表观遗传凝聚体调节染色质活性和肿瘤发生。

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-11-09 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1997040

Bi Shi, Wei Li, Hao Jiang

引用次数: 0

摘要

表观遗传调节剂的改变与癌症广泛相关，但其在癌症调控中的关键分子活动往往不清楚。我们发现赖氨酸去甲基化酶6A (KDM6A，也称为UTX)通过与赖氨酸甲基转移酶2D (KMT2D，也称为MLL4)形成液体状凝聚体并在多个水平上调节染色质活性来抑制癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Epigenetic condensates regulate chromatin activity and tumorigenesis.

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Epigenetic condensates regulate chromatin activity and tumorigenesis.

Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransferase 2D (KMT2D, also known as MLL4) and regulating chromatin activity at multiple levels.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.