Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate.

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2018-06-01 Epub Date: 2018-04-16 DOI:10.1007/s40778-018-0130-z

Nathaniel Magilnick, Mark P Boldin

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引用次数: 2

Abstract

Purpose of review: Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as key, multi-faceted regulators of gene expression. This review explores the function of lncRNAs in the control of HSC homeostasis and hematopoietic differentiation.

Recent findings: Multiple lncRNAs have been implicated in maintaining HSC stemness and enabling progenitors to carry out the correct programs of lineage differentiation. Specific lncRNAs have been identified that regulate the differentiation of multipotent progenitors into terminally differentiated blood cells. These lncRNAs predominantly act by assisting master regulators that drive specific differentiation programs, either by enhancing or repressing the transcription of particular genomic loci.

Summary: Long noncoding RNAs contribute to the correct differentiation and maturation of various hematopoietic lineages by assisting with the activation of transcriptional programs in a time- and cell-dependent manner.

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分子生物学:长链非编码RNA介导HSC命运。

综述目的:造血是一个有序的发育过程，需要动态调节以保证对生理挑战的适当反应和预防恶性肿瘤。长链非编码rna正成为基因表达的关键、多方面调控因子。本文就lncrna在控制HSC稳态和造血分化中的作用进行了综述。最近的研究发现:多个lncrna参与维持HSC的干细胞性，并使祖细胞能够执行正确的谱系分化程序。已经鉴定出特异性lncrna调节多能祖细胞向终分化血细胞的分化。这些lncrna主要通过增强或抑制特定基因组位点的转录来协助驱动特定分化程序的主调控因子。摘要:长链非编码rna通过以时间和细胞依赖的方式协助转录程序的激活，有助于各种造血谱系的正确分化和成熟。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.