Role of the hematopoietic stem cells in immunological memory.

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2022-03-01 DOI:10.1007/s40778-021-00204-7

Vinothini Govindarajah, Damien Reynaud

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引用次数: 1

Abstract

Purpose of review: Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune system, the concept of memory has recently been broadened to the innate immune system. This review summarizes recent studies that highlight the contribution of the hematopoietic stem cells (HSCs) in supporting immunological memory.

Recent findings: Short-lived innate immune cells can build a long-lasting memory of infection to improve their response to secondary challenges. Studies show that these unexpected properties of the innate immune system are sustained by epigenetic and metabolic changes in the HSC compartment.

Summary: HSCs are durably altered in response to pathogens and serve as long-term support for innate immune memory. Many questions remain regarding the mechanisms contributing to the induction and the maintenance of this immune memory in HSCs. Answering these questions will open new perspectives to understand how environmental factors shape the HSC activity over time.

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造血干细胞在免疫记忆中的作用。

综述目的:免疫记忆是免疫系统的一种重要的进化适应。记忆的概念以前仅限于适应性免疫系统，最近已扩大到先天免疫系统。本文综述了造血干细胞(hsc)在支持免疫记忆中的作用。近期发现:短命的先天免疫细胞可以建立长期的感染记忆，以改善其对继发性挑战的反应。研究表明，先天免疫系统的这些意想不到的特性是由HSC细胞室的表观遗传和代谢变化维持的。摘要:造血干细胞在对病原体的反应中发生持久的改变，并作为先天免疫记忆的长期支持。关于造血干细胞诱导和维持这种免疫记忆的机制仍然存在许多问题。回答这些问题将为理解环境因素如何随着时间的推移影响HSC活动开辟新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.