Current Stem Cell Reports最新文献

筛选
英文 中文
Metabolic Regulation of Stem Cells in Aging. 干细胞衰老过程中的代谢调控
IF 2.3
Current Stem Cell Reports Pub Date : 2021-06-01 Epub Date: 2021-04-23 DOI: 10.1007/s40778-021-00186-6
Andrea Keller, Tyus Temple, Behnam Sayanjali, Maria M Mihaylova
{"title":"Metabolic Regulation of Stem Cells in Aging.","authors":"Andrea Keller, Tyus Temple, Behnam Sayanjali, Maria M Mihaylova","doi":"10.1007/s40778-021-00186-6","DOIUrl":"10.1007/s40778-021-00186-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>From invertebrates to vertebrates, the ability to sense nutrient availability is critical for survival. Complex organisms have evolved numerous signaling pathways to sense nutrients and dietary fluctuations, which influence many cellular processes. Although both overabundance and extreme depletion of nutrients can lead to deleterious effects, dietary restriction without malnutrition can increase lifespan and promote overall health in many model organisms. In this review, we focus on age-dependent changes in stem cell metabolism and dietary interventions used to modulate stem cell function in aging.</p><p><strong>Recent findings: </strong>Over the last half-century, seminal studies have illustrated that dietary restriction confers beneficial effects on longevity in many model organisms. Many researchers have now turned to dissecting the molecular mechanisms by which these diets affect aging at the cellular level. One subpopulation of cells of particular interest are adult stem cells, the most regenerative cells of the body. It is generally accepted that the regenerative capacity of stem cells declines with age, and while the metabolic requirements of each vary across tissues, the ability of dietary interventions to influence stem cell function is striking.</p><p><strong>Summary: </strong>In this review, we will focus primarily on how metabolism plays a role in adult stem cell homeostasis with respect to aging, with particular emphasis on intestinal stem cells while also touching on hematopoietic, skeletal muscle, and neural stem cells. We will also discuss key metabolic signaling pathways influenced by both dietary restriction and the aging process, and will examine their role in improving tissue homeostasis and lifespan. Understanding the mechanisms behind the metabolic needs of stem cells will help bridge the divide between a basic science interpretation of stem cell function and a whole-organism view of nutrition, thereby providing insight into potential dietary or therapeutic interventions.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"72-84"},"PeriodicalIF":2.3,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49633720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Encapsulation Strategies for Pancreatic Islet Transplantation without Immune Suppression 无免疫抑制的胰岛移植包封策略
IF 1.4
Current Stem Cell Reports Pub Date : 2021-05-14 DOI: 10.1007/s40778-021-00190-w
S. Sittadjody, E. Opara
{"title":"Encapsulation Strategies for Pancreatic Islet Transplantation without Immune Suppression","authors":"S. Sittadjody, E. Opara","doi":"10.1007/s40778-021-00190-w","DOIUrl":"https://doi.org/10.1007/s40778-021-00190-w","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"49 - 71"},"PeriodicalIF":1.4,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00190-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45828743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Amnion Epithelial Cells — a Therapeutic Source 羊膜上皮细胞-一种治疗来源
IF 1.4
Current Stem Cell Reports Pub Date : 2021-03-01 DOI: 10.1007/s40778-021-00187-5
R. Schwab, Mihiri Goonetilleke, Dandan Zhu, G. Kusuma, E. Wallace, W. Sievert, R. Lim
{"title":"Amnion Epithelial Cells — a Therapeutic Source","authors":"R. Schwab, Mihiri Goonetilleke, Dandan Zhu, G. Kusuma, E. Wallace, W. Sievert, R. Lim","doi":"10.1007/s40778-021-00187-5","DOIUrl":"https://doi.org/10.1007/s40778-021-00187-5","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"13 - 29"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00187-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45151203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria Transfer in Bone Marrow Hematopoietic Activity. 骨髓造血活性中的线粒体转移。
IF 1.4
Current Stem Cell Reports Pub Date : 2021-03-01 DOI: 10.1007/s40778-020-00185-z
Abhishek K Singh, Jose A Cancelas
{"title":"Mitochondria Transfer in Bone Marrow Hematopoietic Activity.","authors":"Abhishek K Singh,&nbsp;Jose A Cancelas","doi":"10.1007/s40778-020-00185-z","DOIUrl":"https://doi.org/10.1007/s40778-020-00185-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>The well-established crosstalk between hematopoietic stem cells (HSC) and bone marrow (BM) microenvironment is critical for the homeostasis and hematopoietic regeneration in response to blood formation emergencies. Past decade has witnessed that the intercellular communication mediated by the transfer of cytoplasmic material and organelles between cells can regenerate and/or repair the damaged cells. Mitochondria have recently emerged as a potential regulator of HSC fate. This review intends to discuss recent advances in the understanding of the mitochondrial dynamics, specifically focused on the role of mitochondrial transfer, in the maintenance of HSC activity with clear implications in stem cell transplantation and regenerative medicine.</p><p><strong>Recent findings: </strong>HSC are highly heterogeneous in their mitochondrial metabolism, and the quiescence and potency of HSC depend on the status of mitochondrial dynamics and the clearance of damaged mitochondria. Recent evidence has shown that in stress response, BM stromal cells transfer healthy mitochondria to HSC, facilitate HSC bioenergetics shift towards oxidative phosphorylation, and subsequently stimulate leukocyte expansion. Furthermore, metabolic rewiring following mitochondria transfer from HSPC to BM stromal cells likely to repair the damaged BM niche and accelerate limiting HSC transplantation post myeloablative conditioning.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00185-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10859844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Biomechanical Regulation of Stem Cell Fate 干细胞命运的生物力学调控
IF 1.4
Current Stem Cell Reports Pub Date : 2021-03-01 DOI: 10.1007/s40778-020-00183-1
Linlin Jin, Ping Wang, Fang Ni
{"title":"Biomechanical Regulation of Stem Cell Fate","authors":"Linlin Jin, Ping Wang, Fang Ni","doi":"10.1007/s40778-020-00183-1","DOIUrl":"https://doi.org/10.1007/s40778-020-00183-1","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 1","pages":"30-38"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00183-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49637077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of mechanical and ECM microenvironment signals in the determination of cancer stem cell states. 机械和ECM微环境信号在肿瘤干细胞状态测定中的整合。
IF 1.4
Current Stem Cell Reports Pub Date : 2021-03-01 Epub Date: 2020-11-23 DOI: 10.1007/s40778-020-00182-2
Tiina A Jokela, Mark A LaBarge
{"title":"Integration of mechanical and ECM microenvironment signals in the determination of cancer stem cell states.","authors":"Tiina A Jokela,&nbsp;Mark A LaBarge","doi":"10.1007/s40778-020-00182-2","DOIUrl":"https://doi.org/10.1007/s40778-020-00182-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Cancer stem cells (CSCs) are increasingly understood to play a central role in tumor progression. Growing evidence implicates tumor microenvironments as a source of signals that regulate or even impose CSC states on tumor cells. This review explores points of integration for microenvironment-derived signals that are thought to regulate CSCs in carcinomas.</p><p><strong>Recent findings: </strong>CSC states are directly regulated by the mechanical properties and extra cellular matrix (ECM) composition of tumor microenvironments that promote CSC growth and survival, which may explain some modes of therapeutic resistance. CSCs sense mechanical forces and ECM composition through integrins and other cell surface receptors, which then activate a number of intracellular signaling pathways. The relevant signaling events are dynamic and context-dependent.</p><p><strong>Summary: </strong>CSCs are thought to drive cancer metastases and therapeutic resistance. Cells that are in CSC states and more differentiated states appear to be reversible and conditional upon the components of the tumor microenvironment. Signals imposed by tumor microenvironment are of a combinatorial nature, ultimately representing the integration of multiple physical and chemical signals. Comprehensive understanding of the tumor microenvironment-imposed signaling that maintains cells in CSC states may guide future therapeutic interventions.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 ","pages":"39-47"},"PeriodicalIF":1.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00182-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25525564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Cellular Complexity of Hemochorial Placenta: Stem Cell Populations, Insights from scRNA-seq, and SARS-CoV-2 Susceptibility. 止血胎盘的细胞复杂性:干细胞群体,scRNA-seq的见解和严重急性呼吸系统综合征冠状病毒2型易感性。
IF 2.3
Current Stem Cell Reports Pub Date : 2021-01-01 Epub Date: 2021-10-20 DOI: 10.1007/s40778-021-00194-6
Christopher S Mallery, Maira Carrillo, Ariel Mei, Ana Correia-Branco, Olga Kashpur, Mary C Wallingford
{"title":"Cellular Complexity of Hemochorial Placenta: Stem Cell Populations, Insights from scRNA-seq, and SARS-CoV-2 Susceptibility.","authors":"Christopher S Mallery, Maira Carrillo, Ariel Mei, Ana Correia-Branco, Olga Kashpur, Mary C Wallingford","doi":"10.1007/s40778-021-00194-6","DOIUrl":"10.1007/s40778-021-00194-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>The placenta is a transient organ that forms de novo and serves a critical role in supporting fetal growth and development. Placental oxygen, nutrients, and waste are transported through processes that depend on vascular structure and cell type-specific expression and localization of membrane transporters. Understanding how the placenta develops holds great significance for maternal-fetal medicine. The purpose of this review is to examine current information regarding placental progenitor populations.</p><p><strong>Recent findings: </strong>Recent advancements in single-cell RNA sequencing (scRNA-seq) provide unprecedented depth for the investigation of cell type-specific gene expression patterns in the placenta. Thus far, several mouse placenta scRNA-seq studies have been conducted which produced and analyzed transcriptomes of placental progenitors and cells of the fully developed placenta between embryonic day (E) 7.0 and E12.5. Together with human placenta scRNA-seq data which, in part, has been produced through coordinated research campaigns in the scientific community to understand the potential for SARS-CoV-2 infection, these mammalian studies lend fundamental insight into the cellular and molecular composition of hemochorial placentae found in both mouse and human.</p><p><strong>Summary: </strong>Single-cell placenta research has advanced understanding of tissue-resident stem cells and molecules that are poised to support maternal-fetal communication and nutrient transport. Herein, we provide context for these recent findings by reviewing placental anatomy and cell populations, and discuss recent scRNA-seq mouse placenta findings. Further research is needed to evaluate the utility of placental stem cells in the development of new therapeutic approaches for the treatment of wound healing and disease.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 4","pages":"185-193"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10612494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical Studies and Clinical Prospects of Wharton's Jelly-Derived MSC for Treatment of Acute Radiation Syndrome. 沃顿果冻源MSC治疗急性放射综合征的临床前研究和临床前景。
IF 1.4
Current Stem Cell Reports Pub Date : 2021-01-01 Epub Date: 2021-04-28 DOI: 10.1007/s40778-021-00188-4
Mayuri Bandekar, Dharmendra K Maurya, Deepak Sharma, Santosh K Sandur
{"title":"Preclinical Studies and Clinical Prospects of Wharton's Jelly-Derived MSC for Treatment of Acute Radiation Syndrome.","authors":"Mayuri Bandekar,&nbsp;Dharmendra K Maurya,&nbsp;Deepak Sharma,&nbsp;Santosh K Sandur","doi":"10.1007/s40778-021-00188-4","DOIUrl":"https://doi.org/10.1007/s40778-021-00188-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have received widespread attention from researchers owing to the remarkable benefits offered by these cells over other stem cells. The primitive nature of WJ-MSCs, ease of isolation, differentiation ability, and immuno-modulatory nature make these cells superior to bone marrow MSCs and ideal to treat various human ailments. This review explores ability of WJ-MSCs to mitigate acute radiation syndrome caused by planned or unplanned radiation exposure.</p><p><strong>Recent findings: </strong>Recent reports suggest that WJ-MSCs home to damaged tissues in irradiated host and mitigate radiation induced damage to radiosensitive tissues such as hematopoietic and gastrointestinal systems. WJ-MSCs and conditioned media were found to protect mice from radiation induced mortality and also prevent radiation dermatitis. Local irradiation-induced lung toxicity in mice was significantly reduced by CXCR4 over-expressing WJ-MSCs.</p><p><strong>Summary: </strong>Emerging evidences support safety and effectiveness of WJ-MSCs for treatment of acute radiation syndrome and lung injury after planned or accidental exposure. Additionally, conditioned media collected after culturing WJ-MSCs can also be used for mitigation of radiation dermatitis. Clinical translation of these findings would be possible after careful evaluation of resilience, effectiveness, and molecular mechanism of action of xenogeneic WJ-MSCs in non-human primates.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"7 2","pages":"85-94"},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-021-00188-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38940648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hematopoietic Stem Cell Stress and Regeneration 造血干细胞应激与再生
IF 1.4
Current Stem Cell Reports Pub Date : 2020-12-01 DOI: 10.1007/s40778-020-00181-3
C. Termini, J. Chute
{"title":"Hematopoietic Stem Cell Stress and Regeneration","authors":"C. Termini, J. Chute","doi":"10.1007/s40778-020-00181-3","DOIUrl":"https://doi.org/10.1007/s40778-020-00181-3","url":null,"abstract":"","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"6 1","pages":"134 - 143"},"PeriodicalIF":1.4,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00181-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46682639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The role of RNA epigenetic modification in normal and malignant hematopoiesis. RNA表观遗传修饰在正常和恶性造血中的作用。
IF 1.4
Current Stem Cell Reports Pub Date : 2020-12-01 Epub Date: 2020-08-12 DOI: 10.1007/s40778-020-00178-y
Radovan Vasic, Yimeng Gao, Chengyang Liu, Stephanie Halene
{"title":"The role of RNA epigenetic modification in normal and malignant hematopoiesis.","authors":"Radovan Vasic,&nbsp;Yimeng Gao,&nbsp;Chengyang Liu,&nbsp;Stephanie Halene","doi":"10.1007/s40778-020-00178-y","DOIUrl":"https://doi.org/10.1007/s40778-020-00178-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>RNA epigenetic modifications have been identified as novel, dynamic regulators of gene expression, with important impacts on stem cell fate decisions. Here we examine the functions of RNA modifications, with a focus on <i>N</i> <sup>6</sup>-methyladenosine (m<sup>6</sup>A), in hematopoietic stem cells under normal conditions and in malignancy.</p><p><strong>Recent findings: </strong>The m<sup>6</sup>A RNA modification is a critical regulator of hematopoiesis. Disruption of different elements of the m<sup>6</sup>A machinery can skew the balance of self-renewal and differentiation in normal hematopoietic stem cells. The m<sup>6</sup>A reader, writer, and eraser proteins are also overexpressed in myeloid leukemia, and disruption of their function impairs leukemogenesis. RNA m<sup>6</sup>A modification governs important aspects of immune system function, including immune cell development, immune signaling, and recognition of RNA as foreign or self. In hematopoietic stem cells, endogenously-derived double stranded RNA can form in the absence of m<sup>6</sup>A, inducing deleterious inflammatory pathways which compromise stem cell function.</p><p><strong>Summary: </strong>The RNA modification m<sup>6</sup>A exerts a variety of functions in normal hematopoietic stem cells as well as leukemic cells. Pharmacologic modulation of different elements of the m<sup>6</sup>A machinery provides a promising avenue for <i>ex vivo</i> expansion of hematopoietic stem cells in the transplant setting, as well as for leukemia therapy.</p>","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"6 4","pages":"144-155"},"PeriodicalIF":1.4,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00178-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25525563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信