Current Stem Cell Reports最新文献_第7页

In Vivo Genome Engineering for the Treatment of Muscular Dystrophies 体内基因组工程治疗肌肉萎缩症

IF 1.4

Current Stem Cell Reports Pub Date : 2020-06-19 DOI: 10.1007/s40778-020-00173-3

M. Kustermann, M. Rok, R. Cohn, E. Ivakine

引用次数: 2

Virus-specific T cells for malignancies - then, now and where to? 针对恶性肿瘤的病毒特异性T细胞——过去、现在和去向?

IF 1.4

Current Stem Cell Reports Pub Date : 2020-06-01 Epub Date: 2020-05-07 DOI: 10.1007/s40778-020-00170-6

Sandhya Sharma, Wingchi K Leung, Helen E Heslop

{"title":"Virus-specific T cells for malignancies - then, now and where to?","authors":"Sandhya Sharma, Wingchi K Leung, Helen E Heslop","doi":"10.1007/s40778-020-00170-6","DOIUrl":"https://doi.org/10.1007/s40778-020-00170-6","url":null,"abstract":"Purpose of review: Virus-associated malignancies are a global health burden, constituting 10-12% of cancers worldwide. As these tumors express foreign viral antigens that can elicit specific T cell responses, virus-directed immunotherapies are a promising treatment strategy. Specifically, adoptive cell transfer of virus-specific T cells (VSTs) has demonstrated the potential to eradicate cancers associated with certain viruses.Recent findings: Initial studies in 1990s first showed that VSTs specific for the Epstein-Barr virus (EBVSTs) can induce complete remissions in patients with post-transplant lymphoproliferative disease. Since then, studies have validated the specificity and safety of VSTs in multiple lymphomas and solid malignancies. However, challenges remain to optimize this platform for widespread use, including enhancing potency and persistence, overcoming the immunosuppressive tumor microenvironment, and streamlining manufacturing processes that comply with regulatory requirements.Summary: This review focuses on data from clinical trials evaluating VSTs directed against three viruses (EBV, HPV and MCPyV), as well as recent preclinical and clinical advances, and potential future directions.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-020-00170-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25493734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cell Therapy for Lung Disease: Current Status and Future Prospects 肺部疾病的细胞治疗：现状与展望

IF 1.4

Current Stem Cell Reports Pub Date : 2020-05-15 DOI: 10.1007/s40778-020-00171-5

S. Rolandsson Enes, D. Weiss

引用次数: 10

The Role of ASXL1/2 and Their Associated Proteins in Malignant Hematopoiesis ASXL1/2及其相关蛋白在恶性造血中的作用

IF 1.4

Current Stem Cell Reports Pub Date : 2020-01-21 DOI: 10.1007/s40778-020-00168-0

Peng Zhang, Mingjiang Xu, Feng-Chun Yang

引用次数: 4

Responsible Translational Pathways for Germline Gene Editing? 种系基因编辑的负责任转化途径？

IF 2.3

Current Stem Cell Reports Pub Date : 2020-01-01 Epub Date: 2020-08-21 DOI: 10.1007/s40778-020-00179-x

Bryan Cwik

引用次数: 0

Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology. 炎症的常见来源及其对造血干细胞生物学的影响。

IF 2.3

Current Stem Cell Reports Pub Date : 2020-01-01 Epub Date: 2020-08-17 DOI: 10.1007/s40778-020-00177-z

Daniel Hormaechea-Agulla, Duy T Le, Katherine Y King

{"title":"Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology.","authors":"Daniel Hormaechea-Agulla, Duy T Le, Katherine Y King","doi":"10.1007/s40778-020-00177-z","DOIUrl":"10.1007/s40778-020-00177-z","url":null,"abstract":"Purpose of review: Inflammatory signals have emerged as critical regulators of hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute changes in systemic inflammation and this influences not only their division rate but also their lineage fate. Identifying how inflammation regulates HSCs and shapes the blood system is crucial to understanding the mechanisms underpinning these processes, as well as potential links between them.Recent findings: A widening array of physiologic and pathologic processes involving heightened inflammation are now recognized to critically affect HSC biology and blood lineage production. Conditions documented to affect HSC function include not only acute and chronic infections but also autoinflammatory conditions, irradiation injury, and physiologic states such as aging and obesity.Summary: Recognizing the contexts during which inflammation affects primitive hematopoiesis is essential to improving our understanding of HSC biology and informing new therapeutic interventions against maladaptive hematopoiesis that occurs during inflammatory diseases, infections, and cancer-related disorders.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38302851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradigms that define lung epithelial progenitor cell fate in development and regeneration. 确定肺上皮祖细胞在发育和再生中的命运的模式。

IF 1.4

Current Stem Cell Reports Pub Date : 2019-12-01 Epub Date: 2019-11-18 DOI: 10.1007/s40778-019-00166-x

Aravind Sivakumar, David B Frank

{"title":"Paradigms that define lung epithelial progenitor cell fate in development and regeneration.","authors":"Aravind Sivakumar, David B Frank","doi":"10.1007/s40778-019-00166-x","DOIUrl":"https://doi.org/10.1007/s40778-019-00166-x","url":null,"abstract":"Purpose of review: Throughout the lifespan, lung injury impedes the primary critical function essential for life-respiration. To repair quickly and efficiently is critical and is orchestrated by a diverse repertoire of progenitor cells and their niche. This review incorporates knowledge gained from early studies in lung epithelial morphogenesis and cell fate and explores its relevance to more recent findings of lung progenitor and stem cells in development and regeneration.Recent findings: Cell fate in the lung is organized into an early specification phase and progressive differentiation phase in lung development. The advent of single cell analysis combined with lineage analysis and projections is uncovering new functional cell types in the lung providing a topographical atlas for progenitor cell lineage commitment during development, homeostasis, and regeneration.Summary: Lineage commitment of lung progenitor cells is spatiotemporally regulated during development. Single cell sequencing technologies have significantly advanced our understanding of the similarities and differences between developmental and regenerative cell fate trajectories. Subsequent unraveling of the molecular mechanisms underlying these cell fate decisions will be essential to manipulating progenitor cells for regeneration.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-00166-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38086037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Mechanistic Insights into Factor VIII Immune Tolerance Induction via Prenatal Cell Therapy in Hemophilia A. 血友病A产前细胞治疗诱导因子VIII免疫耐受的机制

IF 1.4

Current Stem Cell Reports Pub Date : 2019-12-01 Epub Date: 2019-11-20 DOI: 10.1007/s40778-019-00165-y

Martin Rodriguez, Christopher D Porada, Graҫa Almeida-Porada

{"title":"Mechanistic Insights into Factor VIII Immune Tolerance Induction via Prenatal Cell Therapy in Hemophilia A.","authors":"Martin Rodriguez, Christopher D Porada, Graҫa Almeida-Porada","doi":"10.1007/s40778-019-00165-y","DOIUrl":"https://doi.org/10.1007/s40778-019-00165-y","url":null,"abstract":"Purpose of review: Prenatal stem cell and gene therapy approaches are amongst the few therapies that can promise the birth of a healthy infant with specific known genetic diseases. This review describes fetal immune cell signaling and its potential influence on donor cell engraftment, and summarizes mechanisms of central T cell tolerance to peripherally-acquired antigen in the context of prenatal therapies for Hemophilia A.Recent findings: During early gestation, different subsets of antigen presenting cells take up peripherally-acquired, non-inherited antigens and induce the deletion of antigen-reactive T-cell precursors in the thymus, demonstrating the potential for using prenatal cell and gene therapies to induce central tolerance to FVIII in the context of prenatal diagnosis/therapy of Hemophilia A.Summary: Prenatal cell and gene therapies are promising approaches to treat several genetic disorders including Hemophilia A and B. Understanding the mechanisms of how FVIII-specific tolerance is achieved during ontogeny could help develop novel therapies for HA and better approaches to overcome FVIII inhibitors.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-00165-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37887074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Impact of Mosaic Embryos on Procreative Liberty and Procreative Responsibility: Time to Put Innovative Technology on “Pause” 马赛克胚胎对生育自由和生育责任的影响：是时候让创新技术“暂停”了

IF 1.4

Current Stem Cell Reports Pub Date : 2019-09-04 DOI: 10.1007/s40778-019-00164-z

Shizuko Takahashi, P. Patrizio

引用次数: 2

Examining Resources, Initiatives, and Regulatory Pathways to Advance Regenerative Medicine Manufacturing 检查资源，倡议和监管途径，以推进再生医学制造

IF 1.4

Current Stem Cell Reports Pub Date : 2019-08-27 DOI: 10.1007/s40778-019-00163-0

J. Hunsberger, M. Lundberg, J. Allickson, C. Simon, C. Zylberberg, S. Beachy

引用次数: 3