Current Stem Cell Reports最新文献_第9页

Tuning of the Hematopoietic Stem Cell Compartment in its Inflammatory Environment. 造血干细胞室在炎症环境中的调节。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-09-01 Epub Date: 2018-07-13 DOI: 10.1007/s40778-018-0131-y

Vinothini Govindarajah, Damien Reynaud

{"title":"Tuning of the Hematopoietic Stem Cell Compartment in its Inflammatory Environment.","authors":"Vinothini Govindarajah, Damien Reynaud","doi":"10.1007/s40778-018-0131-y","DOIUrl":"https://doi.org/10.1007/s40778-018-0131-y","url":null,"abstract":"Purpose of review: The hematopoietic stem cell (HSC) compartment is the cornerstone of a lifelong blood cell production but also contributes to the ability of the hematopoietic system to dynamically respond to environmental challenges. This review summarizes our knowledge about the interaction between HSCs and its inflammatory environment during life and questions how its disruption could affect the health of the hematopoietic system.Recent findings: The latest research demonstrates the direct role of inflammatory signals in promoting the emergence of the HSCs during development and in setting their steady-state activity in adults. They indicate that inflammatory patho-physiological conditions or immunological history could shape the structure and biology of the HSC compartment, therefore altering its overall fitness.Summary: Through instructive and/or selective mechanisms, the inflammatory environment seems to provide a key homeostatic signal for HSCs. Although the mechanistic basis of this complex interplay remains to be fully understood, its dysregulation has broad consequences on HSC physiology and the development of hematological diseases. As such, developing experimental models that fully recapitulate a normal basal inflammatory state could be essential to fully assess HSC biology in native conditions.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0131-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36916965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clonal Hematopoiesis in Aging. 衰老中的克隆造血。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-09-01 Epub Date: 2018-07-19 DOI: 10.1007/s40778-018-0133-9

Soo J Park, Rafael Bejar

{"title":"Clonal Hematopoiesis in Aging.","authors":"Soo J Park, Rafael Bejar","doi":"10.1007/s40778-018-0133-9","DOIUrl":"https://doi.org/10.1007/s40778-018-0133-9","url":null,"abstract":"Purpose of review: Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-associated condition characterized by the acquisition of somatic mutations. This concise review explores our current understanding of the mechanisms that influence the development of clonality with aging and its potential malignant and non-malignant clinical implications.Recent findings: Aging of the hematopoietic system results in phenotypic changes that favor clonal dominance. Cell-extrinsic factors provide additional selective pressures that further shape clonal architecture. Even so, small clones with candidate driver mutations appear to be ubiquitous with age and largely benign in the absence of strong selective pressures. Benign clonal expansion may compensate for the loss of regenerative HSC capacity as we age.Summary: CHIP is a marker of aging that reflects the biologic interplay between HSC aging and cell-extrinsic factors. The clinical significance of CHIP is highly variable and dependent on clinical context. Distinguishing the causal relationships and confounding factors that regulate clonal behavior will be essential to define the mechanistic role of CHIP in aging and potentially mitigate its clinical consequences.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0133-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37203126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Dynamic regulation of hematopoietic stem cells by bone marrow niches. 骨髓生态位对造血干细胞的动态调控。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-09-01 Epub Date: 2018-08-02 DOI: 10.1007/s40778-018-0132-x

Margot May, Anastasiya Slaughter, Daniel Lucas

{"title":"Dynamic regulation of hematopoietic stem cells by bone marrow niches.","authors":"Margot May, Anastasiya Slaughter, Daniel Lucas","doi":"10.1007/s40778-018-0132-x","DOIUrl":"https://doi.org/10.1007/s40778-018-0132-x","url":null,"abstract":"Purpose of review: Hematopoietic stem cells (HSC) reside in a specialized microenvironment called the HSC niche. While key components of the niche have been known for several years, recent advances have identified several additional cell types that regulate HSC in the bone marrow (BM). Here we review our current understanding of the components and dynamics of the HSC niche.Recent findings: While the niche has been considered a stable structure, recent advances clearly show that the niche is regulated in a dynamic manner to control HSC traffic and function. Moreover the niche can rapidly remodel in response to insults to the BM in a process controlled by positive and negative regulators.Summary: Multiple niche cells have been shown to be dynamically regulated by systemic and local signals to influence how the niche controls HSC function. Elucidating how different components of the niche coordinate to orchestrate HSC behavior is essential to understand how the hematopoietic system adjusts blood cell production to the demands of the body.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0132-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37150701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Gene Editing of Stem Cells to Model and Treat Disease 干细胞基因编辑模型和治疗疾病

IF 1.4

Current Stem Cell Reports Pub Date : 2018-07-17 DOI: 10.1007/s40778-018-0140-x

J. Hollywood, D. Sanz, A. Davidson, P. Harrison

引用次数: 0

Regulation of Stem Cell Therapy Travel 干细胞治疗旅行的调控

IF 1.4

Current Stem Cell Reports Pub Date : 2018-07-14 DOI: 10.1007/s40778-018-0134-8

I. Glenn Cohen, Shelly Simana

引用次数: 6

The Ethics of Chimera Creation in Stem Cell Research 干细胞研究中嵌合体产生的伦理问题

IF 1.4

Current Stem Cell Reports Pub Date : 2018-07-09 DOI: 10.1007/s40778-018-0136-6

I. Hyun

引用次数: 10

Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate. 分子生物学:长链非编码RNA介导HSC命运。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-04-16 DOI: 10.1007/s40778-018-0130-z

Nathaniel Magilnick, Mark P Boldin

{"title":"Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate.","authors":"Nathaniel Magilnick, Mark P Boldin","doi":"10.1007/s40778-018-0130-z","DOIUrl":"https://doi.org/10.1007/s40778-018-0130-z","url":null,"abstract":"Purpose of review: Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as key, multi-faceted regulators of gene expression. This review explores the function of lncRNAs in the control of HSC homeostasis and hematopoietic differentiation.Recent findings: Multiple lncRNAs have been implicated in maintaining HSC stemness and enabling progenitors to carry out the correct programs of lineage differentiation. Specific lncRNAs have been identified that regulate the differentiation of multipotent progenitors into terminally differentiated blood cells. These lncRNAs predominantly act by assisting master regulators that drive specific differentiation programs, either by enhancing or repressing the transcription of particular genomic loci.Summary: Long noncoding RNAs contribute to the correct differentiation and maturation of various hematopoietic lineages by assisting with the activation of transcriptional programs in a time- and cell-dependent manner.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0130-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36665758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation. 母体和胎儿对子宫内干细胞移植的免疫反应。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-05-03 DOI: 10.1007/s40778-018-0129-5

Amir Alhajjat, Aimen Shaaban

{"title":"Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation.","authors":"Amir Alhajjat, Aimen Shaaban","doi":"10.1007/s40778-018-0129-5","DOIUrl":"https://doi.org/10.1007/s40778-018-0129-5","url":null,"abstract":"Purpose of review: In Utero Hematopoietic Cellular Transplantation (IUHCT) is a promising intervention for the non-toxic treatment of congenital disease that hinges on the assumption of fetal immunologic immaturity and an inability to reject a hematopoietic allograft. However, clinical IUCHT has failed except in cases where the fetus is severely immunocompromised. The current review examines recent studies of engraftment barriers stemming from either the fetal or maternal immune system.Recent findings: New reports have illuminated roles for maternal humoral and cellular immunity and fetal innate cellular immunity in the resistance to allogeneic IUHCT. These experimental findings have inspired new approaches to overcome these barriers. Despite these advances, postulates regarding a maternal immune barrier to IUHCT provide an inadequate explanation for the well-documented clinical success only in the treatment of fetal immunodeficiency with normal maternal immunity.Summary: Characterization of the maternal and fetal immune response to allogeneic IUHCT provides new insight into the complexity of prenatal tolerance. Future work in this area should aim to provide a unifying explanation for the observed patterns of success and failure with clinical IUHCT.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0129-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37057229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

It's Electric: When Technology Gives a Boost to Stem Cell Science. 它是电的:当技术推动干细胞科学。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-04-24 DOI: 10.1007/s40778-018-0124-x

Abraham P Lee, Mohammad Aghaamoo, Tayloria N G Adams, Lisa A Flanagan

引用次数: 12

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil. 干细胞调控中的缺氧信号通路:好与坏。

IF 1.4

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-04-30 DOI: 10.1007/s40778-018-0127-7

Xinxin Huang, Thao Trinh, Arafat Aljoufi, Hal E Broxmeyer

{"title":"Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil.","authors":"Xinxin Huang, Thao Trinh, Arafat Aljoufi, Hal E Broxmeyer","doi":"10.1007/s40778-018-0127-7","DOIUrl":"https://doi.org/10.1007/s40778-018-0127-7","url":null,"abstract":"Purpose of review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell systems. Stem cells for different lineages/tissues reside in distinct niches, and are exposed to diverse oxygen concentrations. Recent studies have revealed the importance of the hypoxia signaling pathway for stem cell functions.Recent findings: Hypoxia and HIFs contribute to maintenance of embryonic stem cells, generation of induced pluripotent stem cells, functionality of hematopoietic stem cells, and survival of leukemia stem cells. Harvest and collection of mouse bone marrow and human cord blood cells in ambient air results in fewer hematopoietic stem cells recovered due to the phenomenon of Extra PHysiologic Oxygen Shock/Stress (EPHOSS).Summary: Oxygen is an important factor in the stem cell microenvironment. Hypoxia signaling and HIFs play important roles in modeling cellular metabolism in both stem cells and niches to regulate stem cell biology, and represent an additional dimension that allows stem cells to maintain an undifferentiated status and multilineage differentiation potential.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-018-0127-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37397569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48