CircZNF609 as a prototype to elucidate the biological function of circRNA-mRNA interactions

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2022-04-11 DOI:10.1080/23723556.2022.2055939

M. Beltran, F. Rossi, I. Bozzoni

引用次数: 3

Abstract

ABSTRACT Circular RNAs (circRNAs) are expressed and are regulated in many biological processes but little is known about their ability to directly control mRNA homeostasis. We show that circRNA zinc finger protein 609 (circZNF609) interacts with several mRNAs increasing the final protein levels, which in the case of the cytoskeleton-associated protein 5 (CKAP5) leads to a stabilized microtubule cytoskeleton and an enhanced tumor cell proliferation.

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CircZNF609作为原型来阐明circRNA-mRNA相互作用的生物学功能

环状rna (circRNAs)在许多生物过程中表达和调控，但对其直接控制mRNA稳态的能力知之甚少。我们发现circRNA锌指蛋白609 (circZNF609)与几种mrna相互作用，增加最终蛋白水平，在细胞骨架相关蛋白5 (CKAP5)的情况下，导致稳定的微管细胞骨架和增强的肿瘤细胞增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.