"},"PeriodicalIF":1.4,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00191-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52903055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Regulation of Stem Cells in Aging.","authors":"Andrea Keller, Tyus Temple, Behnam Sayanjali, Maria M Mihaylova","doi":"10.1007/s40778-021-00186-6","DOIUrl":"10.1007/s40778-021-00186-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>From invertebrates to vertebrates, the ability to sense nutrient availability is critical for survival. Complex organisms have evolved numerous signaling pathways to sense nutrients and dietary fluctuations, which influence many cellular processes. Although both overabundance and extreme depletion of nutrients can lead to deleterious effects, dietary restriction without malnutrition can increase lifespan and promote overall health in many model organisms. In this review, we focus on age-dependent changes in stem cell metabolism and dietary interventions used to modulate stem cell function in aging.</p><p><strong>Recent findings: </strong>Over the last half-century, seminal studies have illustrated that dietary restriction confers beneficial effects on longevity in many model organisms. Many researchers have now turned to dissecting the molecular mechanisms by which these diets affect aging at the cellular level. One subpopulation of cells of particular interest are adult stem cells, the most regenerative cells of the body. It is generally accepted that the regenerative capacity of stem cells declines with age, and while the metabolic requirements of each vary across tissues, the ability of dietary interventions to influence stem cell function is striking.</p><p><strong>Summary: </strong>In this review, we will focus primarily on how metabolism plays a role in adult stem cell homeostasis with respect to aging, with particular emphasis on intestinal stem cells while also touching on hematopoietic, skeletal muscle, and neural stem cells. We will also discuss key metabolic signaling pathways influenced by both dietary restriction and the aging process, and will examine their role in improving tissue homeostasis and lifespan. Understanding the mechanisms behind the metabolic needs of stem cells will help bridge the divide between a basic science interpretation of stem cell function and a whole-organism view of nutrition, thereby providing insight into potential dietary or therapeutic interventions.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"72-84"},"PeriodicalIF":2.3,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49633720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulation Strategies for Pancreatic Islet Transplantation without Immune Suppression","authors":"S. Sittadjody, E. Opara","doi":"10.1007/s40778-021-00190-w","DOIUrl":"https://doi.org/10.1007/s40778-021-00190-w","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"49 - 71"},"PeriodicalIF":1.4,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00190-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45828743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amnion Epithelial Cells — a Therapeutic Source","authors":"R. Schwab, Mihiri Goonetilleke, Dandan Zhu, G. Kusuma, E. Wallace, W. Sievert, R. Lim","doi":"10.1007/s40778-021-00187-5","DOIUrl":"https://doi.org/10.1007/s40778-021-00187-5","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"13 - 29"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00187-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45151203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria Transfer in Bone Marrow Hematopoietic Activity.","authors":"Abhishek K Singh,&nbsp;Jose A Cancelas","doi":"10.1007/s40778-020-00185-z","DOIUrl":"https://doi.org/10.1007/s40778-020-00185-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>The well-established crosstalk between hematopoietic stem cells (HSC) and bone marrow (BM) microenvironment is critical for the homeostasis and hematopoietic regeneration in response to blood formation emergencies. Past decade has witnessed that the intercellular communication mediated by the transfer of cytoplasmic material and organelles between cells can regenerate and/or repair the damaged cells. Mitochondria have recently emerged as a potential regulator of HSC fate. This review intends to discuss recent advances in the understanding of the mitochondrial dynamics, specifically focused on the role of mitochondrial transfer, in the maintenance of HSC activity with clear implications in stem cell transplantation and regenerative medicine.</p><p><strong>Recent findings: </strong>HSC are highly heterogeneous in their mitochondrial metabolism, and the quiescence and potency of HSC depend on the status of mitochondrial dynamics and the clearance of damaged mitochondria. Recent evidence has shown that in stress response, BM stromal cells transfer healthy mitochondria to HSC, facilitate HSC bioenergetics shift towards oxidative phosphorylation, and subsequently stimulate leukocyte expansion. Furthermore, metabolic rewiring following mitochondria transfer from HSPC to BM stromal cells likely to repair the damaged BM niche and accelerate limiting HSC transplantation post myeloablative conditioning.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00185-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10859844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Regulation of Stem Cell Fate","authors":"Linlin Jin, Ping Wang, Fang Ni","doi":"10.1007/s40778-020-00183-1","DOIUrl":"https://doi.org/10.1007/s40778-020-00183-1","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"30-38"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00183-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49637077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}