造血急性辐射综合征 (H-ARS) 和急性辐射照射延迟效应 (DEARE) 小鼠模型中年龄、性别和遗传多样性的影响。

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Current Stem Cell Reports Pub Date : 2022-09-01 Epub Date: 2022-07-14 DOI:10.1007/s40778-022-00214-z

Christie M Orschell, Tong Wu, Andrea M Patterson

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引用次数: 0

摘要

审查目的：恶意或意外辐照会增加造血急性辐射综合征（H-ARS）和急性辐照延迟效应（DEARE）的风险。辐射医疗对策（MCM）的开发依赖于反映所有年龄组和性别的可靠动物模型。本综述详细介绍了小鼠 H-ARS 和 DEARE 模型开发中的关键注意事项，包括因年龄、性别和遗传多样性而产生的不同辐射反应：最新发现：从小儿到老年，小鼠的放射抗性随着年龄的增长而增加。在不同性别的小鼠中，雄性断奶小鼠、青春期雌性小鼠和老年雄性小鼠的抗辐射能力较强，这与骨髓造血加速有关。杰克逊杂交小鼠（JDO）在辐射反应方面与非人灵长类动物相似，可用于模拟人类的多样性。小结：H-ARS 和 DEARE 小鼠模型具有高度的年龄、性别和多样性特征，为所有辐射受害者的 MCM 开发提供了强大而重要的工具。

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Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE).

Purpose of review: Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Radiation medical countermeasure (MCM) development relies on robust animal models reflective of all age groups and both sexes. This review details critical considerations in murine H-ARS and DEARE model development including divergent radiation responses dependent on age, sex, and genetic diversity.

Recent findings: Radioresistance increases with murine age from pediatrics through geriatrics. Between sexes, radioresistance is higher in male weanlings, pubescent females, and aged males, corresponding with accelerated myelopoiesis. Jackson diversity outbred (JDO) mice resemble non-human primates in radiation response for modeling human diversity. Weanlings and JDO models exhibit less DEARE than other models.

Summary: Highly characterized age-, sex- and diversity-conscious murine models of H-ARS and DEARE provide powerful and essential tools in MCM development for all radiation victims.

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.