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Molecular and Cellular Oncology最新文献

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Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer. 全基因组CRISPR筛选揭示了RIT1-驱动的癌症的新治疗靶点。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-16 DOI: 10.1080/23723556.2021.2000318
Amanda K Riley, Alice H Berger
{"title":"Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer.","authors":"Amanda K Riley,&nbsp;Alice H Berger","doi":"10.1080/23723556.2021.2000318","DOIUrl":"https://doi.org/10.1080/23723556.2021.2000318","url":null,"abstract":"<p><p>In recent work, we performed CRISPR/Cas9 screening in <i>RIT1 (Ras-like in all tissues)-</i>mutant cancer cells. We found that <i>RIT1</i>-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in oncogenesis. These findings can be leveraged to identify targeted therapies for <i>RIT1</i>-mutant cancer.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 6","pages":"2000318"},"PeriodicalIF":2.1,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997261/pdf/KMCO_8_2000318.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41145264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic condensates regulate chromatin activity and tumorigenesis. 表观遗传凝聚体调节染色质活性和肿瘤发生。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-09 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1997040
Bi Shi, Wei Li, Hao Jiang
{"title":"Epigenetic condensates regulate chromatin activity and tumorigenesis.","authors":"Bi Shi,&nbsp;Wei Li,&nbsp;Hao Jiang","doi":"10.1080/23723556.2021.1997040","DOIUrl":"https://doi.org/10.1080/23723556.2021.1997040","url":null,"abstract":"<p><p>Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransferase 2D (KMT2D, also known as MLL4) and regulating chromatin activity at multiple levels.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1997040"},"PeriodicalIF":2.1,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/d8/KMCO_8_1997040.PMC8632315.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39688332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A therapeutic window for preventive therapy in NF1-associated optic pathway glioma nf1相关视神经胶质瘤预防性治疗的治疗窗口期
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.1989262
Yuan Zhu, Wang Zheng, Emmanuelle S. Jecrois, Brianna R. Pierce, Daniel M. Treisman
{"title":"A therapeutic window for preventive therapy in NF1-associated optic pathway glioma","authors":"Yuan Zhu, Wang Zheng, Emmanuelle S. Jecrois, Brianna R. Pierce, Daniel M. Treisman","doi":"10.1080/23723556.2021.1989262","DOIUrl":"https://doi.org/10.1080/23723556.2021.1989262","url":null,"abstract":"ABSTRACT Pediatric low-grade gliomas (pLGGs) are almost universally driven by abnormal activation of RAS-mediated MEK-ERK/MAPK signaling pathway. pLGGs predominantly occur in children, suggesting that they originate in an ERK-dependent neural stem/progenitor population(s) transiently present in the developing brain. Our recent preclinical study reveals a cell-lineage-of-origin and develops a chemopreventative therapeutic strategy.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44070503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Interdisciplinary team science to understand and intercept rare cancers 跨学科团队科学理解和拦截罕见癌症
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.1997331
S. Fröhling
{"title":"Interdisciplinary team science to understand and intercept rare cancers","authors":"S. Fröhling","doi":"10.1080/23723556.2021.1997331","DOIUrl":"https://doi.org/10.1080/23723556.2021.1997331","url":null,"abstract":"ABSTRACT For most rare cancers, precision oncology approaches are not established because these entities are poorly understood and their investigation requires the collaboration of many centers. The MASTER precision oncology network demonstrates that clinical whole-genome/exome and RNA sequencing yield molecular mechanism-aware treatments that benefit a substantial proportion of patients with advanced rare cancers and will prepare the ground for future clinical trials.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47283118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Greasy GLUT1 maintains glioblastoma malignancy 油腻的GLUT1维持胶质母细胞瘤的恶性
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.2009423
Caiyun Liu, Xinjian Li
{"title":"Greasy GLUT1 maintains glioblastoma malignancy","authors":"Caiyun Liu, Xinjian Li","doi":"10.1080/23723556.2021.2009423","DOIUrl":"https://doi.org/10.1080/23723556.2021.2009423","url":null,"abstract":"ABSTRACT How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane localization. DHHC9-mediated GLUT1 palmitoylation supports glycolysis, proliferation, colony formation, and tumorigenicity of glioblastoma cells.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42374549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity PTEN的完美转录调控决定了肉瘤的特性
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.2002120
C. G. Langdon, M. Hatley
{"title":"The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity","authors":"C. G. Langdon, M. Hatley","doi":"10.1080/23723556.2021.2002120","DOIUrl":"https://doi.org/10.1080/23723556.2021.2002120","url":null,"abstract":"ABSTRACT Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell identity. These results highlight the importance between transcriptional state, cell of origin, and genetic perturbation in tumorigenesis.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43439788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
ZNF768: controlling cellular senescence and proliferation with ten fingers ZNF768：用十指控制细胞衰老和增殖
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.1985930
Romain Villot, Audrey Poirier, R. Devillers, A. Kolnoguz, S. Elowe, V. Manem, P. Joubert, Frédérick A. Mallette, M. Laplante
{"title":"ZNF768: controlling cellular senescence and proliferation with ten fingers","authors":"Romain Villot, Audrey Poirier, R. Devillers, A. Kolnoguz, S. Elowe, V. Manem, P. Joubert, Frédérick A. Mallette, M. Laplante","doi":"10.1080/23723556.2021.1985930","DOIUrl":"https://doi.org/10.1080/23723556.2021.1985930","url":null,"abstract":"ABSTRACT We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senescence, while its overexpression allows cells to bypass oncogene-induced senescence. Elevated ZNF768 levels is common in tumors, suggesting that ZNF768 may help to escape cellular senescence, sustain proliferation and promote malignant transformation. Here, we discuss these recent findings and highlight key questions emerging from our work.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46161742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Filling in the gaps in PARP inhibitor-induced synthetic lethality 填补PARP抑制剂诱导的合成致死率的空白
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.2010512
Mariana Paes Dias, J. Jonkers
{"title":"Filling in the gaps in PARP inhibitor-induced synthetic lethality","authors":"Mariana Paes Dias, J. Jonkers","doi":"10.1080/23723556.2021.2010512","DOIUrl":"https://doi.org/10.1080/23723556.2021.2010512","url":null,"abstract":"ABSTRACT Tumors with loss of breast cancer type 1 susceptibility protein (BRCA1) are homologous recombination (HR) deficient and hypersensitive to poly(ADP-ribose) polymerase inhibitors (PARPi). However, these tumors may restore HR and acquire PARPi resistance via loss of end-protection of DNA double-strand breaks. We found that loss of nuclear DNA ligase III resensitizes HR-restored BRCA1-deficient cells to PARPi by exposing post-replicative single-stranded DNA (ssDNA) gaps. Our work, and that of others, identifies ssDNA gaps as a key determinant of PARPi response.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46061335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma KRAS突变型肺腺癌RTK依赖性转移表型的新见解
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.2013723
Mariana Cooke
{"title":"Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma","authors":"Mariana Cooke","doi":"10.1080/23723556.2021.2013723","DOIUrl":"https://doi.org/10.1080/23723556.2021.2013723","url":null,"abstract":"ABSTRACT In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation of membrane ruffles in response to growth factor receptor stimulation.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49485087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy SPF45/ rbm17依赖性剪接与肿瘤化疗多药耐药
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-11-02 DOI: 10.1080/23723556.2021.1996318
Kazuhiro Fukumura, J. Venables, A. Mayeda
{"title":"SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy","authors":"Kazuhiro Fukumura, J. Venables, A. Mayeda","doi":"10.1080/23723556.2021.1996318","DOIUrl":"https://doi.org/10.1080/23723556.2021.1996318","url":null,"abstract":"ABSTRACT The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43957415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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