European Journal of Obstetrics and Gynecology and Reproductive Biology: X最新文献

{"title":"Selective versus routine preoperative testing in minor gynecologic surgical procedures: A two-center comparative cohort study of perioperative outcomes and resource utilization","authors":"Stefano Restaino,&nbsp;Alice Poli,&nbsp;Martina Arcieri,&nbsp;Federico Paparcura,&nbsp;Giulia Pellecchia,&nbsp;Silvia Zermano,&nbsp;Annalisa Graziano,&nbsp;Chiara Paglietti,&nbsp;Emma Bonetti,&nbsp;Federica Bernardini,&nbsp;Eleonora La Fera,&nbsp;Federica Campolo,&nbsp;Valeria Masciullo,&nbsp;Gaetano Draisci,&nbsp;Stefano Catarci,&nbsp;Teresa Dogareschi,&nbsp;Anna Biasioli,&nbsp;Tiziana Bove,&nbsp;Lorenza Driul,&nbsp;Francesco Fanfani,&nbsp;Ursula Catena","doi":"10.1016/j.eurox.2026.100487","DOIUrl":"10.1016/j.eurox.2026.100487","url":null,"abstract":"<div><h3>Background</h3><div>Routine preoperative testing remains common in minor gynaecological surgery, offering opportunities to reduce costs by avoiding unnecessary tests.</div></div><div><h3>Objectives</h3><div>To compare the clinical safety and cost impact of selective versus routine preoperative laboratory testing in women undergoing minor gynecologic surgical procedures.</div></div><div><h3>Methods</h3><div>Retrospective two-center comparative cohort study in two tertiary gynecologic centers adopting different preoperative testing policies. A total of 5240 consecutive women undergoing elective minor gynecologic surgical procedures for benign gynecologic pathology were included. Patients were managed according to two different preoperative strategies: routine laboratory testing (Roma cohort) and selective testing based on clinical assessment and comorbidity (Udine cohort). The study aims to compare perioperative outcomes and healthcare costs between routine and selective preoperative testing strategies.</div></div><div><h3>Outcomes</h3><div>Intraoperative and postoperative complications, healthcare costs in two groups.</div></div><div><h3>Results</h3><div>Postoperative complications were infrequent in both cohorts and did not differ significantly between routine and selective testing strategies (p = 0.345). In multivariable logistic regression analysis, selective testing was not independently associated with postoperative complications (p = 0.345). Independent predictors of complications included age (p = 0.041), ASA score ≥ 3 (p = 0.021), and operative time (p = 0.050). Selective testing was associated with a significant reduction in preoperative laboratory costs without negatively affecting perioperative safety.</div></div><div><h3>Conclusion</h3><div>In minor gynecologic surgical procedures, selective preoperative laboratory testing based on clinical evaluation appears to be as safe as routine testing while reducing healthcare expenditures.</div></div><div><h3>What is new?</h3><div>A more tailored and guideline-concordant preoperative assessment strategy in minor gynecologic surgery may reduce healthcare expenditure.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"31 ","pages":"Article 100487"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep infiltrating endometriosis-related quality of life after laparoscopic excision: A prospective cohort study from Latin America using validated questionnaires","authors":"Agustina Lucila Larrea,&nbsp;Edwin Gomez Ibarra,&nbsp;Carolina Rendon Restrepo,&nbsp;Lila Cuesta Roa,&nbsp;Diego Fernando Rojas-Gualdron,&nbsp;Elsa Maria Vasquez Trespalacios,&nbsp;Sergio Adrian Terrasa,&nbsp;Claudia López Ruiz,&nbsp;Victorio Tomas Viglierchio,&nbsp;Jose Fernando de los Rios","doi":"10.1016/j.eurox.2026.100485","DOIUrl":"10.1016/j.eurox.2026.100485","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep infiltrating endometriosis (DIE) is associated with substantial impairment in health-related quality of life (HRQoL), affecting pain, emotional well-being, sexual functioning, and daily activities. Previous studies have shown that laparoscopic surgical excision may improve HRQoL in women with symptomatic DIE. However, evidence simultaneously assessing disease-specific and generic HRQoL using minimal clinically important differences (MCID) -based interpretation in Latin American women with DIE remains limited. We therefore aimed to evaluate changes in HRQoL at 6 and 12 months after laparoscopic excision of DIE in two high-volume Latin American referral centers, using the Endometriosis Health Profile-30 (EHP-30), including its sexual intercourse module, and the EuroQol-5D (EQ-5D), applying their MCID thresholds.</div></div><div><h3>Materials and Methods</h3><div>This prospective cohort study was conducted at two academic referral centers in Colombia and Argentina between 2021 and 2023. Women with imaging-confirmed deep infiltrating endometriosis undergoing laparoscopic excision after failed medical therapy, or as first-line treatment due to organ involvement, were included. HRQoL was assessed preoperatively and at 6 and 12 months postoperatively using the validated EHP-30, including its sexual intercourse module, and EQ-5D questionnaires. Surgical findings were classified using the Enzian classification system, complications according to Clavien–Dindo, and HRQoL changes were interpreted using established MCID thresholds.</div></div><div><h3>Results</h3><div>Of 159 eligible patients, 120 completed baseline and at least one postoperative assessment. Mean age was 36.7 years, and 47.5% had previous endometriosis surgery. At 6 months, all EHP-30 domains improved significantly (p &lt; .001), with the greatest median reductions in pain (−29.54; 95% CI, −36.36 to −27.27), control and powerlessness (−29.17; 95% CI, −41.66 to −20.83), and sexual functioning (−20.00; 95% CI, −30 to −10). Improvements were sustained at 12 months, with changes meeting or exceeding the published MCID thresholds in all domains, except control and powerlessness, which fell just short of one of the two available thresholds. The EQ-5D index improved at 6 months (+0.28; 95% CI, 0.21–0.42) and 12 months (+0.35; 95% CI, 0.18–0.42; both p &lt; .001), exceeding the proposed MCID at both timepoints. Major postoperative complications (Clavien–Dindo grade ≥ III) occurred in 8.3% of patients.</div></div><div><h3>Conclusion</h3><div>This Latin American cohort showed sustained, clinically meaningful improvements in multiple HRQoL domains, including sexual functioning, after laparoscopic excision of DIE. Interpreting changes from validated disease-specific and generic instruments against MCID thresholds supports the role of surgical excision in symptomatic DIE refractory to medical therapy.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"31 ","pages":"Article 100485"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of hysterosalpingo-contrast sonography with Sonazoid®: a single-center experience","authors":"Jun Kitazawa,&nbsp;Hiromi Kawaguchi,&nbsp;Izumi Suganuma,&nbsp;Kounosuke Suzuki,&nbsp;Koichi Takebayashi","doi":"10.1016/j.eurox.2026.100488","DOIUrl":"10.1016/j.eurox.2026.100488","url":null,"abstract":"<div><h3>Objective</h3><div>This study describes the examination procedure and clinical outcomes of hysterosalpingo-contrast sonography (HyCoSy) with perflubutane used as the ultrasound contrast agent for tubal patency evaluation.</div></div><div><h3>Methods</h3><div>Infertile women who attended our clinic between May and December 2023 were assessed. HyCoSy using perflubutane (Sonazoid®) was performed between the end of menstruation and ovulation, after confirmation of the absence of bacterial vaginosis and chlamydia infection. Following insertion of an 8-Fr balloon catheter into the uterine cavity, a diluted perflubutane contrast was slowly infused under transvaginal ultrasonographic guidance. Tubal patency and intraperitoneal spillage was evaluated using color Doppler imaging. Thereafter, clinical characteristics, adverse events, and pregnancy outcomes up to December 2024 were retrospectively analyzed using medical records.</div></div><div><h3>Results</h3><div>A total of 100 patients underwent HyCoSy using perflubutane between May and December 2023. Of them, 94 had confirmed bilateral tubal patency; 5, unilateral patency; and 1, bilateral tubal occlusion. One patient experienced mild abdominal pain during the procedure; no other adverse events occurred. Among the 90 patients who were followed after the examination, 24 achieved pregnancies through timed intercourse, 7 through intrauterine insemination, and 32 through in vitro fertilization.</div></div><div><h3>Conclusions</h3><div>HyCoSy using perflubutane is a safe, simple, and effective method for tubal patency evaluation that does not involve radiation exposure or pose iodine-related risks. This technique may serve as a valuable alternative to conventional hysterosalpingography for the initial evaluation of infertile women.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"31 ","pages":"Article 100488"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sophisticated predictive framework for identifying obstructive sleep apnea syndrome in women with obesity during pregnancy","authors":"Chen Jiang,&nbsp;Hong Zhou,&nbsp;Jiao Yi,&nbsp;Xianxia Chen","doi":"10.1016/j.eurox.2026.100465","DOIUrl":"10.1016/j.eurox.2026.100465","url":null,"abstract":"<div><h3>Objective</h3><div>To develop a risk prediction model of obstructive sleep apnea syndrome (OSAS) in obese pregnant women in order to facilitate early intervention.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed polysomnography confirmed OSAS cases (n = 828) from Hefei Maternal and Child Health Hospital (Jan 1st,2023-Jan 1st,2025). Cases were classified according to the onset of the OSAS during pregnancy: non-occurrence (n = 526) and occurrence (n = 302). Predictive factors were determined using univariate logistic regression (<em>P</em> &lt; 0.1), LASSO regularization (λ = 0.007) and multivariate logistic regression.</div></div><div><h3>Results</h3><div>Five independent predictors were identified: tongue size, sleep position, neck circumference, Berlin Questionnaire score and Epworth Sleepiness Scale score. The model was found to have an area under the curve (AUC) of 0.811, good calibration (Hosmer-Lemeshow <em>P</em> = 0.275), low average absolute error (0.017), and net clinical benefit across risk thresholds (0.04–0.95).</div></div><div><h3>Conclusion</h3><div>This five-variable model is a reliable predictor of the risk of OSAS in obese pregnant women and is useful for timely prenatal screening, risk stratification, and early management.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"30 ","pages":"Article 100465"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The benefits of testosterone therapy for menopausal symptoms","authors":"Jillian Chan ,&nbsp;Julia Cunningham ,&nbsp;Colin Cunningham ,&nbsp;John Cunningham ,&nbsp;Catherine Cunningham","doi":"10.1016/j.eurox.2025.100440","DOIUrl":"10.1016/j.eurox.2025.100440","url":null,"abstract":"<div><h3>Objectives</h3><div>This study will address the effects of testosterone pellet therapy in menopausal women treated over a ten-year period.</div></div><div><h3>Study design</h3><div>A retrospective review of a single gynecologic practice was performed to evaluate patients treated with subcutaneous testosterone pellet therapy for androgen deficiency. Consent was obtained from all patients before pellet placement. Women completed a menopause rating scale (MRS) questionnaire prior to starting therapy and before the third pellet placement. Patients were treated every 3 months. Blood work was obtained prior to treatment, before the third pellet insertion and then yearly. Non-parametric analysis was performed using the Wilcoxon signed-rank test and the Bonferroni test was used to correct for comparisons across multiple domains. A p value of less than 0.05 was considered significant.</div></div><div><h3>Main outcome measures</h3><div>Scores on the MRS were calculated as medians and compared from the initial MRS to the subsequent MRS questionnaire. Patient’s age and peak testosterone levels were used to evaluate the effect of therapy on menopausal symptoms. Side effects from therapy were noted at follow-up visits.</div></div><div><h3>Results</h3><div>There were 78 patients who completed both MRS questionnaires. A comparison of results from the initial and subsequent MRS questionnaire showed that median scores were significantly reduced in all eleven categories of symptoms. Scores improved in all categories of patient age and peak testosterone levels. The most common side effects were acne and facial hair. These were treated with dose reduction and or spironolactone therapy.</div></div><div><h3>Conclusions</h3><div>The use of testosterone pellet therapy in women with androgen deficiency results in rapid and sustained relief of menopausal symptoms in all age groups and at all testosterone levels. Further studies are needed to optimize the use of testosterone in women with menopausal symptoms.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"29 ","pages":"Article 100440"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pregnancy outcomes using a novel hysterosalpingography scoring system for tubal patency","authors":"Huijun Yang ,&nbsp;Yali Xu ,&nbsp;Saiming Cheng ,&nbsp;Haixia Zhang ,&nbsp;Jiejun Cheng ,&nbsp;Feng Gao","doi":"10.1016/j.eurox.2025.100437","DOIUrl":"10.1016/j.eurox.2025.100437","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate pregnancy rates using a novel classification system based on hysterosalpingography (HSG) findings, categorizing tubal patency as either patent or functionally deficient. Furthermore, the study assesses the predictive value of this scoring system for fertility outcomes.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted involving 4461 patients who underwent HSG at an academic radiology center between January 2020 and December 2022. HSG findings and subsequent pregnancy outcomes were systematically analyzed.</div></div><div><h3>Results</h3><div>Of the 2461 patients initially followed up, 301 were excluded due to incomplete data, resulting in a final cohort of 2160 patients. Within two years post-HSG, 970 patients (44.9 %) achieved natural pregnancy, 808 (83.2 %) of whom resulted in live births. In vitro fertilization (IVF) pregnancies accounted for 35.8 % (n = 775). Ectopic pregnancies occurred in 1.8 % of patients, with a higher incidence in those with unilateral tubal occlusion. Using the novel scoring system—where Score 0 indicates bilateral patency, Score 1 indicates unilateral functional deficiency, and Score 2 indicates bilateral functional deficiency—the Score 0 group exhibited the highest natural pregnancy rate (51.1 %), which was significantly higher than that of the Score 1 and Score 2 groups. Natural pregnancy rates were 20.8 % for unilateral hydrosalpinx and 36.7 % for unilateral occlusion. Only 5 % of patients with bilateral hydrosalpinx conceived naturally. Age was a significant factor; women under 35 years had a natural pregnancy rate of 46.8 %, compared to 10.2 % in those over 40 years.</div></div><div><h3>Conclusion</h3><div>Tubal patency status is significantly associated with pregnancy outcomes, and functional deficiencies appear to reduce fertility. The proposed HSG-based scoring system serves as a valuable predictive tool for pregnancy potential. Additionally, the presence of hydrosalpinx is associated with adverse pregnancy rates.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"29 ","pages":"Article 100437"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145665556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvaginal radiofrequency ablation for uterine myomas: A preliminary ecuadorian study","authors":"Hernan Sabay ,&nbsp;Maritza Freire ,&nbsp;Belen Tite ,&nbsp;Eduardo Pilatuna ,&nbsp;Paola Solis- Pazmino","doi":"10.1016/j.eurox.2025.100443","DOIUrl":"10.1016/j.eurox.2025.100443","url":null,"abstract":"<div><h3>Background</h3><div>Transvaginal radiofrequency ablation (TVRFA) is a minimally invasive, incisionless, outpatient procedure. This study evaluates the feasibility, outcomes, and complications of TVRFA in women with symptomatic uterine myomas (UMs).</div></div><div><h3>Methods</h3><div>This preliminary single-center, retrospective study included 79 women treated with TVRFA between December 2021 and April 2024 in Quito, Ecuador. Women with 1–4 UMs of any size or type were eligible. Preoperative and follow-up assessments included transvaginal ultrasound (TVUS) for both uterine and myoma volume. Outcomes (uterine and myoma volume + complications) were assessed at 45 days and 6 months. Complications were classified by Clavien–Dindo. Statistical analyses used paired tests for baseline vs. follow-up comparisons, with missing data excluded from each analysis.</div></div><div><h3>Results</h3><div>The median baseline uterine volume was 160.0 mL. At 6 months, this decreased to 91.0 mL (−43.1 %, p &lt; 0.001). The median baseline myoma volume was 22.5 mL, which decreased to 7.7 mL at 45 days (−55.1 %) and 3.7 mL at 6 months (−81.5 %, p &lt; 0.001). Follow-up was completed by 68/79 patients (86.1 %) at 45 days and 59/79 (74.7 %) at 6 months. Minor complications occurred in 12.7 %, most commonly skin burns at the electrode site. Two patients (2.5 %) experienced intestinal perforation requiring surgery.</div></div><div><h3>Conclusion</h3><div>TVRFA significantly reduced both uterine and myoma volumes, supporting its role as a minimally invasive alternative for fibroid management. However, the observed complication rate, particularly intestinal perforation, requires critical attention to operator training and procedural refinements. Prospective studies with standardized symptom measures are warranted.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"29 ","pages":"Article 100443"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of obesity on perioperative outcomes in robot-assisted surgery for endometrial cancer: A single-center study of 119 cases","authors":"Yasushi Iida ,&nbsp;Miwako Shimazaki ,&nbsp;Ayane Kosuge ,&nbsp;Takahiro Matsunami ,&nbsp;Kosuke Kato ,&nbsp;Teppei Ichikawa ,&nbsp;Taichi Irie ,&nbsp;Makoto Iizuka ,&nbsp;Daishi Hirano ,&nbsp;Satoshi Takakura","doi":"10.1016/j.eurox.2026.100446","DOIUrl":"10.1016/j.eurox.2026.100446","url":null,"abstract":"<div><h3>Introduction</h3><div>Whether obesity (body mass index [BMI] ≥30 kg/m²) independently affects perioperative outcomes in robot-assisted surgery for endometrial cancer remains uncertain.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective single-center cohort including 119 consecutive patients who underwent a uniform robotic procedure—total hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy using the da Vinci Xi system—between November 2018 and June 2025. Patients were grouped by BMI ≥ 30 (n = 32) versus &lt; 30 (n = 87). Outcomes were estimated blood loss (EBL), operative time, lymph-node yield, and length of stay (LOS). Multivariable linear regression adjusted for age, prior abdominal/pelvic surgery, comorbidity history (diabetes, hypertension, dyslipidemia), operating surgeon, and surgical year (2018–2020 vs 2021–2025).</div></div><div><h3>Results</h3><div>BMI ≥ 30 was independently associated with higher EBL and longer operative time, and prior surgery also prolonged operative time. Surgeon effects were pronounced for efficiency and nodal retrieval; BMI was not associated with lymph-node yield. LOS was not associated with BMI; however, LOS was higher in later surgical years and varied by surgeon.</div></div><div><h3>Conclusion</h3><div>In standardized robot-assisted endometrial cancer surgery, obesity increased intraoperative workload (blood loss and operative time) without reducing lymph-node yield. LOS reflected surgeon- and time-related factors rather than BMI. These findings support the feasibility of robotic surgery in patients with obesity and underscore the importance of surgeon experience, pathway fidelity, and ongoing quality improvement.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"29 ","pages":"Article 100446"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted metabolomics and fatty acid profiling in lean and obese polycystic ovarian syndrome patients: A pilot study","authors":"Emilin Zacharias ,&nbsp;Rukmini Mysore Srikantiah ,&nbsp;Sindhu H ,&nbsp;Shraddha Shetty K ,&nbsp;Aparna Rajesh Bhat ,&nbsp;Shrinath Pratap Shetty ,&nbsp;Sonali Ullal ,&nbsp;Himani Kotian ,&nbsp;Varashree B.S ,&nbsp;YS Phaneendra Mallimoggala","doi":"10.1016/j.eurox.2026.100445","DOIUrl":"10.1016/j.eurox.2026.100445","url":null,"abstract":"<div><h3>Introduction</h3><div>Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting approximately 10 % of women globally, with variations in prevalence across geographic regions. It is strongly associated with metabolic disturbances causing dyslipidaemia, increased risk for diabetes and cardiovascular diseases. This study investigates the metabolic implications of body mass index (BMI) in PCOS, focusing on targeted metabolomics and fatty acid profiling.</div></div><div><h3>Methodology</h3><div>23 PCOS patients and 12 normal healthy female participants in the age group 17–35 years were recruited. PCOS was diagnosed based on revised Rotterdam criteria and classified into respective phenotypes. PCOS patients were further categorized into lean (n = 15) and obese (n = 8) groups based on BMI. Absolute quantification of fatty acids was done by Gas Chromatography (GC)-mass spectrometry (MS). ANOVA was used to compare between the PCOS subgroups. Metabolic enrichment pathway analysis was used for the identified fatty acids.</div></div><div><h3>Results</h3><div>Significantly different fatty acid profiles were observed between the PCOS and control groups. Elevated level of hexadecenoic acid (8.819 ± 2.63 µg/mL) was found in PCOS subjects compared to controls. Cis-10-heptadecenoic acid levels were highest in control (59.8 ± 3.17 µg/mL) and lean PCOS (59.0 ± 3.35 µg/mL) subjects. The phenotype B demonstrated significantly higher levels of 9-hexadecenoic acid (13.576 ± 0.132 µg/mL) than other phenotypes. Functional enrichment analysis and Variable Importance in Projection (VIP) score calculation revealed dysregulated very long-chain fatty acid oxidation, fatty acid biosynthesis, and arachidonic acid metabolism in PCOS.</div></div><div><h3>Conclusion</h3><div>Fatty acid profiling and metabolic analysis showed dysregulation between PCOS subjects based on BMI. The lean PCOS could be more involved with hormonal regulation than the adipocyte dysfunction.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"29 ","pages":"Article 100445"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of umbilical cord venoarterial differences, ΔpH, to morbidity and mortality up to 20 years of follow-up: A cohort study","authors":"Tiia-Marie Sundberg ,&nbsp;Karin Källén ,&nbsp;Mehreen Zaigham","doi":"10.1016/j.eurox.2026.100447","DOIUrl":"10.1016/j.eurox.2026.100447","url":null,"abstract":"<div><h3>Introduction</h3><div>Umbilical cord blood measurement is the gold standard of evaluating neonatal metabolic status at birth. Dual sampling of cord blood vessels is clinical routine, yet the long-term value of venoarterial differences (ΔpH) is undetermined. The objective was to investigate the association of ΔpH, to long-term mortality and morbidity up to 20 years.</div></div><div><h3>Material and methods</h3><div>This was a retrospective cohort study with singleton births 1997–2012 at Skåne University hospital, Malmö, Sweden. Validated umbilical cord blood records were crosslinked to data from high quality national registers. Hazard ratios (HR) for diagnosis according to International Classification of Disease version 10 (00−99) during the follow-up period were calculated for the ≤ 10th/10th–90th/≥ 90th percentiles of ΔpH, adjusted for maternal age, smoking, body mass index, parity and gestational age.</div></div><div><h3>Results</h3><div>The study population was comprised of 35 171 births meeting the inclusion criteria after validation. Of the included births 4 956/14.1% had a small ΔpH (≤0.040), 26 690/75.9% normal ΔpH (0.041–0.150) and 3 525/10.0% large ΔpH (≥0.151). HR were statistically significant for small ΔpH for diseases of the eye and adnexa, crude HR:1.095 (95%CI:1.021–1.175), adjusted HR:1.081 (95%CI 1.007–1.160). No other organ system diseases were associated with small/large ΔpH.</div></div><div><h3>Conclusion</h3><div>ΔpH showed no strong long-term association of increased risk of organ-system related morbidity or mortality with twenty years of follow-up time. Multiple comparison may explain statistically significant finding of HR diseases of the eye and adnexa. Dual umbilical cord blood sampling remains vital clinically, ensuring correct sampling.</div></div>","PeriodicalId":37085,"journal":{"name":"European Journal of Obstetrics and Gynecology and Reproductive Biology: X","volume":"29 ","pages":"Article 100447"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}