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Yta7, a chromatin segregase regulated by the cell cycle machinery Yta7，一种受细胞周期机制调节的染色质分离酶
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-03-17 DOI: 10.1080/23723556.2022.2039577
Priyanka Bansal, Christoph F. Kurat
{"title":"Yta7, a chromatin segregase regulated by the cell cycle machinery","authors":"Priyanka Bansal, Christoph F. Kurat","doi":"10.1080/23723556.2022.2039577","DOIUrl":"https://doi.org/10.1080/23723556.2022.2039577","url":null,"abstract":"ABSTRACT We have recently revealed the existence of a cell cycle-regulated chromatin segregase, Yta7 (Yeast Tat-binding Analog 7), involved in chromosome replication. Phosphorylation of Yta7 by S-CDK (S-phase Cyclin-Dependent Kinase) regulates its function. These findings link the cell cycle to chromatin biology and suggest how chromatin-modifying enzymes become S phase-specific.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44218697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Escape from senescence: revisiting cancer therapeutic strategies 逃离衰老：重新审视癌症治疗策略
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-02-15 DOI: 10.1080/23723556.2022.2030158
C. Zampetidis, A. Papantonis, V. Gorgoulis
{"title":"Escape from senescence: revisiting cancer therapeutic strategies","authors":"C. Zampetidis, A. Papantonis, V. Gorgoulis","doi":"10.1080/23723556.2022.2030158","DOIUrl":"https://doi.org/10.1080/23723556.2022.2030158","url":null,"abstract":"ABSTRACT Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may benefit if revisited to include senolytic agents.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43985178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma. 脂质代谢异常是侵袭性结直肠癌的一个可操作的弱点
IF 2.6
Molecular and Cellular Oncology Pub Date : 2022-01-27 eCollection Date: 2022-01-01 DOI: 10.1080/23723556.2021.2024051
Daria Capece, Guido Franzoso
{"title":"Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma.","authors":"Daria Capece, Guido Franzoso","doi":"10.1080/23723556.2021.2024051","DOIUrl":"10.1080/23723556.2021.2024051","url":null,"abstract":"<p><p>Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":"2024051"},"PeriodicalIF":2.6,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8890390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42614938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes Barrett食管分期与SBS17相关DNA突变的相关性及组织学标志基因的鉴定
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-22 DOI: 10.1080/23723556.2022.2026559
Georg A. Busslinger
{"title":"Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes","authors":"Georg A. Busslinger","doi":"10.1080/23723556.2022.2026559","DOIUrl":"https://doi.org/10.1080/23723556.2022.2026559","url":null,"abstract":"ABSTRACT We have recently reported a correlation between the accumulation of specific T > C and T > G mutations and the chromosomal instability in cells of Barrett's esophagus (BE), which represents a premalignant condition of esophageal adenocarcinoma. Additionally, we identified seven marker genes that facilitate the distinction of individual BE stages by histopathological examination.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49398877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment 肿瘤抑制途径影响EGFR驱动的肺部肿瘤进展和治疗反应
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-14 DOI: 10.1080/23723556.2021.1994328
G. Foggetti, Chuan Li, Hongchen Cai, D. Petrov, M. Winslow, K. Politi
{"title":"Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment","authors":"G. Foggetti, Chuan Li, Hongchen Cai, D. Petrov, M. Winslow, K. Politi","doi":"10.1080/23723556.2021.1994328","DOIUrl":"https://doi.org/10.1080/23723556.2021.1994328","url":null,"abstract":"ABSTRACT In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosine kinase inhibitors and reflect the mutational landscape and treatment outcomes in the human disease.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45382571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα. 抑制细胞死亡：线粒体与 IκΒα 之间意想不到的联系。
IF 2.6
Molecular and Cellular Oncology Pub Date : 2022-01-11 eCollection Date: 2021-01-01 DOI: 10.4161/23723556.2014.995020
Evangelos Pazarentzos
{"title":"Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα.","authors":"Evangelos Pazarentzos","doi":"10.4161/23723556.2014.995020","DOIUrl":"10.4161/23723556.2014.995020","url":null,"abstract":"<p><p>IκΒα (the protein product of <i>NFKBIA</i> gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activity at the outer mitochondria membrane (OMM). This function we uncovered is distinct from its ability to sequester and inhibit NFκB. IκΒα instead binds to voltage dependent anion channel 1 (VDAC1) and Hexokinase 2 (HK2), stabilizes this complex and prevents mitochondria outer membrane permeabilisation (MOMP) and apoptosis.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 1","pages":"995020"},"PeriodicalIF":2.6,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70555083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APOBEC3 as a driver of genetic intratumor heterogeneity. APOBEC3作为肿瘤内遗传异质性的驱动因素
IF 2.6
Molecular and Cellular Oncology Pub Date : 2022-01-03 eCollection Date: 2023-01-01 DOI: 10.1080/23723556.2021.2014734
Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton
{"title":"APOBEC3 as a driver of genetic intratumor heterogeneity.","authors":"Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton","doi":"10.1080/23723556.2021.2014734","DOIUrl":"10.1080/23723556.2021.2014734","url":null,"abstract":"<p><p>Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"1 1","pages":"2014734"},"PeriodicalIF":2.6,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47306257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment, authenticity, and characterization of cervical cancer cell lines. 子宫颈癌细胞系的建立、真实性和特性。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-01 DOI: 10.1080/23723556.2022.2078628
Ma de Lourdes Zuñiga Martinez, Carlos Miguel López Mendoza, Jared Tenorio Salazar, Alejandro Manuel García Carrancá, Marco Antonio Cerbón Cervantes, Luz Eugenia Alcántara-Quintana
{"title":"Establishment, authenticity, and characterization of cervical cancer cell lines.","authors":"Ma de Lourdes Zuñiga Martinez,&nbsp;Carlos Miguel López Mendoza,&nbsp;Jared Tenorio Salazar,&nbsp;Alejandro Manuel García Carrancá,&nbsp;Marco Antonio Cerbón Cervantes,&nbsp;Luz Eugenia Alcántara-Quintana","doi":"10.1080/23723556.2022.2078628","DOIUrl":"https://doi.org/10.1080/23723556.2022.2078628","url":null,"abstract":"<p><p>Cell lines have been considered excellent research models in many areas of biomedicine and, specifically, in the study of carcinogenesis. However, they cease to be effective models if their behavior changes. Although studies on the cross-contamination of cell lines originating from different tissues have been performed, little is known about cell lines derived from cervical neoplasia. We know that high-risk HPV (HR-HPV) is associated with the development of this type of cancer. This link between HPV infection and cancer was first established over 35 years ago when HPV16 DNA was found to be present in a large proportion of cervical cancer biopsies. The present review paper aims to report the status of the establishment, authenticity, and characterization of cervical cancer (CC) cell lines. This is a systematic review of articles on the establishment, authenticity, and characterization of CC cell lines, published from 1960 to date in the databases and in cell repository databases. 52 cell lines were identified in the literature. Only 25 cell lines were derived from cervical neoplasia, of which only 45.8% have a reported identity test (genomic fingerprint). Despite the increase in the establishment of cell lines of cervical neoplasia and the standards for the regulation of these study models, the criteria for their characterization continue to be diverse.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"9 1","pages":"2078628"},"PeriodicalIF":2.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer. 全基因组CRISPR筛选揭示了RIT1-驱动的癌症的新治疗靶点。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-16 DOI: 10.1080/23723556.2021.2000318
Amanda K Riley, Alice H Berger
{"title":"Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer.","authors":"Amanda K Riley,&nbsp;Alice H Berger","doi":"10.1080/23723556.2021.2000318","DOIUrl":"https://doi.org/10.1080/23723556.2021.2000318","url":null,"abstract":"<p><p>In recent work, we performed CRISPR/Cas9 screening in <i>RIT1 (Ras-like in all tissues)-</i>mutant cancer cells. We found that <i>RIT1</i>-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in oncogenesis. These findings can be leveraged to identify targeted therapies for <i>RIT1</i>-mutant cancer.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 6","pages":"2000318"},"PeriodicalIF":2.1,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997261/pdf/KMCO_8_2000318.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41145264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic condensates regulate chromatin activity and tumorigenesis. 表观遗传凝聚体调节染色质活性和肿瘤发生。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-09 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1997040
Bi Shi, Wei Li, Hao Jiang
{"title":"Epigenetic condensates regulate chromatin activity and tumorigenesis.","authors":"Bi Shi,&nbsp;Wei Li,&nbsp;Hao Jiang","doi":"10.1080/23723556.2021.1997040","DOIUrl":"https://doi.org/10.1080/23723556.2021.1997040","url":null,"abstract":"<p><p>Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransferase 2D (KMT2D, also known as MLL4) and regulating chromatin activity at multiple levels.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1997040"},"PeriodicalIF":2.1,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/d8/KMCO_8_1997040.PMC8632315.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39688332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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