YES，一种新的肝细胞癌治疗靶点

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2022-05-01 DOI:10.1080/23723556.2022.2069993

Marjorie Lapouge, S. Meloche

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引用次数: 1

摘要

摘要：识别显性、可操作的致癌信号通路是指导晚期肝细胞癌（HCC）新靶向治疗方法开发的关键。我们最近公布了一种新型的YES-YAP/TAZ信号轴，它与癌症的发展有关。我们的研究确定酪氨酸激酶YES是HCC的潜在治疗靶点。

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YES, a novel therapeutic target in hepatocellular carcinoma

ABSTRACT Identification of dominant, actionable oncogenic signaling pathways is key to guide the development of new targeted treatments for advanced-stage hepatocellular carcinoma (HCC). We have recently unveiled a novel YES-YAP/TAZ signaling axis involved in liver cancer development. Our study identifies the tyrosine kinase YES as a potential therapeutic target in HCC.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.