How often is each gene mutated within the cancer patient population?

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2022-05-01 eCollection Date: 2022-01-01 DOI:10.1080/23723556.2022.2065176

Gaurav Mendiratta, Michael K Jones, Edward C Stites

引用次数: 0

Abstract

Genome sequenced samples from cancer patients helped identify roles of different mutation types and enabled targeted therapy development. However, critical questions like what are the gene mutation rates among the patients? or what genes are most commonly mutated, pan-cancer? have only been recently answered. Here, we highlight this recent advance.

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在癌症患者群体中，每种基因突变的频率是多少？

癌症患者的基因组测序样本有助于确定不同突变类型的作用，并促进靶向疗法的开发。然而，诸如患者的基因突变率是多少、哪些基因是泛癌症中最常见的突变基因等关键问题直到最近才有了答案。在此，我们将重点介绍这一最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.