Current Stem Cell Reports最新文献_第10页

Personalizing Cancer Treatments Empirically in the Laboratory: Patient-Specific Tumor Organoids for Optimizing Precision Medicine 实验室经验个性化癌症治疗:优化精准医疗的患者特异性肿瘤类器官

IF 1.4

Current Stem Cell Reports Pub Date : 2018-04-14 DOI: 10.1007/s40778-018-0122-z

Andrea Mazzocchi, K. Votanopoulos, A. Skardal

引用次数: 4

Epigenetic and Epitranscriptomic Factors Make a Mark on Hematopoietic Stem Cell Development. 表观遗传和表转录组学因素在造血干细胞发育中的作用

IF 1.4

Current Stem Cell Reports Pub Date : 2018-03-01

Dionna M Kasper, Stefania Nicoli

{"title":"Epigenetic and Epitranscriptomic Factors Make a Mark on Hematopoietic Stem Cell Development.","authors":"Dionna M Kasper, Stefania Nicoli","doi":"","DOIUrl":"","url":null,"abstract":"Purpose of the review: Blood specification is a highly dynamic process, whereby committed hemogenic endothelial cells (ECs) progressively transdifferentiate into multipotent, self-renewing hematopoietic stem cells (HSCs). Massive changes in gene expression must occur to switch cell identity, however the factors that mediate such an effect were a mystery until recently. This review summarizes the higher-order mechanisms involved in endothelial to hematopoietic reprogramming identified thus far.Recent findings: Accumulating evidence from mouse and zebrafish studies reveal that numerous chromatin-modifying (epigenetic) and RNA-modifying (epitranscriptomic) factors are required for the formation of HSCs from hemogenic endothelium. These genes function throughout the endothelial-hematopoietic transition, suggesting a dynamic interplay between 'epi'-machineries.Summary: Epigenetic and epitranscriptomic regulation are key mechanisms for reshaping global EC gene expression patterns to those that support HSC production. Future studies that capture modification dynamics should bring us closer to a complete understanding of how HSCs transition from hemogenic endothelium at the molecular level.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999335/pdf/nihms939941.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10441003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hurdles Associated with the Translational Use of Genetically Modified Cells. 与转基因细胞转化使用相关的障碍。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-03-01 Epub Date: 2018-02-17 DOI: 10.1007/s40778-018-0115-y

Sunil S Raikar, H Trent Spencer

{"title":"Hurdles Associated with the Translational Use of Genetically Modified Cells.","authors":"Sunil S Raikar, H Trent Spencer","doi":"10.1007/s40778-018-0115-y","DOIUrl":"https://doi.org/10.1007/s40778-018-0115-y","url":null,"abstract":"Purpose of review: Recent advancements in the use of genetically modified hematopoietic stem cells (HSCs) and the emergent use of chimeric antigen receptor (CAR) T-cell immunotherapy has highlighted issues associated with the use of genetically engineered cellular products. This review explores some of the challenges linked with translating the use of genetically modified cells.Recent findings: The use of genetically modified HSCs for ADA-SCID now has European approval and the U.S. Food and Drug Administration recently approved the use of CAR-T cells for relapsed/refractory B-cell acute lymphoblastic leukemia. Current good manufacturing processes have now been developed for the collection, expansion, storage, modification, and administration of genetically modified cells.Summary: Genetically engineered cells can be used for several therapeutic purposes. However, significant challenges remain in making these cellular therapeutics readily available. A better understanding of this technology along with improvements in the manufacturing process is allowing the translation process to become more standardized.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0115-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38768115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury 更正:肠干细胞在辐射诱导的肠道损伤后上皮再生中的作用

IF 1.4

Current Stem Cell Reports Pub Date : 2018-02-19 DOI: 10.1007/s40778-018-0121-0

Chang-Kyung Kim, V. Yang, A. Bialkowska

引用次数: 1

Development of the Artificial Womb 人工子宫的发展

IF 1.4

Current Stem Cell Reports Pub Date : 2018-02-05 DOI: 10.1007/s40778-018-0120-1

E. Partridge, M. Davey, A. Flake

引用次数: 5

Optimizing T Cell Expansion in a Hollow-Fiber Bioreactor. 在中空纤维生物反应器中优化T细胞扩增。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-02-27 DOI: 10.1007/s40778-018-0116-x

Brian Nankervis, Mark Jones, Boah Vang, R Brent Rice, Claire Coeshott, Jim Beltzer

{"title":"Optimizing T Cell Expansion in a Hollow-Fiber Bioreactor.","authors":"Brian Nankervis, Mark Jones, Boah Vang, R Brent Rice, Claire Coeshott, Jim Beltzer","doi":"10.1007/s40778-018-0116-x","DOIUrl":"https://doi.org/10.1007/s40778-018-0116-x","url":null,"abstract":"Purpose of review: Recent developments in regenerative medicine have precipitated the need to expand gene-modified human T cells to numbers that exceed the capacity of well-plate-based, and flask-based processes. This review discusses the changes in process development that are needed to meet the cell expansion requirements by utilizing hollow-fiber bioreactors. Maintenance of cell proliferation over long periods can become limited by unfilled demands for nutrients and oxygen and by the accumulation of waste products in the local environment.Recent findings: Perfusion feeding, improved gas exchange, and the efficient removal of lactate can increase the yield of T cells from an average of 10.8E +09 to more than 28E +09 in only 10 days.Summary: Aggressively feeding cells and actively keeping cells in the bioreactor improves gas exchange and metabolite management over semi-static methods. The ability to remove the environmental constraints that can limit cell expansion by using a two-chamber hollow-fiber bioreactor will be discussed.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0116-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35961274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

How and Why to Replace the 14-Day Rule. 如何以及为什么要替换14天规则。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-07-16 DOI: 10.1007/s40778-018-0135-7

Sarah Chan

引用次数: 24

The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells. 类固醇激素在乳腺中的作用及其对癌症干细胞的影响

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-03-13 DOI: 10.1007/s40778-018-0114-z

Denis G Alferez, Bruno M Simões, Sacha J Howell, Robert B Clarke

{"title":"The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.","authors":"Denis G Alferez, Bruno M Simões, Sacha J Howell, Robert B Clarke","doi":"10.1007/s40778-018-0114-z","DOIUrl":"10.1007/s40778-018-0114-z","url":null,"abstract":"Purpose of review: This review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a hierarchical organization in tumors where at its apex lies a subpopulation of cancer cells endowed with self-renewal and differentiation capacity.Recent findings: In breast cancer (BC), CSCs have been suggested to play a key role in tumor maintenance, disease progression, and the formation of metastases. In preclinical models of BC, only a few CSCs are required sustain tumor re-growth, especially after conventional anti-endocrine treatments. CSCs include therapy-resistant clones that survive standard of care treatments like chemotherapy, irradiation, and hormonal therapy.Summary: The relevance of hormones for both normal mammary gland and BC development is well described, but it was only recently that the activities of hormones on CSCs have been investigated, opening new directions for future BC treatments and CSCs.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35961278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Instructive Role of the Bone Marrow Niche in Aging and Leukemia. 骨髓生态位在衰老和白血病中的指导作用。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-10-12 DOI: 10.1007/s40778-018-0143-7

Elisa Lazzari, Jason M Butler

{"title":"The Instructive Role of the Bone Marrow Niche in Aging and Leukemia.","authors":"Elisa Lazzari, Jason M Butler","doi":"10.1007/s40778-018-0143-7","DOIUrl":"https://doi.org/10.1007/s40778-018-0143-7","url":null,"abstract":"Purpose of review: In this review, we aim to discuss the role of the bone marrow microenvironment in supporting hematopoiesis, with particular focus on the contribution of the endothelial niche in dictating hematopoietic stem cell (HSC) fate.Recent findings: Evidence gathered in the past two decades revealed that specific cell types within the bone marrow niche influence the hematopoietic system. Endothelial cells have emerged as a key component of the HSC niche, directly affecting stem cell quiescence, self-renewal, and lineage differentiation. Physiological alterations of the bone marrow niche occurring in aging have been described to be sufficient to promote functional aging of young HSCs. Furthermore, a growing body of evidence suggests that aberrant activation of endothelial-derived signaling pathways can aid or trigger neoplastic transformation.Summary: Several groups have contributed to the characterization of the different cell types that comprise the complex bone marrow environment, whose function was long perceived as an undiscernible sum of many parts. Further studies will need to uncover niche cell-type-specific pathways, in order to provide new targets and therapeutic options that aim at withdrawing the microenvironmental support to malignant cells while sparing normal HSCs.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0143-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36758993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease. 干扰素γ在造血干细胞发育、体内平衡和疾病中的作用。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-01-01 Epub Date: 2018-07-23 DOI: 10.1007/s40778-018-0139-3

Daniel E Morales-Mantilla, Katherine Y King

引用次数: 59