Current Stem Cell Reports最新文献_第10页

Human iPSC Models to Study Orphan Diseases: Muscular Dystrophies. 研究孤儿疾病的人类iPSC模型:肌肉萎缩症。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-10-04 DOI: 10.1007/s40778-018-0145-5

Guangbin Xia, Naohiro Terada, Tetsuo Ashizawa

{"title":"Human iPSC Models to Study Orphan Diseases: Muscular Dystrophies.","authors":"Guangbin Xia, Naohiro Terada, Tetsuo Ashizawa","doi":"10.1007/s40778-018-0145-5","DOIUrl":"https://doi.org/10.1007/s40778-018-0145-5","url":null,"abstract":"Purpose of review: Muscular dystrophies (MDs) are a spectrum of muscle disorders, which are caused by a number of gene mutations. The studies of MDs are limited due to lack of appropriate models, except for Duchenne muscular dystrophy (DMD), myotonic dystrophy type 1 (DM1), facioscapulohumeral muscular dystrophy (FSHD), and certain type of limb-girdle muscular dystrophy (LGMD). Human induced pluripotent stem cell (iPSC) technologies are emerging to offer a useful model for mechanistic studies, drug discovery, and cell-based therapy to supplement in vivo animal models. This review will focus on current applications of iPSC as disease models of MDs for studies of pathogenic mechanisms and therapeutic development.Recent findings: Many and more human disease-specific iPSCs have been or being established, which carry the natural mutation of MDs with human genomic background. These iPSCs can be differentiated into specific cell types affected in a particular MDs such as skeletal muscle progenitor cells, skeletal muscle fibers, and cardiomyocytes. Human iPSCs are particularly useful for studies of the pathogenicity at the early stage or developmental phase of MDs. High-throughput screening using disease-specific human iPSCs has become a powerful technology in drug discovery. While MD iPSCs have been generated for cell-based replacement therapy, recent advances in genome editing technologies enabled correction of genetic mutations in these cells in culture, raising hope for in vivo genome therapy, which offers a fundamental cure for these daunting inherited MDs.Summary: Human disease-specific iPSC models for MDs are emerging as an additional tool to current disease models for elucidating disease mechanisms and developing therapeutic intervention.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"4 4","pages":"299-309"},"PeriodicalIF":1.4,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0145-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36804249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease. 干扰素γ在造血干细胞发育、体内平衡和疾病中的作用。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-07-23 DOI: 10.1007/s40778-018-0139-3

Daniel E Morales-Mantilla, Katherine Y King

引用次数: 59

Multifaceted Roles of Connexin 43 in Stem Cell Niches. 连接蛋白43在干细胞龛中的多面作用。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-02-15 DOI: 10.1007/s40778-018-0110-3

Nafiisha Genet, Neha Bhatt, Antonin Bourdieu, Karen K Hirschi

引用次数: 21

Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy. 胎儿间充质间质细胞:产前细胞治疗的机会。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-02-15 DOI: 10.1007/s40778-018-0118-8

Rachel Sagar, Lilian Walther-Jallow, Anna L David, Cecilia Götherström, Magnus Westgren

引用次数: 28

Stem Cell Therapies for the Resolution of Radiation Injury to the Brain. 干细胞治疗解决脑辐射损伤。

IF 1.4

Current Stem Cell Reports Pub Date : 2017-12-01 Epub Date: 2017-10-11 DOI: 10.1007/s40778-017-0105-5

Sarah M Smith, Charles L Limoli

{"title":"Stem Cell Therapies for the Resolution of Radiation Injury to the Brain.","authors":"Sarah M Smith, Charles L Limoli","doi":"10.1007/s40778-017-0105-5","DOIUrl":"https://doi.org/10.1007/s40778-017-0105-5","url":null,"abstract":"Purpose of review: To encapsulate past and current research efforts focused on stem cell transplantation strategies to resolve radiation-induced cognitive dysfunction.Recent findings: Transplantation of human stem cells in the irradiated brain was first shown to resolve radiation-induced cognitive dysfunction in a landmark paper by Acharya et al., appearing in PNAS in 2009. Since that time, work from the same laboratory as well as other groups have reported on the beneficial (as well as detrimental) effects of stem cell grafting after cranial radiation exposure. Improved learning and memory found many months after engraftment has since been associated with a preservation of host neuronal morphology, a suppression of neuroinflammation, improved myelination and increased cerebral blood flow. Interestingly, many (if not all) of these beneficial effects can be demonstrated by substituting stem cells with microvesicles derived from human stem cells during transplantation, thereby eliminating many of the more long-standing concerns related to immunorejection and teratoma formation.Summary: Stem cell and microvesicle transplantation into the irradiated brain of rodents has uncovered some unexpected benefits that hold promise for ameliorating many of adverse neurocognitive complications associated with major cancer treatments. Properly developed, such approaches may provide much needed clinical recourse to millions of cancer survivors suffering from the unintended side effects of their cancer therapies.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"3 4","pages":"342-347"},"PeriodicalIF":1.4,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-017-0105-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35814943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Radiotherapy and Glioma Stem Cells: Searching for Chinks in Cellular Armor. 放射治疗与胶质瘤干细胞:寻找细胞盔甲的缝隙。

IF 1.4

Current Stem Cell Reports Pub Date : 2017-12-01 Epub Date: 2017-10-02 DOI: 10.1007/s40778-017-0102-8

Seamus P Caragher, Sean Sachdev, Atique Ahmed

{"title":"Radiotherapy and Glioma Stem Cells: Searching for Chinks in Cellular Armor.","authors":"Seamus P Caragher, Sean Sachdev, Atique Ahmed","doi":"10.1007/s40778-017-0102-8","DOIUrl":"https://doi.org/10.1007/s40778-017-0102-8","url":null,"abstract":"Purpose of the review: Radiation became a pillar of oncologic treatment in the last century and provided a powerful and effective locoregional treatment of solid malignancies. After achieving some of the first cures in lymphomas and skin cancers, it assumed a key role in curative treatment of epithelioid malignancies. Despite success across a variety of histologic types, glioblastoma (GBM), the most common primary brain tumor afflicting adults, remains ultimately resistant to current radiation strategies. While GBMs demonstrate an initial response, recurrence is essentially universal and fatal, and typically reoccur in the areas that received the most intense radiation.Recent findings: Glioma stem cells (GSCs), a subpopulation of tumor cells with expression profiles similar to neural stem cells and marked self-renewal capacities, have been shown to drive tumor recurrence and preclude curative radiotherapy. Recent research has shown that these cells have enhanced DNA repair capacity, elevated resistance to cytotoxic ion fluxes and escape multi-modality therapies.Summary: We will analyze the current understanding of GSCs and radiation by highlighting key discoveries probing their ability to withstand radiotherapy. We then speculate on novel mechanisms by which GSC can be made sensitive to or specifically targeted by radiation therapy.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"3 4","pages":"348-357"},"PeriodicalIF":1.4,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-017-0102-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35754505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

NK Cells and γδT Cells for Relapse Protection After Allogeneic Hematopoietic Cell Transplantation (HCT). NK细胞和γδT细胞对同种异体造血细胞移植术后复发的保护作用。

IF 1.4

Current Stem Cell Reports Pub Date : 2017-12-01 Epub Date: 2017-10-16 DOI: 10.1007/s40778-017-0106-4

Moniek A de Witte, Jürgen Kuball, Jeffrey S Miller

{"title":"NK Cells and γδT Cells for Relapse Protection After Allogeneic Hematopoietic Cell Transplantation (HCT).","authors":"Moniek A de Witte, Jürgen Kuball, Jeffrey S Miller","doi":"10.1007/s40778-017-0106-4","DOIUrl":"https://doi.org/10.1007/s40778-017-0106-4","url":null,"abstract":"Purpose of review: The outcome of allogeneic stem cell transplantation (allo-HCT) is still compromised by relapse and complications. NK cells and γδT cells, effectors which both function through MHC-unrestricted mechanisms, can target transformed and infected cells without inducing Graft-versus-Host Disease (GVHD). Allo-HCT platforms based on CD34+ selection or αβ-TCR depletion result in low grades of GVHD, early immune reconstitution (IR) of NK and γδT cells and minimal usage of GVHD prophylaxis. In this review we will discuss strategies to retain and expand the quantity, diversity and functionality of these reconstituting innate cell types.Recent findings: Bisphosphonates, IL-15 cytokine administration, specific antibodies, checkpoint inhibitors and (CMV based) vaccination are currently being evaluated to enhance IR. All these approaches have shown to potentially enhance both NK and γδT cell immuno-repertoires.Summary: Rapidly accumulating data linking innate biology to proposed clinical immune interventions, will give unique opportunities to unravel shared pathways which determine the Graft-versus-Tumor effects of NK and γδT cells.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"3 4","pages":"301-311"},"PeriodicalIF":1.4,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-017-0106-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35791990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

How Will the Hematopoietic System Deal with Space Radiation on the Way to Mars? 在前往火星的途中，造血系统将如何应对太空辐射?

IF 1.4

Current Stem Cell Reports Pub Date : 2017-10-03 DOI: 10.1007/s40778-017-0104-6

R. Patel, S. Welford

引用次数: 2

CAR T Cells for Solid Tumors CAR - T细胞用于实体瘤

IF 1.4

Current Stem Cell Reports Pub Date : 2017-09-30 DOI: 10.1007/s40778-017-0101-9

B. Moghimi, D. Barrett

引用次数: 13

The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche. 将轴足类肢体再生模型作为干细胞利基工程的探索工具。

IF 1.4

Current Stem Cell Reports Pub Date : 2017-09-01 Epub Date: 2017-07-27 DOI: 10.1007/s40778-017-0085-5

Negar Seyedhassantehrani, Takayoshi Otsuka, Shambhavi Singh, David M Gardiner

{"title":"The Axolotl Limb Regeneration Model as a Discovery Tool for Engineering the Stem Cell Niche.","authors":"Negar Seyedhassantehrani, Takayoshi Otsuka, Shambhavi Singh, David M Gardiner","doi":"10.1007/s40778-017-0085-5","DOIUrl":"10.1007/s40778-017-0085-5","url":null,"abstract":"Purpose of review: Recent advances in genomics and gene editing have expanded the range of model organisms to include those with interesting biological capabilities such as regeneration. Among these are the classic models of regeneration biology, the salamander. Although stimulating endogenous regeneration in humans likely is many years away, with advances in stem cell biology and biomedical engineering (e.g. bio-inspired materials), it is evident that there is great potential to enhance regenerative outcomes by approaching the problem from an engineering perspective. The question at this point is what do we need to engineer?Recent findings: The value of regeneration models is that they show us how regeneration works, which then can guide efforts to mimic these developmental processes therapeutically. Among these models, the Accessory Limb Model (ALM) was developed in the axolotl as a gain-of-function assay for the sequential steps that are required for successful regeneration. To date, this model has identified a number of proregenerative signals, including growth factor signaling associated with nerves, and signals associated with the extracellular matrix (ECM) that induce pattern formation.Summary: Identification of these signals through the use of models in highly regenerative vertebrates (e.g. the axolotl) offers a wide range of possible modifications for engineering bio-inspired, biomimetic materials to create a dynamic stem cell niche for regeneration and scar-free repair.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"3 3","pages":"156-163"},"PeriodicalIF":1.4,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722022/pdf/nihms895878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35331694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0