Current Stem Cell Reports最新文献_第7页

Paradigms that define lung epithelial progenitor cell fate in development and regeneration. 确定肺上皮祖细胞在发育和再生中的命运的模式。

IF 1.4

Current Stem Cell Reports Pub Date : 2019-12-01 Epub Date: 2019-11-18 DOI: 10.1007/s40778-019-00166-x

Aravind Sivakumar, David B Frank

{"title":"Paradigms that define lung epithelial progenitor cell fate in development and regeneration.","authors":"Aravind Sivakumar, David B Frank","doi":"10.1007/s40778-019-00166-x","DOIUrl":"https://doi.org/10.1007/s40778-019-00166-x","url":null,"abstract":"Purpose of review: Throughout the lifespan, lung injury impedes the primary critical function essential for life-respiration. To repair quickly and efficiently is critical and is orchestrated by a diverse repertoire of progenitor cells and their niche. This review incorporates knowledge gained from early studies in lung epithelial morphogenesis and cell fate and explores its relevance to more recent findings of lung progenitor and stem cells in development and regeneration.Recent findings: Cell fate in the lung is organized into an early specification phase and progressive differentiation phase in lung development. The advent of single cell analysis combined with lineage analysis and projections is uncovering new functional cell types in the lung providing a topographical atlas for progenitor cell lineage commitment during development, homeostasis, and regeneration.Summary: Lineage commitment of lung progenitor cells is spatiotemporally regulated during development. Single cell sequencing technologies have significantly advanced our understanding of the similarities and differences between developmental and regenerative cell fate trajectories. Subsequent unraveling of the molecular mechanisms underlying these cell fate decisions will be essential to manipulating progenitor cells for regeneration.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"5 4","pages":"133-144"},"PeriodicalIF":1.4,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-00166-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38086037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Mechanistic Insights into Factor VIII Immune Tolerance Induction via Prenatal Cell Therapy in Hemophilia A. 血友病A产前细胞治疗诱导因子VIII免疫耐受的机制

IF 1.4

Current Stem Cell Reports Pub Date : 2019-12-01 Epub Date: 2019-11-20 DOI: 10.1007/s40778-019-00165-y

Martin Rodriguez, Christopher D Porada, Graҫa Almeida-Porada

{"title":"Mechanistic Insights into Factor VIII Immune Tolerance Induction via Prenatal Cell Therapy in Hemophilia A.","authors":"Martin Rodriguez, Christopher D Porada, Graҫa Almeida-Porada","doi":"10.1007/s40778-019-00165-y","DOIUrl":"https://doi.org/10.1007/s40778-019-00165-y","url":null,"abstract":"Purpose of review: Prenatal stem cell and gene therapy approaches are amongst the few therapies that can promise the birth of a healthy infant with specific known genetic diseases. This review describes fetal immune cell signaling and its potential influence on donor cell engraftment, and summarizes mechanisms of central T cell tolerance to peripherally-acquired antigen in the context of prenatal therapies for Hemophilia A.Recent findings: During early gestation, different subsets of antigen presenting cells take up peripherally-acquired, non-inherited antigens and induce the deletion of antigen-reactive T-cell precursors in the thymus, demonstrating the potential for using prenatal cell and gene therapies to induce central tolerance to FVIII in the context of prenatal diagnosis/therapy of Hemophilia A.Summary: Prenatal cell and gene therapies are promising approaches to treat several genetic disorders including Hemophilia A and B. Understanding the mechanisms of how FVIII-specific tolerance is achieved during ontogeny could help develop novel therapies for HA and better approaches to overcome FVIII inhibitors.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"5 4","pages":"145-161"},"PeriodicalIF":1.4,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40778-019-00165-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37887074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Impact of Mosaic Embryos on Procreative Liberty and Procreative Responsibility: Time to Put Innovative Technology on “Pause” 马赛克胚胎对生育自由和生育责任的影响：是时候让创新技术“暂停”了

IF 1.4

Current Stem Cell Reports Pub Date : 2019-09-04 DOI: 10.1007/s40778-019-00164-z

Shizuko Takahashi, P. Patrizio

引用次数: 2

Examining Resources, Initiatives, and Regulatory Pathways to Advance Regenerative Medicine Manufacturing 检查资源，倡议和监管途径，以推进再生医学制造

IF 1.4

Current Stem Cell Reports Pub Date : 2019-08-27 DOI: 10.1007/s40778-019-00163-0

J. Hunsberger, M. Lundberg, J. Allickson, C. Simon, C. Zylberberg, S. Beachy

引用次数: 3

Human Hematopoietic Stem Cells: Concepts and Perspectives on the Biology and Use of Fresh Versus In Vitro–Generated Cells for Therapeutic Applications 人造血干细胞:生物学的概念和观点，以及新鲜细胞与体外细胞在治疗应用中的应用

IF 1.4

Current Stem Cell Reports Pub Date : 2019-07-20 DOI: 10.1007/s40778-019-00162-1

H. Mayani

引用次数: 4

How to Characterize Stem Cells? Contributions from Mathematical Modeling 如何描述干细胞?数学建模的贡献

IF 1.4

Current Stem Cell Reports Pub Date : 2019-05-23 DOI: 10.1007/s40778-019-00155-0

T. Stiehl, A. Marciniak-Czochra

引用次数: 10

Translating HSC Niche Biology for Clinical Applications 转化造血干细胞生态位生物学用于临床应用

IF 1.4

Current Stem Cell Reports Pub Date : 2019-02-21 DOI: 10.1007/s40778-019-0152-1

T. Olson

引用次数: 1

Non-apoptotic Roles of Caspases in Stem Cell Biology, Carcinogenesis, and Radiotherapy 半胱天冬酶在干细胞生物学、癌变和放疗中的非凋亡作用

IF 1.4

Current Stem Cell Reports Pub Date : 2019-01-30 DOI: 10.1007/s40778-019-0151-2

R. Kaakati, Ruya Zhao, Xuhui Bao, Andrew K. Lee, Xinjian Liu, Fang Li, Chuan-Yuan Li

引用次数: 2

Engineered Biomimetic Neural Stem Cell Niche. 工程仿生神经干细胞。

IF 1.4

Current Stem Cell Reports Pub Date : 2019-01-01 Epub Date: 2019-05-20 DOI: 10.1007/s40778-019-00161-2

Rita Matta, Anjelica L Gonzalez

{"title":"Engineered Biomimetic Neural Stem Cell Niche.","authors":"Rita Matta, Anjelica L Gonzalez","doi":"10.1007/s40778-019-00161-2","DOIUrl":"10.1007/s40778-019-00161-2","url":null,"abstract":"Purpose of review: Neural stem cells (NSCs) have the potential to proliferate and differentiate into functional neurons, heightening their potential use for therapeutic applications. This review explores bioengineered systems which recapitulate NSC niche cell-cell and cell-matrix interactions.Recent findings: Delivery of NSCs to the cytotoxic injured brain is limited by low cell survival rates post-transplantation and poor maintenance of native niche bioactive components. The use of biomaterial platforms can mimic in vivo the environment of the two germinal areas of the adult brain in which NSCs thrive. An environmental mimic that includes extracellular proteins and moieties, along with appropriate biomechanical cues has recently demonstrated promising results in enhancing neurogenesis, aiding the production of a bioengineered niche.Summary: Biocomposition, biomechanics, and biostructure can be manipulated through engineered platforms to re-create the biofunctionality of an NSC niche. Upon transplantation and delivery with biomimetic scaffolds, NSCs show potential to promote functional recovery and rebuild neural circuitry post neurological trauma.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"5 3","pages":"109-114"},"PeriodicalIF":1.4,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451115/pdf/nihms-1529882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38325612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral blood stem cell mobilization; a look ahead. 外周血干细胞动员；展望未来。

IF 2.3

Current Stem Cell Reports Pub Date : 2018-12-01 Epub Date: 2018-10-23 DOI: 10.1007/s40778-018-0141-9

Louis M Pelus, Hal E Broxmeyer

{"title":"Peripheral blood stem cell mobilization; a look ahead.","authors":"Louis M Pelus, Hal E Broxmeyer","doi":"10.1007/s40778-018-0141-9","DOIUrl":"10.1007/s40778-018-0141-9","url":null,"abstract":"The purpose of review: Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers are difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remains an area of interest.This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment.Recent findings: Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress, identify strategies to collect more potent competing HSC and new methods to optimize stem cell collection and engraftment are being evaluated.Summary: Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.","PeriodicalId":37444,"journal":{"name":"Current Stem Cell Reports","volume":"4 4","pages":"273-281"},"PeriodicalIF":2.3,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532982/pdf/nihms-1510358.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37274005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0