Yta7，一种受细胞周期机制调节的染色质分离酶

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2022-03-17 DOI:10.1080/23723556.2022.2039577

Priyanka Bansal, Christoph F. Kurat

引用次数: 2

摘要

我们最近发现了一种细胞周期调节的染色质分离酶Yta7(酵母tat结合类似物7)的存在，它参与了染色体复制。S-CDK (s期周期蛋白依赖激酶)磷酸化Yta7调控其功能。这些发现将细胞周期与染色质生物学联系起来，并提示染色质修饰酶如何成为S期特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Yta7, a chromatin segregase regulated by the cell cycle machinery

ABSTRACT We have recently revealed the existence of a cell cycle-regulated chromatin segregase, Yta7 (Yeast Tat-binding Analog 7), involved in chromosome replication. Phosphorylation of Yta7 by S-CDK (S-phase Cyclin-Dependent Kinase) regulates its function. These findings link the cell cycle to chromatin biology and suggest how chromatin-modifying enzymes become S phase-specific.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.