逃离衰老：重新审视癌症治疗策略

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2022-02-15 DOI:10.1080/23723556.2022.2030158

C. Zampetidis, A. Papantonis, V. Gorgoulis

引用次数: 3

摘要

虽然衰老被认为是一种不可逆的细胞停滞状态，但越来越多的证据挑战了这一观点。因此，衰老似乎是阻止癌症进展的不完美屏障，是疾病复发之前的一个步骤。因此，如果重新考虑包括抗衰老药物在内的癌症治疗策略，可能会受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Escape from senescence: revisiting cancer therapeutic strategies

ABSTRACT Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may benefit if revisited to include senolytic agents.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.