European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"Quality of life, sexual function and metabolic parameters of women during 10 years of using the etonogestrel implant","authors":"Salvatore Caruso ,&nbsp;Angelo Cagnacci ,&nbsp;Giuseppe Caruso ,&nbsp;Stefano Cianci ,&nbsp;Marco Palumbo","doi":"10.1016/j.eurox.2025.100421","DOIUrl":"10.1016/j.eurox.2025.100421","url":null,"abstract":"<div><h3>Objective</h3><div>To study the effects on the quality of life (QoL), sexual function and metabolic aspects in women using a subcutaneous implant containing Etonogestrel (ENG-implant) over 10 years of observation period.</div></div><div><h3>Study design</h3><div>This study was performed from January 2011 to September 2023. A database was set up to collect data from women. Counseling on the ENG-implant to be inserted at the termination of pregnancy, and on insert a new device every 3 years was adopted. The Short Form-36 (SF-36), the Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) questionnaires were used to investigate the QoL, sexual function and sexual distress, respectively, of women at baseline and at 6, 12, 24, 36, 72 and 108-month follow-ups. Blood samples were collected from women to measure metabolic parameters.</div></div><div><h3>Results</h3><div>32 of 52 (61.5 %) enrolled women completed the study. In summary, after removing the first (at 36th month of use) and the second implant (at 72nd month of use), 44 (84.6 %) and 32 (61.5 %) women asked for the insertion of a new device, respectively. Somatic (p &lt; 0.001) and mental (p = 0.04) categories of SF-36 improved from the 12-month follow-up to the 108-month follow-up (p &lt; 0.001). FSFI scores also increased from 12-month follow-up to the 108-month follow-up (p &lt; 0.001). The improvement of the total scores depended on the gradual increase in each FSFI item (p &lt; 0.001).</div><div>FSDS score became statistically significant starting from the 12-month follow-up to the 108-month follow-up (p &lt; 0.001). Although lipid metabolism, fasting glucose, liver function and hemostatic parameters were slightly reduced, they remained within the range of the normal values.</div></div><div><h3>Conclusions</h3><div>The long observation period of 10 years allowed us to state that the ENG-implant could have neutral effects on metabolic parameters, promote a better quality of life, and improve sexuality in the users. The main limitation of our study was the small number of women enrolled, mainly due to the cost of the implant. These results should be confirmed on a larger sample.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100421"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical guidance paper VVOG primary and secondary prevention of preterm birth in singleton pregnancies","authors":"François Emilia ,&nbsp;Kouloujian Laurence ,&nbsp;Langermans Lisa-Marie ,&nbsp;Mannaerts Dominique ,&nbsp;Nulens Katrien ,&nbsp;Page Geert ,&nbsp;Ponnet Sophie ,&nbsp;Scheire Eline ,&nbsp;Van Holsbeke Caroline ,&nbsp;Dehaene Isabelle","doi":"10.1016/j.eurox.2025.100401","DOIUrl":"10.1016/j.eurox.2025.100401","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100401"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical guidance paper VVOG HPV vaccination in women undergoing conisation for CIN2 + lesions to prevent recurrence.","authors":"Stephanie Orye ,&nbsp;Saliha Hamici ,&nbsp;Fabian Desimpel ,&nbsp;Sander Dumont ,&nbsp;Ruben Heremans ,&nbsp;Babette Jaime Moens ,&nbsp;Geert Page ,&nbsp;Eline Salaets ,&nbsp;Rawand Salihi ,&nbsp;Adriaan Vanderstichele ,&nbsp;Kobe Dewilde","doi":"10.1016/j.eurox.2025.100404","DOIUrl":"10.1016/j.eurox.2025.100404","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100404"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison between laparoscopy and hysteroscopy approaches in the treatment of symptomatic isthmocele: A systematic review and meta-analysis","authors":"Zahra Ramezani ,&nbsp;Saba Goodarzi ,&nbsp;Pegah Rashidian ,&nbsp;Shima Mohammadian ,&nbsp;Hadis Rastad ,&nbsp;Mona Esmi ,&nbsp;Arman Shafiee ,&nbsp;Mahmood Bakhtiyari","doi":"10.1016/j.eurox.2025.100405","DOIUrl":"10.1016/j.eurox.2025.100405","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the clinical outcomes of laparoscopy and hysteroscopy in the treatment of symptomatic isthmocele using a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>A comprehensive search of PubMed, Scopus, and Web of Science was performed until November 11, 2024. Studies evaluating outcomes of laparoscopy or hysteroscopy intervention for treating symptomatic isthmocele were included in this study. A random-effects model was employed for heterogeneous data. The study is registered in PROSPERO with registration number CRD420251028603.</div></div><div><h3>Results</h3><div>Nine studies involving 797 patients were included. Hysteroscopy demonstrated significantly less intraoperative blood loss (SMD: −2.28, 95 % CI: −3.65 to −0.90) and shorter hospital stays (SMD: −2.62, 95 % CI: −3.52 to −1.72), but the operative time difference was non-significant. Both approaches were equally effective in symptom resolution and defect repair (OR: 0.80, 95 % CI: 0.21–2.97). However, laparoscopic repair was associated with better outcomes for dysmenorrhea improvement (OR: 3.46, 95 % CI: 1.42–8.45) and higher postoperative pregnancy rates (OR: 4.17, 95 % CI: 1.89–9.09). High heterogeneity was noted in some outcomes, reflecting variability in study designs and populations.</div></div><div><h3>Conclusions</h3><div>Both laparoscopy and hysteroscopy are effective in treating symptomatic isthmocele, with each approach offering distinct advantages. Hysteroscopy is less invasive with faster recovery and better fertility.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100405"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical guidance VVOG: Antenatal care for twin pregnancies","authors":"Senna van der Heijden ,&nbsp;Noortje van Oostrum ,&nbsp;Roxanne Van Nuland ,&nbsp;Magali Verheecke ,&nbsp;Liesbeth Lewi","doi":"10.1016/j.eurox.2025.100414","DOIUrl":"10.1016/j.eurox.2025.100414","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100414"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring woman’s perception of support and control during childbirth: Psychometric proprieties of the SCIB scale in an Italian sample","authors":"Sara Molgora ,&nbsp;Federica Bonazza ,&nbsp;Maurizio Barbieri Carones ,&nbsp;Enrico Maria Ferrazzi ,&nbsp;Elizabeth Ford","doi":"10.1016/j.eurox.2025.100424","DOIUrl":"10.1016/j.eurox.2025.100424","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to develop an Italian version of the Support and Control in Birth (SCIB) and to test its reliability and validity.</div></div><div><h3>Methods</h3><div>The sample included 414 post-partum women, who were recruited 24/48 h after giving birth. A study-specific online questionnaire was designed to collect sociodemographic information and administer the translated Italian version of the SCIB. The construct validity of the Italian SCIB was first analyzed using Confirmatory Factor Analysis (CFA). Based on metrics showing a poor fit, Exploratory Factor Analysis (EFA) was then executed. The reliability of the instrument was verified through Cronbach’s alpha for each subscale and the total scale and test-retest correlation coefficient.</div></div><div><h3>Results</h3><div>CFA was performed to test the original three-factor theoretical model; however, the CFA solution showed a poor fit. Specifically, χ2 = 2100, df= 492, p &lt; 0.001, RMSEA = 0.0888 (0.085 – 0.0928), and CFI = 0.45. The theoretical model did not adequately fit the observed data. Thus, EFA was conducted; it yielded a six-factor structure. The six factors were named: Support: healthcare professionals’ guidance; Support: healthcare professionals’ presence; External control: control over medical procedures; External control: control over the informational process; Internal control: control over emotional and physical reactions; Internal control: control over pain. These factors replicate the originals dimensions, each divided into two further subfactors.</div></div><div><h3>Conclusion</h3><div>Findings enhance knowledge about childbirth by cross-culturally adapting an instrument to assess perceptions of control and support, fundamental factors in birth experience. SCIB could help health professionals to monitor women's childbirth experiences and introduce tailored interventions.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100424"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment strategies for intra-amniotic infection and/or inflammation in preterm labor cases","authors":"Satoshi Yoneda ,&nbsp;Noriko Yoneda ,&nbsp;Hideki Niimi ,&nbsp;Shigeru Saito","doi":"10.1016/j.eurox.2025.100408","DOIUrl":"10.1016/j.eurox.2025.100408","url":null,"abstract":"<div><div>Spontaneous preterm birth (sPTB) is caused by multiple factors; however, the main cause is intra-amniotic infection and/or inflammation. The frequency of intra-amniotic infection/inflammation is higher in extremely sPTB (&lt;28 weeks) and causes long-term cognitive impairments, such as cerebral palsy and mental retardation. The rate of intra-amniotic superinfections, such as <em>Ureaplasma</em>/<em>Mycoplasma</em> and bacteria, is high in sPTB &lt; 27 weeks of gestation. Obstetrical strategies based on accurate information on intra-amniotic infection/inflammation are needed to prevent sPTB (particularly extremely sPTB) and improve the long-term prognosis of preterm infants. Our PCR method, which is sensitive and free from false positives, accurately identifies whether intra-amniotic infection is present. Appropriate antibiotic therapy against intra-amniotic infection (macrolides against <em>Ureaplasma</em>/<em>Mycoplasma</em> and beta-lactams against bacteria) in preterm labor (PTL) cases effectively prolongs the gestational period by 4 weeks. In contrast, the use of antibiotics shortens the gestational period in cases without intra-amniotic infection. We previously reported that 17-alpha-hydroxyprogesterone caproate (17OHP-C) effectively prolonged pregnancy by 4 weeks in PTL cases with mild intra-amniotic inflammation, but not in those with severe intra-amniotic inflammation. Treatment strategies based on accurate intra-amniotic information is expected to prolong pregnancy. However, obstetrical interventions are limited once severe clinical symptoms appear. In addition to the use of drugs to control uterine contractions, antibiotics and/or 17OHP-C may be necessary in the treatment of PTL cases following the accurate assessment of intrauterine infection and/or inflammation is confirmed.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100408"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical guidance paper VVOG-CRGOLFB prevention and management of obstetrical perineal trauma","authors":"Marit Iliaens ,&nbsp;Esther Van Elslander ,&nbsp;Elien Baert ,&nbsp;Emma Bauters ,&nbsp;Lauren Becu ,&nbsp;Laurent de Landsheere ,&nbsp;Katrien De Maeyer ,&nbsp;Charlotte Deltour ,&nbsp;Inge Geraerts ,&nbsp;Susanne Housmans ,&nbsp;Elise Maes ,&nbsp;Mathilde Maskens ,&nbsp;Tinne Mesens ,&nbsp;Bram Packet ,&nbsp;Ann-Sophie Page ,&nbsp;Geert Page ,&nbsp;Inge Tency ,&nbsp;Bart Vergauwe ,&nbsp;Ann Pastijn","doi":"10.1016/j.eurox.2025.100416","DOIUrl":"10.1016/j.eurox.2025.100416","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100416"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprapubic pressure: A marker of cervical insufficiency? A case report","authors":"Athina Efthymiou,&nbsp;Effrosyni Birbas,&nbsp;Theofilos Kanavos,&nbsp;Charikleia Skentou,&nbsp;Nadia Almousa,&nbsp;George Makrydimas","doi":"10.1016/j.eurox.2025.100411","DOIUrl":"10.1016/j.eurox.2025.100411","url":null,"abstract":"","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100411"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal NOTES adnexal surgery: Results of a retrospective cohort study in The Netherlands","authors":"Rebecca Henschen ,&nbsp;Anouk J.M. Bus ,&nbsp;Nicol A.C. Smeets ,&nbsp;Marlies Y. Bongers ,&nbsp;Martine M.L.H. Wassen","doi":"10.1016/j.eurox.2025.100422","DOIUrl":"10.1016/j.eurox.2025.100422","url":null,"abstract":"<div><h3>Objective</h3><div>Vaginal natural orifice transluminal endoscopy (vNOTES) is a minimally invasive technique gaining popularity for several gynaecological procedures. This study presents the first 81 adnexal cases, performed in The Netherlands.</div></div><div><h3>Design, setting, participants, and intervention</h3><div>This retrospective cohort study included patients who underwent vNOTES adnexal surgery for benign indications at Zuyderland Medical Centre between March 2020 and August 2024. Baseline characteristics, surgical outcomes, and per- and postoperative outcomes were analysed. Two expert vaginal and endoscopic gynaecological surgeons performed all procedures.</div></div><div><h3>Results</h3><div>A total of 81 patients underwent adnexal surgery using vNOTES. Indications were definitive contraception (60.5 %; n = 49), ovarian cysts (18.5 %; n = 15), risk-reducing surgery for gene mutation carriers (16.0 %; n = 13), ectopic pregnancy (3.7 %; n = 3), and request for artificial menopause due to complaints (1.2 %; n = 1). Procedures performed were bilateral salpingectomy (60.5 %; n = 49), bilateral salpingo-oophorectomy (28.4 %; n = 23), unilateral salpingo-oophorectomy (4.9 %; n = 4), unilateral salpingectomy (3.7 %; n = 3), unilateral ovariectomy (1.2 %; n = 1), and unilateral salpingo-oophorectomy with unilateral salpingectomy (1.2 %; n = 1). The mean surgical time was 38.7 min (SD 17.9 min), with a mean blood loss of 26 mL (SD 42.4 mL). There was one (1.2 %) conversion to laparoscopy, and two (2.5 %) intra-operative complications without re-interventions. Most patients (88.8 %) were treated in a day-care setting. Four postoperative complications (4.9 %) were reported within six weeks after surgery.</div></div><div><h3>Conclusion</h3><div>This study shows that vNOTES is a safe and feasible, less invasive and scarless alternative to laparoscopic and open surgery for benign adnexal pathology. More evidence is needed to compare vNOTES adnexal surgery with laparoscopy.</div></div><div><h3>Summation</h3><div>vNOTES is a safe and feasible, less invasive alternative without abdominal scars compared to laparoscopic and open abdominal surgery for benign adnexal pathology.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"27 ","pages":"Article 100422"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}