Peripheral blood stem cell mobilization; a look ahead.

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2018-12-01 Epub Date: 2018-10-23 DOI:10.1007/s40778-018-0141-9

Louis M Pelus, Hal E Broxmeyer

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引用次数: 0

Abstract

The purpose of review: Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers are difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remains an area of interest.This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment.

Recent findings: Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress, identify strategies to collect more potent competing HSC and new methods to optimize stem cell collection and engraftment are being evaluated.

Summary: Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.

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外周血干细胞动员；展望未来。

综述的目的：动员的外周血是血液移植干细胞和祖细胞的主要来源。成功的移植需要足够高质量的干细胞来恢复终身造血，但在一些患者和正常捐献者中，很难达到临界干细胞数量。新的战略，特别是那些提供快速动员和降低成本的战略，仍然是一个令人感兴趣的领域。这篇综述总结了理解干细胞动员过程的关键科学基础，重点是有效收集和移植干细胞的新策略或改进策略。最近的发现：研究为干细胞动员的复杂性提供了新的见解。针对HSC排出等新途径的试剂，确定收集更有力的竞争性HSC的策略，以及优化干细胞收集和移植的新方法正在评估中。摘要：已经确定了直接解决目前造血干细胞动员和移植不足的药物和更有效的策略，并有可能促进动员干细胞的收集和扩大使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.