Application of adult stem cells in obstetrics and gynecology: A scoping review

IF 1.5 Q3 OBSTETRICS & GYNECOLOGY

European Journal of Obstetrics and Gynecology and Reproductive Biology: X Pub Date : 2025-01-22 DOI:10.1016/j.eurox.2025.100367

Andi Kurniadi , Muhammad Ary Zucha , Ardhanu Kusumanto , Siti Salima , Ali Budi Harsono

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引用次数: 0

Abstract

Background

Advancements in regenerative medicine have led to the applicability of stem cell technology in various diseases. Stem cells that have self-renewable abilities may differentiate into several cell types to provide therapeutic potential. Among different stem cells, adult stem cells are considered as the safest with remarkable potential for therapeutic application. In this review, we provide current available evidence regarding the application of adult stem cells in medicine, especially in the field of obstetrics and gynecology.

Objective

This scoping review aims to map and describe the current research on adult stem cell application in obstetrics and gynecology.

Methods

We performed a systematic search on PubMed, Google Scholar, and Cochrane Library in August 2024 to identify research articles involving adult stem cells in the field of obstetrics and gynecology. We used the Deduplicate website to filter articles based on keywords that met our inclusion and exclusion criteria. The results were presented based on recommendations from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.

Results

We found 42 articles that met the inclusion criteria. Some studies were clinical studies, whereas the majority were preclinical studies. We categorized the articles into clinical and preclinical studies to understand their applicability in human subjects.

Conclusions

Adult stem cell therapy is a candidate treatment for several pathologies in obstetrics and gynecology. The promising results of adult stem cell therapy, especially in degenerative gynecologic diseases, may lead to further application of the technology in the near future.

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成体干细胞在妇产科中的应用：综述

再生医学的进步使得干细胞技术可以应用于各种疾病。具有自我再生能力的干细胞可以分化成多种细胞类型，以提供治疗潜力。在不同的干细胞中，成体干细胞被认为是最安全的，具有显著的治疗应用潜力。在这篇综述中，我们提供了目前可用的证据关于成体干细胞在医学上的应用，特别是在妇产科领域。目的综述成体干细胞在妇产科中的应用研究现状。方法于2024年8月系统检索PubMed、谷歌Scholar和Cochrane Library，检索涉及成体干细胞在妇产科领域的研究文章。我们使用Deduplicate网站根据符合纳入和排除标准的关键词来过滤文章。结果是根据系统评价的首选报告项目和范围评价的元分析扩展的建议提出的。结果42篇文章符合纳入标准。一些研究是临床研究，而大多数是临床前研究。我们将文章分为临床研究和临床前研究，以了解它们在人类受试者中的适用性。结论成体干细胞治疗是多种妇产科病理的候选治疗方法。成体干细胞治疗，特别是在退行性妇科疾病方面的有希望的结果，可能导致该技术在不久的将来进一步应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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