肿瘤抑制途径影响EGFR驱动的肺部肿瘤进展和治疗反应

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2022-01-14 DOI:10.1080/23723556.2021.1994328

G. Foggetti, Chuan Li, Hongchen Cai, D. Petrov, M. Winslow, K. Politi

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引用次数: 0

摘要

体内建模结合CRISPR/ cas9介导的体细胞基因组编辑有助于阐明人类肿瘤中特定遗传改变的功能重要性。我们最近的工作揭示了影响egfr驱动的肺肿瘤生长和对酪氨酸激酶抑制剂敏感性的肿瘤抑制通路，并反映了人类疾病的突变景观和治疗结果。

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Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment

ABSTRACT In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosine kinase inhibitors and reflect the mutational landscape and treatment outcomes in the human disease.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.