Barrett食管分期与SBS17相关DNA突变的相关性及组织学标志基因的鉴定

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2022-01-22 DOI:10.1080/23723556.2022.2026559

Georg A. Busslinger

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引用次数: 0

摘要

摘要：我们最近报道了特异性T>C和T>G突变的积累与巴雷特食管（BE）细胞中染色体不稳定之间的相关性，这代表了食管腺癌的癌前状态。此外，我们通过组织病理学检查鉴定了七个有助于区分个体BE分期的标记基因。

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Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes

ABSTRACT We have recently reported a correlation between the accumulation of specific T > C and T > G mutations and the chromosomal instability in cells of Barrett's esophagus (BE), which represents a premalignant condition of esophageal adenocarcinoma. Additionally, we identified seven marker genes that facilitate the distinction of individual BE stages by histopathological examination.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.