发布求助
文献互助 智能选刊 最新文献

Molecular and Cellular Oncology最新文献

筛选
英文 中文
RAD51 wrestles with SUMO RAD51与相扑摔跤
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-03-31 DOI: 10.1080/23723556.2022.2054263
Y. Kee, Jung-Hee Lee, H. You
{"title":"RAD51 wrestles with SUMO","authors":"Y. Kee, Jung-Hee Lee, H. You","doi":"10.1080/23723556.2022.2054263","DOIUrl":"https://doi.org/10.1080/23723556.2022.2054263","url":null,"abstract":"ABSTRACT RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42435538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological effects of olive oil phenolic compounds on mitochondria 橄榄油酚类化合物对线粒体的生物学效应
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-03-20 DOI: 10.1080/23723556.2022.2044263
Mercedes Blanco-Benítez, Ana Calderón-Fernández, Saray Canales-Cortés, Eva Alegre-Cortés, E. Uribe-Carretero, Marta Paredes-Barquero, Alberto Giménez-Bejarano, Gema Duque González, P. Gomez-Suaga, J. Ortega-Vidal, S. Salido, J. Altarejos, G. Martínez-Chacón, M. Niso-Santano, J. M. Fuentes, R. González-Polo, S. M. Yakhine-Diop
{"title":"Biological effects of olive oil phenolic compounds on mitochondria","authors":"Mercedes Blanco-Benítez, Ana Calderón-Fernández, Saray Canales-Cortés, Eva Alegre-Cortés, E. Uribe-Carretero, Marta Paredes-Barquero, Alberto Giménez-Bejarano, Gema Duque González, P. Gomez-Suaga, J. Ortega-Vidal, S. Salido, J. Altarejos, G. Martínez-Chacón, M. Niso-Santano, J. M. Fuentes, R. González-Polo, S. M. Yakhine-Diop","doi":"10.1080/23723556.2022.2044263","DOIUrl":"https://doi.org/10.1080/23723556.2022.2044263","url":null,"abstract":"ABSTRACT Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in oxidative capacity, mitochondrial respiration, and energetic demands. This review focuses on the versatile role of oleuropein, a potent antioxidant that regulates the AMPK/SIRT1/mTOR pathway to modulate autophagy/mitophagy and maintain metabolic homeostasis.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41289739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Yta7, a chromatin segregase regulated by the cell cycle machinery Yta7，一种受细胞周期机制调节的染色质分离酶
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-03-17 DOI: 10.1080/23723556.2022.2039577
Priyanka Bansal, Christoph F. Kurat
{"title":"Yta7, a chromatin segregase regulated by the cell cycle machinery","authors":"Priyanka Bansal, Christoph F. Kurat","doi":"10.1080/23723556.2022.2039577","DOIUrl":"https://doi.org/10.1080/23723556.2022.2039577","url":null,"abstract":"ABSTRACT We have recently revealed the existence of a cell cycle-regulated chromatin segregase, Yta7 (Yeast Tat-binding Analog 7), involved in chromosome replication. Phosphorylation of Yta7 by S-CDK (S-phase Cyclin-Dependent Kinase) regulates its function. These findings link the cell cycle to chromatin biology and suggest how chromatin-modifying enzymes become S phase-specific.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44218697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Escape from senescence: revisiting cancer therapeutic strategies 逃离衰老：重新审视癌症治疗策略
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-02-15 DOI: 10.1080/23723556.2022.2030158
C. Zampetidis, A. Papantonis, V. Gorgoulis
{"title":"Escape from senescence: revisiting cancer therapeutic strategies","authors":"C. Zampetidis, A. Papantonis, V. Gorgoulis","doi":"10.1080/23723556.2022.2030158","DOIUrl":"https://doi.org/10.1080/23723556.2022.2030158","url":null,"abstract":"ABSTRACT Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may benefit if revisited to include senolytic agents.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43985178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma 脂质代谢异常是侵袭性结直肠癌的一个可操作的弱点
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-27 DOI: 10.1080/23723556.2021.2024051
D. Capece, G. Franzoso
{"title":"Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma","authors":"D. Capece, G. Franzoso","doi":"10.1080/23723556.2021.2024051","DOIUrl":"https://doi.org/10.1080/23723556.2021.2024051","url":null,"abstract":"ABSTRACT Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42614938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes Barrett食管分期与SBS17相关DNA突变的相关性及组织学标志基因的鉴定
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-22 DOI: 10.1080/23723556.2022.2026559
Georg A. Busslinger
{"title":"Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes","authors":"Georg A. Busslinger","doi":"10.1080/23723556.2022.2026559","DOIUrl":"https://doi.org/10.1080/23723556.2022.2026559","url":null,"abstract":"ABSTRACT We have recently reported a correlation between the accumulation of specific T > C and T > G mutations and the chromosomal instability in cells of Barrett's esophagus (BE), which represents a premalignant condition of esophageal adenocarcinoma. Additionally, we identified seven marker genes that facilitate the distinction of individual BE stages by histopathological examination.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49398877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment 肿瘤抑制途径影响EGFR驱动的肺部肿瘤进展和治疗反应
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-14 DOI: 10.1080/23723556.2021.1994328
G. Foggetti, Chuan Li, Hongchen Cai, D. Petrov, M. Winslow, K. Politi
{"title":"Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment","authors":"G. Foggetti, Chuan Li, Hongchen Cai, D. Petrov, M. Winslow, K. Politi","doi":"10.1080/23723556.2021.1994328","DOIUrl":"https://doi.org/10.1080/23723556.2021.1994328","url":null,"abstract":"ABSTRACT In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosine kinase inhibitors and reflect the mutational landscape and treatment outcomes in the human disease.","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45382571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα. 抑制细胞死亡：线粒体与 IκΒα 之间意想不到的联系。
IF 2.6
Molecular and Cellular Oncology Pub Date : 2022-01-11 eCollection Date: 2021-01-01 DOI: 10.4161/23723556.2014.995020
Evangelos Pazarentzos
{"title":"Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα.","authors":"Evangelos Pazarentzos","doi":"10.4161/23723556.2014.995020","DOIUrl":"10.4161/23723556.2014.995020","url":null,"abstract":"<p><p>IκΒα (the protein product of <i>NFKBIA</i> gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activity at the outer mitochondria membrane (OMM). This function we uncovered is distinct from its ability to sequester and inhibit NFκB. IκΒα instead binds to voltage dependent anion channel 1 (VDAC1) and Hexokinase 2 (HK2), stabilizes this complex and prevents mitochondria outer membrane permeabilisation (MOMP) and apoptosis.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 1","pages":"995020"},"PeriodicalIF":2.6,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70555083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APOBEC3 as a driver of genetic intratumor heterogeneity. APOBEC3作为肿瘤内遗传异质性的驱动因素
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-03 eCollection Date: 2023-01-01 DOI: 10.1080/23723556.2021.2014734
Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton
{"title":"APOBEC3 as a driver of genetic intratumor heterogeneity.","authors":"Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton","doi":"10.1080/23723556.2021.2014734","DOIUrl":"10.1080/23723556.2021.2014734","url":null,"abstract":"<p><p>Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"1 1","pages":"2014734"},"PeriodicalIF":2.1,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47306257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment, authenticity, and characterization of cervical cancer cell lines. 子宫颈癌细胞系的建立、真实性和特性。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2022-01-01 DOI: 10.1080/23723556.2022.2078628
Ma de Lourdes Zuñiga Martinez, Carlos Miguel López Mendoza, Jared Tenorio Salazar, Alejandro Manuel García Carrancá, Marco Antonio Cerbón Cervantes, Luz Eugenia Alcántara-Quintana
{"title":"Establishment, authenticity, and characterization of cervical cancer cell lines.","authors":"Ma de Lourdes Zuñiga Martinez,&nbsp;Carlos Miguel López Mendoza,&nbsp;Jared Tenorio Salazar,&nbsp;Alejandro Manuel García Carrancá,&nbsp;Marco Antonio Cerbón Cervantes,&nbsp;Luz Eugenia Alcántara-Quintana","doi":"10.1080/23723556.2022.2078628","DOIUrl":"https://doi.org/10.1080/23723556.2022.2078628","url":null,"abstract":"<p><p>Cell lines have been considered excellent research models in many areas of biomedicine and, specifically, in the study of carcinogenesis. However, they cease to be effective models if their behavior changes. Although studies on the cross-contamination of cell lines originating from different tissues have been performed, little is known about cell lines derived from cervical neoplasia. We know that high-risk HPV (HR-HPV) is associated with the development of this type of cancer. This link between HPV infection and cancer was first established over 35 years ago when HPV16 DNA was found to be present in a large proportion of cervical cancer biopsies. The present review paper aims to report the status of the establishment, authenticity, and characterization of cervical cancer (CC) cell lines. This is a systematic review of articles on the establishment, authenticity, and characterization of CC cell lines, published from 1960 to date in the databases and in cell repository databases. 52 cell lines were identified in the literature. Only 25 cell lines were derived from cervical neoplasia, of which only 45.8% have a reported identity test (genomic fingerprint). Despite the increase in the establishment of cell lines of cervical neoplasia and the standards for the regulation of these study models, the criteria for their characterization continue to be diverse.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"9 1","pages":"2078628"},"PeriodicalIF":2.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信